{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:40:17Z","timestamp":1792741217912,"version":"4.5.0"},"reference-count":51,"publisher":"e-Century Publishing Corporation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Cancer Res"],"DOI":"10.62347\/hxqd4274","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:08:31Z","timestamp":1772248111000},"page":"453-469","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic value of systemic inflammatory and nutritional markers in patients with resectable colon cancer: a retrospective observational study"],"prefix":"10.62347","volume":"16","author":[{"given":"Fang","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"1592425","DOI":"10.3389\/fnut.2025.1592425","article-title":"Global burden of disease for colorectal cancer due to diet low in whole grains from 1990 to 2021 and its projections to 2050: analysis of the global burden of disease study 2021","volume":"12","author":"Yang","year":"2025","unstructured":"Yang M, Huang G, Jiang F and Guo Z. Global burden of disease for colorectal cancer due to diet low in whole grains from 1990 to 2021 and its projections to 2050: analysis of the global burden of disease study 2021. Front Nutr 2025; 12: 1592425.","journal-title":"Front Nutr"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2024; 74: 229-263.","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/DCR.0000000000002323","article-title":"The american society of colon and rectal surgeons clinical practice guidelines for the management of colon cancer","volume":"65","author":"Vogel","year":"2022","unstructured":"Vogel JD, Felder SI, Bhama AR, Hawkins AT, Langenfeld SJ, Shaffer VO, Thorsen AJ, Weiser MR, Chang GJ, Lightner AL, Feingold DL and Paquette IM. The american society of colon and rectal surgeons clinical practice guidelines for the management of colon cancer. Dis Colon Rectum 2022; 65: 148-177.","journal-title":"Dis Colon Rectum"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1186\/s12890-024-03221-4","article-title":"Characteristics of molecular subtypes and cinical outcomes in the immunotherapy queue of extensive-stage small cell lung cancer patients","volume":"24","author":"Li","year":"2024","unstructured":"Li J, Zhang W, Zhao Y, Li J, Nie Y, Feng A, Li Q, Zhou F, Zeng R and Yang Z. Characteristics of molecular subtypes and cinical outcomes in the immunotherapy queue of extensive-stage small cell lung cancer patients. BMC Pulm Med 2024; 24: 423.","journal-title":"BMC Pulm Med"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Lin NC, Hsu JT and Tsai KY. Survival and clinicopathological characteristics of different histological grades of oral cavity squamous cell carcinoma: a single-center retrospective study. PLoS One 2020; 15: e0238103.","DOI":"10.1371\/journal.pone.0238103"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1245\/s10434-024-14892-y","article-title":"AJCC cancer staging system version 9: appendiceal adenocarcinoma","volume":"31","author":"Hanna","year":"2024","unstructured":"Hanna N, Hanna AN and Hanna DN. AJCC cancer staging system version 9: appendiceal adenocarcinoma. Ann Surg Oncol 2024; 31: 2177-2180.","journal-title":"Ann Surg Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"169","DOI":"10.6004\/jnccn.2025.0022","article-title":"2025, NCCN clinical practice guidelines in oncology","volume":"23","author":"JA","year":"2025","unstructured":"Ajani JA, D’Amico TA, Bentrem DJ, Corvera CU, Das P, Enzinger PC, Enzler T, Gerdes H, Gibson MK, Grierson P, Gupta G, Hofstetter WL, Ilson DH, Jalal S, Kim S, Kleinberg LR, Klempner S, Lacy J, Lee B, Licciardi F, Lloyd S, Ly QP, Matsukuma K, McNamara M, Merkow RP, Miller AM, Mukherjee S, Mulcahy MF, Perry KA, Pimiento JM, Reddi DM, Reznik S, Roses RE, Strong VE, Su S, Uboha N, Wainberg ZA, Willett CG, Woo Y, Yoon HH, McMillian NR and Stein M. Gastric cancer, version 2.2025, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 2025; 23: 169-191.","journal-title":"J Natl Compr Canc Netw"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"78","DOI":"10.5230\/jgc.2011.11.2.78","article-title":"Evaluation of the 7th UICC TNM staging system of gastric cancer","volume":"11","author":"Kwon","year":"2011","unstructured":"Kwon SJ. Evaluation of the 7th UICC TNM staging system of gastric cancer. J Gastric Cancer 2011; 11: 78-85.","journal-title":"J Gastric Cancer"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.3390\/cancers15082284","article-title":"Intestinal microbes and hematological