{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:49:01Z","timestamp":1790689741973,"version":"4.1.0"},"reference-count":46,"publisher":"e-Century Publishing Corporation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/kvcv7377","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T03:47:41Z","timestamp":1740714461000},"page":"1170-1177","source":"Crossref","is-referenced-by-count":10,"title":["Prognostic value of the neutrophil to lymphocyte ratio for cardiovascular diseases: research progress"],"prefix":"10.62347","volume":"17","author":[{"given":"Xinyue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Goldsborough E 3rd, Osuji N and Blaha MJ. Assessment of cardiovascular disease risk: a 2022 update. Endocrinol Metab Clin North Am 2022; 51: 483-509.","DOI":"10.1016\/j.ecl.2022.02.005"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Saito Y, Tanaka A, Node K and Kobayashi Y. Uric acid and cardiovascular disease: a clinical review. J Cardiol 2021; 78: 51-57.","DOI":"10.1016\/j.jjcc.2020.12.013"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Soppert J, Lehrke M, Marx N, Jankowski J and Noels H. Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting. Adv Drug Deliv Rev 2020; 159: 4-33.","DOI":"10.1016\/j.addr.2020.07.019"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Sue LY and Leung AM. Levothyroxine for the treatment of subclinical hypothyroidism and cardiovascular disease. Front Endocrinol (Lausanne) 2020; 11: 591588.","DOI":"10.3389\/fendo.2020.591588"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Barzilay JI, Farag YMK and Durthaler J. Albuminuria: an underappreciated risk factor for cardiovascular disease. J Am Heart Assoc 2024; 13: e030131.","DOI":"10.1161\/JAHA.123.030131"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Rao K, Brieger D, Baer A, Nour D, Allum J and Bhindi R. Cardiovascular disease in australians experiencing homelessness. Heart Lung Circ 2022; 31: 1585-1593.","DOI":"10.1016\/j.hlc.2022.08.017"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Garcia-Rios A and Ordovas JM. Chronodisruption and cardiovascular disease. Clin Investig Arterioscler 2022; 34 Suppl 1: S32-S37.","DOI":"10.1016\/j.arteri.2021.12.004"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Hopkins S, Gajagowni S, Qadeer Y, Wang Z, Virani SS, Meurman JH and Krittanawong C. Oral health and cardiovascular disease. Am J Med 2024; 137: 304-307.","DOI":"10.1016\/j.amjmed.2023.11.022"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Samson R, Ennezat PV, Le Jemtel TH and Oparil S. Cardiovascular disease risk reduction and body mass index. Curr Hypertens Rep 2022; 24: 535-546.","DOI":"10.1007\/s11906-022-01213-5"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Siasos G, Bletsa E, Stampouloglou PK, Oikonomou E, Tsigkou V, Paschou SA, Vlasis K, Marinos G, Vavuranakis M, Stefanadis C and Tousoulis D. MicroRNAs in cardiovascular disease. Hellenic J Cardiol 2020; 61: 165-173.","DOI":"10.1016\/j.hjc.2020.03.003"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Polytarchou K, Varvarousis D and Manolis AS. Cardiovascular disease in antiphospholipid syndrome. Curr Vasc Pharmacol 2020; 18: 538-548.","DOI":"10.2174\/1570161117666190830101341"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Sethwala AM, Goh I and Amerena JV. Combating inflammation in cardiovascular disease. Heart Lung Circ 2021; 30: 197-206.","DOI":"10.1016\/j.hlc.2020.09.003"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Zhou Y, Huang C, Hu Y, Xu Q and Hu X. Lymphatics in cardiovascular disease. Arterioscler Thromb Vasc Biol 2020; 40: e275-e283.","DOI":"10.1161\/ATVBAHA.120.314735"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Lewis CV and Taylor WR. Intestinal barrier dysfunction as a therapeutic target for cardiovascular disease. Am J Physiol Heart Circ Physiol 2020; 319: H1227-H1233.","DOI":"10.1152\/ajpheart.00612.2020"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Almourani R, Chinnakotla B, Patel R, Kurukulasuriya LR and Sowers J. Diabetes and cardiovascular disease: an update. Curr Diab Rep 2019; 19: 161.","DOI":"10.1007\/s11892-019-1239-x"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Sunbao L, Hui C, Li Z, Hehe C, Siwen L and Hongwei L. Neutrophil-to-lymphocyte ratio predicts coronary artery lesion severity and long-term cardiovascular mortality in patients with unstable angina pectoris. Acta Cardiol 2022; 77: 708-715.","DOI":"10.1080\/00015385.2021.1963564"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Mehmet