{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T21:00:36Z","timestamp":1773522036103,"version":"3.50.1"},"reference-count":42,"publisher":"e-Century Publishing Corporation","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/dieo8870","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T03:36:55Z","timestamp":1717385815000},"page":"2011-2023","source":"Crossref","is-referenced-by-count":1,"title":["Metal copper and silver revealed potent antimicrobial activity for treating Caenorhabditis elegans infected with carbapenemase-producing Klebsiella pneumonia"],"prefix":"10.62347","volume":"16","author":[{"given":"Ling","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/nature.2017.21550","article-title":"The drug-resistant bacteria that pose the greatest health threats","volume":"543","author":"Willyard","year":"2017","unstructured":"Willyard C. The drug-resistant bacteria that pose the greatest health threats. Nature 2017; 543: 15.","journal-title":"Nature"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"147464","DOI":"10.1016\/j.scitotenv.2021.147464","article-title":"Hormetic dose-responses for silver antibacterial compounds, quorum sensing inhibitors, and their binary mixtures on bacterial resistance of Escherichia coli","volume":"786","author":"Shen","year":"2021","unstructured":"Shen H, Liu Y, Liu Y, Duan Z, Wu P, Lin Z and Sun H. Hormetic dose-responses for silver antibacterial compounds, quorum sensing inhibitors, and their binary mixtures on bacterial resistance of Escherichia coli. Sci Total Environ 2021; 786: 147464.","journal-title":"Sci Total Environ"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s12011-020-02143-6","article-title":"In vivo and in vitro assessments of the antibacterial potential of chitosan-silver nanocomposite against methicillin-resistant staphylococcus aureus-induced infection in rats","volume":"199","author":"Hassanen","year":"2021","unstructured":"Hassanen EI and Ragab E. In vivo and in vitro assessments of the antibacterial potential of chitosan-silver nanocomposite against methicillin-resistant staphylococcus aureus-induced infection in rats. Biol Trace Elem Res 2021; 199: 244-257.","journal-title":"Biol Trace Elem Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"7147","DOI":"10.3390\/ma15207147","article-title":"Antibacterial activity of copper particles embedded in knitted fabrics","volume":"15","author":"Ivanauskas","year":"2022","unstructured":"Ivanauskas R, Bronusiene A, Ivanauskas A, &#x160;arkinas A and Ancutiene I. Antibacterial activity of copper particles embedded in knitted fabrics. Materials (Basel) 2022; 15: 7147.","journal-title":"Materials (Basel)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ijpharm.2016.06.121","article-title":"Bactericidal effect of graphene oxide\/Cu\/Ag nanoderivatives against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus","volume":"511","author":"Jankauskait&#x13F","year":"2016","unstructured":"Jankauskait&#x13F; V, Vitkauskien&#x13F; A, Lazauskas A, Baltrusaitis J, Prosy&#x13F;evas I and Andrulevi&#x13F;ius M. Bactericidal effect of graphene oxide\/Cu\/Ag nanoderivatives against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus. Int J Pharm 2016; 511: 90-97.","journal-title":"Int J Pharm"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.biomaterials.2014.12.022","article-title":"A dual function of copper in designing regenerative implants","volume":"44","author":"Burghardt","year":"2015","unstructured":"Burghardt I, L&#xFC;then F, Prinz C, Kreikemeyer B, Zietz C, Neumann HG and Rychly J. A dual function of copper in designing regenerative implants. Biomaterials 2015; 44: 36-44.","journal-title":"Biomaterials"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1159\/000348572","article-title":"In vitro activity of doripenem plus fosfomycin against drug-resistant clinical blood isolates","volume":"91","author":"Lingscheid","year":"2013","unstructured":"Lingscheid T, Tobudic S, Poeppl