malignancies","volume":"15","author":"Zhu","year":"2023","unstructured":"Zhu Y, Yang Q, Yang Q, He Y and Zhou W. Intestinal microbes and hematological malignancies. Cancers (Basel) 2023; 15: 2284.","journal-title":"Cancers (Basel)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1186\/s12885-024-13181-x","article-title":"Combined effects of nutrition, inflammatory status, and sleep quality on mortality in cancer survivors","volume":"24","author":"Zhao","year":"2024","unstructured":"Zhao T, Zhao H, Zhang X, Jiang X, Liang Q, Ni S, Jiao Y, Yu J, Dai J, Du M and Liu L. Combined effects of nutrition, inflammatory status, and sleep quality on mortality in cancer survivors. BMC Cancer 2024; 24: 1456.","journal-title":"BMC Cancer"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"573","DOI":"10.2147\/JIR.S484962","article-title":"Interleukin-6 as a pan-cancer prognostic inflammatory biomarker: a population-based study and comprehensive bioinformatics analysis","volume":"18","author":"Xie","year":"2025","unstructured":"Xie H, Wei L, Ruan G, Zhang H and Shi H. Interleukin-6 as a pan-cancer prognostic inflammatory biomarker: a population-based study and comprehensive bioinformatics analysis. J Inflamm Res 2025; 18: 573-587.","journal-title":"J Inflamm Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"7212","DOI":"10.1002\/fsn3.4347","article-title":"The healthy eating index 2020 components contributed unequally to systemic inflammatory biomarkers: a large national cross-sectional study","volume":"12","author":"Yang","year":"2024","unstructured":"Yang H, Liu Y, Huang Z and Deng G. The healthy eating index 2020 components contributed unequally to systemic inflammatory biomarkers: a large national cross-sectional study. Food Sci Nutr 2024; 12: 7212-7222.","journal-title":"Food Sci Nutr"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1642091","DOI":"10.3389\/fimmu.2025.1642091","article-title":"Tumor-associated macrophages in colon cancer immunotherapy: mechanisms, natural product interventions, and microenvironment remodeling","volume":"16","author":"He","year":"2025","unstructured":"He Q, Xiang L, Luo Y, Wang R, Zheng C, Gao Y and Yao H. Tumor-associated macrophages in colon cancer immunotherapy: mechanisms, natural product interventions, and microenvironment remodeling. Front Immunol 2025; 16: 1642091.","journal-title":"Front Immunol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"5336","DOI":"10.3390\/ijms26115336","article-title":"Regulation and function of tumor-associated macrophages (TAMs) in colorectal cancer (CRC): the role of the SRIF system in macrophage regulation","volume":"26","author":"Geltz","year":"2025","unstructured":"Geltz A, Geltz J and Kasprzak A. Regulation and function of tumor-associated macrophages (TAMs) in colorectal cancer (CRC): the role of the SRIF system in macrophage regulation. Int J Mol Sci 2025; 26: 5336.","journal-title":"Int J Mol Sci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1186\/s12885-025-14060-9","article-title":"Peripheral blood inflammatory biomarkers neutrophil\/lymphocyte ratio, platelet\/lymphocyte ratio and systemic immune-inflammation index\/albumin ratio predict prognosis and efficacy in non-small cell lung cancer patients receiving immunotherapy and opioids","volume":"25","author":"Lei","year":"2025","unstructured":"Lei Y, Cao C, Tang R and Liu Y. Peripheral blood inflammatory biomarkers neutrophil\/lymphocyte ratio, platelet\/lymphocyte ratio and systemic immune-inflammation index\/albumin ratio predict prognosis and efficacy in non-small cell lung cancer patients receiving immunotherapy and opioids. BMC Cancer 2025; 25: 664.","journal-title":"BMC Cancer"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1143154","DOI":"10.3389\/fonc.2023.1143154","article-title":"Single and combined use of the platelet-lymphocyte ratio, neutrophil-lymphocyte ratio, and systemic immune-inflammation index in gastric cancer diagnosis","volume":"13","author":"Zhang","year":"2023","unstructured":"Zhang J, Zhang L, Duan S, Li Z, Li G and Yu H. Single and combined use of the platelet-lymphocyte ratio, neutrophil-lymphocyte ratio, and systemic immune-inflammation index in gastric cancer diagnosis. Front Oncol 2023; 13: 1143154.","journal-title":"Front Oncol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1509689","DOI":"10.3389\/fnut.2025.1509689","article-title":"Expert opinion on the current conceptual, clinical and therapeutic aspects of disease related malnutrition