{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:46:15Z","timestamp":1784331975045,"version":"3.55.0"},"reference-count":51,"publisher":"e-Century Publishing Corporation","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Cancer Res"],"DOI":"10.62347\/lbyg9841","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T02:10:13Z","timestamp":1759111813000},"page":"3854-3870","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic stress-induced dysregulation of the Hippo signaling pathway inhibits the occurrence of hepatocarcinoma"],"prefix":"10.62347","volume":"15","author":[{"given":"Shengming","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","unstructured":"Kisseleva T and Brenner D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol 2021; 18: 151-166.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","unstructured":"Parola M and Pinzani M. Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues. Mol Aspects Med 2019; 65: 37-55.","journal-title":"Mol Aspects Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41575-023-00746-7","article-title":"Lactylation and HCC progression","volume":"20","author":"Kotsiliti","year":"2023","unstructured":"Kotsiliti E. Lactylation and HCC progression. Nat Rev Gastroenterol Hepatol 2023; 20: 131.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/liv.14390","article-title":"Collagen biology and non-invasive biomarkers of liver fibrosis","volume":"40","author":"Karsdal","year":"2020","unstructured":"Karsdal MA, Daniels SJ, Holm Nielsen S, Bager C, Rasmussen DGK, Loomba R, Surabattula R, Villesen IF, Luo Y, Shevell D, Gudmann NS, Nielsen MJ, George J, Christian R, Leeming DJ and Schuppan D. Collagen biology and non-invasive biomarkers of liver fibrosis. Liver Int 2020; 40: 736-750.","journal-title":"Liver Int"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Berumen J, Baglieri J, Kisseleva T and Mekeel K. Liver fibrosis: pathophysiology and clinical implications. WIREs Mech Dis 2021; 13: e1499.","DOI":"10.1002\/wsbm.1499"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00268-021-06373-0","article-title":"Mortality following appendicectomy in patients with liver cirrhosis: a systematic review and meta-analysis","volume":"46","author":"Rashid","year":"2022","unstructured":"Rashid A, Gupta A, Adiamah A, West J, Grainge M and Humes DJ. Mortality following appendicectomy in patients with liver cirrhosis: a systematic review and meta-analysis. World J Surg 2022; 46: 531-541.","journal-title":"World J Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"875","DOI":"10.3390\/cells9040875","article-title":"Liver fibrosis: mechanistic concepts and therapeutic perspectives","volume":"9","author":"Roehlen","year":"2020","unstructured":"Roehlen N, Crouchet E and Baumert TF. Liver fibrosis: mechanistic concepts and therapeutic perspectives. Cells 2020; 9: 875.","journal-title":"Cells"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/hep.32285","article-title":"Hepatic fibrosis 2022: unmet needs and a blueprint for the future","volume":"75","author":"Friedman","year":"2022","unstructured":"Friedman SL and Pinzani M. Hepatic fibrosis 2022: unmet needs and a blueprint for the future. Hepatology 2022; 75: 473-488.","journal-title":"Hepatology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"119298","DOI":"10.1016\/j.jep.2024.119298","article-title":"The advancement of targeted regulation of hepatic stellate cells using traditional Chinese medicine for the treatment of liver fibrosis","volume":"341","author":"Liang","year":"2025","unstructured":"Liang C, Liu J, Jiang M, Zhu Y and Dong P. The advancement of targeted regulation of hepatic stellate cells using traditional Chinese medicine for the treatment of liver fibrosis. J Ethnopharmacol 2025; 341: 119298.","journal-title":"J Ethnopharmacol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.hbpd.2022.10.003","article-title":"Wnt\/beta-catenin signaling and its modulators in nonalcoholic fatty liver diseases","volume":"22","author":"Shree Harini","year":"2023","unstructured":"Shree Harini K and Ezhilarasan D. Wnt\/beta-catenin signaling and its modulators in nonalcoholic fatty liver diseases. Hepatobiliary Pancreat Dis Int 2023; 22: 333-345.","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"108563","DOI":"10.1016\/j.pharmthera.2023.108563","article-title":"Therapeutic potential of stem cells in regeneration of liver in chronic liver diseases: current perspectives and future challenges","volume":"253","author":"Yadav","year":"2024","unstructured":"Yadav P, Singh SK, Rajput S, Allawadhi P, Khurana A, Weiskirchen R and Navik