{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:42:38Z","timestamp":1782412958307,"version":"3.54.5"},"reference-count":31,"publisher":"e-Century Publishing Corporation","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/osbm8396","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T08:26:39Z","timestamp":1762763199000},"page":"8281-8295","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of pancreatic exocrine insufficiency and efficacy of pancreatic enzyme replacement therapy in acute pancreatitis patients"],"prefix":"10.62347","volume":"17","author":[{"given":"Dun","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1053\/j.gastro.2024.02.052","article-title":"Diagnosis and management of acute pancreatitis","volume":"167","author":"Trikudanathan","year":"2024","unstructured":"Trikudanathan G, Yazici C, Evans Phillips A and Forsmark CE. Diagnosis and management of acute pancreatitis. Gastroenterology 2024; 167: 673-688.","journal-title":"Gastroenterology"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41575-018-0087-5","article-title":"Global epidemiology and holistic prevention of pancreatitis","volume":"16","author":"Petrov","year":"2019","unstructured":"Petrov MS and Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol 2019; 16: 175-184.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","article-title":"New insights into acute pancreatitis","volume":"16","author":"Lee","year":"2019","unstructured":"Lee PJ and Papachristou GI. New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol 2019; 16: 479-496.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1177\/2050640620938987","article-title":"Pancreatic exocrine insufficiency and pancreatic enzyme replacement therapy in patients with advanced pancreatic cancer: a systematic review and meta-analysis","volume":"8","author":"Iglesia","year":"2020","unstructured":"Iglesia D, Avci B, Kiriukova M, Panic N, Bozhychko M, Sandru V, de-Madaria E and Capurso G. Pancreatic exocrine insufficiency and pancreatic enzyme replacement therapy in patients with advanced pancreatic cancer: a systematic review and meta-analysis. United European Gastroenterol J 2020; 8: 1115-1125.","journal-title":"United European Gastroenterol J"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1053\/j.gastro.2023.07.007","article-title":"AGA clinical practice update on the epidemiology, evaluation, and management of exocrine pancreatic insufficiency: expert review","volume":"165","author":"DC","year":"2023","unstructured":"Whitcomb DC, Buchner AM and Forsmark CE. AGA clinical practice update on the epidemiology, evaluation, and management of exocrine pancreatic insufficiency: expert review. Gastroenterology 2023; 165: 1292-1301.","journal-title":"Gastroenterology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"595649","DOI":"10.1155\/2015\/595649","article-title":"Exocrine pancreatic insufficiency in diabetic patients: prevalence, mechanisms, and treatment","volume":"2015","author":"Piciucchi","year":"2015","unstructured":"Piciucchi M, Capurso G, Archibugi L, Delle Fave MM, Capasso M and Delle Fave G. Exocrine pancreatic insufficiency in diabetic patients: prevalence, mechanisms, and treatment. Int J Endocrinol 2015; 2015: 595649.","journal-title":"Int J Endocrinol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.pan.2024.03.003","article-title":"Alterations in exocrine pancreatic function after acute pancreatitis","volume":"24","author":"Bejjani","year":"2024","unstructured":"Bejjani J, Ramsey ML, Lee PJ, Phillips AE, Singh VK, Yadav D, Papachristou GI and Hart PA. Alterations in exocrine pancreatic function after acute pancreatitis. Pancreatology 2024; 24: 505-510.","journal-title":"Pancreatology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.pan.2022.02.003","article-title":"a multicentre study of 1869 patients","volume":"22","author":"Erchinger","year":"2022","unstructured":"Erchinger F, Engjom T, Dimcevski G, Drewes AM, Olesen SS, Vujasinovic M, Löhr JM, Nøjgaard C, Novovic S, Laukkarinen J, Parhiala M, Björn L, Waage A, Hauge T, Pukitis A, Ozola-Zalite I, Kalaitzakis E, Okhlobystin A, Barauskas G, Eva Efsen D and Tjora E. Exocrine pancreas insufficiency in chronic pancreatitis - risk factors and associations with complications. a multicentre study of 1869 patients. Pancreatology 2022; 22: 374-380.","journal-title":"Pancreatology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/cts.12837","article-title":"Exocrine pancreatic dysfunction increases the risk of new-onset diabetes mellitus: results of a nationwide cohort study","volume":"14","author":"Cho","year":"2021","unstructured":"Cho J, Scragg R, Pandol SJ and Petrov MS. Exocrine pancreatic dysfunction increases the risk of new-onset diabetes mellitus: results of a nationwide cohort study. Clin Transl Sci 2021; 14: 170-178.","journal-title":"Clin Transl Sci"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Barkin JA, Harb D, Kort J and Barkin JS. Real-world patient experience with pancreatic enzyme replacement therapy in the treatment of exocrine pancreatic insufficiency. Pancreas 2024; 53: e16-e21.","DOI":"10.1097\/MPA.0000000000002273"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Berry AJ and Bilbo A. Exocrine pancreatic insufficiency and pancreatic exocrine replacement therapy in clinical practice. Nutr Clin Pract 2024; 39 Suppl 1: S78-S88.","DOI":"10.1002\/ncp.11124"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13098-024-01265-4","article-title":"Pancreatic enzyme replacement therapy in subjects with exocrine pancreatic insufficiency and diabetes mellitus: a real-life, case-control study","volume":"16","author":"Alexandre-Heymann","year":"2024","unstructured":"Alexandre-Heymann L, Yaker F, Lassen PB, Dubois-Laforgue D and Larger E. Pancreatic enzyme replacement therapy in subjects with exocrine pancreatic insufficiency and diabetes mellitus: a real-life, case-control study. Diabetol Metab Syndr 2024; 16: 39.","journal-title":"Diabetol Metab Syndr"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.3390\/healthcare11162316","article-title":"Survey of pancreatic enzyme replacement therapy dosing experiences in adults with exocrine pancreatic insufficiency","volume":"11","author":"Lewis","year":"2023","unstructured":"Lewis DM and Shahid A. Survey of pancreatic enzyme replacement therapy dosing experiences in adults with exocrine pancreatic insufficiency. Healthcare (Basel) 2023; 11: 2316.","journal-title":"Healthcare (Basel)"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.2147\/JIR.S392932","article-title":"Predictive risk factors of pancreatic exocrine insufficiency developed after acute pancreatitis: a retrospective cohort study","volume":"16","author":"Guo","year":"2023","unstructured":"Guo Y, Wang X, Wang S, Li A, Cao F and Li F. Predictive risk factors of pancreatic exocrine insufficiency developed after acute pancreatitis: a retrospective cohort study. J Inflamm Res 2023; 16: 1157-1167.","journal-title":"J Inflamm Res"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Sirera-Sirera P, Lluís N, Lluís F, Zapater P, López-Guillén P, Ramia-Ángel JM, Amrani R, Castillo-García T, Andreu-Viseras J, Cárdenas-Jaén K, Guilabert L, Pérez-Brotons S, Martínez-Moneo E, Gendive-Martin N, Hermoso IG, de-Madaria E and Ferri MJ. Fecal elastase-1 and (13)C-mixed triglyceride breath test vs. coefficient of fat absorption to diagnose exocrine pancreatic insufficiency after pancreatic surgery. Gastroenterol Hepatol 2025; 502492.","DOI":"10.1016\/j.gastrohep.2025.502492"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"100636","DOI":"10.1016\/j.ejro.2025.100636","article-title":"MRI and CT radiomics for the diagnosis of acute pancreatitis","volume":"14","author":"Tartari","year":"2025","unstructured":"Tartari C, Porões F, Schmidt S, Abler D, Vetterli T, Depeursinge A, Dromain C, Violi NV and Jreige M. MRI and CT radiomics for the diagnosis of acute pancreatitis. Eur J Radiol Open 2025; 14: 100636.","journal-title":"Eur J Radiol Open"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Huta Y, Ashorov O, Hamouda D, Boltin D, Dickman R and Perets TT. A novel fecal elastase assay for the detection of pancreatic exocrine insufficiency. Clin Lab 2022; 68.","DOI":"10.7754\/Clin.Lab.2021.211206"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.clnu.2018.08.037","article-title":"ESPEN guideline on clinical nutrition in the intensive care unit","volume":"38","author":"Singer","year":"2019","unstructured":"Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, Hiesmayr M, Mayer K, Montejo JC, Pichard C, Preiser JC, van Zanten ARH, Oczkowski S, Szczeklik W and Bischoff SC. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr 2019; 38: 48-79.","journal-title":"Clin Nutr"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/ueg2.12674","article-title":"European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations","volume":"13","author":"Dominguez-Mu&#xF1","year":"2025","unstructured":"Dominguez-Muñoz JE, Vujasinovic M, de la Iglesia D, Cahen D, Capurso G, Gubergrits N, Hegyi P, Hungin P, Ockenga J, Paiella S, Perkhofer L, Rebours V, Rosendahl J, Salvia R, Scheers I, Szentesi A, Bonovas S, Piovani D and Löhr JM. European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations. United European Gastroenterol J 2025; 13: 125-172.","journal-title":"United European Gastroenterol J"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Butt B, Ghulam B, Bashir Z, Abbasi SR, Hussain S, Jadoon SK, Akbar A and Khan MA. Enhanced creatinine level in diabetic patients maximizing the possibilities of nephropathy and its association with blood urea nitrogen and glomerular filtration rate. Cureus 2024; 16: e70482.","DOI":"10.7759\/cureus.70482"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Mogekar S, Jayakar S, Sri Sai Teja Sampath K and Badangi V. A study on urinary amylase and serum amylase in diagnosing acute pancreatitis. Cureus 2024; 16: e70809.","DOI":"10.7759\/cureus.70809"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"8283","DOI":"10.3390\/ijms25158283","article-title":"Role of interleukin 6 in acute pancreatitis: a possible marker for disease prognosis","volume":"25","author":"Mititelu","year":"2024","unstructured":"Mititelu A, Grama A, Colceriu MC, Benţa G, Popoviciu MS and Pop TL. Role of interleukin 6 in acute pancreatitis: a possible marker for disease prognosis. Int J Mol Sci 2024; 25: 8283.","journal-title":"Int J Mol Sci"},{"key":"ref22","unstructured":"Liao Q, He WH, Li TM, Lai C, Yu L, Xia LY, Luo Y, Zhu P, Liu H, Zeng Y, Zhu NH and Lyu N. Evaluation of severity and prognosis of acute pancreatitis by CT severity index and modified CT severity index. Zhonghua Yi Xue Za Zhi 2022; 102: 2011-2017."