and muscle loss: a multidisciplinary perspective","volume":"12","author":"Doganay","year":"2025","unstructured":"Doganay M, Halil MG, Kaymak C, Selek U, Topcuoglu MA and Yalcin S. Expert opinion on the current conceptual, clinical and therapeutic aspects of disease related malnutrition and muscle loss: a multidisciplinary perspective. Front Nutr 2025; 12: 1509689.","journal-title":"Front Nutr"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.3390\/cancers14143439","article-title":"Association between nutritional status and treatment response and survival in patients treated with immunotherapy for lung cancer: a retrospective french study","volume":"14","author":"Gouez","year":"2022","unstructured":"Gouez M, Delrieu L, Bouleuc C, Girard N, Raynard B and Marchal T. Association between nutritional status and treatment response and survival in patients treated with immunotherapy for lung cancer: a retrospective french study. Cancers (Basel) 2022; 14: 3439.","journal-title":"Cancers (Basel)"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1117764","DOI":"10.3389\/fonc.2023.1117764","article-title":"Prognostic value of prognostic nutritional index score and controlling nutritional status score in patients with glioblastoma: a comprehensive meta-analysis","volume":"13","author":"Peng","year":"2023","unstructured":"Peng J, Li X, Huang M, Ma M, Huang Q, Huang N and Cheng Y. Prognostic value of prognostic nutritional index score and controlling nutritional status score in patients with glioblastoma: a comprehensive meta-analysis. Front Oncol 2023; 13: 1117764.","journal-title":"Front Oncol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1186\/s12876-025-03874-3","article-title":"Inflammatory and nutritional markers predict response and prognosis of patients with locally advanced gastric cancer receiving neoadjuvant immunochemotherapy","volume":"25","author":"Sun","year":"2025","unstructured":"Sun Y, Liang M, Wang X, Dong W, Wu Z, Sun F, Lu X, Wang F, Liu S, Wang M, Ai S, Shen X and Guan W. Inflammatory and nutritional markers predict response and prognosis of patients with locally advanced gastric cancer receiving neoadjuvant immunochemotherapy. BMC Gastroenterol 2025; 25: 478.","journal-title":"BMC Gastroenterol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"809","DOI":"10.21037\/tau-23-55","article-title":"Inflammation-related indicators have a potential to increase overall quality of the prostate cancer management: a narrative review","volume":"12","author":"Zhou","year":"2023","unstructured":"Zhou M, Liang J, Hui J and Xu J. Inflammation-related indicators have a potential to increase overall quality of the prostate cancer management: a narrative review. Transl Androl Urol 2023; 12: 809-822.","journal-title":"Transl Androl Urol"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Su J, Yu S, Xu Y, Zhao J, Hu W and Ni X. Predictive role of systemic immune-inflammation index in the prognosis of patients with advanced left-sided colorectal cancer: a retrospective study. PeerJ 2025; 13: e20095.","DOI":"10.7717\/peerj.20095"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Wang S, Yuan Z, Ni K, Zhan Y, Zhao X, Liu Z, Liu Y, Yi B, Lai S, Yin X, Zhou X, Wang Y, Ping H, Xin R, Wang W, Li H, Zhao Y, Han Y, Gao W, Jin X, Wang G, Zhang Z, Li G, Zhang Q, Zhang X, Ma H and Zhang C. Young patients with colorectal cancer have higher early mortality but better long-term survival. Clin Transl Gastroenterol 2022; 13: e00543.","DOI":"10.14309\/ctg.0000000000000543"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"4465592","DOI":"10.1155\/2024\/4465592","article-title":"Impact of preoperative neutrophil to prealbumin ratio index (NPRI) on short-term complications and long-term prognosis in patients undergoing laparoscopic radical surgery for colorectal cancer","volume":"2024","author":"Jiang","year":"2024","unstructured":"Jiang W, Xia Y, Liu Y, Cheng S, Wang W, Guan Z, Dou H, Zhang C and Wang H. Impact of preoperative neutrophil to prealbumin ratio index (NPRI) on short-term complications and long-term prognosis in patients undergoing laparoscopic radical surgery for colorectal cancer. Mediators Inflamm 2024; 2024: 4465592.","journal-title":"Mediators Inflamm"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"7362","DOI":"10.1097\/ms9.0000000000003963","article-title":"Integrating neutrophil-to-lymphocyte ratio into cervical cancer management: implications for prognostic assessment and therapeutic strategies - a