{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:51:38Z","timestamp":1784764298006,"version":"3.55.0"},"reference-count":43,"publisher":"e-Century Publishing Corporation","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Cancer Res"],"DOI":"10.62347\/ntqd6644","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T07:22:47Z","timestamp":1762327367000},"page":"4452-4469","source":"Crossref","is-referenced-by-count":1,"title":["High plasma histidine concentration predicts a favorable prognosis in patients with ampullary cancer"],"prefix":"10.62347","volume":"15","author":[{"given":"Cheng-Han","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12986-020-00439-x","article-title":"Dietary restriction of amino acids for cancer therapy","volume":"17","author":"Kang","year":"2020","unstructured":"Kang JS. Dietary restriction of amino acids for cancer therapy. Nutr Metab (Lond) 2020; 17: 20.","journal-title":"Nutr Metab (Lond)"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/s41419-024-06435-w","article-title":"Amino acid metabolism in tumor biology and therapy","volume":"15","author":"Chen","year":"2024","unstructured":"Chen J, Cui L, Lu S and Xu S. Amino acid metabolism in tumor biology and therapy. Cell Death Dis 2024; 15: 42.","journal-title":"Cell Death Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"5691","DOI":"10.3390\/cancers14225691","article-title":"Amino acids in cancer and cachexia: an integrated view","volume":"14","author":"Ragni","year":"2022","unstructured":"Ragni M, Fornelli C, Nisoli E and Penna F. Amino acids in cancer and cachexia: an integrated view. Cancers (Basel) 2022; 14: 5691.","journal-title":"Cancers (Basel)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/0003-9861(59)90225-5","article-title":"The forced feeding of diets each lacking in one essential amino acid","volume":"81","author":"Sugimura","year":"1959","unstructured":"Sugimura T, Birnbaum SM, Winitz M and Greenstein JP. Quantitative nutritional studies with water-soluble, chemically defined diets. VIII. The forced feeding of diets each lacking in one essential amino acid. Arch Biochem Biophys 1959; 81: 448-455.","journal-title":"Arch Biochem Biophys"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12916-023-02739-4","article-title":"Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts","volume":"21","author":"JA","year":"2023","unstructured":"Rothwell JA, Bešević J, Dimou N, Breeur M, Murphy N, Jenab M, Wedekind R, Viallon V, Ferrari P, Achaintre D, Gicquiau A, Rinaldi S, Scalbert A, Huybrechts I, Prehn C, Adamski J, Cross AJ, Keun H, Chadeau-Hyam M, Boutron-Ruault MC, Overvad K, Dahm CC, Nøst TH, Sandanger TM, Skeie G, Zamora-Ros R, Tsilidis KK, Eichelmann F, Schulze MB, van Guelpen B, Vidman L, Sánchez MJ, Amiano P, Ardanaz E, Smith-Byrne K, Travis R, Katzke V, Kaaks R, Derksen JWG, Colorado-Yohar S, Tumino R, Bueno-de-Mesquita B, Vineis P, Palli D, Pasanisi F, Eriksen AK, Tjønneland A, Severi G and Gunter MJ. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts. BMC Med 2023; 21: 80.","journal-title":"BMC Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1038\/s41416-021-01304-1","article-title":"Investigation of circulating metabolites associated with breast cancer risk by untargeted metabolomics: a case-control study nested within the French E3N cohort","volume":"124","author":"Jobard","year":"2021","unstructured":"Jobard E, Dossus L, Baglietto L, Fornili M, Lécuyer L, Mancini FR, Gunter MJ, Trédan O, Boutron-Ruault MC, Elena-Herrmann B, Severi G and Rothwell JA. Investigation of circulating metabolites associated with breast cancer risk by untargeted metabolomics: a case-control study nested within the French E3N cohort. Br J Cancer 2021; 124: 1734-1743.","journal-title":"Br J Cancer"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/0006-291X(62)90323-6","article-title":"The enzymatic defect in histidinemia","volume":"7","author":"BN","year":"1962","unstructured":"La Du BN, Howell RR, Jacoby GA, Seegmiller JE and Zannoni VG. The enzymatic defect in histidinemia. Biochem Biophys Res Commun 1962; 7: 398-402.","journal-title":"Biochem Biophys Res Commun"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/s41586-018-0316-7","article-title":"Histidine