{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:56:28Z","timestamp":1766022988335,"version":"3.48.0"},"reference-count":41,"publisher":"e-Century Publishing Corporation","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Clin Exp Pathol"],"DOI":"10.62347\/ltao2386","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:05:13Z","timestamp":1735603513000},"page":"492-505","source":"Crossref","is-referenced-by-count":0,"title":["Prophylactic administration of PEPITEM in experimental autoimmune encephalomyelitis delays disease onset, inhibits leukocyte infiltration, and alleviates severity"],"prefix":"10.62347","volume":"17","author":[{"given":"Mohammed","family":"Alassiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41572-018-0041-4","article-title":"Multiple sclerosis","volume":"4","author":"Filippi","year":"2018","unstructured":"Filippi M, Bar-Or A, Piehl F, Preziosa P, Solari A, Vukusic S and Rocca MA. Multiple sclerosis. Nat Rev Dis Primers 2018; 4: 43.","journal-title":"Nat Rev Dis Primers"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1002\/ana.22609","article-title":"Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci","volume":"70","author":"Patsopoulos","year":"2011","unstructured":"Patsopoulos NA; Bayer Pharma MS Genetics Working Group; Steering Committees of Studies Evaluating IFNβ-1b and a CCR1-Antagonist; ANZgene Consortium; GeneMSA; International Multiple Sclerosis Genetics Consortium; Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalban J, Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S, Filippi M, Goodin DS, Jeffery D, O’Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth DR, Broadley S, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg JR, Pericak-Vance M, Sawcer SJ, De Jager PL, Hafler DA and de Bakker PI. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol 2011; 70: 897-912.","journal-title":"Ann Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","unstructured":"Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintore M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC and Cohen JA. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 2018; 17: 162-173.","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","unstructured":"Bjornevik K, Cortese M, Healy BC, Kuhle J, Mina MJ, Leng Y, Elledge SJ, Niebuhr DW, Scher AI, Munger KL and Ascherio A. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science 2022; 375: 296-301.","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2055217320960499","DOI":"10.1177\/2055217320960499","article-title":"Familial aggregation of multiple sclerosis: results from the national registry of the disease in Saudi Arabia","volume":"6","author":"AlJumah","year":"2020","unstructured":"AlJumah M, Otaibi HA, Al Towaijri G, Hassan A, Kareem A, Kalakatawi M, Alrajeh S, Al Mejally M, Algahtani H, Almubarak A, Alawi S, Qureshi S, Al Malik Y, El-Metwally A, Shami S, Ishak S and Bunyan R. Familial aggregation of multiple sclerosis: results from the national registry of the disease in Saudi Arabia. Mult Scler J Exp Transl Clin 2020; 6: 2055217320960499.","journal-title":"Mult Scler J Exp Transl Clin"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Gombash SE, Lee PW, Sawdai E and Lovett-Racke AE. Vitamin D as a risk factor for multiple sclerosis: immunoregulatory or neuroprotective? Front Neurol 2022; 13: 796933.","DOI":"10.3389\/fneur.2022.796933"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"802380","DOI":"10.3389\/fneur.2022.802380","article-title":"Preventing multiple sclerosis: the pediatric perspective","volume":"13","author":"Hardy","year":"2022","unstructured":"Hardy D, Chitnis T, Waubant E and Banwell B. Preventing multiple sclerosis: the pediatric perspective. Front Neurol 2022; 13: 802380.","journal-title":"Front Neurol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"757795","DOI":"10.3389\/fneur.2021.757795","article-title":"Vitamin D in multiple sclerosis-lessons from animal studies","volume":"12","author":"Haindl","year":"2021","unstructured":"Haindl MT and Hochmeister S. Vitamin D in multiple sclerosis-lessons from animal studies. Front Neurol 2021; 12: 757795.","journal-title":"Front Neurol"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Palanichamy A, Apeltsin L, Kuo TC, Sirota M, Wang S, Pitts SJ, Sundar PD, Telman D, Zhao LZ, Derstine M, Abounasr A, Hauser SL and von Budingen HC. Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis. Sci Transl Med 2014; 6: 248ra106.","DOI":"10.1126\/scitranslmed.3008930"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/jfmk3010013","article-title":"Insights into the role of neuroinflammation in the pathogenesis of multiple sclerosis","volume":"3","author":"Al-Badri","year":"2018","unstructured":"Al-Badri G and Castorina A. Insights into the role of neuroinflammation in the pathogenesis of multiple sclerosis. J Funct Morphol Kinesiol 2018; 3: 13.","journal-title":"J Funct Morphol Kinesiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"CH","year":"2011","unstructured":"Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O’Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B and Wolinsky JS. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69: 292-302.","journal-title":"Ann Neurol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.neurol.2015.10.006","article-title":"Epidemiology of multiple sclerosis","volume":"172","author":"Leray","year":"2016","unstructured":"Leray E, Moreau T, Fromont A and Edan G. Epidemiology of multiple sclerosis. Rev Neurol (Paris) 2016; 172: 3-13.","journal-title":"Rev Neurol (Paris)"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Grytten N, Aarseth JH, Lunde HM and Myhr KM. A 60-year follow-up of the incidence and prevalence of multiple sclerosis in Hordaland County, Western Norway. J Neurol Neurosurg Psychiatry 2016; 87: 100-105.","DOI":"10.1136\/jnnp-2014-309906"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","unstructured":"Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Angood Napier C, Rijke N and Baneke P. Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS, third edition. Mult Scler 2020; 26: 1816-1821.","journal-title":"Mult Scler"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1177\/1352458512459291","article-title":"Prevalence, demographics and clinical characteristics of multiple sclerosis in Qatar","volume":"19","author":"Deleu","year":"2013","unstructured":"Deleu D, Mir D, Al Tabouki A, Mesraoua R, Mesraoua B, Akhtar N, Al Hail H, D’Souza A, Melikyan G, Imam YZ, Osman Y, Elalamy O, Sokrab T, Kamran S, Ruiz Miyares F and Ibrahim F. Prevalence, demographics and clinical characteristics of multiple sclerosis in Qatar. Mult Scler 2013; 19: 816-819.","journal-title":"Mult Scler"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.pathog.2016.04.001","article-title":"Multiple sclerosis is prominent in the Gulf states: review","volume":"3","author":"Mohammed","year":"2016","unstructured":"Mohammed EMA. Multiple sclerosis is prominent in the Gulf states: review. Pathogenesis 2016; 3: 19-38.","journal-title":"Pathogenesis"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/s41582-022-00735-5","article-title":"Social determinants of health in multiple sclerosis","volume":"18","author":"Dobson","year":"2022","unstructured":"Dobson R, Rice DR, D’hooghe M, Horne R, Learmonth Y, Mateen FJ, Marck CH, Reyes S, Williams MJ, Giovannoni G and Ford HL. Social determinants of health in multiple sclerosis. Nat Rev Neurol 2022; 18: 723-734.","journal-title":"Nat Rev Neurol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/s41598-022-04836-5","article-title":"Age-period-cohort analysis of the incidence of multiple sclerosis over twenty years in Lorraine, France","volume":"12","author":"Gbaguidi","year":"2022","unstructured":"Gbaguidi