{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:56:15Z","timestamp":1778824575258,"version":"3.51.4"},"reference-count":26,"publisher":"e-Century Publishing Corporation","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/evjg5641","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T06:15:14Z","timestamp":1753942514000},"page":"5453-5464","source":"Crossref","is-referenced-by-count":1,"title":["Hypothermia therapy enhances cognitive and motor recovery in patients with traumatic brain injury: a 6-month retrospective cohort study"],"prefix":"10.62347","volume":"17","author":[{"given":"Shanshan","family":"Xiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1093\/brain\/awae005","article-title":"Autologous bone marrow mononuclear cells to treat severe traumatic brain injury in children","volume":"147","author":"CS Jr","year":"2024","unstructured":"Cox CS Jr, Notrica DM, Juranek J, Miller JH, Triolo F, Kosmach S, Savitz SI, Adelson PD, Pedroza C, Olson SD, Scott MC, Kumar A, Aertker BM, Caplan HW, Jackson ML, Gill BS, Hetz RA, Lavoie MS and Ewing-Cobbs L. Autologous bone marrow mononuclear cells to treat severe traumatic brain injury in children. Brain 2024; 147: 1914-1925.","journal-title":"Brain"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Hoffman JM, Curran M, Barber J, Lucas S, Fann JR and Zumsteg JM. Collaborative care for chronic pain after traumatic brain injury: a randomized clinical trial. JAMA Netw Open 2024; 7: e2413459.","DOI":"10.1001\/jamanetworkopen.2024.13459"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.apmr.2023.03.013","article-title":"Traumatic brain injury positive strategies for families: a pilot randomized controlled trial of an online parent-training program","volume":"104","author":"Karns","year":"2023","unstructured":"Karns CM, Wade SL, Slocumb J, Keating T, Gau JM, Slomine BS, Suskauer SJ and Glang A. Traumatic brain injury positive strategies for families: a pilot randomized controlled trial of an online parent-training program. Arch Phys Med Rehabil 2023; 104: 1026-1034.","journal-title":"Arch Phys Med Rehabil"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Montaldo P, Cirillo M, Burgod C, Caredda E, Ascione S, Carpentieri M, Puzone S, D&#x2019;Amico A, Garegrat R, Lanza M, Moreno Morales M, Atreja G, Shivamurthappa V, Kariholu U, Aladangady N, Fleming P, Mathews A, Palanisami B, Windrow J, Harvey K, Soe A, Pattnayak S, Sashikumar P, Harigopal S, Pressler R, Wilson M, De Vita E, Shankaran S and Thayyil S. Whole-body hypothermia vs targeted normothermia for neonates with mild encephalopathy: a multicenter pilot randomized clinical trial. JAMA Netw Open 2024; 7: e249119.","DOI":"10.1001\/jamanetworkopen.2024.9119"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1089\/ther.2023.0003","article-title":"Heat transfer capabilities of surface cooling systems for inducing therapeutic hypothermia","volume":"13","author":"Leclerc","year":"2023","unstructured":"Leclerc C, Talebian Nia M and Giesbrecht GG. Heat transfer capabilities of surface cooling systems for inducing therapeutic hypothermia. Ther Hypothermia Temp Manag 2023; 13: 149-158.","journal-title":"Ther Hypothermia Temp Manag"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Wang Y, Huang C, Tian R and Yang X. Target temperature management and therapeutic hypothermia in sever neuroprotection for traumatic brain injury: clinic value and effect on oxidative stress. Medicine (Baltimore) 2023; 102: e32921.","DOI":"10.1097\/MD.0000000000032921"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/JSM.0000000000001198","article-title":"Reduced concussion symptom burden in early adolescent athletes using a head-neck cooling device","volume":"34","author":"Smith","year":"2024","unstructured":"Smith