{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:57:46Z","timestamp":1766023066153,"version":"3.48.0"},"reference-count":31,"publisher":"e-Century Publishing Corporation","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/mcpd8618","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T05:48:47Z","timestamp":1714456127000},"page":"1442-1453","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the mechanism of cytisine in treating respiratory depression following venomous snake bites based on network pharmacology and molecular docking"],"prefix":"10.62347","volume":"16","author":[{"given":"Shiling","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"17063","DOI":"10.1038\/nrdp.2017.63","article-title":"Snakebite envenoming","volume":"3","author":"Guti&#xE9","year":"2017","unstructured":"Gutiérrez JM, Calvete JJ, Habib AG, Harrison RA, Williams DJ and Warrell DA. Snakebite envenoming. Nat Rev Dis Primers 2017; 3: 17063.","journal-title":"Nat Rev Dis Primers"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jprot.2016.02.028","article-title":"Proteomic characterization and comparison of venoms from two elapid snakes (Bungarus multicinctus and Naja atra) from China","volume":"138","author":"Shan","year":"2016","unstructured":"Shan LL, Gao JF, Zhang YX, Shen SS, He Y, Wang J, Ma XM and Ji X. Proteomic characterization and comparison of venoms from two elapid snakes (Bungarus multicinctus and Naja atra) from China. J Proteomics 2016; 138: 83-94.","journal-title":"J Proteomics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3390\/toxins13010049","article-title":"In vitro neurotoxicity of chinese krait (bungarus multicinctus) venom and neutralization by antivenoms","volume":"13","author":"Liang","year":"2021","unstructured":"Liang Q, Huynh TM, Ng YZ, Isbister GK and Hodgson WC. In vitro neurotoxicity of chinese krait (bungarus multicinctus) venom and neutralization by antivenoms. Toxins (Basel) 2021; 13: 49.","journal-title":"Toxins (Basel)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"386","DOI":"10.4103\/jfmpc.jfmpc_1652_21","article-title":"Dramatic neuromuscular paralysis following occult snakebites: an awareness for the primary care physician","volume":"11","author":"Mehta","year":"2022","unstructured":"Mehta V, Kumar R, Prabhakar R, Sharma CB and Thomas A. Dramatic neuromuscular paralysis following occult snakebites: an awareness for the primary care physician. J Family Med Prim Care 2022; 11: 386-389.","journal-title":"J Family Med Prim Care"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.toxicon.2019.03.009","article-title":"Crotalus durissus terrificus (viperidae; crotalinae) envenomation: respiratory failure and treatment with antivipmyn TRI® antivenom","volume":"163","author":"Baum","year":"2019","unstructured":"Baum RA, Bronner J, Akpunonu PDS, Plott J, Bailey AM and Keyler DE. Crotalus durissus terrificus (viperidae; crotalinae) envenomation: respiratory failure and treatment with antivipmyn TRI® antivenom. Toxicon 2019; 163: 32-35.","journal-title":"Toxicon"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1177\/0049475514521802","article-title":"Premonitory signs and symptoms of envenoming by common krait (Bungarus caeruleus)","volume":"44","author":"HS","year":"2014","unstructured":"Bawaskar HS, Bawaskar PH and Bawaskar PH. Premonitory signs and symptoms of envenoming by common krait (Bungarus caeruleus). Trop Doct 2014; 44: 82-85.","journal-title":"Trop Doct"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Dogar O, Keding A, Gabe R, Marshall AM, Huque R, Barua D, Fatima R, Khan A, Zahid R, Mansoor S, Kotz D, Boeckmann M, Elsey H, Kralikova E, Parrott S, Li J, Readshaw A, Sheikh A and Siddiqi K; TB and Tobacco Consortium. Cytisine for smoking cessation in patients with tuberculosis: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial. Lancet Glob Health 2020; 8: e1408-e1417.","DOI":"10.1016\/S2214-109X(20)30312-0"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"105700","DOI":"10.1016\/j.phrs.2021.105700","article-title":"More than smoking cessation aids","volume":"170","author":"Gotti","year":"2021","unstructured":"Gotti C and Clementi F. Cytisine and cytisine derivatives. More than smoking cessation aids. Pharmacol Res 2021; 170: 105700.","journal-title":"Pharmacol Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s12551-013-0130-2","article-title":"Receptor-ligand molecular docking","volume":"6","author":"IA","year":"2014","unstructured":"Guedes IA, de Magalhães CS and Dardenne LE. Receptor-ligand molecular docking. Biophys Rev 2014; 6: 75-87.","journal-title":"Biophys Rev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00213-016-4461-0","article-title":"Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice","volume":"234","author":"Tutka","year":"2017","unstructured":"Tutka P, Kondrat-Wróbel MW, Zaluska K, Żółkowska D, Florek-Łuszczki M and Łuszczki JJ. Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice. Psychopharmacology (Berl) 2017; 234: 281-291.","journal-title":"Psychopharmacology (Berl)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.emc.2016.12.003","article-title":"North american snake envenomation","volume":"35","author":"Corbett","year":"2017","unstructured":"Corbett B and Clark RF. North american snake envenomation. Emerg Med Clin North Am 2017; 35: 339-354.","journal-title":"Emerg Med Clin North Am"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3390\/toxins9040143","article-title":"Antivenom for neuromuscular paralysis resulting from snake envenoming","volume":"9","author":"Silva","year":"2017","unstructured":"Silva A, Hodgson WC and Isbister GK. Antivenom for neuromuscular paralysis resulting from snake envenoming. Toxins (Basel) 2017; 9: 143.","journal-title":"Toxins (Basel)"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"617","DOI":"10.6026\/97320630010617","article-title":"Predicted structure model of Bungarotoxin from Bungarus fasciatus snake","volume":"10","author":"Roly","year":"2014","unstructured":"Roly ZY, Hasan SN, Ferdaus K and Reza MA. Predicted structure model of Bungarotoxin from Bungarus fasciatus snake. Bioinformation 2014; 10: 617-622.","journal-title":"Bioinformation"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1159\/000477155","article-title":"Homology modeling and protein interaction map of CHRNA7 neurogenesis protein","volume":"24","author":"Yadav","year":"2017","unstructured":"Yadav R, Deepshikha D and Srivastava P. Homology modeling and protein interaction map of CHRNA7 neurogenesis protein. Ann Neurosci 2017; 24: 173-179.","journal-title":"Ann Neurosci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"636","DOI":"10.2174\/138945012800398928","article-title":"Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia","volume":"13","author":"Neri","year":"2012","unstructured":"Neri M, Bonassi S and Russo P. Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia. Curr Drug Targets 2012; 13: 636-643.","journal-title":"Curr Drug Targets"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"111891","DOI":"10.1016\/j.exger.2022.111891","article-title":"CHRNA1 induces sarcopenia through neuromuscular synaptic elimination","volume":"166","author":"Liao","year":"2022","unstructured":"Liao Z, Xiao M, Chen J, Yang Y, Lyu Q, Zhou J, Sun Y, Zhao Y, Fan Z, Yu J, Wu Y, Chen Q, Wu J and Xiao Q. CHRNA1 induces sarcopenia through neuromuscular synaptic elimination. Exp Gerontol 2022; 166: 111891.","journal-title":"Exp Gerontol"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Irumudomon O and Ghosh PS. Clinical reasoning: a child with arthrogryposis: congenital myasthenic syndrome-CHRNA1 mutation. Neurology 2018; 91: e995-e998.","DOI":"10.1212\/WNL.0000000000006126"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1002\/ajmg.a.62011","article-title":"CHRNB1-associated congenital myasthenia syndrome: expanding the clinical spectrum","volume":"185","author":"Freed","year":"2021","unstructured":"Freed AS, Schwarz AC, Brei BK, Clowes Candadai SV, Thies J, Mah JK, Chabra S, Wang L, Innes AM and Bennett JT. CHRNB1-associated congenital myasthenia syndrome: expanding the clinical spectrum. Am J Med Genet A 2021; 185: 827-835.","journal-title":"Am J Med Genet A"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12863-016-0382-5","article-title":"Truncating CHRNG mutations associated with interfamilial variability of the severity of the Escobar variant of multiple pterygium syndrome","volume":"17","author":"Kariminejad","year":"2016","unstructured":"Kariminejad A, Almadani N, Khoshaeen A, Olsson B, Moslemi AR and Tajsharghi H. Truncating CHRNG mutations associated with interfamilial variability of the severity of the Escobar variant of multiple pterygium syndrome. BMC Genet 2016; 17: 71.","journal-title":"BMC Genet"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jneuroim.2017.08.004","article-title":"False positive immunoassay for acetyl choline receptor antibody (AChR Ab) in patients exposed to polyvalent antisnake venom","volume":"311","author":"Sundar","year":"2017","unstructured":"Sundar K, Venkatasubramanian S, Shanmugam S, Arthur P, Subbaraya R and Hazeena P. False positive immunoassay for acetyl choline receptor antibody (AChR Ab) in patients exposed to polyvalent antisnake venom. J Neuroimmunol 2017; 311: 68-70.","journal-title":"J Neuroimmunol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"103359","DOI":"10.1016\/j.etap.2020.103359","article-title":"Effect of pterois volitans (lionfish) venom on cholinergic and dopaminergic systems","volume":"77","author":"Becerra-Amezcua MP","year":"2020","unstructured":"Becerra-Amezcua MP, Hernández-Sámano AC, Puch-Hau C, Aguilar MB and Collí-Dulá RC. Effect