{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:47:17Z","timestamp":1784040437203,"version":"3.55.0"},"reference-count":50,"publisher":"e-Century Publishing Corporation","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Cancer Res"],"DOI":"10.62347\/kgbq9641","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T05:43:10Z","timestamp":1746510190000},"page":"1790-1805","source":"Crossref","is-referenced-by-count":2,"title":["Impact of doxycycline on mycoplasma pneumonia treatment and cancer prognosis in pediatric leukemia patients post-chemotherapy: a target trial emulation"],"prefix":"10.62347","volume":"15","author":[{"given":"Jun","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"1612702","DOI":"10.1155\/2022\/1612702","article-title":"The global burden of leukemia and its attributable factors in 204 countries and territories: findings from the global burden of disease 2019 study and projections to 2030","volume":"2022","author":"Du","year":"2022","unstructured":"Du M, Chen W, Liu K, Wang L, Hu Y, Mao Y, Sun X, Luo Y, Shi J, Shao K, Huang H and Ye D. The global burden of leukemia and its attributable factors in 204 countries and territories: findings from the global burden of disease 2019 study and projections to 2030. J Oncol 2022; 2022: 1612702.","journal-title":"J Oncol"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3322\/caac.21219","article-title":"Childhood and adolescent cancer statistics, 2014","volume":"64","author":"Ward","year":"2014","unstructured":"Ward E, DeSantis C, Robbins A, Kohler B and Jemal A. Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin 2014; 64: 83-103.","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1182\/blood-2016-08-733196","article-title":"Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel","volume":"129","author":"D&#xF6","year":"2017","unstructured":"Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, Dombret H, Ebert BL, Fenaux P, Larson RA, Levine RL, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz M, Sierra J, Tallman MS, Tien HF, Wei AH, Löwenberg B and Bloomfield CD. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood 2017; 129: 424-447.","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1513\/AnnalsATS.201304-097OC","article-title":"Pneumonia during remission induction chemotherapy in patients with acute leukemia","volume":"10","author":"Garcia","year":"2013","unstructured":"Garcia JB, Lei X, Wierda W, Cortes JE, Dickey BF, Evans SE and Ost DE. Pneumonia during remission induction chemotherapy in patients with acute leukemia. Ann Am Thorac Soc 2013; 10: 432-440.","journal-title":"Ann Am Thorac Soc"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1080\/21505594.2016.1141161","article-title":"Bloodstream infections in patients with solid tumors","volume":"7","author":"Gudiol","year":"2016","unstructured":"Gudiol C, Aguado JM and Carratalà J. Bloodstream infections in patients with solid tumors. Virulence 2016; 7: 298-308.","journal-title":"Virulence"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1200\/JCO.2016.71.7017","article-title":"Guideline for the management of fever and neutropenia in children with cancer and hematopoietic stem-cell transplantation recipients: 2017 update","volume":"35","author":"Lehrnbecher","year":"2017","unstructured":"Lehrnbecher T, Robinson P, Fisher B, Alexander S, Ammann RA, Beauchemin M, Carlesse F, Groll AH, Haeusler GM, Santolaya M, Steinbach WJ, Castagnola E, Davis BL, Dupuis LL, Gaur AH, Tissing WJE, Zaoutis T, Phillips R and Sung L. Guideline for the management of fever and neutropenia in children with cancer and hematopoietic stem-cell transplantation recipients: 2017 update. J Clin Oncol 2017; 35: 2082-2094.","journal-title":"J Clin Oncol"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Su M, Wang Q, Li D, Wang LL, Wang CY, Wang JL, Zhang Q, Du LY, Liu JY and Xie GC. Prevalence and clinical characteristics of hospitalized children with community-acquired Mycoplasma pneumoniae pneumonia during 2017\/2018, Chengde, China. Medicine (Baltimore) 2021; 100: e23786.","DOI":"10.1097\/MD.0000000000023786"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"535","DOI":"10.14740\/jocmr3421w","article-title":"Mycoplasma pneumoniae: a potentially severe