{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:41:27Z","timestamp":1792662087173,"version":"4.5.0"},"reference-count":27,"publisher":"e-Century Publishing Corporation","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/mkhi8232","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T02:53:22Z","timestamp":1767754402000},"page":"9377-9388","source":"Crossref","is-referenced-by-count":0,"title":["Post-procedural anticoagulation enhances cognitive function and reduces stroke risk in atrial fibrillation patients after left atrial appendage occlusion"],"prefix":"10.62347","volume":"17","author":[{"given":"Biyong","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1177\/1747493019897870","article-title":"Global epidemiology of atrial fibrillation: an increasing epidemic and public health challenge","volume":"16","author":"Lippi","year":"2021","unstructured":"Lippi G, Sanchis-Gomar F and Cervellin G. Global epidemiology of atrial fibrillation: an increasing epidemic and public health challenge. Int J Stroke 2021; 16: 217-221.","journal-title":"Int J Stroke"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1001\/jama.2015.4369","article-title":"Stroke prevention in atrial fibrillation: a systematic review","volume":"313","author":"Lip","year":"2015","unstructured":"Lip GY and Lane DA. Stroke prevention in atrial fibrillation: a systematic review. JAMA 2015; 313: 1950-1962.","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/CRD.0000000000000489","article-title":"Anticoagulation for atrial fibrillation: a review of current literature and views","volume":"32","author":"Cui","year":"2024","unstructured":"Jin Cui, Cui C, Seplowe M, Lee KI, Vegunta R, Li B, Frishman WH and Iwai S. Anticoagulation for atrial fibrillation: a review of current literature and views. Cardiol Rev 2024; 32: 131-139.","journal-title":"Cardiol Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1161\/CIRCULATIONAHA.119.043308","article-title":"Antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome treated medically or with percutaneous coronary intervention or undergoing elective percutaneous coronary intervention: insights from the AUGUSTUS trial","volume":"140","author":"Windecker","year":"2019","unstructured":"Windecker S, Lopes RD, Massaro T, Jones-Burton C, Granger CB, Aronson R, Heizer G, Goodman SG, Darius H, Jones WS, Aschermann M, Brieger D, Cura F, Engstrøm T, Fridrich V, Halvorsen S, Huber K, Kang HJ, Leiva-Pons JL, Lewis BS, Malaga G, Meneveau N, Merkely B, Milicic D, Morais J, Potpara TS, Raev D, Sabaté M, de Waha-Thiele S, Welsh RC, Xavier D, Mehran R and Alexander JH; AUGUSTUS Investigators. Antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome treated medically or with percutaneous coronary intervention or undergoing elective percutaneous coronary intervention: insights from the AUGUSTUS trial. Circulation 2019; 140: 1921-1932.","journal-title":"Circulation"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Favaloro EJ, Pasalic L and Lippi G. Oral anticoagulation therapy: an update on usage, costs and associated risks. Pathology 2020; 52: 736-741.","DOI":"10.1016\/j.pathol.2020.05.006"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"5821","DOI":"10.1109\/embc.2013.6610875","article-title":"Noninvasive prediction of catheter ablation acute outcome in persistent atrial fibrillation based on logistic regression of ECG fibrillatory wave amplitude and spatio-temporal variability","volume":"2013","author":"Meo","year":"2013","unstructured":"Meo M, Zarzoso V, Meste O, Latcu DG and Saoudi N. Noninvasive prediction of catheter ablation acute outcome in persistent atrial fibrillation based on logistic regression of ECG fibrillatory wave amplitude and spatio-temporal variability. Annu Int Conf IEEE Eng Med Biol Soc 2013; 2013: 