of pterois volitans (lionfish) venom on cholinergic and dopaminergic systems. Environ Toxicol Pharmacol 2020; 77: 103359.","journal-title":"Environ Toxicol Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1152\/jn.1947.10.1.11","article-title":"Generality of the role of acetylcholine in nerve and muscle conduction","volume":"10","author":"Bullock","year":"1947","unstructured":"Bullock TH, Grundfest H, et al. Generality of the role of acetylcholine in nerve and muscle conduction. J Neurophysiol 1947; 10: 11-21.","journal-title":"J Neurophysiol"},{"key":"ref22","unstructured":"Ueta R and Yamanashi Y. Homeostasis and disorder of musculoskeletal system.Molecular signaling and its pathogenic alterations in neuromuscular junction formation. Clin Calcium 2018; 28: 360-366."},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Kong Y, Liang X, Liu L, Zhang D, Wan C, Gan Z and Yuan L. High throughput sequencing identifies MicroRNAs mediating α-synuclein toxicity by targeting neuroactive-ligand receptor interaction pathway in early stage of drosophila Parkinson’s disease model. PLoS One 2015; 10: e0137432.","DOI":"10.1371\/journal.pone.0137432"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"13323","DOI":"10.1523\/JNEUROSCI.2764-11.2011","article-title":"Identification of a cholinergic modulatory and rhythmogenic mechanism within the lamprey respiratory network","volume":"31","author":"Mutolo","year":"2011","unstructured":"Mutolo D, Cinelli E, Bongianni F and Pantaleo T. Identification of a cholinergic modulatory and rhythmogenic mechanism within the lamprey respiratory network. J Neurosci 2011; 31: 13323-13332.","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1152\/japplphysiol.00818.2009","article-title":"Airway response to emotional stimuli in asthma: the role of the cholinergic pathway","volume":"108","author":"Ritz","year":"2010","unstructured":"Ritz T, Kullowatz A, Goldman MD, Smith HJ, Kanniess F, Dahme B and Magnussen H. Airway response to emotional stimuli in asthma: the role of the cholinergic pathway. J Appl Physiol (1985) 2010; 108: 1542-1549.","journal-title":"J Appl Physiol (1985)"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3390\/pharmaceutics15010031","article-title":"Physiologic functions and therapeutic applications of α7 nicotinic acetylcholine receptor in brain disorders","volume":"15","author":"Lee","year":"2022","unstructured":"Lee CH and Hung SY. Physiologic functions and therapeutic applications of α7 nicotinic acetylcholine receptor in brain disorders. Pharmaceutics 2022; 15: 31.","journal-title":"Pharmaceutics"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.3390\/ijms23073463","article-title":"The human-restricted isoform of the α7 nAChR, CHRFAM7A: a double-edged sword in neurological and inflammatory disorders","volume":"23","author":"Lascio S","year":"2022","unstructured":"Di Lascio S, Fornasari D and Benfante R. The human-restricted isoform of the α7 nAChR, CHRFAM7A: a double-edged sword in neurological and inflammatory disorders. Int J Mol Sci 2022; 23: 3463.","journal-title":"Int J Mol Sci"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Chen X, Zhang C, Wei T, Chen J, Pan T, Li M, Wang L, Song J, Chen C, Zhang Y, Song Y and Su X. α7nAChR activation in AT2 cells promotes alveolar regeneration through WNT7B signaling in acute lung injury. JCI Insight 2023; 8: e162547.","DOI":"10.1172\/jci.insight.162547"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41392-022-01124-6","article-title":"Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway","volume":"7","author":"Zhang","year":"2022","unstructured":"Zhang X, Wei X, Deng Y, Yuan X, Shi J, Huang W, Huang J, Chen X, Zheng S, Chen J, Chen K, Xu R, Wang H, Li W, Li S, Yi H and Xiang AP. Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway. Signal Transduct Target Ther 2022; 7: 307.","journal-title":"Signal Transduct Target Ther"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"3730","DOI":"10.3390\/ijms24043730","article-title":"Clinical and pathologic features of congenital myasthenic syndromes caused by 35 genes-a comprehensive review","volume":"24","author":"Ohno","year":"2023","unstructured":"Ohno K, Ohkawara B, Shen XM, Selcen D and Engel AG. Clinical and pathologic features of congenital myasthenic syndromes caused by 35 genes-a comprehensive review. Int J Mol Sci 2023; 24: 3730.","journal-title":"Int J Mol Sci"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/16\/4\/ajtr0156331.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:52:58Z","timestamp":1766022778000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/16\/4\/ajtr0156331.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.62347\/mcpd8618","relation":{},"ISSN":["1943-8141"],"issn-type":[{"type":"electronic","value":"1943-8141"}],"subject":[],"published":{"date-parts":[[2024]]}}}