catabolism is a major determinant of methotrexate sensitivity","volume":"559","author":"Kanarek","year":"2018","unstructured":"Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD and Sabatini DM. Histidine catabolism is a major determinant of methotrexate sensitivity. Nature 2018; 559: 632-636.","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Petrova B and Kanarek N. Potential benefits and pitfalls of histidine supplementation for cancer therapy enhancement. J Nutr 2020; 150 Suppl 1: 2580S-2587S.","DOI":"10.1093\/jn\/nxaa132"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.3390\/cancers15092593","article-title":"Histidine enhances the anticancer effect of gemcitabine against pancreatic cancer via disruption of amino acid homeostasis and oxidant-antioxidant balance","volume":"15","author":"Kumar","year":"2023","unstructured":"Kumar N, Rachagani S, Natarajan G, Crook A, Gopal T, Rajamanickam V, Kaushal JB, Nagabhishek SN, Powers R, Batra SK and Saraswathi V. Histidine enhances the anticancer effect of gemcitabine against pancreatic cancer via disruption of amino acid homeostasis and oxidant-antioxidant balance. Cancers (Basel) 2023; 15: 2593.","journal-title":"Cancers (Basel)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.3390\/cancers14051205","article-title":"Impact of exogenous treatment with histidine on hepatocellular carcinoma cells","volume":"14","author":"Park","year":"2022","unstructured":"Park Y, Han Y, Kim D, Cho S, Kim W, Hwang H, Lee HW, Han DH, Kim KS, Yun M and Lee M. Impact of exogenous treatment with histidine on hepatocellular carcinoma cells. Cancers (Basel) 2022; 14: 1205.","journal-title":"Cancers (Basel)"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3238\/arztebl.m2023.0195","article-title":"The diagnosis and treatment of ampullary carcinoma","volume":"120","author":"Walter","year":"2023","unstructured":"Walter D, Schnitzbauer AA, Schulze F and Trojan J. The diagnosis and treatment of ampullary carcinoma. Dtsch Arztebl Int 2023; 120: 729-735.","journal-title":"Dtsch Arztebl Int"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1245\/s10434-008-9886-1","article-title":"Survival after resection of ampullary carcinoma: a national population-based study","volume":"15","author":"O&#x2019","year":"2008","unstructured":"O’Connell JB, Maggard MA, Manunga J Jr, Tomlinson JS, Reber HA, Ko CY and Hines OJ. Survival after resection of ampullary carcinoma: a national population-based study. Ann Surg Oncol 2008; 15: 1820-1827.","journal-title":"Ann Surg Oncol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/jso.21493","article-title":"Loss of E-cadherin and beta-catenin is correlated with poor prognosis of ampullary neoplasms","volume":"101","author":"Hsu","year":"2010","unstructured":"Hsu HP, Shan YS, Jin YT, Lai MD and Lin PW. Loss of E-cadherin and beta-catenin is correlated with poor prognosis of ampullary neoplasms. J Surg Oncol 2010; 101: 356-362.","journal-title":"J Surg Oncol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"13255","DOI":"10.1038\/s41598-020-69899-8","article-title":"Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence","volume":"10","author":"Cheng","year":"2020","unstructured":"Cheng LC, Chao YJ, Overman MJ, Wang CY, Phan NN, Chen YL, Wang TW, Hsu HP, Shan YS and Lai MD. Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence. Sci Rep 2020; 10: 13255.","journal-title":"Sci Rep"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1186\/s12885-015-1924-3","article-title":"Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44ν is an indicator for recurrence in advanced cancer","volume":"15","author":"CL","year":"2015","unstructured":"Wu CL, Chao YJ, Yang TM, Chen YL, Chang KC, Hsu HP, Shan YS and Lai MD. Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44ν is an indicator for recurrence in advanced cancer. BMC Cancer 2015; 15: 903.","journal-title":"BMC Cancer"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3892\/or.2014.3588","article-title":"Nestin predicts a favorable prognosis in early ampullary adenocarcinoma and functions as a promoter of metastasis in advanced cancer","volume":"33","author":"Shan","year":"2015","unstructured":"Shan YS, Chen YL, Lai MD and Hsu HP. Nestin predicts a favorable prognosis in early ampullary adenocarcinoma and functions as a promoter of metastasis in advanced cancer. Oncol Rep 2015; 33: 40-48.","journal-title":"Oncol Rep"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"144","DOI":"10.4161\/cbt.10.2.12160","article-title":"Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival","volume":"10","author":"Hsu","year":"2010","unstructured":"Hsu HP, Shan YS, Lai MD and Lin PW. Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival. Cancer Biol Ther 2010; 10: 144-154.","journal-title":"Cancer Biol Ther"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.3892\/or.2016.5011","article-title":"Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia","volume":"36","author":"Chen","year":"2016","unstructured":"Chen MC, Chen YL, Wang TW, Hsu HP and Lai MD. Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia. Oncol Rep 2016; 36: 1997-2008.","journal-title":"Oncol Rep"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"256","DOI":"10.7150\/ijms.48123","article-title":"Upregulation of peroxisome proliferator-activated receptor-α and the lipid metabolism pathway promotes carcinogenesis of ampullary cancer","volume":"18","author":"Wang","year":"2021","unstructured":"Wang CY, Chao YJ, Chen YL, Wang TW, Phan NN, Hsu HP, Shan YS and Lai MD. Upregulation of peroxisome proliferator-activated receptor-α and the lipid metabolism pathway promotes carcinogenesis of ampullary cancer. Int J Med Sci 2021; 18: 256-269.","journal-title":"Int J Med Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1186\/s12885-024-12320-8","article-title":"Preoperative profiles of plasma amino acids and derivatives distinguish periampullary cancer and benign disease","volume":"24","author":"St&#xE5","year":"2024","unstructured":"Stålberg SM, Silwal-Pandit L, Bastani NE, Nebdal DJH, Lingjærde OC, Skålhegg BS and Kure EH. Preoperative profiles of plasma amino acids and derivatives distinguish periampullary cancer and benign disease. BMC Cancer 2024; 24: 555.","journal-title":"BMC Cancer"},{"key":"ref21","unstructured":"Remmele W and Stegner HE. Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe 1987; 8: 138-140."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1023\/A:1007924430570","article-title":"Growth stimulation of tumor-specific cytotoxic T lymphocytes on concanavalin a-immobilized carrier beads","volume":"26","author":"SQ","year":"1998","unstructured":"Liu SQ, Liu LS and Ohno T. Growth stimulation of tumor-specific cytotoxic T lymphocytes on concanavalin a-immobilized carrier beads. Cytotechnology 1998; 26: 13-21.","journal-title":"Cytotechnology"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/sj.bjc.6600440","article-title":"Establishment and characterisation of six human biliary tract cancer cell lines","volume":"87","author":"JL","year":"2002","unstructured":"Ku JL, Yoon KA, Kim IJ, Kim WH, Jang JY, Suh KS, Kim SW, Park YH, Hwang JH, Yoon YB and Park JG. Establishment and characterisation of six human biliary tract cancer cell lines. Br J Cancer 2002; 87: 187-193.","journal-title":"Br J Cancer"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4143\/crt.2005.37.1.1","article-title":"Biology of SNU cell lines","volume":"37","author":"JL","year":"2005","unstructured":"Ku JL and Park JG. Biology of SNU cell lines. Cancer Res Treat 2005; 37: 1-19.","journal-title":"Cancer Res Treat"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1038\/jid.2014.120","article-title":"Histamine contributes to tissue remodeling via periostin expression","volume":"134","author":"Yang","year":"2014","unstructured":"Yang L, Murota H, Serada S, Fujimoto M, Kudo A, Naka T and Katayama I. Histamine contributes to tissue remodeling via periostin expression. J Invest Dermatol 2014; 134: 2105-2113.","journal-title":"J Invest Dermatol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.1038\/s41467-019-11311-9","article-title":"A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals","volume":"10","author":"Deelen","year":"2019","unstructured":"Deelen J, Kettunen J, Fischer K, van der Spek A, Trompet S, Kastenmüller G, Boyd A, Zierer J, van den Akker