W, Mitteregger D and Burgmann H. In vitro activity of doripenem plus fosfomycin against drug-resistant clinical blood isolates. Pharmacology 2013; 91: 214-218.","journal-title":"Pharmacology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"116602","DOI":"10.1016\/j.envpol.2021.116602","article-title":"Towards a general model for predicting minimal metal concentrations co-selecting for antibiotic resistance plasmids","volume":"275","author":"Arya","year":"2021","unstructured":"Arya S, Williams A, Reina SV, Knapp CW, Kreft JU, Hobman JL and Stekel DJ. Towards a general model for predicting minimal metal concentrations co-selecting for antibiotic resistance plasmids. Environ Pollut 2021; 275: 116602.","journal-title":"Environ Pollut"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1557\/s43579-022-00294-2","article-title":"Copper-carbon hybrid nanoparticles as antimicrobial additives","volume":"12","author":"Coley","year":"2022","unstructured":"Coley WC, Akhavi A, Sandu C, Pena PA, Lee I, Ozkan M and Ozkan CS. Copper-carbon hybrid nanoparticles as antimicrobial additives. MRS Commun 2022; 12: 1197-1203.","journal-title":"MRS Commun"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"142","DOI":"10.2341\/07-50","article-title":"Anticariogenic and antibacterial properties of a copper varnish using an in vitro microbial caries model","volume":"33","author":"Thneibat","year":"2008","unstructured":"Thneibat A, Fontana M, Cochran MA, Gonzalez-Cabezas C, Moore BK, Matis BA and Lund MR. Anticariogenic and antibacterial properties of a copper varnish using an in vitro microbial caries model. Oper Dent 2008; 33: 142-148.","journal-title":"Oper Dent"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1289\/ehp.1104782","article-title":"Wind of change challenges toxicological regulators","volume":"120","author":"Tralau","year":"2012","unstructured":"Tralau T, Riebeling C, Pirow R, Oelgeschl&#xE4;ger M, Seiler A, Liebsch M and Luch A. Wind of change challenges toxicological regulators. Environ Health Perspect 2012; 120: 1489-1494.","journal-title":"Environ Health Perspect"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Nass R and Hamza I. The nematode C. elegans as an animal model to explore toxicology in vivo: solid and axenic growth culture conditions and compound exposure parameters. Curr Protoc Toxicol 2007; Chapter 1: Unit1.9.","DOI":"10.1002\/0471140856.tx0109s31"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/978-1-4939-8549-4_23","article-title":"Challenges for integrating immunotoxicology into the twenty-first-century toxicology testing paradigm","volume":"1803","author":"Karmaus","year":"2018","unstructured":"Karmaus PWF and Karmaus AL. Challenges for integrating immunotoxicology into the twenty-first-century toxicology testing paradigm. Methods Mol Biol 2018; 1803: 385-396.","journal-title":"Methods Mol Biol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.copbio.2017.01.008","article-title":"elegans and its bacterial diet as a model for systems-level understanding of host-microbiota interactions","volume":"46","author":"Zhang","year":"2017","unstructured":"Zhang J, Holdorf AD and Walhout AJ. C. elegans and its bacterial diet as a model for systems-level understanding of host-microbiota interactions. Curr Opin Biotechnol 2017; 46: 74-80.","journal-title":"Curr Opin Biotechnol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1021\/acs.chemrestox.9b00489","article-title":"Toxicity and gene expression profiling of copper- and titanium-based nanoparticles using air-liquid interface exposure","volume":"33","author":"Hufnagel","year":"2020","unstructured":"Hufnagel M, Schoch S, Wall J, Strauch BM and Hartwig A. Toxicity and gene expression profiling of copper- and titanium-based nanoparticles using air-liquid interface exposure. Chem Res Toxicol 2020; 33: 1237-1249.","journal-title":"Chem Res Toxicol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1242\/dev.116.3.755","article-title":"elegans","volume":"116","author":"Beanan","year":"1992","unstructured":"Beanan MJ and Strome S. Characterization of a germ-line proliferation mutation in C. elegans. Development 1992; 116: 755-766.","journal-title":"Development"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1126\/science.1073759","article-title":"A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity","volume":"297","author":"Kim","year":"2002","unstructured":"Kim DH, Feinbaum R, Alloing G, Emerson FE, Garsin DA, Inoue H, Tanaka-Hino M, Hisamoto N, Matsumoto K, Tan MW and Ausubel FM. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 2002; 297: 623-626.","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.chemosphere.2014.01.078","article-title":"Comparative toxicity of silver nanoparticles on oxidative stress and DNA damage in the nematode, Caenorhabditis elegans","volume":"108","author":"Ahn","year":"2014","unstructured":"Ahn JM, Eom HJ, Yang X, Meyer JN and Choi J. Comparative toxicity of silver nanoparticles on oxidative stress and DNA damage in the nematode, Caenorhabditis elegans. Chemosphere 2014; 108: 343-352.","journal-title":"Chemosphere"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1258\/002367700780578055","article-title":"Euthanasia of rats with carbon dioxide--animal welfare aspects","volume":"34","author":"Hackbarth","year":"2000","unstructured":"Hackbarth H, K&#xFC;ppers N and Bohnet W. Euthanasia of rats with carbon dioxide--animal welfare aspects. Lab Anim 2000; 34: 91-96.","journal-title":"Lab Anim"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00204-011-0759-1","article-title":"Subacute oral toxicity investigation of nanoparticulate and ionic silver in rats","volume":"86","author":"Hadrup","year":"2012","unstructured":"Hadrup N, Loeschner K, Bergstr&#xF6;m A, Wilcks A, Gao X, Vogel U, Frandsen HL, Larsen EH, Lam HR and Mortensen A. Subacute oral toxicity investigation of nanoparticulate and ionic silver in rats. Arch Toxicol 2012; 86: 543-551.","journal-title":"Arch Toxicol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"667062","DOI":"10.3389\/fgene.2021.667062","article-title":"elegans infection model","volume":"12","author":"Diamandas","year":"2021","unstructured":"Diamandas A, Razon MR, Ramirez-Arcos S and Brassinga AKC. The virulence of S. marcescens strains isolated from contaminated blood products is divergent in the C. elegans infection model. Front Genet 2021; 12: 667062.","journal-title":"Front Genet"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ijpddr.2017.11.004","article-title":"elegans and parasitic nematodes","volume":"8","author":"Partridge","year":"2018","unstructured":"Partridge FA, Brown AE, Buckingham SD, Willis NJ, Wynne GM, Forman R, Else KJ, Morrison AA, Matthews JB, Russell AJ, Lomas DA and Sattelle DB. An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes. Int J Parasitol Drugs Drug Resist 2018; 8: 8-21.","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/s42003-021-02863-y","article-title":"elegans while improving locomotion and longevity","volume":"4","author":"Huang","year":"2021","unstructured":"Huang Q, Li R, Yi T, Cong F, Wang D, Deng Z and Zhao YL. Phosphorothioate-DNA bacterial diet reduces the ROS levels in C. elegans while improving locomotion and longevity. Commun Biol 2021; 4: 1335.","journal-title":"Commun Biol"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Back P, Braeckman BP and Matthijssens F. ROS in aging Caenorhabditis elegans: damage or signaling? Oxid Med Cell Longev 2012; 2012: 608478.","DOI":"10.1155\/2012\/608478"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/j.tiv.2015.06.009","article-title":"Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells","volume":"29","author":"Zijno","year":"2015","unstructured":"Zijno A, De Angelis I, De Berardis B, Andreoli C, Russo MT, Pietraforte D, Scorza G, Degan P, Ponti J, Rossi F and Barone F. Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells. Toxicol In Vitro 2015; 29: 1503-1512.","journal-title":"Toxicol In Vitro"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.3390\/nano5031163","article-title":"Nanotoxicity: an interplay of oxidative stress, inflammation and cell death","volume":"5","author":"Khanna","year":"2015","unstructured":"Khanna P, Ong C, Bay BH and Baeg GH. Nanotoxicity: an interplay of oxidative stress, inflammation and cell death. Nanomaterials (Basel) 2015; 5: 1163-1180.","journal-title":"Nanomaterials (Basel)"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"994","DOI":"10.3109\/17435390.2014.993345","article-title":"Metabolomics reveals the perturbations in the metabolome of Caenorhabditis elegans exposed to titanium dioxide nanoparticles","volume":"9","author":"Ch","year":"2015","unstructured":"Ratnasekhar Ch, Sonane M, Satish A and Mudiam MK. Metabolomics reveals the perturbations in the metabolome of Caenorhabditis elegans exposed to titanium dioxide nanoparticles. Nanotoxicology 2015; 9: 994-1004.","journal-title":"Nanotoxicology"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"111637","DOI":"10.1016\/j.jphotobiol.2019.111637","article-title":"Protective effect of neglected plant Diplocyclos palmatus on quorum sensing mediated infection of Serratia marcescens and UV-A induced photoaging in model Caenorhabditis elegans","volume":"201","author":"Alexpandi","year":"2019","unstructured":"Alexpandi R, Prasanth MI, Ravi AV, Balamurugan K, Durgadevi R, Srinivasan R, De Mesquita JF and Pandian SK. Protective effect of neglected plant Diplocyclos palmatus on quorum sensing mediated infection of Serratia marcescens and UV-A induced photoaging in model Caenorhabditis elegans. J Photochem Photobiol B 2019; 201: 111637.","journal-title":"J Photochem Photobiol B"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3002","DOI":"10.1016\/j.bbagen.2016.09.029","article-title":"Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells","volume":"1861","author":"Thangamani","year":"2017","unstructured":"Thangamani S, Eldesouky HE, Mohammad H, Pascuzzi PE, Avramova L, Hazbun TR and Seleem MN. Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells. Biochim Biophys Acta Gen Subj 2017; 1861: 3002-3010.","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/nature03193","article-title":"Navigating chemical space for biology and medicine","volume":"432","author":"Lipinski","year":"2004","unstructured":"Lipinski C and Hopkins A. Navigating chemical space for biology and medicine. Nature 2004; 432: 855-861.","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Projan SJ and Shlaes DM. Antibacterial drug discovery: is it all downhill from here? Clin Microbiol Infect 2004; 10 Suppl 4: 18-22.","DOI":"10.1111\/j.1465-0691.2004.1006.x"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/ng.2201","article-title":"Self-fertilization sweeps up variation in the worm genome","volume":"44","author":"Phillips","year":"2012","unstructured":"Phillips PC. Self-fertilization sweeps up variation in the worm genome. Nat Genet 2012; 44: 237-238.","journal-title":"Nat Genet"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.coi.2018.06.003","article-title":"Caenorhabditis elegans in high-throughput screens for anti-infective compounds","volume":"54","author":"Peterson","year":"2018","unstructured":"Peterson ND and Pukkila-Worley R. Caenorhabditis elegans in high-throughput screens for anti-infective compounds. Curr Opin Immunol 2018; 54: 59-65.","journal-title":"Curr Opin Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"10892","DOI":"10.1073\/pnas.191378698","article-title":"A simple model host for identifying Gram-positive virulence factors","volume":"98","author":"Garsin","year":"2001","unstructured":"Garsin DA, Sifri CD, Mylonakis E, Qin X, Singh KV, Murray BE, Calderwood SB and Ausubel FM. A simple model host for identifying Gram-positive virulence factors. Proc Natl Acad Sci U S A 2001; 98: 10892-10897.