{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:03:31Z","timestamp":1784153011690,"version":"3.55.0"},"reference-count":35,"publisher":"e-Century Publishing Corporation","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/kfgi9710","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:28:32Z","timestamp":1756373312000},"page":"6403-6413","source":"Crossref","is-referenced-by-count":2,"title":["Latrophilin-1 and latrophilin-2 as androgen receptor-responsive G protein-coupled receptors promote bladder cancer progression"],"prefix":"10.62347","volume":"17","author":[{"given":"Takuro","family":"Goto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","unstructured":"Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015; 65: 87-108.","journal-title":"CA Cancer J Clin"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2024; 74: 229-263.","journal-title":"CA Cancer J Clin"},{"key":"ref2","unstructured":"SEER Cancer Stat Facts: Bladder Cancer. National Cancer Institute, Bethesda, MD. Available online: http:\/\/seer.cancer.gov\/statfacts\/html\/urinb.html [Last accessed on June 17, 2025]."},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Goto T and Miyamoto H. Why has the prognosis for muscle-invasive bladder cancer not significantly improved after decades of therapeutic advancements? Expert Rev Anticancer Ther 2020; 20: 229-231.","DOI":"10.1080\/14737140.2020.1744437"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3390\/cancers15030566","article-title":"Current and future landscape of perioperative treatment for muscle-invasive bladder cancer","volume":"15","author":"Esteban-Villarrubia J","year":"2023","unstructured":"Esteban-Villarrubia J, Torres-Jiménez J, Bueno-Bravo C, Garcia-Mondaray R, Subiela JD and Gajate P. Current and future landscape of perioperative treatment for muscle-invasive bladder cancer. Cancers (Basel) 2023; 15: 566.","journal-title":"Cancers (Basel)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/jnci\/djk113","article-title":"Promotion of bladder cancer development and progression by androgen receptor signals","volume":"99","author":"Miyamoto","year":"2007","unstructured":"Miyamoto H, Yang Z, Chen YT, Ishiguro H, Uemura H, Kubota Y, Nagashima Y, Chang YJ, Hu YC, Tsai MY, Yeh S, Messing EM and Chang C. Promotion of bladder cancer development and progression by androgen receptor signals. J Natl Cancer Inst 2007; 99: 558-568.","journal-title":"J Natl Cancer Inst"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.mce.2017.06.021","article-title":"Role of the androgen receptor in urothelial cancer","volume":"465","author":"Inoue","year":"2018","unstructured":"Inoue S, Mizushima T and Miyamoto H. Role of the androgen receptor in urothelial cancer. Mol Cell Endocrinol 2018; 465: 73-81.","journal-title":"Mol Cell Endocrinol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.3390\/cells10051169","article-title":"Sex hormone receptor signaling in bladder cancer: a potential target for enhancing the efficacy of conventional non-surgical therapy","volume":"10","author":"Ide","year":"2021","unstructured":"Ide H and Miyamoto H. Sex hormone receptor signaling in bladder cancer: a potential target for enhancing the efficacy of conventional non-surgical therapy. Cells 2021; 10: 1169.","journal-title":"Cells"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.32604\/or.2025.062142","article-title":"Recent advances in understanding the role of sex hormone receptors in urothelial cancer","volume":"33","author":"Najafi MA","year":"2025","unstructured":"Elahi Najafi MA, Matsukawa T and Miyamoto H. Recent advances in understanding the role of sex hormone receptors in urothelial cancer. Oncol Res 2025; 33: 1255-1270.","journal-title":"Oncol Res"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Kawahara T, Ide H, Kashiwagi E, El-Shishtawy KA, Li Y, Reis LO, Zheng Y and Miyamoto H. Enzalutamide inhibits androgen receptor-positive bladder cancer cell