infection","volume":"10","author":"Bajantri","year":"2018","unstructured":"Bajantri B, Venkatram S and Diaz-Fuentes G. Mycoplasma pneumoniae: a potentially severe infection. J Clin Med Res 2018; 10: 535-544.","journal-title":"J Clin Med Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"7147","DOI":"10.1038\/s41598-019-43451-9","article-title":"Immunosuppression reduces lung injury caused by mycoplasma pneumoniae infection","volume":"9","author":"Shi","year":"2019","unstructured":"Shi S, Zhang X, Zhou Y, Tang H, Zhao D and Liu F. Immunosuppression reduces lung injury caused by mycoplasma pneumoniae infection. Sci Rep 2019; 9: 7147.","journal-title":"Sci Rep"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.trsl.2020.03.011","article-title":"Microbiota-based approaches to mitigate infectious complications of intensive chemotherapy in patients with acute leukemia","volume":"220","author":"Rashidi","year":"2020","unstructured":"Rashidi A and Weisdorf DJ. Microbiota-based approaches to mitigate infectious complications of intensive chemotherapy in patients with acute leukemia. Transl Res 2020; 220: 167-181.","journal-title":"Transl Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s10753-020-01188-y","article-title":"Immunomodulatory effect of doxycycline ameliorates systemic and pulmonary inflammation in a murine polymicrobial sepsis model","volume":"43","author":"Patel","year":"2020","unstructured":"Patel A, Khande H, Periasamy H and Mokale S. Immunomodulatory effect of doxycycline ameliorates systemic and pulmonary inflammation in a murine polymicrobial sepsis model. Inflammation 2020; 43: 1035-1043.","journal-title":"Inflammation"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1093\/cid\/ciac615","article-title":"Efficacy of doxycycline for mild-to-moderate community-acquired pneumonia in adults: a systematic review and meta-analysis of randomized controlled trials","volume":"76","author":"Choi","year":"2023","unstructured":"Choi SH, Cesar A, Snow TAC, Saleem N, Arulkumaran N and Singer M. Efficacy of doxycycline for mild-to-moderate community-acquired pneumonia in adults: a systematic review and meta-analysis of randomized controlled trials. Clin Infect Dis 2023; 76: 683-691.","journal-title":"Clin Infect Dis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3322\/caac.21697","article-title":"Antibiotic resistance in the patient with cancer: escalating challenges and paths forward","volume":"71","author":"Nanayakkara","year":"2021","unstructured":"Nanayakkara AK, Boucher HW, Fowler VG Jr, Jezek A, Outterson K and Greenberg DE. Antibiotic resistance in the patient with cancer: escalating challenges and paths forward. CA Cancer J Clin 2021; 71: 488-504.","journal-title":"CA Cancer J Clin"},{"key":"ref13","unstructured":"Hematology Committee of Chinese Medical Association; Hematological Oncology Committee of China Anti-Cancer Association; Chinese Working Group for Chronic Lymphocytic Leukemia. The guidelines for diagnosis and treatment of chronic lymphocytic leukemia\/small lymphocytic lymphoma in China (2022). Zhonghua Xue Ye Xue Za Zhi 2022; 43: 353-358."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.6004\/jnccn.2015.0153","article-title":"2015","volume":"13","author":"Alvarnas","year":"2015","unstructured":"Alvarnas JC, Brown PA, Aoun P, Ballen KK, Barta SK, Borate U, Boyer MW, Burke PW, Cassaday R, Castro JE, Coccia PF, Coutre SE, Damon LE, DeAngelo DJ, Douer D, Frankfurt O, Greer JP, Johnson RA, Kantarjian HM, Klisovic RB, Kupfer G, Litzow M, Liu A, Rao AV, Shah B, Uy GL, Wang ES, Zelenetz AD, Gregory K and Smith C. Acute lymphoblastic leukemia, version 2.2015. J Natl Compr Canc Netw 2015; 13: 1240-1279.","journal-title":"J Natl Compr Canc Netw"},{"key":"ref15","unstructured":"Huang X; Chinese Society of Hematology, Chinese Medical Association. Chinese CML Committee. Guideline for the diagnosis and management in the disease monitoring of patients with Chronic Myeloid Leukemia in China (2014). Zhonghua Xue Ye Xue Za Zhi 2014; 35: 781-784."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s12519-024-00831-0","article-title":"Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children","volume":"20","author":"Wang","year":"2024","unstructured":"Wang YS, Zhou YL, Bai GN, Li SX, Xu D, Chen LN, Chen X, Dong XY, Fu HM, Fu Z, Hao CL, Hong JG, Liu EM, Liu HM, Lu XX, Luo ZX, Tang LF, Tian M, Yin Y, Zhang XB, Zhang JH, Zhang HL, Zhao DY, Zhao SY, Zhu GH, Zou YX, Lu Q, Zhang YY and Chen ZM. Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children. World J Pediatr 2024; 20: 901-914.","journal-title":"World J Pediatr"},{"key":"ref17","unstructured":"Bai XL. Clinical efficacy of azithromycin and clarithromycin in treatment of mycoplasmal pneumonia in children. Chinese Journal of Microecology 2015; [Epub ahead of print]."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3390\/antibiotics10020192","article-title":"Clinical efficacy of doxycycline for treatment of macrolide-resistant mycoplasma pneumoniae pneumonia in children","volume":"10","author":"Lee","year":"2021","unstructured":"Lee H, Choi YY, Sohn YJ, Kim YK, Han MS, Yun KW, Kim K, Park JY, Choi JH, Cho EY and Choi EH. Clinical efficacy of doxycycline for treatment of macrolide-resistant mycoplasma pneumoniae pneumonia in children. Antibiotics (Basel) 2021; 10: 192.","journal-title":"Antibiotics (Basel)"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"118","DOI":"10.30895\/2312-7821-2022-10-2-118-127","article-title":"Evaluation of the efficacy and safety of initial empirical antibiotic therapy for community-acquired pneumonia in middle-aged people","volume":"10","author":"Alexandrova","year":"2022","unstructured":"Alexandrova T, Muslimova O, Zhuravleva M, Alexandrov A, Gorodetskaya G, Demchenkova E, Demidova O, Sokova E, Mazerkina I and Smirnova Y. Evaluation of the efficacy and safety of initial empirical antibiotic therapy for community-acquired pneumonia in middle-aged people. Safety and Risk of Pharmacotherapy 2022; 10: 118-127.","journal-title":"Safety and Risk of Pharmacotherapy"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cmi.2015.01.003","article-title":"Blood culture-based diagnosis of bacteraemia: state of the art","volume":"21","author":"Opota","year":"2015","unstructured":"Opota O, Croxatto A, Prod’hom G and Greub G. Blood culture-based diagnosis of bacteraemia: state of the art. Clin Microbiol Infect 2015; 21: 313-322.","journal-title":"Clin Microbiol Infect"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13052-024-01615-y","article-title":"Efficacy of doxycycline therapy for macrolide-resistant Mycoplasma pneumoniae pneumonia in children at different periods","volume":"50","author":"Chen","year":"2024","unstructured":"Chen Y, Zhang Y, Tang QN and Shi HB. Efficacy of doxycycline therapy for macrolide-resistant Mycoplasma pneumoniae pneumonia in children at different periods. Ital J Pediatr 2024; 50: 38.","journal-title":"Ital J Pediatr"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"102589","DOI":"10.1016\/j.eclinm.2024.102589","article-title":"Effectiveness and safety of tetracyclines and quinolones in people with Mycoplasma pneumonia: a systematic review and network meta-analysis","volume":"71","author":"Cai","year":"2024","unstructured":"Cai F, Li J, Liang W, Wang L and Ruan J. Effectiveness and safety of tetracyclines and quinolones in people with Mycoplasma pneumonia: a systematic review and network meta-analysis. EClinicalMedicine 2024; 71: 102589.","journal-title":"EClinicalMedicine"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Yang D, Chen L and Chen Z. The timing of azithromycin treatment is not associated with the clinical prognosis of childhood Mycoplasma pneumoniae pneumonia in high macrolide-resistant prevalence settings. PLoS One 2018; 13: e0191951.","DOI":"10.1371\/journal.pone.0191951"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1161\/CIRCULATIONAHA.121.055953","article-title":"Doxycycline combined with bortezomib-cyclophosphamide-dexamethasone chemotherapy for newly diagnosed cardiac light-chain amyloidosis: a multicenter randomized controlled trial","volume":"145","author":"Shen","year":"2022","unstructured":"Shen KN, Fu WJ, Wu Y, Dong YJ, Huang ZX, Wei YQ, Li CR, Sun CY, Chen Y, Miao HL, Zhang YL, Cao XX, Zhou DB and Li J. Doxycycline combined with bortezomib-cyclophosphamide-dexamethasone chemotherapy for newly diagnosed cardiac light-chain amyloidosis: a multicenter randomized controlled trial. Circulation 2022; 145: 