narrative review","volume":"87","author":"Obeagu","year":"2025","unstructured":"Obeagu EI. Integrating neutrophil-to-lymphocyte ratio into cervical cancer management: implications for prognostic assessment and therapeutic strategies - a narrative review. Ann Med Surg (Lond) 2025; 87: 7362-7368.","journal-title":"Ann Med Surg (Lond)"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Tan D, Fu Y, Su Q and Wang H. Prognostic role of platelet-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis. Medicine (Baltimore) 2016; 95: e3837.","DOI":"10.1097\/MD.0000000000003837"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4103\/tjem.tjem_198_23","article-title":"Unraveling the clinical significance and prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response index, and delta neutrophil index: an extensive literature review","volume":"24","author":"MM","year":"2024","unstructured":"Islam MM, Satici MO and Eroglu SE. Unraveling the clinical significance and prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response index, and delta neutrophil index: an extensive literature review. Turk J Emerg Med 2024; 24: 8-19.","journal-title":"Turk J Emerg Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1618111","DOI":"10.3389\/fsurg.2025.1618111","article-title":"Prognostic value of prognostic nutritional index in patients undergoing surgery for gastric cancer","volume":"12","author":"M&#xFC","year":"2025","unstructured":"Mülküt F, Ofluoğlu CB, Başdoğan MK, Aydın İC, Akdoğan O, Gündoğdu A and Subaşı İE. Prognostic value of prognostic nutritional index in patients undergoing surgery for gastric cancer. Front Surg 2025; 12: 1618111.","journal-title":"Front Surg"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Ikeya Y, Saito Y, Nakai T, Kogawa R, Otsuka N, Wakamatsu Y, Kurokawa S, Ohkubo K, Nagashima K and Okumura Y. Prognostic importance of the controlling nutritional status (CONUT) score in patients undergoing cardiac resynchronisation therapy. Open Heart 2021; 8: e001740.","DOI":"10.1136\/openhrt-2021-001740"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"103948","DOI":"10.1016\/j.otsr.2024.103948","article-title":"Predictive value of the C-reactive protein to albumin ratio in the treatment of septic arthritis in young children: a retrospective study","volume":"111","author":"Chen","year":"2025","unstructured":"Chen X, Liu Y, Zou C, Sun Y, Zhuang T, Zhao C, Sun Q, Li M, Zheng W and Wang X. Predictive value of the C-reactive protein to albumin ratio in the treatment of septic arthritis in young children: a retrospective study. Orthop Traumatol Surg Res 2025; 111: 103948.","journal-title":"Orthop Traumatol Surg Res"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.31557\/APJCP.2022.23.4.1137","article-title":"A systematic review on overall survival and disease-free survival following total pelvic exenteration","volume":"23","author":"Miri","year":"2022","unstructured":"Miri SR, Akhavan S, Mousavi AS, Hashemi SR, Sheikhhasan S, Almasi-Hashiani A, Sadegh Fakhari M and Esmailzadeh A. A systematic review on overall survival and disease-free survival following total pelvic exenteration. Asian Pac J Cancer Prev 2022; 23: 1137-1145.","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/s41575-024-00934-z","article-title":"Mechanisms of metastatic colorectal cancer","volume":"21","author":"Ca&#xF1","year":"2024","unstructured":"Cañellas-Socias A, Sancho E and Batlle E. Mechanisms of metastatic colorectal cancer. Nat Rev Gastroenterol Hepatol 2024; 21: 609-625.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"5356","DOI":"10.3390\/curroncol28060447","article-title":"Pathological features and prognostication in colorectal cancer","volume":"28","author":"Chen","year":"2021","unstructured":"Chen K, Collins G, Wang H and Toh JWT. Pathological features and prognostication in colorectal cancer. Curr Oncol 2021; 28: 5356-5383.","journal-title":"Curr Oncol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s12254-025-01077-w","article-title":"Chronic inflammation and cancer: ASCO 2025 update","volume":"18","author":"Dosser","year":"2025","unstructured":"Dosser C, Wolf D and Zimmer K. Chronic inflammation and cancer: ASCO 2025 update. Memo Mag Eur Med Oncol 2025; 18: 311-315.","journal-title":"Memo Mag Eur Med Oncol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.trecan.2022.07.002","article-title":"Inflammation: the incubator of the tumor microenvironment","volume":"8","author":"Denk","year":"2022","unstructured":"Denk