growth. Urol Oncol 2016; 34: 432.e15-432.e23.","DOI":"10.1016\/j.urolonc.2016.05.016"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"23239","DOI":"10.1074\/jbc.271.38.23239","article-title":"Isolation and biochemical characterization of a Ca2+-independent α-latrotoxin-binding protein","volume":"271","author":"Davletov","year":"1996","unstructured":"Davletov BA, Shamotienko OG, Lelianova VG, Grishin EV and Ushkaryov YA. Isolation and biochemical characterization of a Ca2+-independent α-latrotoxin-binding protein. J Biol Chem 1996; 271: 23239-23245.","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1006\/bbrc.1996.1598","article-title":"The calcium-independent receptor of α-latrotoxin is not a neurexin","volume":"227","author":"Krasnoperov","year":"1996","unstructured":"Krasnoperov VG, Beavis R, Chepurny OG, Little AR, Plotnikov AN and Petrenko AG. The calcium-independent receptor of α-latrotoxin is not a neurexin. Biochem Biophys Res Commun 1996; 227: 868-875.","journal-title":"Biochem Biophys Res Commun"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1515\/bmc-2014-0032","article-title":"Latrophilins updated","volume":"5","author":"Meza-Aguilar","year":"2014","unstructured":"Meza-Aguilar DG and Boucard AA. Latrophilins updated. Biomol Concepts 2014; 5: 457-478.","journal-title":"Biomol Concepts"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"32715","DOI":"10.1074\/jbc.273.49.32715","article-title":"G-protein coupling not required for triggering exocytosis","volume":"273","author":"Sugita","year":"1998","unstructured":"Sugita S, Ichtchenko K, Khvotchev M and Südhof TC. α-Latrotoxin receptor CIRL\/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis. J Biol Chem 1998; 273: 32715-32724.","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1074\/jbc.M113.504779","article-title":"Latrophilins function as heterophilic cell-adhesion molecules by binding to teneurins: regulation by alternative splicing","volume":"289","author":"AA","year":"2014","unstructured":"Boucard AA, Maxeiner S and Südhol TC. Latrophilins function as heterophilic cell-adhesion molecules by binding to teneurins: regulation by alternative splicing. J Biol Chem 2014; 289: 387-402.","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1158\/1535-7163.MCT-20-0050","article-title":"Androgen receptor signaling reduces the efficacy of bacillus Calmette-Guérin therapy for bladder cancer via modulating Rab27b-induced exocytosis","volume":"191","author":"Mizushima","year":"2020","unstructured":"Mizushima T, Jiang G, Kawahara T, Li P, Han B, Inoue S, Ide H, Kato I, Jalalizadeh M, Miyagi E, Fukuda M, Reis LO and Miyamoto H. Androgen receptor signaling reduces the efficacy of bacillus Calmette-Guérin therapy for bladder cancer via modulating Rab27b-induced exocytosis. Mol Cancer Ther 2020; 191: 1930-1942.","journal-title":"Mol Cancer Ther"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1007\/s12672-024-01324-2","article-title":"Latrophilin-3 as a downstream effector of the androgen receptor induces bladder cancer progression","volume":"15","author":"Goto","year":"2024","unstructured":"Goto T, Teramoto Y, Nagata Y and Miyamoto H. Latrophilin-3 as a downstream effector of the androgen receptor induces bladder cancer progression. Discov Oncol 2024; 15: 440.","journal-title":"Discov Oncol"},{"key":"ref17","unstructured":"Li Y, Ishiguro H, Kawahara T, Miyamoto Y, Izumi K and Miyamoto H. GATA3 in the urinary bladder: suppression of neoplastic transformation and down-regulation by androgens. Am J Cancer Res 2014; 4: 461-473."