U. Therapeutic potential of stem cells in regeneration of liver in chronic liver diseases: current perspectives and future challenges. Pharmacol Ther 2024; 253: 108563.","journal-title":"Pharmacol Ther"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.jhep.2022.05.040","article-title":"The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis","volume":"77","author":"Bresciani","year":"2022","unstructured":"Bresciani N, Demagny H, Lemos V, Pontanari F, Li X, Sun Y, Li H, Perino A, Auwerx J and Schoonjans K. The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. J Hepatol 2022; 77: 1071-1082.","journal-title":"J Hepatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/s41401-021-00658-9","article-title":"Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1\/alpha-KG-mediated glycolysis","volume":"43","author":"Xu","year":"2022","unstructured":"Xu L, Yang TY, Zhou YW, Wu MF, Shen J, Cheng JL, Liu QX, Cao SY, Wang JQ and Zhang L. Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1\/alpha-KG-mediated glycolysis. Acta Pharmacol Sin 2022; 43: 316-329.","journal-title":"Acta Pharmacol Sin"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1080\/14728222.2019.1615883","article-title":"Aberrant lipid metabolism as a therapeutic target in liver cancer","volume":"23","author":"ED 3rd","year":"2019","unstructured":"Pope ED 3rd, Kimbrough EO, Vemireddy LP, Surapaneni PK, Copland JA 3rd and Mody K. Aberrant lipid metabolism as a therapeutic target in liver cancer. Expert Opin Ther Targets 2019; 23: 473-483.","journal-title":"Expert Opin Ther Targets"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.tem.2023.02.007","article-title":"ncRNA-mediated fatty acid metabolism reprogramming in HCC","volume":"34","author":"Xu","year":"2023","unstructured":"Xu K, Xia P, Chen X, Ma W and Yuan Y. ncRNA-mediated fatty acid metabolism reprogramming in HCC. Trends Endocrinol Metab 2023; 34: 278-291.","journal-title":"Trends Endocrinol Metab"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.jhep.2019.12.015","article-title":"OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism","volume":"72","author":"Dai","year":"2020","unstructured":"Dai W, Xu L, Yu X, Zhang G, Guo H, Liu H, Song G, Weng S, Dong L, Zhu J, Liu T, Guo C and Shen X. OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism. J Hepatol 2020; 72: 909-923.","journal-title":"J Hepatol"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Kar A, Samanta A, Mukherjee S, Barik S and Biswas A. The HBV web: an insight into molecular interactomes between the hepatitis B virus and its host en route to hepatocellular carcinoma. J Med Virol 2023; 95: e28436.","DOI":"10.1002\/jmv.28436"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Tu T, McQuaid TJ and Jacobson IM. HBV-induced carcinogenesis: mechanisms, correlation with viral suppression, and implications for treatment. Liver Int 2025; 45: e16202.","DOI":"10.1111\/liv.16202"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"8011","DOI":"10.3390\/ijms22158011","article-title":"Role of immune cells in patients with hepatitis B virus-related hepatocellular carcinoma","volume":"22","author":"Cho","year":"2021","unstructured":"Cho HJ and Cheong JY. Role of immune cells in patients with hepatitis B virus-related hepatocellular carcinoma. Int J Mol Sci 2021; 22: 8011.","journal-title":"Int J Mol Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"862","DOI":"10.3390\/v13050862","article-title":"Hepatitis B virus Pre-S gene deletions and Pre-S deleted proteins: clinical and molecular implications in hepatocellular carcinoma","volume":"13","author":"Lin","year":"2021","unstructured":"Lin YT, Jeng LB, Chan WL, Su IJ and Teng CF. Hepatitis B virus Pre-S gene deletions and Pre-S deleted proteins: clinical and molecular implications in hepatocellular carcinoma. Viruses 2021; 13: 862.","journal-title":"Viruses"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1234903","DOI":"10.3389\/fcimb.2023.1234903","article-title":"Decoding the multifaceted interventions between human sirtuin 2 and dynamic hepatitis B viral proteins to confirm their roles in HBV replication","volume":"13","author":"Piracha","year":"2023","unstructured":"Piracha ZZ, Saeed U, Piracha IE, Noor S and Noor E. Decoding the multifaceted interventions between human sirtuin 2 and dynamic hepatitis B viral proteins to confirm their roles in HBV replication. Front Cell Infect Microbiol 2023; 13: 1234903.","journal-title":"Front Cell Infect Microbiol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1053\/j.gastro.2023.01.033","article-title":"Global epidemiology and genetics of hepatocellular carcinoma","volume":"164","author":"Toh","year":"2023","unstructured":"Toh MR, Wong EYT, Wong SH, Ng AWT, Loo LH, Chow PK and Ngeow J. Global epidemiology and genetics of hepatocellular carcinoma. Gastroenterology 2023; 164: 766-782.","journal-title":"Gastroenterology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/s41571-023-00825-3","article-title":"Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy","volume":"20","author":"AG","year":"2023","unstructured":"Singal AG, Kanwal F and Llovet JM. Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy. Nat Rev Clin Oncol 2023; 20: 864-884.","journal-title":"Nat Rev Clin Oncol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/S2468-1253(22)00270-9","article-title":"Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial","volume":"7","author":"ML","year":"2022","unstructured":"Schilsky ML, Czlonkowska A, Zuin M, Cassiman D, Twardowschy C, Poujois A, Gondim FAA, Denk G, Cury RG, Ott P, Moore J, Ala A, D&#x2019;Inca R, Couchonnal-Bedoya E, D&#x2019;Hollander K, Dubois N, Kamlin COF and Weiss KH; CHELATE trial investigators. Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial. Lancet Gastroenterol Hepatol 2022; 7: 1092-1102.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41572-018-0018-3","article-title":"Wilson disease","volume":"4","author":"Czlonkowska","year":"2018","unstructured":"Czlonkowska A, Litwin T, Dusek P, Ferenci P, Lutsenko S, Medici V, Rybakowski JK, Weiss KH and Schilsky ML. Wilson disease. Nat Rev Dis Primers 2018; 4: 21.","journal-title":"Nat Rev Dis Primers"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Polishchuk EV, Merolla A, Lichtmannegger J, Romano A, Indrieri A, Ilyechova EY, Concilli M, De Cegli R, Crispino R, Mariniello M, Petruzzelli R, Ranucci G, Iorio R, Pietrocola F, Einer C, Borchard S, Zibert A, Schmidt HH, Di Schiavi E, Puchkova LV, Franco B, Kroemer G, Zischka H and Polishchuk RS. Activation of autophagy, observed in liver tissues from patients with Wilson disease and from ATP7B-deficient animals, protects hepatocytes from copper-induced apoptosis. Gastroenterology 2019; 156: 1173-1189, e1175.","DOI":"10.1053\/j.gastro.2018.11.032"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Haber PS, Riordan BC, Winter DT, Barrett L, Saunders J, Hides L, Gullo M, Manning V, Day CA, Bonomo Y, Burns L, Assan R, Curry K, Mooney-Somers J, Demirkol A, Monds L, McDonough M, Baillie AJ, Clark P, Ritter A, Quinn C, Cunningham J, Lintzeris N, Rombouts S, Savic M, Norman A, Reid S, Hutchinson D, Zheng C, Iese Y, Black N, Draper B, Ridley N, Gowing L, Stapinski L, Taye B, Lancaster K, Stjepanovic D, Kay-Lambkin F, Jamshidi N, Lubman D, Pastor A, White N, Wilson S, Jaworski AL, Memedovic S, Logge W, Mills K, Seear K, Freeburn B, Lea T, Withall A, Marel C, Boffa J, Roxburgh A, Purcell-Khodr G, Doyle M, Conigrave K, Teesson M, Butler K, Connor J and Morley KC. New Australian guidelines for the treatment of alcohol problems: an overview of recommendations. Med J Aust 2021; 215 Suppl 7: S3-S32.","DOI":"10.5694\/mja2.51254"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s40121-022-00725-6","article-title":"Metabolic syndrome, nonalcoholic fatty liver disease, and chronic hepatitis B: a narrative review","volume":"12","author":"Diao","year":"2023","unstructured":"Diao Y, Tang J, Wang X, Deng W, Tang J and You C. Metabolic syndrome, nonalcoholic fatty liver disease, and chronic hepatitis B: a narrative review. Infect Dis Ther 2023; 12: 53-66.","journal-title":"Infect Dis Ther"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"106872","DOI":"10.1016\/j.phrs.2023.106872","article-title":"Dibenzocyclooctadiene lignans from the family schisandraceae: a review of phytochemistry, structure-activity relationship, and hepatoprotective effects","volume":"195","author":"Liu","year":"2023","unstructured":"Liu SQ, Yang YP, Hussain N, Jian YQ, Li B, Qiu YX, Yu HH, Wang HZ and Wang W. Dibenzocyclooctadiene lignans from the family schisandraceae: a review of phytochemistry, structure-activity relationship, and hepatoprotective effects. Pharmacol Res 2023; 195: 106872.","journal-title":"Pharmacol Res"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.cmet.2024.05.003","article-title":"Metabolic reprogramming in liver fibrosis","volume":"36","author":"Horn","year":"2024","unstructured":"Horn P and Tacke F. Metabolic reprogramming in liver fibrosis. Cell Metab 2024; 36: 1439-1455.","journal-title":"Cell Metab"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002\/cbf.3767","article-title":"AMP-activated protein kinase is a key regulator of obesity-associated