8-17.","journal-title":"Circulation"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jiac.2014.01.001","article-title":"Management of refractory Mycoplasma pneumoniae pneumonia: utility of measuring serum lactate dehydrogenase level","volume":"20","author":"Inamura","year":"2014","unstructured":"Inamura N, Miyashita N, Hasegawa S, Kato A, Fukuda Y, Saitoh A, Kondo E, Teranishi H, Wakabayashi T, Akaike H, Tanaka T, Ogita S, Nakano T, Terada K and Ouchi K. Management of refractory Mycoplasma pneumoniae pneumonia: utility of measuring serum lactate dehydrogenase level. J Infect Chemother 2014; 20: 270-273.","journal-title":"J Infect Chemother"},{"key":"ref26","unstructured":"Du J, Wu C, Li A, Chen J, Li Q and Wu X. Effectiveness of enhanced recovery after surgery-based respiratory function exercise in elderly patients with lung cancer and its effect on postoperative functional recovery. Altern Ther Health Med 2023; 29: 56-61."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1007\/s00520-013-1768-9","article-title":"Breakthrough febrile neutropenia and associated complications among elderly cancer patients receiving myelosuppressive chemotherapy for solid tumors and lymphomas","volume":"21","author":"Chan","year":"2013","unstructured":"Chan A, Lee CP, Chiang J and Ng R. Breakthrough febrile neutropenia and associated complications among elderly cancer patients receiving myelosuppressive chemotherapy for solid tumors and lymphomas. Support Care Cancer 2013; 21: 2137-2143.","journal-title":"Support Care Cancer"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.17650\/1818-8346-2024-19-3-99-111","article-title":"Treatment efficiency in patients with acute myeloid leukemia from 2019 to 2023 according to the Moscow Cancer Registry","volume":"19","author":"TN","year":"2024","unstructured":"Tolstykh TN, Misyurina EN, Mingalimov MA, Baryakh EA, Zhelnova EI, Gagloeva DE, Kardovskaya SA, Chudnova TS, Zotina EN, Ivanova DD, Kochneva OL, Yatskov KV, Shimanovskaya LT, Mar’in DS, Makeshova AB, Chernova NG, Dudina GA, Granatkin MA, Semina TA, Misyurin AV and Lysenko MA. Treatment efficiency in patients with acute myeloid leukemia from 2019 to 2023 according to the Moscow Cancer Registry. Oncohematology 2024; 19: 99-111.","journal-title":"Oncohematology"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"8019","DOI":"10.1074\/jbc.M113.535765","article-title":"Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization","volume":"289","author":"He","year":"2014","unstructured":"He L and Marneros AG. Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization. J Biol Chem 2014; 289: 8019-8028.","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"171","DOI":"10.5603\/FHC.a2016.0022","article-title":"Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-κB signaling in LPS-induced PC3 cells","volume":"54","author":"Ogut","year":"2016","unstructured":"Ogut D, Reel B, Gonen Korkmaz C, Arun MZ, Cilaker Micili S and Ergur BU. Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-κB signaling in LPS-induced PC3 cells. Folia Histochem Cytobiol 2016; 54: 171-180.","journal-title":"Folia Histochem Cytobiol"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Spivey J, Wood RC, Sirek HA and Moorman J. Retrospective evaluation of doxycycline versus azithromycin in non-intensive care unit veterans hospitalized with community-acquired pneumonia. J Pharm Pract 2019; [Epub ahead of print].","DOI":"10.33513\/PPPS\/1901-14"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Miow QH, Vallejo AF, Wang Y, Hong JM, Bai C, Teo FS, Wang AD, Loh HR, Tan TZ, Ding Y, She HW, Gan SH, Paton NI, Lum J, Tay A, Chee CB, Tambyah PA, Polak ME, Wang YT, Singhal A, Elkington PT, Friedland JS and Ong CW. Doxycycline host-directed therapy in human pulmonary tuberculosis. J Clin Invest 2021; 131: e141895.","DOI":"10.1172\/JCI141895"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Ravindra D, Huang G, Hallett K, Burgner DP, Gwee A and Silva MJ. Antibiotic exposure and dental health: a systematic review. Pediatrics 2023; 152: e2023061350.","DOI":"10.1542\/peds.2023-061350"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1177\/1060028019863796","article-title":"Doxycycline and tooth discoloration in children: changing of recommendations based on evidence of