{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:55:33Z","timestamp":1766022933013,"version":"3.48.0"},"reference-count":34,"publisher":"e-Century Publishing Corporation","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/jfjx7128","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T04:02:40Z","timestamp":1743134560000},"page":"1824-1833","source":"Crossref","is-referenced-by-count":1,"title":["Testis-enriched Spsb1 is not required for spermatogenesis and fertility in mice"],"prefix":"10.62347","volume":"17","author":[{"given":"Haoyue","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Hess RA and Renato de Franca L. Spermatogenesis and cycle of the seminiferous epithelium. Adv Exp Med Biol 2008; 636: 1-15.","DOI":"10.1007\/978-0-387-09597-4_1"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0027-5107(95)00223-5","article-title":"Comparison of the duration of spermatogenesis between male rodents and humans","volume":"352","author":"Adler","year":"1996","unstructured":"Adler ID. Comparison of the duration of spermatogenesis between male rodents and humans. Mutat Res 1996; 352: 169-172.","journal-title":"Mutat Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/bdrc.20040","article-title":"Mechanisms and consequences of paternally-transmitted chromosomal abnormalities","volume":"75","author":"Marchetti","year":"2005","unstructured":"Marchetti F and Wyrobek AJ. Mechanisms and consequences of paternally-transmitted chromosomal abnormalities. Birth Defects Res C Embryo Today 2005; 75: 112-129.","journal-title":"Birth Defects Res C Embryo Today"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1152\/physrev.00027.2001","article-title":"The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction","volume":"82","author":"Glickman","year":"2002","unstructured":"Glickman MH and Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 2002; 82: 373-428.","journal-title":"Physiol Rev"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/iub.589","article-title":"Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processes","volume":"64","author":"Sadowski","year":"2012","unstructured":"Sadowski M, Suryadinata R, Tan AR, Roesley SN and Sarcevic B. Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processes. IUBMB Life 2012; 64: 136-142.","journal-title":"IUBMB Life"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/s41594-024-01221-w","article-title":"Breaking the K48-chain: linking ubiquitin beyond protein degradation","volume":"31","author":"Rahman","year":"2024","unstructured":"Rahman S and Wolberger C. Breaking the K48-chain: linking ubiquitin beyond protein degradation. Nat Struct Mol Biol 2024; 31: 216-218.","journal-title":"Nat Struct Mol Biol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.tcb.2023.09.001","article-title":"The ubiquitous role of ubiquitination in lipid metabolism","volume":"34","author":"Loix","year":"2024","unstructured":"Loix M, Zelcer N, Bogie JFJ and Hendriks JJA. The ubiquitous role of ubiquitination in lipid metabolism. Trends Cell Biol 2024; 34: 416-429.","journal-title":"Trends Cell Biol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.3390\/cells11061058","article-title":"Ubiquitin-proteasome system-regulated protein degradation in spermatogenesis","volume":"11","author":"Xiong","year":"2022","unstructured":"Xiong Y, Yu C and Zhang Q. Ubiquitin-proteasome system-regulated protein degradation in spermatogenesis. Cells 2022; 11: 1058.","journal-title":"Cells"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.gene.2015.03.032","article-title":"Identification and expression analysis of a Spsb gene in planarian Dugesia japonica","volume":"564","author":"Dong","year":"2015","unstructured":"Dong Z, Cheng F, Yuwen Y, Chen J, Li X, Dou H, Zhang H, Chen G and Liu D. Identification and expression analysis of a Spsb gene in planarian Dugesia japonica. Gene 2015; 564: 168-175.","journal-title":"Gene"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.tibs.2012.10.001","article-title":"2-mediated interactions","volume":"38","author":"Perfetto","year":"2013","unstructured":"Perfetto L, Gherardini PF, Davey NE, Diella F, Helmer-Citterich M and Cesareni G. Exploring the diversity of SPRY\/B30.2-mediated interactions. Trends Biochem Sci 2013; 38: 38-46.","journal-title":"Trends Biochem Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3892\/ol.2021.13123","article-title":"SOCS proteins and their roles in the development of glioblastoma","volume":"23","author":"Dai","year":"2022","unstructured":"Dai L, Li Z, Liang W, Hu W, Zhou S, Yang Z, Tao Y, Hou X, Xing Z, Mao J, Shi Z and Wang X. SOCS proteins and their roles in the development of glioblastoma. Oncol Lett 2022; 23: 5.","journal-title":"Oncol Lett"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1073\/pnas.95.1.114","article-title":"Twenty proteins containing a C-terminal SOCS box form five structural classes","volume":"95","author":"Hilton","year":"1998","unstructured":"Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D and Nicola NA. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci U S A 1998; 95: 114-119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"3798","DOI":"10.4049\/jimmunol.1002993","article-title":"TLR regulation of SPSB1 controls inducible nitric oxide synthase induction","volume":"187","author":"RS","year":"2011","unstructured":"Lewis RS, Kolesnik TB, Kuang Z, D&#x2019;Cruz AA, Blewitt ME, Masters SL, Low A, Willson T, Norton RS and Nicholson SE. TLR regulation of SPSB1 controls inducible nitric oxide synthase induction. J Immunol 2011; 187: 3798-3805.","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1158\/2159-8290.CD-13-0548","article-title":"SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling","volume":"4","author":"Feng","year":"2014","unstructured":"Feng Y, Pan TC, Pant DK, Chakrabarti KR, Alvarez JV, Ruth JR and Chodosh LA. SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. Cancer Discov 2014; 4: 790-803.","journal-title":"Cancer Discov"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.bbrc.2019.01.088","article-title":"SPSB1 enhances ovarian cancer cell survival by destabilizing p21","volume":"510","author":"Kim","year":"2019","unstructured":"Kim HJ, Kim HJ, Kim MK, Bae MK, Sung HY, Ahn JH, Kim YH, Kim SC and Ju W. SPSB1 enhances ovarian cancer cell survival by destabilizing p21. Biochem Biophys Res Commun 2019; 510: 364-369.","journal-title":"Biochem Biophys Res Commun"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"17894","DOI":"10.1074\/jbc.M114.607184","article-title":"SPSB1, a novel negative regulator of the transforming growth factor-&#x3B2; signaling pathway targeting the type II receptor","volume":"290","author":"Liu","year":"2015","unstructured":"Liu S, Nheu T, Luwor R, Nicholson SE and Zhu HJ. SPSB1, a novel negative regulator of the transforming growth factor-&#x3B2; signaling pathway targeting the type II receptor. J Biol Chem 2015; 290: 17894-17908.","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1002\/jcsm.13252","article-title":"SPSB1-mediated inhibition of TGF-&#x3B2; receptor-II impairs myogenesis in inflammation","volume":"14","author":"D&#xF6","year":"2023","unstructured":"Li Y, D&#xF6;rmann N, Brinschwitz B, Kny M, Martin E, Bartels K, Li N, Giri PV, Schwanz S, Boschmann M, Hille S, Fielitz B, Wollersheim T, Grunow J, Felix SB, Weber-Carstens S, Luft FC, M&#xFC;ller OJ and Fielitz J. SPSB1-mediated inhibition of TGF-&#x3B2; receptor-II impairs myogenesis in inflammation. J Cachexia Sarcopenia Muscle 2023; 14: 1721-1736.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.3389\/fimmu.2019.03121","article-title":"Cullin-5 adaptor SPSB1 controls NF-&#x3BA;B activation downstream of multiple signaling pathways","volume":"10","author":"Georgana","year":"2020","unstructured":"Georgana I and Maluquer de Motes C. Cullin-5 adaptor SPSB1 controls NF-&#x3BA;B activation downstream of multiple signaling pathways. Front Immunol 2020; 10: 3121.","journal-title":"Front Immunol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/rmb2.12067","article-title":"Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR\/Cas9","volume":"17","author":"Abbasi","year":"2017","unstructured":"Abbasi F, Miyata H and Ikawa M. Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR\/Cas9. Reprod Med Biol 2017; 17: 3-10.","journal-title":"Reprod Med Biol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"116502","DOI":"10.1016\/j.ecoenv.2024.116502","article-title":"Triptolide exposure triggers testicular vacuolization injury by disrupting the Sertoli cell junction and cytoskeletal organization via the AKT\/mTOR signaling pathway","volume":"279","author":"Yang","year":"2024","unstructured":"Yang X, He L, Li X, Wang L, Bu T, Yun D, Lu X, Gao S, Huang Q, Li J, Zheng B, Yu J and Sun F. Triptolide exposure triggers testicular vacuolization injury by disrupting the Sertoli cell junction and cytoskeletal organization via the AKT\/mTOR signaling pathway. Ecotoxicol Environ Saf 2024; 279: 116502.","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.62347\/STDA4237","article-title":"E3 ligase FBXO22 is not significant for spermatogenesis and male fertility in mice","volume":"16","author":"Wu","year":"2024","unstructured":"Wu T, Jin X, Huang C, Yu X, Xu B, Gao W, Qiu X, Bao M, Zhao D, Feng G, Zheng B and Huang X. E3 ligase FBXO22 is not significant for spermatogenesis and male fertility in mice. Am J Transl Res 2024; 16: 1834-1844.","journal-title":"Am J Transl Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"114827","DOI":"10.1016\/j.ecoenv.2023.114827","article-title":"Gold nanoparticles retrogradely penetrate through testicular barriers via Sertoli-cells mediated endocytosis\/exocytosis and induce immune response in mouse","volume":"255","author":"Yu","year":"2023","unstructured":"Yu J, Xu J, Li H, Wu P, Zhu S, Huang X, Shen C, Zheng B and Li W. Gold nanoparticles retrogradely penetrate through testicular barriers via Sertoli-cells mediated endocytosis\/exocytosis and induce immune response in mouse. Ecotoxicol Environ Saf 2023; 255: 114827.","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"168","DOI":"10.21037\/tau-21-900","article-title":"Testis-enriched Asb12 is not required for spermatogenesis and fertility in mice","volume":"11","author":"Zhang","year":"2022","unstructured":"Zhang R, Xu J, Shen C, Zhang X, Li S, Lv J, Xu D, Huang X, Zheng B, Liu M and Wu Y. Testis-enriched Asb12 is not required for spermatogenesis and fertility in mice. Transl Androl Urol 2022; 11: 168-178.","journal-title":"Transl Androl Urol"},{"key":"ref23","unstructured":"Wu Y, Zhang R, Shen C, Xu J, Wu T, Huang X, Liu M, Li H, Xu D and Zheng B. Testis-enriched Asb15 is not required for spermatogenesis and male fertility in mice. Am J Transl Res 2022; 14: 6978-6990."