5821-5824.","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1109\/TBME.2012.2220639","article-title":"Spatial variability of the 12-lead surface ECG as a tool for noninvasive prediction of catheter ablation outcome in persistent atrial fibrillation","volume":"60","author":"Meo","year":"2013","unstructured":"Meo M, Zarzoso V, Meste O, Latcu DG and Saoudi N. Spatial variability of the 12-lead surface ECG as a tool for noninvasive prediction of catheter ablation outcome in persistent atrial fibrillation. IEEE Trans Biomed Eng 2013; 60: 20-27.","journal-title":"IEEE Trans Biomed Eng"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/s41569-018-0075-z","article-title":"Cognitive dysfunction in atrial fibrillation","volume":"15","author":"Madhavan","year":"2018","unstructured":"Madhavan M, Graff-Radford J, Piccini JP and Gersh BJ. Cognitive dysfunction in atrial fibrillation. Nat Rev Cardiol 2018; 15: 744-756.","journal-title":"Nat Rev Cardiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1093\/eurheartj\/ehx208","article-title":"Atrial fibrillation as a risk factor for cognitive decline and dementia","volume":"38","author":"Singh-Manoux A","year":"2017","unstructured":"Singh-Manoux A, Fayosse A, Sabia S, Canonico M, Bobak M, Elbaz A, Kivimäki M and Dugravot A. Atrial fibrillation as a risk factor for cognitive decline and dementia. Eur Heart J 2017; 38: 2612-2618.","journal-title":"Eur Heart J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.ahj.2014.12.015","article-title":"Atrial fibrillation: a major risk factor for cognitive decline","volume":"169","author":"Hui","year":"2015","unstructured":"Hui DS, Morley JE, Mikolajczak PC and Lee R. Atrial fibrillation: a major risk factor for cognitive decline. Am Heart J 2015; 169: 448-456.","journal-title":"Am Heart J"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Dietzel J, Haeusler KG and Endres M. Does atrial fibrillation cause cognitive decline and dementia? Europace 2018; 20: 408-419.","DOI":"10.1093\/europace\/eux031"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.3390\/jcm13082418","article-title":"Exploring the link between anticoagulation, cognitive impairment and dementia in atrial fibrillation: a systematic review","volume":"13","author":"Agarwal","year":"2024","unstructured":"Agarwal A, Mostafa MA, Ahmad MI and Soliman EZ. Exploring the link between anticoagulation, cognitive impairment and dementia in atrial fibrillation: a systematic review. J Clin Med 2024; 13: 2418.","journal-title":"J Clin Med"},{"key":"ref12","unstructured":"Gutierrez C and Blanchard DG. Diagnosis and treatment of atrial fibrillation. Am Fam Physicia 2016; 94: 442-452."},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Arevalo-Rodriguez I, Smailagic N, Roqué-Figuls M, Ciapponi A, Sanchez-Perez E, Giannakou A, Pedraza OL, Bonfill Cosp X and Cullum S. Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev 2021; 7: CD010783.","DOI":"10.1002\/14651858.CD010783.pub3"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Zeng D, Jiang C, Su C, Tan Y and Wu J. Anticoagulation in atrial fibrillation and cognitive decline: a systematic review and meta-analysis. Medicine (Baltimore) 2019; 98: e14499.","DOI":"10.1097\/MD.0000000000014499"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1001\/jamacardio.2024.0675","article-title":"Atrial fibrillation ablation in heart failure with reduced vs preserved ejection fraction: a systematic review and meta-analysis","volume":"9","author":"Oraii","year":"2024","unstructured":"Oraii A, McIntyre WF, Parkash R, Kowalik K, Razeghi G, Benz AP, Belley-Côté EP, Conen D, Connolly SJ, Tang ASL, Healey JS and Wong JA. Atrial fibrillation ablation in heart failure with reduced vs preserved ejection fraction: a systematic review and meta-analysis. JAMA Cardiol 2024; 9: 545-555.","journal-title":"JAMA Cardiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ahj.2019.01.005","article-title":"Association