safety","volume":"53","author":"Stultz","year":"2019","unstructured":"Stultz JS and Eiland LS. Doxycycline and tooth discoloration in children: changing of recommendations based on evidence of safety. Ann Pharmacother 2019; 53: 1162-1166.","journal-title":"Ann Pharmacother"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.jpeds.2015.02.015","article-title":"No visible dental staining in children treated with doxycycline for suspected Rocky Mountain Spotted Fever","volume":"166","author":"SR","year":"2015","unstructured":"Todd SR, Dahlgren FS, Traeger MS, Beltrán-Aguilar ED, Marianos DW, Hamilton C, McQuiston JH and Regan JJ. No visible dental staining in children treated with doxycycline for suspected Rocky Mountain Spotted Fever. J Pediatr 2015; 166: 1246-1251.","journal-title":"J Pediatr"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.3389\/fphar.2019.01088","article-title":"Pharmacokinetic\/pharmacodynamic integration of doxycycline against mycoplasma hyopneumoniae in an in vitro model","volume":"10","author":"Zhang","year":"2019","unstructured":"Zhang H, Mao C, Li J, Huang Z, Gu X, Shen X and Ding H. Pharmacokinetic\/pharmacodynamic integration of doxycycline against mycoplasma hyopneumoniae in an in vitro model. Front Pharmacol 2019; 10: 1088.","journal-title":"Front Pharmacol"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Arora S and Vyavahare N. Elastin-targeted nanoparticles delivering doxycycline mitigate cytokine storm and reduce immune cell infiltration in LPS-mediated lung inflammation. PLoS One 2023; 18: e0286211.","DOI":"10.1371\/journal.pone.0286211"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.bcp.2014.08.001","article-title":"Doxycycline exerts multiple anti-allergy effects to attenuate murine allergic conjunctivitis and systemic anaphylaxis","volume":"91","author":"Su","year":"2014","unstructured":"Su W, Wan Q, Han L, Huang J, Chen X, Chen G, Zheng SG and Liang D. Doxycycline exerts multiple anti-allergy effects to attenuate murine allergic conjunctivitis and systemic anaphylaxis. Biochem Pharmacol 2014; 91: 359-368.","journal-title":"Biochem Pharmacol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1007\/s00404-022-06813-9","article-title":"Incidence and predictors for chemotherapy modifications and their impact on the outcome of ovarian cancer patients","volume":"307","author":"Hatsy","year":"2023","unstructured":"Hatsy S, Brambs C and Kiechle M. Incidence and predictors for chemotherapy modifications and their impact on the outcome of ovarian cancer patients. Arch Gynecol Obstet 2023; 307: 1891-1899.","journal-title":"Arch Gynecol Obstet"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jinf.2014.10.008","article-title":"The association between infections and chemotherapy interruptions among cancer patients: prospective cohort study","volume":"70","author":"Taha","year":"2015","unstructured":"Taha A, Vinograd I, Sakhnini A, Eliakim-Raz N, Farbman L, Baslo R, Stemmer SM, Gafter-Gvili A, Leibovici L and Paul M. The association between infections and chemotherapy interruptions among cancer patients: prospective cohort study. J Infect 2015; 70: 223-229.","journal-title":"J Infect"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"100715","DOI":"10.1016\/j.drup.2020.100715","article-title":"Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance","volume":"53","author":"Erin","year":"2020","unstructured":"Erin N, Grahovac J, Brozovic A and Efferth T. Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance. Drug Resist Updat 2020; 53: 100715.","journal-title":"Drug Resist Updat"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1200\/JCO.2014.60.2466","article-title":"Continuous therapy versus fixed duration of therapy in patients with newly diagnosed multiple myeloma","volume":"33","author":"Palumbo","year":"2015","unstructured":"Palumbo A, Gay F, Cavallo F, Di Raimondo F, Larocca A, Hardan I, Nagler A, Petrucci MT, Hajek R, Pezzatti S, Delforge M, Patriarca F, Donato F, Cerrato C, Nozzoli C, Yu Z, Boccadifuoco L, Caravita T, Benevolo G, Guglielmelli T, Vincelli D, Jacques C, Dimopoulos MA, Ciccone G, Musto P, Corradini P, Cavo M and Boccadoro M. Continuous therapy versus fixed duration of therapy in patients with newly diagnosed multiple myeloma. J Clin Oncol 