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"103484","DOI":"10.1016\/j.redox.2024.103484","article-title":"ASB1 engages with ELOB to facilitate SQOR ubiquitination and H(2)S homeostasis during spermiogenesis","volume":"79","author":"Lv","year":"2025","unstructured":"Lv J, Wu T, Xue J, Shen C, Gao W, Chen X, Guo Y, Liu M, Yu J, Huang X and Zheng B. ASB1 engages with ELOB to facilitate SQOR ubiquitination and H(2)S homeostasis during spermiogenesis. Redox Biol 2025; 79: 103484.","journal-title":"Redox Biol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.7150\/ijbs.70441","article-title":"BMI1 promotes spermatogonial stem cell maintenance by epigenetically repressing Wnt10b\/&#x3B2;-catenin signaling","volume":"18","author":"Yu","year":"2022","unstructured":"Yu J, Shen C, Lin M, Chen X, Dai X, Li Z, Wu Y, Fu Y, Lv J, Huang X, Zheng B and Sun F. BMI1 promotes spermatogonial stem cell maintenance by epigenetically repressing Wnt10b\/&#x3B2;-catenin signaling. Int J Biol Sci 2022; 18: 2807-2820.","journal-title":"Int J Biol Sci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/molehr\/gat001","article-title":"ADP-ribosylation factor-like 3, a manchette-associated protein, is essential for mouse spermiogenesis","volume":"19","author":"Qi","year":"2013","unstructured":"Qi Y, Jiang M, Yuan Y, Bi Y, Zheng B, Guo X, Huang X, Zhou Z and Sha J. ADP-ribosylation factor-like 3, a manchette-associated protein, is essential for mouse spermiogenesis. Mol Hum Reprod 2013; 19: 327-335.","journal-title":"Mol Hum Reprod"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","unstructured":"Dobbing J and Sands J. Comparative aspects of the brain growth spurt. Early Hum Dev 1979; 3: 79-83.","journal-title":"Early Hum Dev"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.1242\/dev.01209","article-title":"HGF regulates the development of cortical pyramidal dendrites","volume":"131","author":"Gutierrez","year":"2004","unstructured":"Gutierrez H, Dolcet X, Tolcos M and Davies A. HGF regulates the development of cortical pyramidal dendrites. Development 2004; 131: 3717-3726.","journal-title":"Development"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.expneurol.2007.06.007","article-title":"Hepatocyte growth factor promotes the number of PSD-95 clusters in young hippocampal neurons","volume":"207","author":"Nakano","year":"2007","unstructured":"Nakano M, Takagi N, Takagi K, Funakoshi H, Matsumoto K, Nakamura T and Takeo S. Hepatocyte growth factor promotes the number of PSD-95 clusters in young hippocampal neurons. Exp Neurol 2007; 207: 195-202.","journal-title":"Exp Neurol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.21037\/tau-21-789","article-title":"E3 ubiquitin ligase ASB17 is required for spermiation in mice","volume":"10","author":"Shen","year":"2021","unstructured":"Shen C, Xu J, Zhou Q, Lin M, Lv J, Zhang X, Wu Y, Chen X, Yu J, Huang X and Zheng B. E3 ubiquitin ligase ASB17 is required for spermiation in mice. Transl Androl Urol 2021; 10: 4320-4332.","journal-title":"Transl Androl Urol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1073\/pnas.032668599","article-title":"Redundancy, antiredundancy, and the robustness of genomes","volume":"99","author":"Krakauer","year":"2002","unstructured":"Krakauer DC and Plotkin JB. Redundancy, antiredundancy, and the robustness of genomes. Proc Natl Acad Sci U S A 2002; 99: 1405-1409.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"El-Brolosy MA and Stainier DYR. Genetic compensation: a phenomenon in search of mechanisms. PLoS Genet 2017; 13: e1006780.","DOI":"10.1371\/journal.pgen.1006780"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"266","DOI":"10.4103\/aja.aja_63_21","article-title":"CRISPR\/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice","volume":"24","author":"Oyama","year":"2022","unstructured":"Oyama Y, Miyata H, Shimada K, Fujihara Y, Tokuhiro K, Garcia TX, Matzuk MM and Ikawa M. CRISPR\/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Asian J Androl 2022; 24: 266-272.","journal-title":"Asian J Androl"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/3\/ajtr0163148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:50:39Z","timestamp":1766022639000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/3\/ajtr0163148.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/jfjx7128","relation":{},"ISSN":["1943-8141"],"issn-type":[{"type":"electronic","value":"1943-8141"}],"subject":[],"published":{"date-parts":[[2025]]}}}