MA, McNinch NL, Chaney D, Shauver L, Murray T, Kline P, Lesak A, Franco-MacKendrick L, Scott L, Logan K, Ichesco IK, Liebig C and Congeni J. Reduced concussion symptom burden in early adolescent athletes using a head-neck cooling device. Clin J Sport Med 2024; 34: 247-255.","journal-title":"Clin J Sport Med"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Fujita M, Oda Y, Kaneda K, Kaneko T, Suehiro E, Dohi K, Kuroda Y, Kobata H, Tsuruta R and Maekawa T. Temperature difference between jugular bulb and pulmonary artery is associated with neurological outcome in patients with severe traumatic brain injury: a post hoc analysis of a brain hypothermia study. PLoS One 2023; 18: e0285525.","DOI":"10.1371\/journal.pone.0285525"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/aas.14036","article-title":"Diagnostic criteria of CNS infection in patients with external ventricular drainage after traumatic brain injury: a pilot study","volume":"66","author":"Willer-Hansen RS","year":"2022","unstructured":"Willer-Hansen RS, Olsen MH, Hauerberg J, Johansen HK, Andersen &#xC5;B and M&#xF8;ller K. Diagnostic criteria of CNS infection in patients with external ventricular drainage after traumatic brain injury: a pilot study. Acta Anaesthesiol Scand 2022; 66: 507-515.","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.apmr.2023.03.036","article-title":"The American congress of rehabilitation medicine diagnostic criteria for mild traumatic brain injury","volume":"104","author":"Silverberg","year":"2023","unstructured":"Silverberg ND, Iverson GL, Cogan A, Dams OCK, Delmonico R, Graf MJP, Iaccarino MA, Kajankova M, Kamins J, McCulloch KL, McKinney G, Nagele D, Panenka WJ, Rabinowitz AR, Reed N, Wethe JV, Whitehair V, Anderson V, Arciniegas DB, Bayley MT, Bazarian JJ, Bell KR, Broglio SP, Cifu D, Davis GA, Dvorak J, Echemendia RJ, Gioia GA, Giza CC, Hinds SR 2nd, Katz DI, Kurowski BG, Leddy JJ, Sage NL, Lumba-Brown A, Maas AI, Manley GT, McCrea M, Menon DK, Ponsford J, Putukian M, Suskauer SJ, van der Naalt J, Walker WC, Yeates KO, Zafonte R, Zasler ND and Zemek R. The American congress of rehabilitation medicine diagnostic criteria for mild traumatic brain injury. Arch Phys Med Rehabil 2023; 104: 1343-1355.","journal-title":"Arch Phys Med Rehabil"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2176\/nmc.ra.2016-0293","article-title":"Disorder of executive function of the brain after head injury and mild traumatic brain injury - neuroimaging and diagnostic criteria for implementation of administrative support in Japan","volume":"57","author":"Shinoda","year":"2017","unstructured":"Shinoda J and Asano Y. Disorder of executive function of the brain after head injury and mild traumatic brain injury - neuroimaging and diagnostic criteria for implementation of administrative support in Japan. Neurol Med Chir (Tokyo) 2017; 57: 199-209.","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1001\/jama.2018.17121","article-title":"Hypothermia after traumatic brain injury","volume":"320","author":"Docherty","year":"2018","unstructured":"Docherty A, Emelifeonwu J and Andrews PJD. Hypothermia after traumatic brain injury. JAMA 2018; 320: 2204-2206.","journal-title":"JAMA"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/S1474-4422(22)00309-X","article-title":"Traumatic brain injury: progress and challenges in prevention, clinical care, and research","volume":"21","author":"AIR","year":"2022","unstructured":"Maas AIR, Menon DK, Manley GT, Abrams M, &#xC5;kerlund C, Andelic N, Aries M, Bashford T, Bell MJ, Bodien YG, Brett BL, B&#xFC;ki A, Chesnut RM, Citerio G, Clark D, Clasby B, Cooper DJ, Czeiter E, Czosnyka M, Dams-O&#x2019;Connor K, De Keyser V, Diaz-Arrastia R, Ercole A, van Essen