{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:41:03Z","timestamp":1791855663416,"version":"4.3.4"},"reference-count":38,"publisher":"e-Century Publishing Corporation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/mmpe6658","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T02:20:16Z","timestamp":1741227616000},"page":"1437-1447","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and safety of idiopathic normal pressure hydrocephalus shunting: a systematic review and meta-analysis"],"prefix":"10.62347","volume":"17","author":[{"given":"Xiaowei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Alvi MA, Brown D, Yolcu Y, Zreik J, Javeed S, Bydon M, Cutsforth-Gregory JK, Graff-Radford J, Jones DT, Graff-Radford NR, Cogswell PM and Elder BD. Prevalence and trends in management of idiopathic normal pressure hydrocephalus in the united states: insights from the national inpatient sample. World Neurosurgery 2021; 145: E38-E52.","DOI":"10.1016\/j.wneu.2020.09.012"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12987-016-0025-2","article-title":"Nonsurgical therapy for hydrocephalus: a comprehensive and critical review","volume":"13","author":"Del Bigio","year":"2016","unstructured":"Del Bigio MR and Di Curzio DL. Nonsurgical therapy for hydrocephalus: a comprehensive and critical review. Fluids Barriers CNS 2016; 13: 3.","journal-title":"Fluids Barriers CNS"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Karabatsou K, Quigley G, Buxton N, Foy P and Mallucci C. Lumboperitoneal shunts: are the complications acceptable? Acta Neurochirurgica 2004; 146: 1193-1197.","DOI":"10.1007\/s00701-004-0392-3"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.3171\/2015.10.JNS151894","article-title":"One-year outcome in patients with idiopathic normal-pressure hydrocephalus: comparison of lumboperitoneal shunt to ventriculoperitoneal shunt","volume":"125","author":"Miyajima","year":"2016","unstructured":"Miyajima M, Kazui H, Mori E and Ishikawa M; on behalf of the SINPHONI-2 Investigators. One-year outcome in patients with idiopathic normal-pressure hydrocephalus: comparison of lumboperitoneal shunt to ventriculoperitoneal shunt. J Neurosurg 2016; 125: 1483-1492.","journal-title":"J Neurosurg"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"McGovern RA, Kelly KM, Chan AK, Morrissey NJ and McKhann GM 2nd. Should ventriculoatrial shunting be the procedure of choice for normal-pressure hydrocephalus? J Neurosurg 2014; 120: 1458-1464.","DOI":"10.3171\/2014.1.JNS131808"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1227\/NEU.0b013e318285b37c","article-title":"Role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial","volume":"72","author":"Pinto","year":"2013","unstructured":"Pinto FC, Saad F, de Oliveira MF, Pereira RM, de Miranda FL, Tornai JB, Lopes MI, Ribas ES, Valinetti EA and Teixeira MJ. Role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. Neurosurgery 2013; 72: 845-853.","journal-title":"Neurosurgery"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1212\/WNL.0000000000002193","article-title":"Practice guideline: idiopathic normal pressure hydrocephalus: response to shunting and predictors of response: report of the guideline development, dissemination, and implementation subcommittee of the American academy of neurology","volume":"85","author":"Halperin","year":"2015","unstructured":"Halperin JJ, Kurlan R, Schwalb JM, Cusimano MD, Gronseth G and Gloss D. Practice guideline: idiopathic normal pressure hydrocephalus: response to shunting and predictors of response: report of the guideline development, dissemination, and implementation subcommittee of the American academy of neurology. Neurology 2015; 85: 2063-2071.","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2176\/nmc.st.2020-0292","article-title":"Guidelines for management of idiopathic normal pressure hydrocephalus (Third Edition): endorsed by the Japanese society of normal pressure hydrocephalus","volume":"61","author":"Nakajima","year":"2021","unstructured":"Nakajima M, Yamada S, Miyajima M, Ishii K, Kuriyama N, Kazui H, Kanemoto H, Suehiro T, Yoshiyama K, Kameda M, Kajimoto Y, Mase M, Murai H, Kita D, Kimura T, Samejima N, Tokuda T, Kaijima M, Akiba C, Kawamura K, Atsuchi M, Hirata Y, Matsumae M, Sasaki M, Yamashita F, Aoki S, Irie R, Miyake H, Kato T, Mori E, Ishikawa M, Date I and Arai H. Guidelines for management of idiopathic normal pressure hydrocephalus (Third Edition): endorsed by the Japanese society of normal pressure hydrocephalus. Neurol Med Chir (Tokyo) 2021; 61: 63-97.","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"ref8","unstructured":"Wu J, Lu AD, Zhang LP, Zuo YX and Jia YP. Study of clinical outcome and prognosis in pediatric core binding factor-acute myeloid leukemia. Zhonghua Xue Ye Xue Za Zhi 2019; 40: 52-57."