{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:45:33Z","timestamp":1775245533635,"version":"3.50.1"},"reference-count":32,"publisher":"e-Century Publishing Corporation","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/pgbb6148","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T02:48:18Z","timestamp":1743648498000},"page":"2311-2321","source":"Crossref","is-referenced-by-count":4,"title":["Restrictive fluid resuscitation versus liberal fluid resuscitation in patients with septic shock: comparison of outcomes"],"prefix":"10.62347","volume":"17","author":[{"given":"Dengkai","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"962470","DOI":"10.3389\/fcimb.2022.962470","article-title":"Clinical characteristics and risk factors associated with ICU-acquired infections in sepsis: a retrospective cohort study","volume":"12","author":"He","year":"2022","unstructured":"He Y, Xu J, Shang X, Fang X, Gao C, Sun D, Yao L, Zhou T, Pan S, Zou X, Shu H, Yang X and Shang Y. Clinical characteristics and risk factors associated with ICU-acquired infections in sepsis: a retrospective cohort study. Front Cell Infect Microbiol 2022; 12: 962470.","journal-title":"Front Cell Infect Microbiol"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s40272-022-00497-z","article-title":"Medication and fluid management of pediatric sepsis and septic shock","volume":"24","author":"Burgunder","year":"2022","unstructured":"Burgunder L, Heyrend C, Olson J, Stidham C, Lane RD, Workman JK and Larsen GY. Medication and fluid management of pediatric sepsis and septic shock. Paediatr Drugs 2022; 24: 193-205.","journal-title":"Paediatr Drugs"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1089\/sur.2020.047","article-title":"Sepsis and septic shock in low- and middle-income countries","volume":"21","author":"AH","year":"2020","unstructured":"Stephen AH, Montoya RL and Aluisio AR. Sepsis and septic shock in low- and middle-income countries. Surg Infect (Larchmt) 2020; 21: 571-578.","journal-title":"Surg Infect (Larchmt)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3390\/medicina56100527","article-title":"New strategies for treatment of sepsis","volume":"56","author":"Mirijello","year":"2020","unstructured":"Mirijello A and Tosoni A; On Behalf of The Internal Medicine Sepsis Study Group. New strategies for treatment of sepsis. Medicina (Kaunas) 2020; 56: 527.","journal-title":"Medicina (Kaunas)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.2478\/rjim-2020-0012","article-title":"Sepsis, a 2020 review for the internist","volume":"58","author":"Purcarea","year":"2020","unstructured":"Purcarea A and Sovaila S. Sepsis, a 2020 review for the internist. Rom J Intern Med 2020; 58: 129-137.","journal-title":"Rom J Intern Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1007\/s11739-021-02735-7","article-title":"Management of sepsis and septic shock in the emergency department","volume":"16","author":"Gavelli","year":"2021","unstructured":"Gavelli F, Castello LM and Avanzi GC. Management of sepsis and septic shock in the emergency department. Intern Emerg Med 2021; 16: 1649-1661.","journal-title":"Intern Emerg Med"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Qayyum S and Shahid K. Fluid resuscitation in septic patients. Cureus 2023; 15: e44317.","DOI":"10.7759\/cureus.44317"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s00134-021-06595-9","article-title":"Current practice and evolving concepts in septic shock resuscitation","volume":"48","author":"Bakker","year":"2022","unstructured":"Bakker J, Kattan E, Annane D, Castro R, Cecconi M, De Backer D, Dubin A, Evans L, Gong MN, Hamzaoui O, Ince C, Levy B, Monnet X, Ospina Tascón GA, Ostermann M, Pinsky MR, Russell JA, Saugel B, Scheeren TWL, Teboul JL, Vieillard Baron A, Vincent JL, Zampieri FG and Hernandez G. Current practice and evolving concepts in septic shock resuscitation. Intensive Care Med 2022; 48: 148-163.","journal-title":"Intensive Care Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jcrc.2020.02.004","article-title":"The initial resuscitation of septic shock","volume":"57","author":"Cinel","year":"2020","unstructured":"Cinel I, Kasapoglu US, Gul F and Dellinger RP. The initial resuscitation of septic shock. J Crit Care 2020; 57: 108-117.","journal-title":"J Crit Care"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ejim.2023.01.009","article-title":"Active fluid de-resuscitation in critically ill patients with septic shock: a systematic review and meta-analysis","volume":"109","author":"AS","year":"2023","unstructured":"Messmer AS, Dill T, Müller M and Pfortmueller CA. Active fluid de-resuscitation in critically ill patients with septic shock: a systematic review and meta-analysis. Eur J Intern Med 2023; 109: 89-96.","journal-title":"Eur J Intern Med"},{"key":"ref10","unstructured":"Morkar DN, Dwivedi M and Patil P. Comparative study of sofa, apache Ii, Saps Ii, as a predictor of mortality in patients of sepsis admitted in medical ICU. J Assoc Physicians India 2022; 70: 11-12."