of frailty and cognitive impairment with benefits of oral anticoagulation in patients with atrial fibrillation","volume":"211","author":"Madhavan","year":"2019","unstructured":"Madhavan M, Holmes DN, Piccini JP, Ansell JE, Fonarow GC, Hylek EM, Kowey PR, Mahaffey KW, Thomas L, Peterson ED, Chan P, Allen LA and Gersh BJ; ORBIT AF Investigators. Association of frailty and cognitive impairment with benefits of oral anticoagulation in patients with atrial fibrillation. Am Heart J 2019; 211: 77-89.","journal-title":"Am Heart J"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.cjca.2022.10.013","article-title":"Mechanisms and clinical manifestations of cognitive decline in atrial fibrillation patients: potential implications for preventing dementia","volume":"39","author":"Blum","year":"2023","unstructured":"Blum S and Conen D. Mechanisms and clinical manifestations of cognitive decline in atrial fibrillation patients: potential implications for preventing dementia. Can J Cardiol 2023; 39: 159-171.","journal-title":"Can J Cardiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/joa3.12781","article-title":"Impact of anticoagulation therapy on the cognitive decline and dementia in patients with non-valvular atrial fibrillation (cognitive decline and dementia in patients with non-valvular atrial fibrillation [CAF] trial)","volume":"38","author":"Bunch","year":"2022","unstructured":"Bunch TJ, May H, Cutler M, Woller SC, Jacobs V, Stevens SM, Carlquist J, Knowlton KU, Muhlestein JB, Steinberg BA and Anderson JL. Impact of anticoagulation therapy on the cognitive decline and dementia in patients with non-valvular atrial fibrillation (cognitive decline and dementia in patients with non-valvular atrial fibrillation [CAF] trial). J Arrhythm 2022; 38: 997-1008.","journal-title":"J Arrhythm"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1002\/clc.23181","article-title":"Rationale and design of the impact of anticoagulation therapy on the cognitive decline and dementia in patients with nonvalvular atrial fibrillation (CAF) trial: a vanguard study","volume":"42","author":"Bunch","year":"2019","unstructured":"Bunch TJ, Jacobs V, May H, Stevens SM, Crandall B, Cutler M, Day JD, Mallender C, Olson J, Osborn J, Weiss JP and Woller SC. Rationale and design of the impact of anticoagulation therapy on the cognitive decline and dementia in patients with nonvalvular atrial fibrillation (CAF) trial: a vanguard study. Clin Cardiol 2019; 42: 506-512.","journal-title":"Clin Cardiol"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Mohanty S, Mohanty P, Trivedi C, Assadourian J, Mayedo AQ, MacDonald B, Della Rocca DG, Gianni C, Horton R, Al-Ahmad A, Bassiouny M, Burkhardt JD, Di Biase L, Gurol ME and Natale A. Impact of oral anticoagulation therapy versus left atrial appendage occlusion on cognitive function and quality of life in patients with atrial fibrillation. J Am Heart Assoc 2021; 10: e019664.","DOI":"10.1161\/JAHA.120.019664"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.4244\/EIJY19M08_01","article-title":"EHRA\/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion - an update","volume":"15","author":"Glikson","year":"2020","unstructured":"Glikson M, Wolff R, Hindricks G, Mandrola J, Camm AJ, Lip GYH, Fauchier L, Betts TR, Lewalter T, Saw J, Tzikas A, Sternik L, Nietlispach F, Berti S, Sievert H, Bertog S and Meier B. EHRA\/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion - an update. EuroIntervention 2020; 15: 1133-1180.","journal-title":"EuroIntervention"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.jacc.2021.04.098","article-title":"Predictors of device-related thrombus following percutaneous left atrial appendage occlusion","volume":"78","author":"Simard","year":"2021","unstructured":"Simard T, Jung RG, Lehenbauer K, Piayda