TA, Falvey &#xC9;, Ferguson AR, Figaji A, Fitzgerald M, Foreman B, Gantner D, Gao G, Giacino J, Gravesteijn B, Guiza F, Gupta D, Gurnell M, Haagsma JA, Hammond FM, Hawryluk G, Hutchinson P, van der Jagt M, Jain S, Jain S, Jiang JY, Kent H, Kolias A, Kompanje EJO, Lecky F, Lingsma HF, Maegele M, Majdan M, Markowitz A, McCrea M, Meyfroidt G, Mikoli&#x107; A, Mondello S, Mukherjee P, Nelson D, Nelson LD, Newcombe V, Okonkwo D, Ore&#x161;i&#x10D; M, Peul W, Pisic&#x103; D, Polinder S, Ponsford J, Puybasset L, Raj R, Robba C, R&#xF8;e C, Rosand J, Schueler P, Sharp DJ, Smielewski P, Stein MB, von Steinb&#xFC;chel N, Stewart W, Steyerberg EW, Stocchetti N, Temkin N, Tenovuo O, Theadom A, Thomas I, Espin AT, Turgeon AF, Unterberg A, Van Praag D, van Veen E, Verheyden J, Vyvere TV, Wang KKW, Wiegers EJA, Williams WH, Wilson L, Wisniewski SR, Younsi A, Yue JK, Yuh EL, Zeiler FA, Zeldovich M and Zemek R; InTBIR Participants and Investigators. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. Lancet Neurol 2022; 21: 1004-1060.","journal-title":"Lancet Neurol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jamaneurol.2021.0084","article-title":"Recovery of consciousness and functional outcome in moderate and severe traumatic brain injury","volume":"78","author":"Kowalski","year":"2021","unstructured":"Kowalski RG, Hammond FM, Weintraub AH, Nakase-Richardson R, Zafonte RD, Whyte J and Giacino JT. Recovery of consciousness and functional outcome in moderate and severe traumatic brain injury. JAMA Neurol 2021; 78: 548-557.","journal-title":"JAMA Neurol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"105774","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105774","article-title":"Constraint induced movement therapy increases functionality and quality of life after stroke","volume":"30","author":"Rocha","year":"2021","unstructured":"Rocha LSO, Gama GCB, Rocha RSB, Rocha LB, Dias CP, Santos LLS, Santos MCS, Montebelo MIL and Teodori RM. Constraint induced movement therapy increases functionality and quality of life after stroke. J Stroke Cerebrovasc Dis 2021; 30: 105774.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1089\/neu.2021.0199","article-title":"Diagnosing level of consciousness: the limits of the Glasgow coma scale total score","volume":"38","author":"Bodien","year":"2021","unstructured":"Bodien YG, Barra A, Temkin NR, Barber J, Foreman B, Vassar M, Robertson C, Taylor SR, Markowitz AJ, Manley GT, Giacino JT and Edlow BL. Diagnosing level of consciousness: the limits of the Glasgow coma scale total score. J Neurotrauma 2021; 38: 3295-3305.","journal-title":"J Neurotrauma"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.cnc.2020.10.005","article-title":"The Glasgow coma scale: a European and global perspective on enhancing practice","volume":"33","author":"Cook","year":"2021","unstructured":"Cook NF. The Glasgow coma scale: a European and global perspective on enhancing practice. Crit Care Nurs Clin North Am 2021; 33: 89-99.","journal-title":"Crit Care Nurs Clin North Am"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1186\/s12913-016-1595-z","article-title":"Evidence of non-response bias in the Press-Ganey patient satisfaction survey","volume":"16","author":"Tyser","year":"2016","unstructured":"Tyser AR, Abtahi AM, McFadden M and Presson AP. Evidence of non-response bias in the Press-Ganey patient satisfaction survey. BMC Health Serv Res 2016; 16: 350.","journal-title":"BMC Health Serv Res"},{"key":"ref18","unstructured":"Huang J, Ding YL, Gao L, Zhu Y, Lin YY and Lin XZ. Efficacy of therapeutic hypothermia on mild neonatal hypoxic-ischemic encephalopathy: a prospective randomized controlled study. Zhongguo Dang Dai Er Ke Za Zhi 2024; 26: 803-810."