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.3171\/2018.5.JNS1875","article-title":"Outcomes and complications of different surgical treatments for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis","volume":"131","author":"Giordan","year":"2018","unstructured":"Giordan E, Palandri G, Lanzino G, Murad MH and Elder BD. Outcomes and complications of different surgical treatments for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis. J Neurosurg 2018; 131: 1024-1036.","journal-title":"J Neurosurg"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12987-016-0048-8","article-title":"A change in brain white matter after shunt surgery in idiopathic normal pressure hydrocephalus: a tract-based spatial statistics study","volume":"14","author":"Kanno","year":"2017","unstructured":"Kanno S, Saito M, Kashinoura T, Nishio Y, Iizuka O, Kikuchi H, Takagi M, Iwasaki M, Takahashi S and Mori E. A change in brain white matter after shunt surgery in idiopathic normal pressure hydrocephalus: a tract-based spatial statistics study. Fluids Barriers CNS 2017; 14: 1.","journal-title":"Fluids Barriers CNS"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1227\/neu.0000000000002225","article-title":"Placebo-controlled effectiveness of idiopathic normal pressure hydrocephalus shunting: a randomized pilot trial","volume":"92","author":"Luciano","year":"2023","unstructured":"Luciano M, Holubkov R, Williams MA, Malm J, Nagel S, Moghekar A, Eklund A, Zwimpfer T, Katzen H, Hanley DF and Hamilton MG; PENS Co-investigators and AHCRN Site PIs. Placebo-controlled effectiveness of idiopathic normal pressure hydrocephalus shunting: a randomized pilot trial. Neurosurgery 2023; 92: 481-489.","journal-title":"Neurosurgery"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"777","DOI":"10.7326\/M14-2385","article-title":"The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations","volume":"162","author":"Hutton","year":"2015","unstructured":"Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, Ioannidis JP, Straus S, Thorlund K, Jansen JP, Mulrow C, Catalá-López F, Gøtzsche PC, Dickersin K, Boutron I, Altman DG and Moher D. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med 2015; 162: 777-784.","journal-title":"Ann Intern Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","unstructured":"Ouzzani M, Hammady H, Fedorowicz Z and Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev 2016; 5: 210.","journal-title":"Syst Rev"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1227\/01.NEU.0000168188.25559.0E","article-title":"Development of guidelines for idiopathic normal-pressure hydrocephalus: introduction","volume":"57","author":"Marmarou","year":"2005","unstructured":"Marmarou A, Bergsneider M, Relkin N, Klinge P and Black PM. Development of guidelines for idiopathic normal-pressure hydrocephalus: introduction. Neurosurgery 2005; 57: 1-3.","journal-title":"Neurosurgery"},{"key":"ref15","unstructured":"Partners E. Methodological resources. 2011."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s40265-023-01859-8","article-title":"The comparative effectiveness and safety of insomnia drugs: a systematic review and network meta-analysis of 153 randomized trials","volume":"83","author":"Pan","year":"2023","unstructured":"Pan B, Ge L, Lai H, Hou L, Tian C, Wang Q, Yang K, Lu Y, Zhu H, Li M, Wang D, Li X, Zhang Y, Gao Y, Liu M, Ding G, Tian J and Yang K. The comparative effectiveness and safety of insomnia drugs: a systematic review and network meta-analysis of 153 randomized trials. Drugs 2023; 83: 587-619.","journal-title":"Drugs"},{"key":"ref17","unstructured":"Wells G, Shea B, O’Connell D, Robertson J, Peterson J, Welch V, Losos M and Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses 2000; http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"703","DOI":"10.7326\/M19-0655","article-title":"Red and processed meat consumption and risk for all-cause mortality and cardiometabolic outcomes: a systematic review and meta-analysis of cohort studies","volume":"171","author":"Zeraatkar","year":"2019","unstructured":"Zeraatkar D, Han MA, Guyatt GH, Vernooij RWM, El Dib R, Cheung K, Milio K, Zworth M, Bartoszko JJ, Valli C, Rabassa M, Lee Y, Zajac J, Prokop-Dorner A, Lo C, Bala