EB, Ala-Korpela M, Amin N, Demirkan A, Ghanbari M, van Heemst D, Ikram MA, van Klinken JB, Mooijaart SP, Peters A, Salomaa V, Sattar N, Spector TD, Tiemeier H, Verhoeven A, Waldenberger M, Würtz P, Davey Smith G, Metspalu A, Perola M, Menni C, Geleijnse JM, Drenos F, Beekman M, Jukema JW, van Duijn CM and Slagboom PE. A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals. Nat Commun 2019; 10: 3346.","journal-title":"Nat Commun"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1111\/joim.13540","article-title":"The association between plasma metabolites and future risk of all-cause mortality","volume":"292","author":"Yan","year":"2022","unstructured":"Yan Y, Smith E, Melander O and Ottosson F. The association between plasma metabolites and future risk of all-cause mortality. J Intern Med 2022; 292: 804-815.","journal-title":"J Intern Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1186\/1471-2407-10-690","article-title":"Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: a case control study","volume":"10","author":"Maeda","year":"2010","unstructured":"Maeda J, Higashiyama M, Imaizumi A, Nakayama T, Yamamoto H, Daimon T, Yamakado M, Imamura F and Kodama K. Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: a case control study. BMC Cancer 2010; 10: 690.","journal-title":"BMC Cancer"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Fukutake N, Ueno M, Hiraoka N, Shimada K, Shiraishi K, Saruki N, Ito T, Yamakado M, Ono N, Imaizumi A, Kikuchi S, Yamamoto H and Katayama K. A novel multivariate index for pancreatic cancer detection based on the plasma free amino acid profile. PLOS One 2015; 10: e0132223.","DOI":"10.1371\/journal.pone.0132223"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"108866","DOI":"10.1016\/j.reprotox.2025.108866","article-title":"Environmental basis for early onset breast cancer","volume":"133","author":"Teeny","year":"2025","unstructured":"Teeny S, Jarrell ZR, Krigbaum NY, Cirillo PM, Go YM, Cohn BA and Jones DP. Environmental basis for early onset breast cancer. Reprod Toxicol 2025; 133: 108866.","journal-title":"Reprod Toxicol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1159\/000526864","article-title":"Targeted metabolomic profiling of plasma samples in gastric cancer by liquid chromatography-mass spectrometry","volume":"104","author":"Matsumoto","year":"2023","unstructured":"Matsumoto T, Fukuzawa M, Itoi T, Sugimoto M, Aizawa Y, Sunamura M, Kawai T, Nemoto D, Shinohara H, Muramatsu T, Suzuki Y, Kagawa Y, Suguro M, Uchida K, Koyama Y, Madarame A, Morise T, Yamaguchi H, Sugimoto A, Yamauchi Y, Kono S and Naito S. Targeted metabolomic profiling of plasma samples in gastric cancer by liquid chromatography-mass spectrometry. Digestion 2023; 104: 97-108.","journal-title":"Digestion"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"10287","DOI":"10.2147\/OTT.S273107","article-title":"Study of the relationship between serum amino acid metabolism and lymph node metastasis in patients with colorectal cancer","volume":"13","author":"Liu","year":"2020","unstructured":"Liu J, Wang J, Ma X, Feng Y, Chen Y, Wang Y, Xue D and Qiao S. Study of the relationship between serum amino acid metabolism and lymph node metastasis in patients with colorectal cancer. Onco Targets Ther 2020; 13: 10287-10296.","journal-title":"Onco Targets Ther"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"5202","DOI":"10.3390\/jcm13175202","article-title":"Stage-specific plasma metabolomic profiles in colorectal cancer","volume":"13","author":"Ishizaki","year":"2024","unstructured":"Ishizaki T, Sugimoto M, Kuboyama Y, Mazaki J, Kasahara K, Tago T, Udo R, Iwasaki K, Hayashi Y and Nagakawa Y. Stage-specific plasma metabolomic profiles in colorectal cancer. J Clin Med 2024; 13: 5202.","journal-title":"J Clin Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.3892\/ol.2012.928","article-title":"Energy metabolism of cancer: glycolysis versus oxidative phosphorylation (review)","volume":"4","author":"Zheng","year":"2012","unstructured":"Zheng J. Energy metabolism of cancer: glycolysis versus oxidative phosphorylation (review). Oncol Lett 2012; 4: 1151-1157.","journal-title":"Oncol