{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:01:50Z","timestamp":1793379710484,"version":"4.5.0"},"reference-count":34,"publisher":"e-Century Publishing Corporation","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/kpgf8790","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T02:31:51Z","timestamp":1767148311000},"page":"9494-9515","source":"Crossref","is-referenced-by-count":1,"title":["A set of downregulated pleiotropic genes are possible multi-omics biomarkers underlying the irritable bowel syndrome-non-alcoholic fatty liver disease comorbidity"],"prefix":"10.62347","volume":"17","author":[{"given":"Jundong","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"229","DOI":"10.5056\/jnm22037","article-title":"Prevalence of irritable bowel syndrome in Japan, China, and South Korea: an international cross-sectional study","volume":"29","author":"Takeoka","year":"2023","unstructured":"Takeoka A, Kimura T, Hara S, Hamaguchi T, Fukudo S and Tayama J. Prevalence of irritable bowel syndrome in Japan, China, and South Korea: an international cross-sectional study. J Neurogastroenterol Motil 2023; 29: 229-237.","journal-title":"J Neurogastroenterol Motil"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Zhang L, Wang HL, Zhang YF, Mao XT, Wu TT, Huang ZH, Jiang WJ, Fan KQ, Liu DD, Yang B, Zhuang MH, Huang GM, Liang Y, Zhu SJ, Zhong JY, Xu GY, Li XM, Cao Q, Li YY and Jin J. Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon. Cell Metab 2025; 37: 87-103, e10.","DOI":"10.1016\/j.cmet.2024.09.002"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/s41575-023-00794-z","article-title":"Irritable bowel syndrome and mental health comorbidity - approach to multidisciplinary management","volume":"20","author":"Staudacher","year":"2023","unstructured":"Staudacher HM, Black CJ, Teasdale SB, Mikocka-Walus A and Keefer L. Irritable bowel syndrome and mental health comorbidity - approach to multidisciplinary management. Nat Rev Gastroenterol Hepatol 2023; 20: 582-596.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.biopsych.2023.12.024","article-title":"Irritable bowel syndrome is associated with brain health by neuroimaging, behavioral, biochemical, and genetic analyses","volume":"95","author":"Li","year":"2024","unstructured":"Li Z, Ma Q, Deng Y, Rolls ET, Shen C, Li Y, Zhang W, Xiang S, Langley C, Sahakian BJ, Robbins TW, Yu JT, Feng J and Cheng W. Irritable bowel syndrome is associated with brain health by neuroimaging, behavioral, biochemical, and genetic analyses. Biol Psychiatry 2024; 95: 1122-1132.","journal-title":"Biol Psychiatry"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1038\/s41380-023-01972-w","article-title":"The neurobiology of irritable bowel syndrome","volume":"28","author":"EA","year":"2023","unstructured":"Mayer EA, Ryu HJ and Bhatt RR. The neurobiology of irritable bowel syndrome. Mol Psychiatry 2023; 28: 1451-1465.","journal-title":"Mol Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1136\/gutjnl-2023-331003","article-title":"Metabolic dysfunction-associated steatotic liver disease and risk of cardiovascular disease","volume":"73","author":"Lee","year":"2024","unstructured":"Lee HH, Lee HA, Kim EJ, Kim HY, Kim HC, Ahn SH, Lee H and Kim SU. Metabolic dysfunction-associated steatotic liver disease and risk of cardiovascular disease. Gut 2024; 73: 533-540.","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jhep.2022.10.034","article-title":"Enhanced diagnosis of advanced fibrosis and cirrhosis in individuals with NAFLD using fibroscan-based agile scores","volume":"78","author":"Sanyal","year":"2023","unstructured":"Sanyal AJ, Foucquier J, Younossi ZM, Harrison SA, Newsome PN, Chan WK, Yilmaz Y, De Ledinghen V, Costentin C, Zheng MH, Wai-Sun Wong V, Elkhashab M, Huss RS, Myers RP, Roux M, Labourdette A, Destro M, Fournier-Poizat C, Miette V, Sandrin L and Boursier J. Enhanced diagnosis of advanced fibrosis and cirrhosis in individuals with NAFLD using fibroscan-based agile scores. J Hepatol 2023; 78: 247-259.","journal-title":"J Hepatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.jhep.2021.09.007","article-title":"NAFLD-driven HCC: safety and efficacy of current and emerging treatment options","volume":"76","author":"Foerster","year":"2022","unstructured":"Foerster F, Gairing SJ, M&#xFC;ller L and Galle PR. NAFLD-driven HCC: safety and efficacy of current and emerging treatment options. J Hepatol 2022; 76: 446-457.","journal-title":"J Hepatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.jhep.2023.04.036","article-title":"Changing epidemiology, global trends and implications for outcomes of NAFLD","volume":"79","author":"VW","year":"2023","unstructured":"Wong VW, Ekstedt M, Wong GL and Hagstr&#xF6;m H. Changing epidemiology, global trends and implications for outcomes of NAFLD. J Hepatol 2023; 79: 842-852.","journal-title":"J Hepatol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"925","DOI":"10.4254\/wjh.v15.i7.925","article-title":"Associations between irritable bowel syndrome and non-alcoholic fatty liver disease: a systematic review","volume":"15","author":"JJJ","year":"2023","unstructured":"Ng JJJ, Loo WM and Siah KTH. Associations between irritable bowel syndrome and non-alcoholic fatty liver disease: a systematic review. World J Hepatol 2023; 15: 925-938.","journal-title":"World J Hepatol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"8769","DOI":"10.1038\/s41598-023-35774-5","article-title":"The prevalence and burden of Rome IV bowel disorders of gut brain interaction in patients with non-alcoholic fatty liver disease: a cross-sectional study","volume":"13","author":"Purssell","year":"2023","unstructured":"Purssell H, Bennett L, Street O, Hanley KP, Hanley N, Vasant DH and Athwal VS. The prevalence and burden of Rome IV bowel disorders of gut brain interaction in patients with non-alcoholic fatty liver disease: a cross-sectional study. Sci Rep 2023; 13: 8769.","journal-title":"Sci Rep"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Dean YE, Loayza Pintado JJ, Rouzan SS, Nale LL, Abbas A, Aboushaira A, Alkasajy F, Ghanem AA, Patil VM, Gordeyeva Y, Motawea KR, Le MLP, Galal A, Cicani L, Attta R, Soliman A, Alzabidi L, Subedi A, Anjum N, Nahedh A, Mady T, Hazimeh Y, Amin H and Aiash H. The relationship between irritable bowel syndrome and metabolic syndrome: a systematic review and meta-analysis of 49,662 individuals. Endocrinol Diabetes Metab 2025; 8: e70041.","DOI":"10.1002\/edm2.70041"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"4986","DOI":"10.1038\/s41467-023-40552-y","article-title":"Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome","volume":"14","author":"Zhai","year":"2023","unstructured":"Zhai L, Xiao H, Lin C, Wong HLX, Lam YY, Gong M, Wu G, Ning Z, Huang C, Zhang Y, Yang C, Luo J, Zhang L, Zhao L, Zhang C, Lau JY, Lu A, Lau LT, Jia W, Zhao L and Bian ZX. Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome. Nat Commun 2023; 14: 4986.","journal-title":"Nat Commun"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.jcmgh.2023.03.002","article-title":"The multifaceted roles of macrophages in NAFLD pathogenesis","volume":"15","author":"Vonderlin","year":"2023","unstructured":"Vonderlin J, Chavakis T, Sieweke M and Tacke F. The multifaceted roles of macrophages in NAFLD pathogenesis. Cell Mol Gastroenterol Hepatol 2023; 15: 1311-1324.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1093\/ije\/dyh132","article-title":"Mendelian randomization: prospects, potentials, and limitations","volume":"33","author":"Smith","year":"2004","unstructured":"Smith GD and Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 2004; 33: 30-42.","journal-title":"Int J Epidemiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"101345","DOI":"10.1016\/j.jcmgh.2024.04.002","article-title":"Rome III criteria capture higher irritable bowel syndrome SNP-heritability and highlight a novel genetic link with cardiovascular traits","volume":"18","author":"Tavares L","year":"2024","unstructured":"Camargo Tavares L, Lopera-Maya EA, Bonfiglio F, Zheng T, Sinha T, Zanchetta Marques F, Zhernakova A, Sanna S and D&#x2019;Amato M. Rome III criteria capture higher irritable bowel syndrome SNP-heritability and highlight a novel genetic link with cardiovascular traits. Cell Mol Gastroenterol Hepatol 2024; 18: 101345.