MM, Alonso-Coello P, Hanna SE and Johnston BC. Red and processed meat consumption and risk for all-cause mortality and cardiometabolic outcomes: a systematic review and meta-analysis of cohort studies. Ann Intern Med 2019; 171: 703-710.","journal-title":"Ann Intern Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"8908","DOI":"10.1080\/10408398.2021.1937040","article-title":"Association of soft drink and 100% fruit juice consumption with all-cause mortality, cardiovascular diseases mortality, and cancer mortality: a systematic review and dose-response meta-analysis of prospective cohort studies","volume":"62","author":"Pan","year":"2022","unstructured":"Pan B, Ge L, Lai H, Wang Q, Wang Q, Zhang Q, Yin M, Li S, Tian J, Yang K and Wang J. Association of soft drink and 100% fruit juice consumption with all-cause mortality, cardiovascular diseases mortality, and cancer mortality: a systematic review and dose-response meta-analysis of prospective cohort studies. Crit Rev Food Sci Nutr 2022; 62: 8908-8919.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.jclinepi.2013.11.014","article-title":"Addressing continuous data measured with different instruments for participants excluded from trial analysis: a guide for systematic reviewers","volume":"67","author":"Ebrahim","year":"2014","unstructured":"Ebrahim S, Johnston BC, Akl EA, Mustafa RA, Sun X, Walter SD, Heels-Ansdell D, Alonso-Coello P and Guyatt GH. Addressing continuous data measured with different instruments for participants excluded from trial analysis: a guide for systematic reviewers. J Clin Epidemiol 2014; 67: 560-570.","journal-title":"J Clin Epidemiol"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, Carpenter J, Rucker G, Harbord RM, Schmid CH, Tetzlaff J, Deeks JJ, Peters J, Macaskill P, Schwarzer G, Duval S, Altman DG, Moher D and Higgins JP. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 2011; 343: d4002.","DOI":"10.1136\/bmj.d4002"},{"key":"ref22","unstructured":"Xie D, Chen H, Guo X and Liu Y. Comparative study of lumboperitoneal shunt and ventriculoperitoneal shunt in the treatment of idiopathic normal pressure hydrocephalus. Am J Transl Res 2021; 13: 11917-11924."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.3171\/2010.11.JNS10967","article-title":"Shunt surgery in patients with hydrocephalus and white matter changes","volume":"114","author":"Tisell","year":"2011","unstructured":"Tisell M, Tullberg M, Hellstrom P, Edsbagge M, Hogfeldt M and Wikkelso C. Shunt surgery in patients with hydrocephalus and white matter changes. J Neurosurg 2011; 114: 1432-1438.","journal-title":"J Neurosurg"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S1474-4422(15)00046-0","article-title":"Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial","volume":"14","author":"Kazui","year":"2015","unstructured":"Kazui H, Miyajima M, Mori E and Ishikawa M; SINPHONI-2 Investigators. Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial. Lancet Neurol 2015; 14: 585-594.","journal-title":"Lancet Neurol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1111\/cns.13526","article-title":"Pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus","volume":"26","author":"Wang","year":"2020","unstructured":"Wang Z, Zhang Y, Hu F, Ding J and Wang X. Pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus. CNS Neurosci Ther 2020; 26: 1230-1240.","journal-title":"CNS Neurosci Ther"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"660621","DOI":"10.3389\/fnagi.2021.660621","article-title":"White matter microstructural damage associated with gait abnormalities in idiopathic normal pressure hydrocephalus","volume":"13","author":"Tang","year":"2021","unstructured":"Tang YM, Yao Y, Xu S, Li X, Hu F, Wang H, Ding J and Wang X. White matter microstructural damage associated with gait abnormalities in idiopathic normal pressure hydrocephalus. Front Aging Neurosci 2021; 13: 660621.","journal-title":"Front Aging Neurosci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1177\/0271678X18760974","article-title":"Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: a glymphatic magnetic resonance imaging study","volume":"39","author":"Eide","year":"2019","unstructured":"Eide PK and Ringstad G. Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: a glymphatic magnetic resonance imaging study. J Cereb Blood Flow Metab 2019; 39: 1355-1368.","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Wong JM, Ziewacz JE, Ho AL, Panchmatia JR, Bader AM, Garton HJ, Laws ER and Gawande AA. Patterns in neurosurgical adverse events: cerebrospinal fluid shunt surgery. Neurosurg Focus 2012; 33: E13.","DOI":"10.3171\/2012.7.FOCUS12179"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"84","DOI":"10.31083\/j.jin2103084","article-title":"A narrative review of a multifactorial and intractable problem","volume":"21","author":"Panagopoulos","year":"2022","unstructured":"Panagopoulos D, Stranjalis G, Gavra M, Boviatsis E and Korfias S. Shunt over-drainage, slit ventricle syndrome, programmable valves and anti-siphon devices. A narrative review of a multifactorial and intractable problem. J Integr Neurosci 2022; 21: 84.","journal-title":"J Integr Neurosci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1080\/14787210.2021.1866544","article-title":"Healthcare-associated ventriculitis: current and emerging diagnostic and treatment strategies","volume":"19","author":"Hasbun","year":"2021","unstructured":"Hasbun R. Healthcare-associated ventriculitis: current and emerging diagnostic and treatment strategies. Expert Rev Anti Infect Ther 2021; 19: 993-999.","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Donaldson L, Côté E and Margolin E. Positional obstruction of ventriculoperitoneal shunt in a patient with idiopathic intracranial hypertension. J Neuroophthalmol 2022; 42: e588-e590.","DOI":"10.1097\/WNO.0000000000001576"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Hamouda AM, Pennington Z, Shafi M, Astudillo Potes MD, Hallak H, Graff-Radford J, Jones DT, Botha H, Cutsforth-Gregory JK, Cogswell PM and Elder BD. Ventriculoperitoneal shunt placement safety in idiopathic normal pressure hydrocephalus: anticoagulated versus non-anticoagulated patients. World Neurosurg 2024; 186: e622-e629.","DOI":"10.1016\/j.wneu.2024.04.018"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Gangemi M, Maiuri F, Naddeo M, Godano U, Mascari C, Broggi G and Ferroli P. Endoscopic third ventriculostomy in idiopathic normal pressure hydrocephalus. Neurosurgery 2008; 63: 62-69.","DOI":"10.1227\/01.NEU.0000335071.37943.40"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"769216","DOI":"10.3389\/fneur.2021.769216","article-title":"Tap test can predict cognitive improvement in patients with iNPH-results from the multicenter prospective studies SINPHONI-1 and -2","volume":"12","author":"Nakajima","year":"2021","unstructured":"Nakajima M, Yamada S, Miyajima M, Kawamura K, Akiba C, Kazui H, Mori E and Ishikawa M; SINPHONI-2 Investigators. Tap test can predict cognitive improvement in patients with iNPH-results from the multicenter prospective studies SINPHONI-1 and -2. Front Neurol 2021; 12: 769216.","journal-title":"Front Neurol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1007\/s00415-020-09844-x","article-title":"Lumboperitoneal shunt in idiopathic normal pressure hydrocephalus: a prospective controlled study","volume":"267","author":"Todisco","year":"2020","unstructured":"Todisco M, Picascia M, Pisano P, Zangaglia R, Minafra B, Vitali P, Rognone E, Pichiecchio A, Ceravolo R, Vanacore N, Fasano A and Pacchetti C. Lumboperitoneal shunt in idiopathic normal pressure hydrocephalus: a prospective controlled study. J Neurol 2020; 267: 2556-2566.","journal-title":"J Neurol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clineuro.2017.03.014","article-title":"Ventriculoatrial versus ventriculoperitoneal shunt complications in idiopathic normal pressure hydrocephalus","volume":"157","author":"Hung","year":"2017","unstructured":"Hung AL, Vivas-Buitrago T, Adam A, Lu J, Robison J, Elder BD, Goodwin CR, Jusue-Torres I and Rigamonti D. Ventriculoatrial versus ventriculoperitoneal shunt complications in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg 2017; 157: 1-6.","journal-title":"Clin Neurol Neurosurg"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.jocn.2008.12.007","article-title":"A prospective study of ventriculo-peritoneal shunting for idiopathic normal pressure hydrocephalus","volume":"16","author":"Razay","year":"2009","unstructured":"Razay G, Vreugdenhil A and Liddell J. A prospective study of ventriculo-peritoneal shunting for idiopathic normal pressure hydrocephalus. J Clin Neurosci 2009; 16: 1180-1183.","journal-title":"J Clin Neurosci"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/2\/ajtr0160594.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:50:37Z","timestamp":1766022637000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/2\/ajtr0160594.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/mmpe6658","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}