Lett"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1186\/s12964-024-01760-1","article-title":"The significant role of amino acid metabolic reprogramming in cancer","volume":"22","author":"Liu","year":"2024","unstructured":"Liu X, Ren B, Ren J, Gu M, You L and Zhao Y. The significant role of amino acid metabolic reprogramming in cancer. Cell Commun Signal 2024; 22: 380.","journal-title":"Cell Commun Signal"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Thalacker-Mercer AE and Gheller ME. Benefits and adverse effects of histidine supplementation. J Nutr 2020; 150 Suppl 1: 2588S-2592S.","DOI":"10.1093\/jn\/nxaa229"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1111\/j.1440-1827.2004.01641.x","article-title":"Histidine decarboxylase expression in pancreatic endocrine cells and related tumors","volume":"54","author":"Tanimoto","year":"2004","unstructured":"Tanimoto A, Matsuki Y, Tomita T, Sasaguri T, Shimajiri S and Sasaguri Y. Histidine decarboxylase expression in pancreatic endocrine cells and related tumors. Pathol Int 2004; 54: 408-412.","journal-title":"Pathol Int"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1111\/j.1476-5381.2010.00961.x","article-title":"Histamine receptors and cancer pharmacology","volume":"161","author":"Medina","year":"2010","unstructured":"Medina VA and Rivera ES. Histamine receptors and cancer pharmacology. Br J Pharmacol 2010; 161: 755-767.","journal-title":"Br J Pharmacol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1097\/01.MP.0000044485.14910.3A","article-title":"Histidine decarboxylase expression as a new sensitive and specific marker for small cell lung carcinoma","volume":"16","author":"Matsuki","year":"2003","unstructured":"Matsuki Y, Tanimoto A, Hamada T and Sasaguri Y. Histidine decarboxylase expression as a new sensitive and specific marker for small cell lung carcinoma. Mod Pathol 2003; 16: 72-78.","journal-title":"Mod Pathol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/s41416-019-0636-x","article-title":"Study of the antitumour effects and the modulation of immune response by histamine in breast cancer","volume":"122","author":"MB","year":"2020","unstructured":"Nicoud MB, Sterle HA, Massari NA, Táquez Delgado MA, Formoso K, Herrero Ducloux MV, Martinel Lamas D, Cremaschi GA and Medina VA. Study of the antitumour effects and the modulation of immune response by histamine in breast cancer. Br J Cancer 2020; 122: 348-360.","journal-title":"Br J Cancer"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1016\/j.ajpath.2017.06.011","article-title":"Gut microbe-mediated suppression of inflammation-associated colon carcinogenesis by luminal histamine production","volume":"187","author":"Gao","year":"2017","unstructured":"Gao C, Ganesh BP, Shi Z, Shah RR, Fultz R, Major A, Venable S, Lugo M, Hoch K, Chen X, Haag A, Wang TC and Versalovic J. Gut microbe-mediated suppression of inflammation-associated colon carcinogenesis by luminal histamine production. Am J Pathol 2017; 187: 2323-2336.","journal-title":"Am J Pathol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/s41586-018-0409-3","article-title":"Genetic and transcriptional evolution alters cancer cell line drug response","volume":"560","author":"Ben-David U","year":"2018","unstructured":"Ben-David U, Siranosian B, Ha G, Tang H, Oren Y, Hinohara K, Strathdee CA, Dempster J, Lyons NJ, Burns R, Nag A, Kugener G, Cimini B, Tsvetkov P, Maruvka YE, O’Rourke R, Garrity A, Tubelli AA, Bandopadhayay P, Tsherniak A, Vazquez F, Wong B, Birger C, Ghandi M, Thorner AR, Bittker JA, Meyerson M, Getz G, Beroukhim R and Golub TR. Genetic and transcriptional evolution alters cancer cell line drug response. Nature 2018; 560: 325-330.","journal-title":"Nature"}],"container-title":["American Journal of Cancer Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/10\/ajcr0168570.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:56:27Z","timestamp":1768899387000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/10\/ajcr0168570.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":43,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/ntqd6644","relation":{},"ISSN":["2156-6976"],"issn-type":[{"value":"2156-6976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}