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1530\/ERC-11-0010","article-title":"Dihydrtestosterone upregulates the expression of epidermal growth factor receptor and ERBB2 in androgen receptor-positive bladder cancer cells","volume":"18","author":"Zheng","year":"2011","unstructured":"Zheng Y, Izumi K, Yao JL and Miyamoto H. Dihydrtestosterone upregulates the expression of epidermal growth factor receptor and ERBB2 in androgen receptor-positive bladder cancer cells. Endocr Relat Cancer 2011; 18: 451-464.","journal-title":"Endocr Relat Cancer"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/mc.21833","article-title":"Androgen receptor signals regulate UDP-glucuronosyltransferases in the urinary bladder: a potential mechanism of androgen-induced bladder carcinogenesis","volume":"52","author":"Izumi","year":"2013","unstructured":"Izumi K, Zheng Y, Hsu JW, Chang C and Miyamoto H. Androgen receptor signals regulate UDP-glucuronosyltransferases in the urinary bladder: a potential mechanism of androgen-induced bladder carcinogenesis. Mol Carcinog 2013; 52: 94-102.","journal-title":"Mol Carcinog"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1002\/mc.23783","article-title":"Latrophilin-3 as a downstream effector of the androgen receptor induces urothelial tumorigenesis","volume":"63","author":"Goto","year":"2024","unstructured":"Goto T, Yasui M, Teramoto Y, Nagata Y, Mizushima T and Miyamoto H. Latrophilin-3 as a downstream effector of the androgen receptor induces urothelial tumorigenesis. Mol Carcinog 2024; 63: 1847-1854.","journal-title":"Mol Carcinog"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"557","DOI":"10.21873\/cgp.20472","article-title":"GULP1 as a downstream effector of the estrogen receptor-β modulates cisplatin sensitivity in bladder cancer","volume":"21","author":"Tatenuma","year":"2024","unstructured":"Tatenuma T, Matsukawa T, Goto T, Jiang G, Sharma A, Najafi MAE, Teramoto Y and Miyamoto H. GULP1 as a downstream effector of the estrogen receptor-β modulates cisplatin sensitivity in bladder cancer. Cancer Genomics Proteomics 2024; 21: 557-565.","journal-title":"Cancer Genomics Proteomics"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"13733","DOI":"10.3390\/ijms241813733","article-title":"GABBR2 as a downstream effector of the androgen receptor induces cisplatin resistance in bladder cancer","volume":"24","author":"Elahi Najafi","year":"2023","unstructured":"Elahi Najafi MA, Yasui M, Teramoto Y, Tatenuma T, Jiang G and Miyamoto H. GABBR2 as a downstream effector of the androgen receptor induces cisplatin resistance in bladder cancer. Int J Mol Sci 2023; 24: 13733.","journal-title":"Int J Mol Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1111\/j.1464-410X.2011.10706.x","article-title":"Expression of androgen and oestrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder","volume":"109","author":"Miyamoto","year":"2012","unstructured":"Miyamoto H, Yao JL, Chaux A, Zheng Y, Hsu I, Izumi K, Chang C, Messing EM, Netto GJ and Yeh S. Expression of androgen and oestrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder. BJU Int 2012; 109: 1716-1726.","journal-title":"BJU Int"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"7289","DOI":"10.3390\/ijms25137289","article-title":"Latrophilins as downstream effectors of androgen receptors including a splice variant, AR-V7, induce prostate cancer progression","volume":"25","author":"Teramoto","year":"2024","unstructured":"Teramoto Y, Elahi Najafi MA, Matsukawa T, Sharma A, Goto T and Miyamoto H. Latrophilins as downstream effectors of androgen receptors including a splice variant, AR-V7, induce prostate cancer progression. Int J Mol Sci 2024; 25: 7289.","journal-title":"Int J Mol Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics","volume":"48","author":"Kanda","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant 2013; 48: 452-458.","journal-title":"Bone Marrow Transplant"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrc2069","article-title":"G-protein-coupled receptors and cancer","volume":"7","author":"Dorsam","year":"2007","unstructured":"Dorsam RT and Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007; 7: 79-94.","journal-title":"Nat Rev Cancer"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/nchembio.642","article-title":"Inactive-state