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"100437","DOI":"10.1016\/j.xcrm.2021.100437","article-title":"Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease","volume":"2","author":"Ghodsian","year":"2021","unstructured":"Ghodsian N, Abner E, Emdin CA, Gobeil &#xC9;, Taba N, Haas ME, Perrot N, Manikpurage HD, Gagnon &#xC9;, Bourgault J, St-Amand A, Couture C, Mitchell PL, Boss&#xE9; Y, Mathieu P, Vohl MC, Tchernof A, Th&#xE9;riault S, Khera AV, Esko T and Arsenault BJ. Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease. Cell Rep Med 2021; 2: 100437.","journal-title":"Cell Rep Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan BK","year":"2015","unstructured":"Bulik-Sullivan BK, Loh PR, Finucane HK, Ripke S, Yang J; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Patterson N, Daly MJ, Price AL and Neale BM. LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 2015; 47: 291-295.","journal-title":"Nat Genet"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1016\/j.ajhg.2021.09.011","article-title":"Genetic overlap and causality between blood metabolites and migraine","volume":"108","author":"Tanha","year":"2021","unstructured":"Tanha HM and Sathyanarayanan A; International Headache Genetics Consortium, Nyholt DR. Genetic overlap and causality between blood metabolites and migraine. Am J Hum Genet 2021; 108: 2086-2098.","journal-title":"Am J Hum Genet"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"de Leeuw CA, Mooij JM, Heskes T and Posthuma D. MAGMA: generalized gene-set analysis of GWAS data. PLoS Comput Biol 2015; 11: e1004219.","DOI":"10.1371\/journal.pcbi.1004219"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Ma W, Zhong X, Cai B, Shao M, Yu X, Lv M, Xu S, Zhan B, Li Q, Ma M, Kj&#xE6;r M B, Huang J, Luo Y, Gr&#xF8;nb&#xE6;k H and Lin L. Unveiling the pathogenesis of non-alcoholic fatty liver disease by decoding biomarkers through integrated single-cell and single-nucleus profiles. 2023; 2023.10.05.23296635.","DOI":"10.1101\/2023.10.05.23296635"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/s41586-024-07465-2","article-title":"Acquisition of epithelial plasticity in human chronic liver disease","volume":"630","author":"Gribben","year":"2024","unstructured":"Gribben C, Galanakis V, Calderwood A, Williams EC, Chazarra-Gil R, Larraz M, Frau C, Puengel T, Guillot A, Rouhani FJ, Mahbubani K, Godfrey E, Davies SE, Athanasiadis E, Saeb-Parsy K, Tacke F, Allison M, Mohorianu I and Vallier L. Acquisition of epithelial plasticity in human chronic liver disease. Nature 2024; 630: 166-173.","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Stuart T, Butler A, Hoffman P, Hafemeister C, Papalexi E, Mauck WM 3rd, Hao Y, Stoeckius M, Smibert P and Satija R. Comprehensive integration of single-cell data. Cell 2019; 177: 1888-1902, e21.","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/s41589-019-0418-z","article-title":"Choosing a mating site","volume":"15","author":"Bucci","year":"2019","unstructured":"Bucci M. Choosing a mating site. Nat Chem Biol 2019; 15: 1131.","journal-title":"Nat Chem Biol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","unstructured":"Aibar S, Gonz&#xE1;lez-Blas CB, Moerman T, Huynh-Thu VA, Imrichova H, Hulselmans G, Rambow F, Marine JC, Geurts P, Aerts J, van den Oord J, Atak ZK, Wouters J and Aerts S. SCENIC: single-cell regulatory network inference and clustering. Nat Methods 2017; 14: 1083-1086.","journal-title":"Nat Methods"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","unstructured":"Liberzon A, Birger C, Thorvaldsd&#xF3;ttir H, Ghandi M, Mesirov JP and Tamayo P. The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst 2015; 1: 417-425.","journal-title":"Cell Syst"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.3390\/nu15102323","article-title":"Dysregulation