factors","volume":"41","author":"Mohseni","year":"2023","unstructured":"Mohseni R, Teimouri M, Safaei M and Arab Sadeghabadi Z. AMP-activated protein kinase is a key regulator of obesity-associated factors. Cell Biochem Funct 2023; 41: 20-32.","journal-title":"Cell Biochem Funct"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"112563","DOI":"10.1016\/j.biopha.2021.112563","article-title":"AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: a pre-clinical and clinical investigation","volume":"146","author":"Entezari","year":"2022","unstructured":"Entezari M, Hashemi D, Taheriazam A, Zabolian A, Mohammadi S, Fakhri F, Hashemi M, Hushmandi K, Ashrafizadeh M, Zarrabi A, Ertas YN, Mirzaei S and Samarghandian S. AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: a pre-clinical and clinical investigation. Biomed Pharmacother 2022; 146: 112563.","journal-title":"Biomed Pharmacother"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3390\/cells11010030","article-title":"Mitophagy: molecular mechanisms, new concepts on parkin activation and the emerging role of AMPK\/ULK1 axis","volume":"11","author":"Iorio","year":"2021","unstructured":"Iorio R, Celenza G and Petricca S. Mitophagy: molecular mechanisms, new concepts on parkin activation and the emerging role of AMPK\/ULK1 axis. Cells 2021; 11: 30.","journal-title":"Cells"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1080\/15548627.2023.2200554","article-title":"Copper metabolism in cell death and autophagy","volume":"19","author":"Xue","year":"2023","unstructured":"Xue Q, Kang R, Klionsky DJ, Tang D, Liu J and Chen X. Copper metabolism in cell death and autophagy. Autophagy 2023; 19: 2175-2195.","journal-title":"Autophagy"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.3389\/fimmu.2019.02048","article-title":"HBV-induced immune imbalance in the development of HCC","volume":"10","author":"Chen","year":"2019","unstructured":"Chen Y and Tian Z. HBV-induced immune imbalance in the development of HCC. Front Immunol 2019; 10: 2048.","journal-title":"Front Immunol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/s41575-021-00571-w","article-title":"Hippo signalling in the liver: role in development, regeneration and disease","volume":"19","author":"Russell","year":"2022","unstructured":"Russell JO and Camargo FD. Hippo signalling in the liver: role in development, regeneration and disease. Nat Rev Gastroenterol Hepatol 2022; 19: 297-312.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1136\/gutjnl-2017-314061","article-title":"Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma","volume":"67","author":"Kim","year":"2018","unstructured":"Kim W, Khan SK, Liu Y, Xu R, Park O, He Y, Cha B, Gao B and Yang Y. Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma. Gut 2018; 67: 1692-1703.","journal-title":"Gut"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.devcel.2008.02.004","article-title":"Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt","volume":"14","author":"Fulco","year":"2008","unstructured":"Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA and Sartorelli V. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell 2008; 14: 661-673.","journal-title":"Dev Cell"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature11066","article-title":"AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress","volume":"485","author":"SM","year":"2012","unstructured":"Jeon SM, Chandel NS and Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 2012; 485: 661-665.","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Liang J and Mills GB. AMPK: a contextual oncogene or tumor suppressor? Cancer Res 2013; 73: 2929-2935.","DOI":"10.1158\/0008-5472.CAN-12-3876"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1126\/science.1191241","article-title":"Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation","volume":"329","author":"Bungard","year":"2010","unstructured":"Bungard D, Fuerth BJ, Zeng PY, Faubert B, Maas NL, Viollet B, Carling D, Thompson CB, Jones RG and Berger SL. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 2010; 329: 1201-1205.","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41575-023-00754-7","article-title":"Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment","volume":"20","author":"JM","year":"2023","unstructured":"Llovet JM, Willoughby CE, Singal AG, Greten TF, Heikenw&#xE4;lder M, El-Serag HB, Finn RS and Friedman SL. Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment. Nat Rev Gastroenterol Hepatol 2023; 20: 487-503.