B, Guillemin F, Soudant M, Debouverie M, Mathey G and Epstein J. Age-period-cohort analysis of the incidence of multiple sclerosis over twenty years in Lorraine, France. Sci Rep 2022; 12: 1001.","journal-title":"Sci Rep"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"5881","DOI":"10.3390\/app13105881","article-title":"Why is multiple sclerosis more frequent in women? Role of the immune system and of oral and gut microbiota","volume":"13","author":"D&#x2019","year":"2023","unstructured":"D’Anca M, Buccellato FR, Tartaglia GM, Del Fabbro M, Muti P, Scarpini E, Galimberti D and Ghezzi L. Why is multiple sclerosis more frequent in women? Role of the immune system and of oral and gut microbiota. Appl Sci 2023; 13: 5881.","journal-title":"Appl Sci"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Damal K, Stoker E and Foley JF. Optimizing therapeutics in the management of patients with multiple sclerosis: a review of drug efficacy, dosing, and mechanisms of action. Biologics 2013; 7: 247-258.","DOI":"10.2147\/BTT.S53007"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Klareskog L and Alfredsson L. Prevention vs treatment of rheumatoid arthritis. Immunother Adv 2023; 3: ltad016.","DOI":"10.1093\/immadv\/ltad016"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"982411","DOI":"10.3389\/fneur.2022.982411","article-title":"Editorial: preventing multiple sclerosis","volume":"13","author":"Dobson","year":"2022","unstructured":"Dobson R, Tanasescu R and Gran B. Editorial: preventing multiple sclerosis. Front Neurol 2022; 13: 982411.","journal-title":"Front Neurol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"761408","DOI":"10.3389\/fneur.2021.761408","article-title":"The multiple sclerosis prodrome: evidence to action","volume":"12","author":"Tremlett","year":"2022","unstructured":"Tremlett H, Munger KL and Makhani N. The multiple sclerosis prodrome: evidence to action. Front Neurol 2022; 12: 761408.","journal-title":"Front Neurol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1177\/1352458520914844","article-title":"The multiple sclerosis prodrome: emerging evidence, challenges, and opportunities","volume":"27","author":"Tremlett","year":"2021","unstructured":"Tremlett H and Marrie RA. The multiple sclerosis prodrome: emerging evidence, challenges, and opportunities. Mult Scler 2021; 27: 6-12.","journal-title":"Mult Scler"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jneuroim.2013.12.015","article-title":"Downmodulation of peripheral MOG-specific immunity by pVAXhsp65 treatment during EAE does not reach the CNS","volume":"268","author":"Zorzella-Pezavento SF","year":"2014","unstructured":"Zorzella-Pezavento SF, Chiuso-Minicucci F, França TG, Ishikawa LL, da Rosa LC, Colavite PM, Marques C, Ikoma MR, Silva CL and Sartori A. Downmodulation of peripheral MOG-specific immunity by pVAXhsp65 treatment during EAE does not reach the CNS. J Neuroimmunol 2014; 268: 35-42.","journal-title":"J Neuroimmunol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nm.3842","article-title":"Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease","volume":"21","author":"Chimen","year":"2015","unstructured":"Chimen M, McGettrick HM, Apta B, Kuravi SJ, Yates CM, Kennedy A, Odedra A, Alassiri M, Harrison M, Martin A, Barone F, Nayar S, Hitchcock JR, Cunningham AF, Raza K, Filer A, Copland DA, Dick AD, Robinson J, Kalia N, Walker LSK, Buckley CD, Nash GB, Narendran P and Rainger GE. Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. Nat Med 2015; 21: 467-475.","journal-title":"Nat Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"17243","DOI":"10.3390\/ijms242417243","article-title":"PEPITEM treatment ameliorates EAE in mice by reducing CNS inflammation, leukocyte infiltration, demyelination, and proinflammatory cytokine production","volume":"24","author":"Alassiri","year":"2023","unstructured":"Alassiri M, Al Sufiani F, Aljohi M, Alanazi A, Alhazmi AS, Alrfaei BM, Alnakhli H, Alshawakir YA, Alharby SM, Almubarak AY, Alasseiri M, Alorf N and Abdullah ML. PEPITEM treatment ameliorates EAE in mice by reducing CNS inflammation, leukocyte infiltration, demyelination, and proinflammatory cytokine production. Int J Mol Sci 2023; 24: 17243.","journal-title":"Int J Mol Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/cei\/uxad022","article-title":"PEPITEM modulates leukocyte trafficking to reduce obesity-induced inflammation","volume":"212","author":"Pezhman","year":"2023","unstructured":"Pezhman L, Hopkin SJ, Begum J, Heising S, Nasteska D, Wahid M, Ed Rainger G, Hodson DJ, Iqbal AJ, Chimen M and McGettrick HM. PEPITEM modulates leukocyte trafficking to reduce obesity-induced inflammation. Clin Exp Immunol 2023; 212: 1-10.","journal-title":"Clin Exp Immunol"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Kemble S, Croft AP, Desanti G, Saghir A, Buckley CD and McGettrick HM. 02.07 Prophylactic treatment with pepitem inhibits onset of collagen induced arthritis and pepitem therapy reduces disease severity. Ann Rheum Dis 2017; 76: A10-A11.","DOI":"10.1136\/annrheumdis-2016-211050.7"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Kemble S, Croft AP, Desanti G, Saghir AN, Buckley CD and McGettrick H. 246. Prophylactic treatment with pepitem inhibits onset of collagen-induced arthritis and therapeutically pepitem reduces disease severity. Rheumatology 2017; 56: kex062-248.","DOI":"10.1093\/rheumatology\/kex062.248"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3389\/fphar.2020.00161","article-title":"Calcitriol prevents neuroinflammation and reduces blood-brain barrier disruption and local macrophage\/microglia activation","volume":"11","author":"de Oliveira","year":"2020","unstructured":"de Oliveira LRC, Mimura LAN, Fraga-Silva TFC, Ishikawa LLW, Fernandes AAH, Zorzella-Pezavento SFG and Sartori A. Calcitriol prevents neuroinflammation and reduces blood-brain barrier disruption and local macrophage\/microglia activation. Front Pharmacol 2020; 11: 161.","journal-title":"Front Pharmacol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.neuroscience.2015.12.053","article-title":"Association of myelin peptide with vitamin D prevents autoimmune encephalomyelitis development","volume":"317","author":"LA","year":"2016","unstructured":"Mimura LA, Chiuso-Minicucci F, Fraga-Silva TF, Zorzella-Pezavento SF, França TG, Ishikawa LL, Penitenti M, Ikoma MR and Sartori A. Association of myelin peptide with vitamin D prevents autoimmune encephalomyelitis development. Neuroscience 2016; 317: 130-140.","journal-title":"Neuroscience"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0889-1591(02)00028-4","article-title":"Acute stress shortens the time to onset of experimental allergic encephalomyelitis in SJL\/J mice","volume":"16","author":"Chandler","year":"2002","unstructured":"Chandler N, Jacobson S, Esposito P, Connolly R and Theoharides TC. Acute stress shortens the time to onset of experimental allergic encephalomyelitis in SJL\/J mice. Brain Behav Immun 2002; 16: 757-763.","journal-title":"Brain Behav Immun"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1157287","DOI":"10.3389\/fneur.2023.1157287","article-title":"Microglia in the context of multiple sclerosis","volume":"14","author":"Zhang","year":"2023","unstructured":"Zhang X, Chen F, Sun M, Wu N, Liu B, Yi X, Ge R and Fan X. Microglia in the context of multiple sclerosis. Front Neurol 2023; 14: 1157287.","journal-title":"Front Neurol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/s41419-020-03084-7","article-title":"CSF1R signaling is a regulator of pathogenesis in progressive MS","volume":"11","author":"Hagan","year":"2020","unstructured":"Hagan N, Kane JL, Grover D, Woodworth L, Madore C, Saleh J, Sancho J, Liu J, Li Y, Proto J, Zelic M, Mahan A, Kothe M, Scholte AA, Fitzgerald