2015; 33: 3459-3466.","journal-title":"J Clin Oncol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.ygyno.2013.08.009","article-title":"A prospective study evaluating the clinical relevance of a chemoresponse assay for treatment of patients with persistent or recurrent ovarian cancer","volume":"131","author":"Rutherford","year":"2013","unstructured":"Rutherford T, Orr J Jr, Grendys E Jr, Edwards R, Krivak TC, Holloway R, Moore RG, Puls L, Tillmanns T, Schink JC, Brower SL, Tian C and Herzog TJ. A prospective study evaluating the clinical relevance of a chemoresponse assay for treatment of patients with persistent or recurrent ovarian cancer. Gynecol Oncol 2013; 131: 362-367.","journal-title":"Gynecol Oncol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"230","DOI":"10.2478\/jccm-2023-0028","article-title":"Limitation of non-beneficial interventions and their impact on the intensive care unit costs","volume":"9","author":"Koutsouki","year":"2023","unstructured":"Koutsouki S, Kosmidis D, Nagy EO, Tsaroucha A, Anastasopoulos G, Pnevmatikos I and Papaioannou V. Limitation of non-beneficial interventions and their impact on the intensive care unit costs. J Crit Care Med (Targu Mures) 2023; 9: 230-238.","journal-title":"J Crit Care Med (Targu Mures)"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1017\/ice.2022.60","article-title":"Association of fluoroquinolones or cephalosporin plus macrolide with Clostridioides difficile infection (CDI) after treatment for community-acquired pneumonia","volume":"44","author":"Patel","year":"2023","unstructured":"Patel P, Deshpande A, Yu PC, Imrey PB, Lindenauer PK, Zilberberg MD, Haessler S and Rothberg MB. Association of fluoroquinolones or cephalosporin plus macrolide with Clostridioides difficile infection (CDI) after treatment for community-acquired pneumonia. Infect Control Hosp Epidemiol 2023; 44: 47-54.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s10096-014-2254-0","article-title":"Community-acquired pneumonia: impact of empirical antibiotic therapy without respiratory fluoroquinolones nor third-generation cephalosporins","volume":"34","author":"Pradelli","year":"2015","unstructured":"Pradelli J, Risso K, de Salvador FG, Cua E, Ruimy R and Roger PM. Community-acquired pneumonia: impact of empirical antibiotic therapy without respiratory fluoroquinolones nor third-generation cephalosporins. Eur J Clin Microbiol Infect Dis 2015; 34: 511-518.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1097\/INF.0000000000004568","article-title":"Treatment of macrolide-resistant mycoplasma pneumoniae pneumonia in children: a meta-analysis of macrolides versus tetracyclines","volume":"44","author":"Bolormaa","year":"2025","unstructured":"Bolormaa E, Park JY, Choe YJ, Kang CR, Choe SA and Mylonakis E. Treatment of macrolide-resistant mycoplasma pneumoniae pneumonia in children: a meta-analysis of macrolides versus tetracyclines. Pediatr Infect Dis J 2025; 44: 200-206.","journal-title":"Pediatr Infect Dis J"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1037\/met0000209","article-title":"The unappreciated heterogeneity of effect sizes: implications for power, precision, planning of research, and replication","volume":"24","author":"Kenny","year":"2019","unstructured":"Kenny DA and Judd CM. The unappreciated heterogeneity of effect sizes: implications for power, precision, planning of research, and replication. Psychol Methods 2019; 24: 578-589.","journal-title":"Psychol Methods"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s12350-017-1012-y","article-title":"Reducing bias using propensity score matching","volume":"25","author":"Morgan","year":"2018","unstructured":"Morgan CJ. Reducing bias using propensity score matching. J Nucl Cardiol 2018; 25: 404-406.","journal-title":"J Nucl Cardiol"}],"container-title":["American Journal of Cancer Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/4\/ajcr0163470.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:00:18Z","timestamp":1766023218000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/4\/ajcr0163470.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/kgbq9641","relation":{},"ISSN":["2156-6976"],"issn-type":[{"value":"2156-6976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}