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"108593","DOI":"10.1016\/j.pharmthera.2024.108593","article-title":"Berberine prevents NAFLD and HCC by modulating metabolic disorders","volume":"254","author":"Lin","year":"2024","unstructured":"Lin X, Zhang J, Chu Y, Nie Q and Zhang J. Berberine prevents NAFLD and HCC by modulating metabolic disorders. Pharmacol Ther 2024; 254: 108593.","journal-title":"Pharmacol Ther"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3390\/cells14060428","article-title":"Pathogenic Mechanisms of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-associated hepatocellular carcinoma","volume":"14","author":"Nakamura","year":"2025","unstructured":"Nakamura T, Masuda A, Nakano D, Amano K, Sano T, Nakano M and Kawaguchi T. Pathogenic Mechanisms of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-associated hepatocellular carcinoma. Cells 2025; 14: 428.","journal-title":"Cells"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3350\/cmh.2022.0402","article-title":"Clinical practice guidelines and real-life practice in hepatocellular carcinoma: a Chinese perspective","volume":"29","author":"Xie","year":"2023","unstructured":"Xie D, Shi J, Zhou J, Fan J and Gao Q. Clinical practice guidelines and real-life practice in hepatocellular carcinoma: a Chinese perspective. Clin Mol Hepatol 2023; 29: 206-216.","journal-title":"Clin Mol Hepatol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/ncb2936","article-title":"Metabolic control of YAP and TAZ by the mevalonate pathway","volume":"16","author":"Sorrentino","year":"2014","unstructured":"Sorrentino G, Ruggeri N, Specchia V, Cordenonsi M, Mano M, Dupont S, Manfrin A, Ingallina E, Sommaggio R, Piazza S, Rosato A, Piccolo S and Del Sal G. Metabolic control of YAP and TAZ by the mevalonate pathway. Nat Cell Biol 2014; 16: 357-366.","journal-title":"Nat Cell Biol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1080\/21655979.2022.2026550","article-title":"SREBP2 promotes the viability, proliferation, and migration and inhibits apoptosis in TGF-beta1-induced airway smooth muscle cells by regulating TLR2\/NF-kappaB\/NFATc1\/ABCA1 regulatory network","volume":"13","author":"Wang","year":"2022","unstructured":"Wang Y, Yang H, Su X, Cao A, Chen F, Chen P, Yan F and Hu H. SREBP2 promotes the viability, proliferation, and migration and inhibits apoptosis in TGF-beta1-induced airway smooth muscle cells by regulating TLR2\/NF-kappaB\/NFATc1\/ABCA1 regulatory network. Bioengineered 2022; 13: 3137-3147.","journal-title":"Bioengineered"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1101\/gad.1843810","article-title":"A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF (beta-TRCP)","volume":"24","author":"Zhao","year":"2010","unstructured":"Zhao B, Li L, Tumaneng K, Wang CY and Guan KL. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF (beta-TRCP). Genes Dev 2010; 24: 72-85.","journal-title":"Genes Dev"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"6225","DOI":"10.1128\/MCB.25.14.6225-6234.2005","article-title":"Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis","volume":"25","author":"Li","year":"2005","unstructured":"Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O&#x2019;Donnell KA, Kim JW, Yustein JT, Lee LA and Dang CV. Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol 2005; 25: 6225-6234.","journal-title":"Mol Cell Biol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"103159","DOI":"10.1016\/j.redox.2024.103159","article-title":"SLC7A11-ROS\/&#x3B1;KG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression","volume":"72","author":"Lv","year":"2024","unstructured":"Lv T, Fan X, He C, Zhu S, Xiong X, Yan W, Liu M, Xu H, Shi R and He Q. SLC7A11-ROS\/&#x3B1;KG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression. Redox Biology 2024; 72: 103159.","journal-title":"Redox Biology"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"9671","DOI":"10.3390\/ijms24119671","article-title":"Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities","volume":"24","author":"Pei","year":"2023","unstructured":"Pei Q, Yi Q and Tang L. Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities. Int J Mol Sci 2023; 24: 9671.","journal-title":"Int J Mol Sci"}],"container-title":["American Journal of Cancer Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/9\/ajcr0163038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:11:19Z","timestamp":1768889479000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/9\/ajcr0163038.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/lbyg9841","relation":{},"ISSN":["2156-6976"],"issn-type":[{"value":"2156-6976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}