M, Gisevius B, Haghikia A, Butovsky O and Ofengeim D. CSF1R signaling is a regulator of pathogenesis in progressive MS. Cell Death Dis 2020; 11: 904.","journal-title":"Cell Death Dis"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3892\/br.2022.1510","article-title":"Neurodegeneration and convergent factors contributing to the deterioration of the cytoskeleton in Alzheimer’s disease, cerebral ischemia and multiple sclerosis (review)","volume":"16","author":"Guti&#xE9","year":"2022","unstructured":"Gutiérrez-Vargas JA, Castro-Álvarez JF, Zapata-Berruecos JF, Abdul-Rahim K and Arteaga-Noriega A. Neurodegeneration and convergent factors contributing to the deterioration of the cytoskeleton in Alzheimer’s disease, cerebral ischemia and multiple sclerosis (review). Biomed Rep 2022; 16: 27.","journal-title":"Biomed Rep"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.expneurol.2012.06.010","article-title":"Re-expression of N-cadherin in remyelinating lesions of experimental inflammatory demyelination","volume":"237","author":"Hochmeister","year":"2012","unstructured":"Hochmeister S, Romauch M, Bauer J, Seifert-Held T, Weissert R, Linington C, Hartung HP, Fazekas F and Storch MK. Re-expression of N-cadherin in remyelinating lesions of experimental inflammatory demyelination. Exp Neurol 2012; 237: 70-77.","journal-title":"Exp Neurol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1046\/j.1471-4159.1999.0732531.x","article-title":"A novel microtubule-associated protein-2 expressed in oligodendrocytes in multiple sclerosis lesions","volume":"73","author":"Shafit-Zagardo","year":"1999","unstructured":"Shafit-Zagardo B, Kress Y, Zhao ML and Lee SC. A novel microtubule-associated protein-2 expressed in oligodendrocytes in multiple sclerosis lesions. J Neurochem 1999; 73: 2531-2537.","journal-title":"J Neurochem"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41577-020-0286-5","article-title":"IL-17A brings new recruits to EAE","volume":"20","author":"Minton","year":"2020","unstructured":"Minton K. IL-17A brings new recruits to EAE. Nat Rev Immunol 2020; 20: 137.","journal-title":"Nat Rev Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"472","DOI":"10.21037\/atm.2020.03.129","article-title":"Reduction of FoxP3(+) Tregs by an immunosuppressive protocol of rapamycin plus Thymalfasin and Huaier extract predicts positive survival benefits in a rat model of hepatocellular carcinoma","volume":"8","author":"Zhou","year":"2020","unstructured":"Zhou L, Pan LC, Zheng YG, Zhang XX, Liu ZJ, Meng X, Shi HD, Du GS and He Q. Reduction of FoxP3(+) Tregs by an immunosuppressive protocol of rapamycin plus Thymalfasin and Huaier extract predicts positive survival benefits in a rat model of hepatocellular carcinoma. Ann Transl Med 2020; 8: 472.","journal-title":"Ann Transl Med"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"104349","DOI":"10.1016\/j.neuint.2018.11.024","article-title":"Regenerating CNS myelin: emerging roles of regulatory T cells and CCN proteins","volume":"130","author":"Vega Gallardo N","year":"2019","unstructured":"de la Vega Gallardo N, Dittmer M, Dombrowski Y and Fitzgerald DC. Regenerating CNS myelin: emerging roles of regulatory T cells and CCN proteins. Neurochem Int 2019; 130: 104349.","journal-title":"Neurochem Int"}],"container-title":["International Journal of Clinical and Experimental Pathology"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ijcep\/17\/12\/ijcep0158797.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:51:36Z","timestamp":1766022696000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ijcep\/17\/12\/ijcep0158797.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":41,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.62347\/ltao2386","relation":{},"ISSN":["1936-2625"],"issn-type":[{"type":"electronic","value":"1936-2625"}],"subject":[],"published":{"date-parts":[[2024]]}}}