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/S0960-9822(02)00928-4","article-title":"elegans","volume":"12","author":"Mallo","year":"2002","unstructured":"Mallo GV, Kurz CL, Couillault C, Pujol N, Granjeaud S, Kohara Y and Ewbank JJ. Inducible antibacterial defense system in C. elegans. Curr Biol 2002; 12: 1209-1214.","journal-title":"Curr Biol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/9780470559277.ch130160","article-title":"elegans pathogenesis model","volume":"6","author":"Conery","year":"2014","unstructured":"Conery AL, Larkins-Ford J, Ausubel FM and Kirienko NV. High-throughput screening for novel anti-infectives using a C. elegans pathogenesis model. Curr Protoc Chem Biol 2014; 6: 25-37.","journal-title":"Curr Protoc Chem Biol"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Lavigne JP, Cuzon G, Combescure C, Bourg G, Sotto A and Nordmann P. Virulence of Klebsiella pneumoniae isolates harboring bla KPC-2 carbapenemase gene in a Caenorhabditis elegans model. PLoS One 2013; 8: e67847.","DOI":"10.1371\/journal.pone.0067847"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1021\/acs.chemrestox.5b00258","article-title":"Concentration ranges of antibacterial cations for showing the highest antibacterial efficacy but the least cytotoxicity against mammalian cells: implications for a new antibacterial mechanism","volume":"28","author":"Ning","year":"2015","unstructured":"Ning C, Wang X, Li L, Zhu Y, Li M, Yu P, Zhou L, Zhou Z, Chen J, Tan G, Zhang Y, Wang Y and Mao C. Concentration ranges of antibacterial cations for showing the highest antibacterial efficacy but the least cytotoxicity against mammalian cells: implications for a new antibacterial mechanism. Chem Res Toxicol 2015; 28: 1815-1822.","journal-title":"Chem Res Toxicol"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Romo Qui&#xF1;onez CR, Alvarez-Ruiz P, Mej&#xED;a-Ruiz CH, Bogdanchikova N, Pestryakov A, Gamez-Jimenez C, Valenzuela-Qui&#xF1;onez W, Montoya-Mej&#xED;a M and Nava P&#xE9;rez E. Chronic toxicity of shrimp feed added with silver nanoparticles (Argovit-4&#xAE;) in Litopenaeus vannamei and immune response to white spot syndrome virus infection. PeerJ 2022; 10: e14231.","DOI":"10.7717\/peerj.14231"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/etc.4617","article-title":"Importance of surface coating to accumulation dynamics and acute toxicity of copper nanomaterials and dissolved copper in daphnia magna","volume":"39","author":"Gajda-Meissner","year":"2020","unstructured":"Gajda-Meissner Z, Matyja K, Brown DM, Hartl MGJ and Fernandes TF. Importance of surface coating to accumulation dynamics and acute toxicity of copper nanomaterials and dissolved copper in daphnia magna. Environ Toxicol Chem 2020; 39: 287-299.","journal-title":"Environ Toxicol Chem"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3390\/cells9010109","article-title":"DAF-16\/FoxO in Caenorhabditis elegans and its role in metabolic remodeling","volume":"9","author":"Ze&#x10D","year":"2020","unstructured":"Ze&#x10D;i&#x107; A and Braeckman BP. DAF-16\/FoxO in Caenorhabditis elegans and its role in metabolic remodeling. Cells 2020; 9: 109.","journal-title":"Cells"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1039\/c1mb05114h","article-title":"elegans metallothioneins: response to and defence against ROS toxicity","volume":"7","author":"Zeitoun-Ghandour S","year":"2011","unstructured":"Zeitoun-Ghandour S, Leszczyszyn OI, Blindauer CA, Geier FM, Bundy JG and St&#xFC;rzenbaum SR. C. elegans metallothioneins: response to and defence against ROS toxicity. Mol Biosyst 2011; 7: 2397-2406.","journal-title":"Mol Biosyst"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/16\/5\/ajtr0154756.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:53:19Z","timestamp":1766022799000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/16\/5\/ajtr0154756.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":42,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.62347\/dieo8870","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}