D and Greten FR. Inflammation: the incubator of the tumor microenvironment. Trends Cancer 2022; 8: 901-914.","journal-title":"Trends Cancer"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1186\/s12885-025-13919-1","article-title":"NCR as a biomarker for nutritional status and inflammation in predicting outcomes in patients with cancer cachexia: a prospective, multicenter study","volume":"25","author":"Li","year":"2025","unstructured":"Li X, Deng L, Xie H, Li S, Zhao H, Liu T, Liu X, Lin S, Liu C and Shi HP. NCR as a biomarker for nutritional status and inflammation in predicting outcomes in patients with cancer cachexia: a prospective, multicenter study. BMC Cancer 2025; 25: 539.","journal-title":"BMC Cancer"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1186\/s12885-022-10399-5","article-title":"A novel inflammation-nutrition biomarker score for predicting prognosis of patients with cancer: results from a multicenter study","volume":"22","author":"Xie","year":"2022","unstructured":"Xie H, Ruan G, Wei L, Zhang H, Zhang Q, Ge Y, Lin S, Song M, Zhang X, Liu X, Zhang X, Li X, Zhang K, Yang M, Tang M, Deng L and Shi H. A novel inflammation-nutrition biomarker score for predicting prognosis of patients with cancer: results from a multicenter study. BMC Cancer 2022; 22: 1311.","journal-title":"BMC Cancer"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1186\/s12885-025-14509-x","article-title":"Combined association of systemic inflammatory response index and prognostic nutritional index with survival among US cancer survivors","volume":"25","author":"Luo","year":"2025","unstructured":"Luo B, Tan X, Chen L, Zhou K and Lou S. Combined association of systemic inflammatory response index and prognostic nutritional index with survival among US cancer survivors. BMC Cancer 2025; 25: 1114.","journal-title":"BMC Cancer"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.21037\/tcr-24-91","article-title":"A novel inflammatory nutrient index for predicting survival outcomes in patients with non-small cell lung cancer","volume":"13","author":"Li","year":"2024","unstructured":"Li T, Liu Q and Li M. A novel inflammatory nutrient index for predicting survival outcomes in patients with non-small cell lung cancer. Transl Cancer Res 2024; 13: 2605-2617.","journal-title":"Transl Cancer Res"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1279487","DOI":"10.3389\/fonc.2023.1279487","article-title":"Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancer","volume":"13","author":"Cai","year":"2023","unstructured":"Cai H, Li J, Chen Y, Zhang Q, Liu Y and Jia H. Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancer. Front Oncol 2023; 13: 1279487.","journal-title":"Front Oncol"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Li J, Hu X and Zhang S. Integration of systemic inflammation response index (SIRI) and clinicopathological factors enhances survival prediction in colorectal cancer: a retrospective cohort study. Medicine (Baltimore) 2025; 104: e45297.","DOI":"10.1097\/MD.0000000000045297"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00520-023-07829-w","article-title":"Prognostic biomarkers in metastatic colorectal cancer: delta prognostic nutritional index, delta neutrophil to lymphocyte ratio, and delta platelet to lymphocyte ratio","volume":"31","author":"Kocak","year":"2023","unstructured":"Kocak MZ, Coban S, Araz M, Eryilmaz MK and Artac M. Prognostic biomarkers in metastatic colorectal cancer: delta prognostic nutritional index, delta neutrophil to lymphocyte ratio, and delta platelet to lymphocyte ratio. Support Care Cancer 2023; 31: 357.","journal-title":"Support Care Cancer"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s00384-025-04848-3","article-title":"Prognostic value of routine blood biomarkers in 3-year survival of resectable colorectal cancer patients: a prognostic nomogram for clinical practice","volume":"40","author":"Moro-Valdezate D","year":"2025","unstructured":"Moro-Valdezate D, Martín-Arévalo J, Cózar-Lozano C, García-Botello S, Pérez-Santiago L, Casado-Rodrigo D, Martínez-Ciarpaglini C, Tarazona N and Pla-Martí V. Prognostic value of routine blood biomarkers in 3-year survival of resectable colorectal cancer patients: a prognostic nomogram for clinical practice. Int J Colorectal Dis 2025; 40: 58.","journal-title":"Int J Colorectal Dis"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1186\/s12885-018-4201-4","article-title":"Prognostic nutritional index as a predictor