G, Huseyin U, Mehmet E, Murat U, Turgay I, Erkan A, Ceyhan T, Hale UA, Ozgur A and Nevzat U. Predictive value of neutrophil to lymphocyte ratio in clinical outcomes of non-ST elevation myocardial infarction and unstable angina pectoris: a 3-year follow-up. Clin Appl Thromb Hemost 2014; 20: 378-384.","DOI":"10.1177\/1076029612465669"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Bryan GL, Angela FC, Marwa HI, Pierre JJ and Rina A. Hematological biomarkers of troponin, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio serve as effective predictive indicators of high-risk mortality in acute coronary syndrome. Biomedicine (Taipei) 2023; 13: 32-43.","DOI":"10.37796\/2211-8039.1425"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Bucciarelli V, Caterino AL, Bianco F, Caputi CG, Salerni S, Sciomer S, Maffei S and Gallina S. Depression and cardiovascular disease: the deep blue sea of women&#x2019;s heart. Trends Cardiovasc Med 2020; 30: 170-176.","DOI":"10.1016\/j.tcm.2019.05.001"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Ouyang J, Wang H and Huang J. The role of lactate in cardiovascular diseases. Cell Commun Signal 2023; 21: 317.","DOI":"10.1186\/s12964-023-01350-7"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Osman T, Firat O, Ahmet I, Derya T, Erfogan S, Eyup B, Sinan A, Mahmut A and Mehmet GK. Usefulness of the neutrophil-to-lymphocyte ratio to predict bare-metal stent restenosis. Am J Cardiol 2012; 110: 1405-1410.","DOI":"10.1016\/j.amjcard.2012.07.003"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Li C, Zhang F, Shen Y, Xu R, Chen Z, Dai Y, Lu H, Chang S, Qian J, Wang X and Ge J. Impact of neutrophil to lymphocyte ratio (NLR) index and its periprocedural change (NLR(delta)) for percutaneous coronary intervention in patients with chronic total occlusion. Angiology 2017; 68: 640-646.","DOI":"10.1177\/0003319716649112"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Schoch L, Alcover S, PadrP T, Ben-Aicha S, Mendieta G, Badimon L and Vilahur G. Update of HDL in atherosclerotic cardiovascular disease. Clin Investig Arterioscler 2023; 35: 297-314.","DOI":"10.1016\/j.arteri.2023.10.002"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Gong M, Zhang Y, Chen N, Ma LL, Feng XM and Yan YX. Proteomics in cardiovascular disease. Clin Chim Acta 2024; 557: 117877.","DOI":"10.1016\/j.cca.2024.117877"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Valk R, Hammill J and Grip J. Saturated fat: villain and bogeyman in the development of cardiovascular disease? Eur J Prev Cardiol 2022; 29: 2312-2321.","DOI":"10.1093\/eurjpc\/zwac194"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Yi TW and Levin A. Sex, gender, and cardiovascular disease in chronic kidney disease. Semin Nephrol 2022; 42: 197-207.","DOI":"10.1016\/j.semnephrol.2022.04.009"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Shaoqing H, Hongxia H, Peng F, Shuai L and Changyi C. Association of neutrophil-to-lymphocyte ratio and risk of cardiovascular and all-cause mortality in hypertension patients. Heliyon 2024; 10: e27517.","DOI":"10.1016\/j.heliyon.2024.e27517"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Songhong S, Liwen C, Rong Y and Jinxiu Z. Neutrophil-to-lymphocyte ratio as a predictor of all-cause and cardiovascular mortality in coronary heart disease and hypertensive patients: a retrospective cohort study. Front Endocrinol (Lausanne) 2024; 15: 1442165.","DOI":"10.3389\/fendo.2024.1442165"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Khiatah B, Jazayeri S, Yamamoto N, Burt T, Frugoli A and Brooks DL. Cardiovascular disease in women: a review of spontaneous coronary artery dissection. Medicine (Baltimore) 2022; 101: e30433.","DOI":"10.1097\/MD.0000000000030433"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Sopic M, Vilne B, Gerdts E, Trindade F, Uchida S, Khatib S, Wettinger SB, Devaux Y and Magni P; EU-AtheroNET COST Action CA21153. Multiomics tools for improved atherosclerotic cardiovascular disease management. Trends Mol Med 2023; 29: 983-995.","DOI":"10.1016\/j.molmed.2023.09.004"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Birdwell KA and Park M. Post-transplant cardiovascular disease. Clin J Am Soc Nephrol 2021; 16: 1878-1889.","DOI":"10.2215\/CJN.00520121"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Nakashima M, Nakamura K, Nishihara T, Ichikawa K, Nakayama R, Takaya Y, Toh N, Akagi S, Miyoshi T, Akagi T and Ito H. Association between cardiovascular disease and liver disease, from a clinically pragmatic perspective as a cardiologist. Nutrients 2023; 15: 748.","DOI":"10.3390\/nu15030748"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Shimabukuro M. Serotonin and atheroscelotic cardiovascular disease. J Atheroscler Thromb 2022; 29: 315-316.","DOI":"10.5551\/jat.ED182"},{"key":"ref33","unstructured":"Duan JY, Yang P, Wang Y, Zheng RJ, Yuan MY, Yang XC, Li Y and Wang Y. Impact of NLR on atrial fibrillation recurrence after radiofrequency ablation in atrial fibrillation patients combined with heart failure. Zhonghua Xin Xue Guan Bing Za Zhi 2022; 50: 1074-1079."