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13063-023-07828-6","article-title":"Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)","volume":"25","author":"Engel","year":"2024","unstructured":"Engel C, R&#xFC;diger M, Benders M, van Bel F, Allegaert K, Naulaers G, Bassler D, Kleberma&#xDF;-Schrehof K, Vento M, Vilan A, Falck M, Mauro I, Mets&#xE4;ranta M, Vanhatalo S, Mazela J, Metsvaht T, van der Vlught R and Franz AR. Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III). Trials 2024; 25: 81.","journal-title":"Trials"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"113879","DOI":"10.1016\/j.jpeds.2023.113879","article-title":"Feasibility and safety of sildenafil to repair brain injury secondary to birth asphyxia (SANE-01): a randomized, double-blind, placebo-controlled phase Ib clinical trial","volume":"266","author":"Wintermark","year":"2024","unstructured":"Wintermark P, Lapointe A, Steinhorn R, Rampakakis E, Burhenne J, Meid AD, Bajraktari-Sylejmani G, Khairy M, Altit G, Adamo MT, Poccia A, Gilbert G, Saint-Martin C, Toffoli D, Vachon J, Hailu E, Colin P and Haefeli WE. Feasibility and safety of sildenafil to repair brain injury secondary to birth asphyxia (SANE-01): a randomized, double-blind, placebo-controlled phase Ib clinical trial. J Pediatr 2024; 266: 113879.","journal-title":"J Pediatr"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Lilla N, Rinne C, Weiland J, Linsenmann T, Ernestus RI and Westermaier T. Early transient mild hypothermia attenuates neurologic deficits and brain damage after experimental subarachnoid hemorrhage in rats. World Neurosurg 2018; 109: e88-e98.","DOI":"10.1016\/j.wneu.2017.09.109"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Montaldo P, Burgod C, Herberg JA, Kaforou M, Cunnington AJ, Mejias A, Cirillo G, Miraglia Del Giudice E, Capristo C, Bandiya P, Kamalaratnam CN, Chandramohan R, Manerkar S, Rodrigo R, Sumanasena S, Krishnan V, Pant S, Shankaran S and Thayyil S. Whole-blood gene expression profile after hypoxic-ischemic encephalopathy. JAMA Netw Open 2024; 7: e2354433.","DOI":"10.1001\/jamanetworkopen.2023.54433"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Okonkwo DO, McAllister P, Achrol AS, Karasawa Y, Kawabori M, Cramer SC, Lai A, Kesari S, Frishberg BM, Groysman LI, Kim AS, Schwartz NE, Chen JW, Imai H, Yasuhara T, Chida D, Nejadnik B, Bates D, Stonehouse AH, Richardson RM, Steinberg GK, Poggio EC and Weintraub AH. Mesenchymal stromal cell implants for chronic motor deficits after traumatic brain injury: post hoc analysis of a randomized trial. Neurology 2024; 103: e209797.","DOI":"10.1212\/WNL.0000000000209797"},{"key":"ref24","unstructured":"Takebe S, Taguchi S, Obata N and Mizobuchi S. Effect of intravenous lidocaine on rocuronium: a randomized controlled trial. Kobe J Med Sci 2025; 70: E143-E151."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13049-025-01331-4","article-title":"Experimental hypothermia by cold air: a randomized, double-blind, placebo-controlled crossover trial","volume":"33","author":"AM","year":"2025","unstructured":"Helland AM, Mydske S, Assmus J, Bratteb&#xF8; G, Wiggen &#xD8;, Kvidaland HK and Thomassen &#xD8;. Experimental hypothermia by cold air: a randomized, double-blind, placebo-controlled crossover trial. Scand J Trauma Resusc Emerg Med 2025; 33: 16.","journal-title":"Scand J Trauma Resusc Emerg Med"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/7\/ajtr0164748.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:56:35Z","timestamp":1766022995000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/7\/ajtr0164748.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":26,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/evjg5641","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}