},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Wang S, Ma L, Zhuang Y, Jiang B and Zhang X. Screening and risk factors of exocrine pancreatic insufficiency in critically ill adult patients receiving enteral nutrition. Crit Care 2013; 17: R171.","DOI":"10.1186\/cc12850"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1056\/NEJMoa2100826","article-title":"Immediate versus postponed intervention for infected necrotizing pancreatitis","volume":"385","author":"Boxhoorn","year":"2021","unstructured":"Boxhoorn L, van Dijk SM, van Grinsven J, Verdonk RC, Boermeester MA, Bollen TL, Bouwense SAW, Bruno MJ, Cappendijk VC, Dejong CHC, van Duijvendijk P, van Eijck CHJ, Fockens P, Francken MFG, van Goor H, Hadithi M, Hallensleben NDL, Haveman JW, Jacobs M, Jansen JM, Kop MPM, van Lienden KP, Manusama ER, Mieog JSD, Molenaar IQ, Nieuwenhuijs VB, Poen AC, Poley JW, van de Poll M, Quispel R, Römkens TEH, Schwartz MP, Seerden TC, Stommel MWJ, Straathof JWA, Timmerhuis HC, Venneman NG, Voermans RP, van de Vrie W, Witteman BJ, Dijkgraaf MGW, van Santvoort HC and Besselink MG. Immediate versus postponed intervention for infected necrotizing pancreatitis. N Engl J Med 2021; 385: 1372-1381.","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/MPA.0000000000001733","article-title":"Effect of pancrelipase therapy on exocrine pancreatic insufficiency symptoms and coefficient of fat absorption associated with chronic pancreatitis","volume":"50","author":"Barkin","year":"2021","unstructured":"Barkin JA and Barkin JS. Effect of pancrelipase therapy on exocrine pancreatic insufficiency symptoms and coefficient of fat absorption associated with chronic pancreatitis. Pancreas 2021; 50: 176-182.","journal-title":"Pancreas"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"5779","DOI":"10.3390\/jcm10245779","article-title":"Causes of exocrine pancreatic insufficiency other than chronic pancreatitis","volume":"10","author":"Kunovsk&#xFD","year":"2021","unstructured":"Kunovský L, Dítě P, Jabandžiev P, Eid M, Poredská K, Vaculová J, Sochorová D, Janeček P, Tesaříková P, Blaho M, Trna J, Hlavsa J and Kala Z. Causes of exocrine pancreatic insufficiency other than chronic pancreatitis. J Clin Med 2021; 10: 5779.","journal-title":"J Clin Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"94920","DOI":"10.18632\/oncotarget.21659","article-title":"Efficacy and safety of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: a meta-analysis","volume":"8","author":"Gan","year":"2017","unstructured":"Gan C, Chen YH, Liu L, Gao JH, Tong H, Tang CW and Liu R. Efficacy and safety of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: a meta-analysis. Oncotarget 2017; 8: 94920-94931.","journal-title":"Oncotarget"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1007\/s10620-025-09011-0","article-title":"Pancreatic enzyme replacement therapy in pancreatic exocrine insufficiency-real-world’s dosing and effectiveness: a systematic review","volume":"70","author":"Kadaj-Lipka R","year":"2025","unstructured":"Kadaj-Lipka R, Monica M, Stożek-Tutro A, Ryś P and Rydzewska G. Pancreatic enzyme replacement therapy in pancreatic exocrine insufficiency-real-world’s dosing and effectiveness: a systematic review. Dig Dis Sci 2025; 70: 2270-2284.","journal-title":"Dig Dis Sci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.3748\/wjg.v25.i20.2430","article-title":"Contribution of pancreatic enzyme replacement therapy to survival and quality of life in patients with pancreatic exocrine insufficiency","volume":"25","author":"Layer","year":"2019","unstructured":"Layer P, Kashirskaya N and Gubergrits N. Contribution of pancreatic enzyme replacement therapy to survival and quality of life in patients with pancreatic exocrine insufficiency. World J Gastroenterol 2019; 25: 2430-2441.","journal-title":"World J Gastroenterol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.pan.2021.11.005","article-title":"Staging exocrine pancreatic dysfunction","volume":"22","author":"Khan","year":"2022","unstructured":"Khan A, Vege SS, Dudeja V and Chari ST. Staging exocrine pancreatic dysfunction. Pancreatology 2022; 22: 168-172.","journal-title":"Pancreatology"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/10\/ajtr0167747.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T03:18:00Z","timestamp":1769138280000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/10\/ajtr0167747.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":31,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/osbm8396","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}