},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Ding B, Liu P, Zhang F, Hui J and He L. Predicting values of neutrophil-to-lymphocyte ratio (NLR), high-sensitivity C-reactive protein (hs-CRP), and left atrial diameter (LAD) in patients with nonvalvular atrial fibrillation recurrence after radiofrequency ablation. Med Sci Monit 2022; 28: e934569.","DOI":"10.12659\/MSM.934569"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Fischer MA and Vondriska TM. Clinical epigenomics for cardiovascular disease: diagnostics and therapies. J Mol Cell Cardiol 2021; 154: 97-105.","DOI":"10.1016\/j.yjmcc.2021.01.011"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Mehta A, Chandiramani R, Spirito A, Vogel B and Mehran R. Significance of kidney disease in cardiovascular disease patients. Interv Cardiol Clin 2023; 12: 453-467.","DOI":"10.1016\/j.iccl.2023.06.006"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Tousoulis D and Papageorgiou N. Cardiovascular disease: from diagnosis to therapy. Curr Med Chem 2020; 27: 4438-4439.","DOI":"10.2174\/092986732727200619175755"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Vakhshoori M, Nemati S, Sabouhi S, Yavari B, Shakarami M, Bondariyan N, Emami SA and Shafie D. Neutrophil to lymphocyte ratio (NLR) prognostic effects on heart failure; a systematic review and meta-analysis. BMC Cardiovasc Disord 2023; 23: 555.","DOI":"10.1186\/s12872-023-03572-6"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Liu L, Chen Y and Xie J. Association of GNRI, NLR, and FT3 with the clinical prognosis of older patients with heart failure. Int Heart J 2022; 63: 1048-1054.","DOI":"10.1536\/ihj.22-306"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Li Z, Rong H, Wu W, Huang T and Xu J. Application value of NT-proBNP combined with NLR in evaluation of major adverse cardiac events in elderly patients with chronic heart failure. Emerg Med Int 2022; 2022: 3689445.","DOI":"10.1155\/2022\/3689445"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Clifford AH. Cardiovascular disease in large vessel vasculitis: risks, controversies, and management strategies. Rheum Dis Clin North Am 2023; 49: 81-96.","DOI":"10.1016\/j.rdc.2022.08.004"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Quiles-Jim&#xE9;nez A, Dahl TB, Bj&#xF8;r&#xE5;s M, Alseth I, Halvorsen B and Gregersen I. Epitranscriptome in ischemic cardiovascular disease: potential target for therapies. Stroke 2022; 53: 2114-2122.","DOI":"10.1161\/STROKEAHA.121.037581"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Baysal E, Burak C, Cay S, Aksu T, Alt&#x131;nta&#x15F; B, Yaylak B, Sev&#xFC;k U and Bilge &#xD6;. The neutrophil to lymphocyte ratio is associated with severity of rheumatic mitral valve stenosis. J Blood Med 2015; 6: 151-156.","DOI":"10.2147\/JBM.S82423"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Polat N, Yildiz A, Yuksel M, Bilik MZ, Aydin M, Acet H, Akil MA, Oylumlu M, Kaya H, Ertas F and Cil H. Association of neutrophil-lymphocyte ratio with the presence and severity of rheumatic mitral valve stenosis. Clin Appl Thromb Hemost 2014; 20: 793-798.","DOI":"10.1177\/1076029613514131"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Tian H, Jiang X, Duan G, Chen J, Liu Q, Zhang Y, Li S, Bao X and Huang H. Preoperative inflammatory markers predict postoperative clinical outcomes in patients undergoing heart valve surgery: a large-sample retrospective study. Front Immunol 2023; 14: 1159089.","DOI":"10.3389\/fimmu.2023.1159089"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/2\/ajtr0162242.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:59:26Z","timestamp":1766023166000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/2\/ajtr0162242.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/kvcv7377","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}