K, Pracoń R, Jackson GG, Flores-Umanzor E, Faroux L, Korsholm K, Chun JKR, Chen S, Maarse M, Montrella K, Chaker Z, Spoon JN, Pastormerlo LE, Meincke F, Sawant AC, Moldovan CM, Qintar M, Aktas MK, Branca L, Radinovic A, Ram P, El-Zein RS, Flautt T, Ding WY, Sayegh B, Benito-González T, Lee OH, Badejoko SO, Paitazoglou C, Karim N, Zaghloul AM, Agrawal H, Kaplan RM, Alli O, Ahmed A, Suradi HS, Knight BP, Alla VM, Panaich SS, Wong T, Bergmann MW, Chothia R, Kim JS, Pérez de Prado A, Bazaz R, Gupta D, Valderrabano M, Sanchez CE, El Chami MF, Mazzone P, Adamo M, Ling F, Wang DD, O’Neill W, Wojakowski W, Pershad A, Berti S, Spoon D, Kawsara A, Jabbour G, Boersma LVA, Schmidt B, Nielsen-Kudsk JE, Rodés-Cabau J, Freixa X, Ellis CR, Fauchier L, Demkow M, Sievert H, Main ML, Hibbert B, Holmes DR Jr and Alkhouli M. Predictors of device-related thrombus following percutaneous left atrial appendage occlusion. J Am Coll Cardiol 2021; 78: 297-313.","journal-title":"J Am Coll Cardiol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ejcts.2008.02.024","article-title":"Guideline on antiplatelet and anticoagulation management in cardiac surgery","volume":"34","author":"Dunning","year":"2008","unstructured":"Dunning J, Versteegh M, Fabbri A, Pavie A, Kolh P, Lockowandt U and Nashef SA; EACTS Audit and Guidelines Committee. Guideline on antiplatelet and anticoagulation management in cardiac surgery. Eur J Cardiothorac Surg 2008; 34: 73-92.","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1080\/13803390802014594","article-title":"Vascular and cognitive functions associated with cardiovascular disease in the elderly","volume":"31","author":"Cohen","year":"2009","unstructured":"Cohen RA, Poppas A, Forman DE, Hoth KF, Haley AP, Gunstad J, Jefferson AL, Tate DF, Paul RH, Sweet LH, Ono M, Jerskey BA and Gerhard-Herman M. Vascular and cognitive functions associated with cardiovascular disease in the elderly. J Clin Exp Neuropsychol 2009; 31: 96-110.","journal-title":"J Clin Exp Neuropsychol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1056\/NEJMoa2101897","article-title":"Left atrial appendage occlusion during cardiac surgery to prevent stroke","volume":"384","author":"RP","year":"2021","unstructured":"Whitlock RP, Belley-Cote EP, Paparella D, Healey JS, Brady K, Sharma M, Reents W, Budera P, Baddour AJ, Fila P, Devereaux PJ, Bogachev-Prokophiev A, Boening A, Teoh KHT, Tagarakis GI, Slaughter MS, Royse AG, McGuinness S, Alings M, Punjabi PP, Mazer CD, Folkeringa RJ, Colli A, Avezum Á, Nakamya J, Balasubramanian K, Vincent J, Voisine P, Lamy A, Yusuf S and Connolly SJ; LAAOS III Investigators. Left atrial appendage occlusion during cardiac surgery to prevent stroke. N Engl J Med 2021; 384: 2081-2091.","journal-title":"N Engl J Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1111\/jce.14599","article-title":"Epicardial standalone left atrial appendage clipping for prevention of ischemic stroke in patients with atrial fibrillation contraindicated for oral anticaogulation","volume":"31","author":"Branzoli","year":"2020","unstructured":"Branzoli S, Marini M, Guarracini F, Pederzolli C, Pomarolli C, D’Onghia G, Centonze M, Fantinel M, Corsini F, Bonmassari R, Graffigna A and La Meir M. Epicardial standalone left atrial appendage clipping for prevention of ischemic stroke in patients with atrial fibrillation contraindicated for oral anticaogulation. J Cardiovasc Electrophysiol 2020; 31: 2187-2191.","journal-title":"J Cardiovasc Electrophysiol"}],"container-title":["American Journal of Translational Research"],"original-title":[],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:11:23Z","timestamp":1792660283000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/12\/ajtr0168048.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/mkhi8232","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}