of survival in resectable gastric cancer patients with normal preoperative serum carcinoembryonic antigen levels: a propensity score matching analysis","volume":"18","author":"Hirahara","year":"2018","unstructured":"Hirahara N, Tajima Y, Fujii Y, Kaji S, Yamamoto T, Hyakudomi R, Taniura T and Kawabata Y. Prognostic nutritional index as a predictor of survival in resectable gastric cancer patients with normal preoperative serum carcinoembryonic antigen levels: a propensity score matching analysis. BMC Cancer 2018; 18: 285.","journal-title":"BMC Cancer"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s12029-025-01345-2","article-title":"Association of preoperative and postoperative serum albumin levels with colorectal cancer outcomes: a retrospective cohort study","volume":"56","author":"Chen","year":"2025","unstructured":"Chen Y, Li Y, Liu M and Pu H. Association of preoperative and postoperative serum albumin levels with colorectal cancer outcomes: a retrospective cohort study. J Gastrointest Cancer 2025; 56: 219.","journal-title":"J Gastrointest Cancer"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"102144","DOI":"10.1016\/j.clgc.2024.102144","article-title":"Prognostic value of NLR, PLR, SII, and dNLR in urothelial bladder cancer following radical cystectomy","volume":"22","author":"Salari","year":"2024","unstructured":"Salari A, Ghahari M, Bitaraf M, Fard ES, Haddad M, Momeni SA, Inanloo SH, Ghahari P, Mohamoud MM, Mohamadzadeh M, Nowroozi MR and Amini E. Prognostic value of NLR, PLR, SII, and dNLR in urothelial bladder cancer following radical cystectomy. Clin Genitourin Cancer 2024; 22: 102144.","journal-title":"Clin Genitourin Cancer"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"913731","DOI":"10.3389\/fonc.2022.913731","article-title":"The prognostic significance of inflammation-immunity-nutrition score on postoperative survival and recurrence in hepatocellular carcinoma patients","volume":"12","author":"Liang","year":"2022","unstructured":"Liang Y, Zhang Z, Zhong D, Lai C, Dai Z, Zou H, Feng T, Shang J, Shi Y and Huang X. The prognostic significance of inflammation-immunity-nutrition score on postoperative survival and recurrence in hepatocellular carcinoma patients. Front Oncol 2022; 12: 913731.","journal-title":"Front Oncol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1408700","DOI":"10.3389\/fimmu.2024.1408700","article-title":"Prognostic value of inflammatory markers NLR, PLR, and LMR in gastric cancer patients treated with immune checkpoint inhibitors: a meta-analysis and systematic review","volume":"15","author":"Tan","year":"2024","unstructured":"Tan S, Zheng Q, Zhang W, Zhou M, Xia C and Feng W. Prognostic value of inflammatory markers NLR, PLR, and LMR in gastric cancer patients treated with immune checkpoint inhibitors: a meta-analysis and systematic review. Front Immunol 2024; 15: 1408700.","journal-title":"Front Immunol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/S2468-1253(23)00011-0","article-title":"Inflammation and malnutrition in inflammatory bowel disease","volume":"8","author":"Massironi","year":"2023","unstructured":"Massironi S, Viganò C, Palermo A, Pirola L, Mulinacci G, Allocca M, Peyrin-Biroulet L and Danese S. Inflammation and malnutrition in inflammatory bowel disease. Lancet Gastroenterol Hepatol 2023; 8: 579-590.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Liao Y, Zhang W, Liu Y, Zhu C and Zou Z. The role of ubiquitination in health and disease. MedComm (2020) 2024; 5: e736.","DOI":"10.1002\/mco2.736"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3390\/curroncol32040227","article-title":"Prognostic and inflammatory differences between upper and mid-lower rectal cancers in non-metastatic stage II-II disease","volume":"32","author":"M&#xFC","year":"2025","unstructured":"Mülküt F, Ofluoğlu CB, Başdoğan MK, Aydın İC, Doğan A and Subaşı İE. Prognostic and inflammatory differences between upper and mid-lower rectal cancers in non-metastatic stage II-II disease. Curr Oncol 2025; 32: 227.","journal-title":"Curr Oncol"}],"container-title":["American Journal of Cancer Research"],"original-title":[],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:16:41Z","timestamp":1792739801000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajcr\/16\/2\/ajcr0170370.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.62347\/hxqd4274","relation":{},"ISSN":["2156-6976"],"issn-type":[{"value":"2156-6976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}