preassembly of Gq-coupled receptors and Gq heterodimers","volume":"7","author":"Qin","year":"2011","unstructured":"Qin K, Dong C, Wu G and Lambert NA. Inactive-state preassembly of Gq-coupled receptors and Gq heterodimers. Nat Chem Biol 2011; 7: 740-747.","journal-title":"Nat Chem Biol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"676","DOI":"10.4143\/crt.2015.153","article-title":"Aberrant epigenetic modifications of LPHN2 function as a potential cisplatin-specific biomarker for human gastrointestinal cancer","volume":"48","author":"Jeon","year":"2016","unstructured":"Jeon MS, Song SH, Yun J, Kang JY, Kim HP, Han SW and Kim TY. Aberrant epigenetic modifications of LPHN2 function as a potential cisplatin-specific biomarker for human gastrointestinal cancer. Cancer Res Treat 2016; 48: 676-686.","journal-title":"Cancer Res Treat"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"353","DOI":"10.4149\/gpb_2018008","article-title":"Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1","volume":"7","author":"Kocibalova","year":"2018","unstructured":"Kocibalova Z, Guzyova M, Imrichova D, Sulova Z and Breier A. Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1. Gen Physiol Biophys 2018; 7: 353-357.","journal-title":"Gen Physiol Biophys"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.3389\/fimmu.2019.01594","article-title":"The tim-3-galectin-9 pathway and its regulatory mechanisms in human breast cancer","volume":"10","author":"IM","year":"2019","unstructured":"Yasinska IM, Sakhnevych SS, Pavlova L, Teo Hansen Selnø A, Teuscher Abeleira AM, Benlaouer O, Gonçalves Silva I, Mosimann M, Varani L, Bardelli M, Hussain R, Siligardi G, Cholewa D, Berger SM, Gibbs BF, Ushkaryov YA, Fasler-Kan E, Klenova E and Sumbayev VV. The tim-3-galectin-9 pathway and its regulatory mechanisms in human breast cancer. Front Immunol 2019; 10: 1594.","journal-title":"Front Immunol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/s41374-021-00721-3","article-title":"Driver mutations in ADGRL3 are involved in the evolution of ependymoma","volume":"102","author":"Wang","year":"2022","unstructured":"Wang J, Xi SY, Zhao Q, Xia YF, Yang QY, Cai HP, Wang F, Zhao YY, Hu HJ, Yu ZH, Chen FR, Xu PF, Xu RZ, Wang J, Zhang J, Ke C, Zhang XH, Lin FH, Guo CC, Lv YC, Li C, Xie HT, Cui Q, Wu HM, Liu YH, Li Z, Su HK, Zeng J, Han F, Li ZJ, Sai K and Chen ZP. Driver mutations in ADGRL3 are involved in the evolution of ependymoma. Lab Invest 2022; 102: 702-710.","journal-title":"Lab Invest"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"O’Sullivan ML, de Wit J, Savas JN, Comoletti D, Otto-Hitt S, Yates JR 3rd and Ghosh A. Postsynaptic FLRT proteins are endogenous ligands for the black widow spider venom receptor Latrophilin and regulate excitatory synapse development. Neuron 2012; 73; 903-910.","DOI":"10.1016\/j.neuron.2012.01.018"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.neuroscience.2025.03.041","article-title":"Signaling by latrophilin adhesion-GPCRs in synapse assembly","volume":"575","author":"S&#xFC","year":"2025","unstructured":"Südhof TC. Signaling by latrophilin adhesion-GPCRs in synapse assembly. Neuroscience 2025; 575: 150-161.","journal-title":"Neuroscience"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Zhang S, Liu Y, Liu Z, Zhang C, Cao H, Ye Y, Wang S, Zhang Y, Xiao S, Yang P, Li J and Bai Z. Transcriptome profiling of a multiple recurrent muscle-invasive urothelial carcinoma of the bladder by deep sequencing. PLoS One 2014; 9: e91466.","DOI":"10.1371\/journal.pone.0091466"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/8\/ajtr0164140.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:58:27Z","timestamp":1766023107000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/8\/ajtr0164140.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":35,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/kfgi9710","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}