of lipid and glucose metabolism in nonalcoholic fatty liver disease","volume":"15","author":"Bhat","year":"2023","unstructured":"Bhat N and Mani A. Dysregulation of lipid and glucose metabolism in nonalcoholic fatty liver disease. Nutrients 2023; 15: 2323.","journal-title":"Nutrients"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Chao G and Zhang S. Aquaporins 1, 3 and 8 expression and cytokines in irritable bowel syndrome rats&#x2019; colon via cAMP-PKA pathway. Int J Clin Exp Pathol 2018; 11: 4117-4123.","DOI":"10.2139\/ssrn.3228209"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.bbagen.2018.06.002","article-title":"Exploring the major cross-talking edges of competitive endogenous RNA networks in human chronic and acute myeloid leukemia","volume":"1862","author":"Sen","year":"2018","unstructured":"Sen K, Bhattacharyya D, Sarkar A, Das J, Maji N, Basu M, Ghosh Z and Ghosh TC. Exploring the major cross-talking edges of competitive endogenous RNA networks in human chronic and acute myeloid leukemia. Biochim Biophys Acta Gen Subj 2018; 1862: 1883-1892.","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12986-019-0400-5","article-title":"Hepatic PKA inhibition accelerates the lipid accumulation in liver","volume":"16","author":"Yang","year":"2019","unstructured":"Yang J, Zhang X, Yi L, Yang L, Wang WE, Zeng C, Mi M and Chen X. Hepatic PKA inhibition accelerates the lipid accumulation in liver. Nutr Metab 2019; 16: 69.","journal-title":"Nutr Metab"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.2174\/1871530320999201126202706","article-title":"Contribution of Rs780094 and Rs1260326 polymorphisms in GCKR gene to non-alcoholic fatty liver disease: a meta-analysis involving 26,552 participants","volume":"21","author":"Li","year":"2021","unstructured":"Li J, Zhao Y, Zhang H, Hua W, Jiao W, Du X, Rui J, Li S, Teng H, Shi B, Yang X and Zhu L. Contribution of Rs780094 and Rs1260326 polymorphisms in GCKR gene to non-alcoholic fatty liver disease: a meta-analysis involving 26,552 participants. Endocr Metab Immune Disord Drug Targets 2021; 21: 1696-1708.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jhep.2017.09.003","article-title":"Genetics and epigenetics of NAFLD and NASH: clinical impact","volume":"68","author":"Eslam","year":"2018","unstructured":"Eslam M, Valenti L and Romeo S. Genetics and epigenetics of NAFLD and NASH: clinical impact. J Hepatol 2018; 68: 268-279.","journal-title":"J Hepatol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1182\/blood-2010-12-324053","article-title":"ARHGAP25, a novel Rac GTPase-activating protein, regulates phagocytosis in human neutrophilic granulocytes","volume":"119","author":"Cs&#xE9","year":"2012","unstructured":"Cs&#xE9;p&#xE1;nyi-K&#xF6;mi R, Sirokm&#xE1;ny G, Geiszt M and Ligeti E. ARHGAP25, a novel Rac GTPase-activating protein, regulates phagocytosis in human neutrophilic granulocytes. Blood 2012; 119: 573-582.","journal-title":"Blood"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.jhep.2020.04.003","article-title":"Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort&#x2606;","volume":"73","author":"QM","year":"2020","unstructured":"Anstee QM, Darlay R, Cockell S, Meroni M, Govaere O, Tiniakos D, Burt AD, Bedossa P, Palmer J, Liu YL, Aithal GP, Allison M, Yki-J&#xE4;rvinen H, Vacca M, Dufour JF, Invernizzi P, Prati D, Ekstedt M, Kechagias S, Francque S, Petta S, Bugianesi E, Clement K, Ratziu V, Schattenberg JM, Valenti L, Day CP, Cordell HJ and Daly AK; EPoS Consortium Investigators. Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort&#x2606;. J Hepatol 2020; 73: 505-515.","journal-title":"J Hepatol"}],"container-title":["American Journal of Translational Research"],"original-title":[],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:44:02Z","timestamp":1792662242000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/12\/ajtr0168783.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/kpgf8790","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}