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.21037\/apm-20-984","article-title":"Prognostic values of SOFA score, qSOFA score, and LODS score for patients with sepsis","volume":"9","author":"Li","year":"2020","unstructured":"Li Y, Yan C, Gan Z, Xi X, Tan Z, Li J and Li G. Prognostic values of SOFA score, qSOFA score, and LODS score for patients with sepsis. Ann Palliat Med 2020; 9: 1037-1044.","journal-title":"Ann Palliat Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study","volume":"395","author":"Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, Fleischmann-Struzek C, Machado FR, Reinhart KK, Rowan K, Seymour CW, Watson RS, West TE, Marinho F, Hay SI, Lozano R, Lopez AD, Angus DC, Murray CJL and Naghavi M. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study. Lancet 2020; 395: 200-211.","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1097\/CCM.0000000000003960","article-title":"Evaluation and predictors of fluid resuscitation in patients with severe sepsis and septic shock","volume":"47","author":"Kuttab","year":"2019","unstructured":"Kuttab HI, Lykins JD, Hughes MD, Wroblewski K, Keast EP, Kukoyi O, Kopec JA, Hall S and Ward MA. Evaluation and predictors of fluid resuscitation in patients with severe sepsis and septic shock. Crit Care Med 2019; 47: 1582-1590.","journal-title":"Crit Care Med"},{"key":"ref14","unstructured":"Gauer R, Forbes D and Boyer N. Sepsis: diagnosis and management. Am Fam Physician 2020; 101: 409-418."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13613-018-0402-x","article-title":"Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy","volume":"8","author":"Malbrain","year":"2018","unstructured":"Malbrain M, Van Regenmortel N, Saugel B, De Tavernier B, Van Gaal PJ, Joannes-Boyau O, Teboul JL, Rice TW, Mythen M and Monnet X. Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy. Ann Intensive Care 2018; 8: 66.","journal-title":"Ann Intensive Care"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s44231-022-00019-y","article-title":"Effect of fluid resuscitation strategies for obese patients with sepsis and septic shock: a systematic review","volume":"3","author":"Zhang","year":"2023","unstructured":"Zhang Y, Wang M, Lu Z and Yang M. Effect of fluid resuscitation strategies for obese patients with sepsis and septic shock: a systematic review. Intensive Care Res 2023; 3: 61-68.","journal-title":"Intensive Care Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1186\/s13054-022-04255-y","article-title":"A plea for personalization of the hemodynamic management of septic shock","volume":"26","author":"Backer D","year":"2022","unstructured":"De Backer D, Cecconi M, Chew MS, Hajjar L, Monnet X, Ospina-Tascón GA, Ostermann M, Pinsky MR and Vincent JL. A plea for personalization of the hemodynamic management of septic shock. Crit Care 2022; 26: 372.","journal-title":"Crit Care"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1002\/ncp.10892","article-title":"Intravenous fluid therapy in sepsis","volume":"37","author":"KP","year":"2022","unstructured":"Seitz KP, Qian ET and Semler MW. Intravenous fluid therapy in sepsis. Nutr Clin Pract 2022; 37: 990-1003.","journal-title":"Nutr Clin Pract"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"162","DOI":"10.5114\/ait.2021.105252","article-title":"Aiming for zero fluid accumulation: first, do no harm","volume":"53","author":"Nieto OR","year":"2021","unstructured":"Perez Nieto OR, Wong A, Lopez Fermin J, Zamarron Lopez EI, Meade Aguilar JA, Deloya Tomas E, Carrion Moya JD, Castillo Gutierrez G, G Olvera Ramos M, García Montes X, Alberto Guerrero Gutiérrez M, George Aguilar F, Salvador Sánchez Díaz J, Soriano Orozco R, Ríos Argaiz E, Hernandez-Gilsoul T, Secchi Del Rio R and Ñamendys-Silva SA; L N G Malbrain M. Aiming for zero fluid accumulation: first, do no harm. Anaesthesiol Intensive Ther 2021; 53: 162-178.","journal-title":"Anaesthesiol Intensive Ther"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1056\/NEJMoa2212663","article-title":"Early restrictive or liberal fluid management for sepsis-induced hypotension","volume":"388","author":"Shapiro","year":"2023","unstructured":"Shapiro NI, Douglas IS, Brower RG, Brown SM, Exline MC, Ginde AA, Gong MN, Grissom CK, Hayden D, Hough CL, Huang W, Iwashyna TJ, Jones AE, Khan A, Lai P, Liu KD, Miller CD, Oldmixon K, Park PK, Rice TW, Ringwood N, Semler MW, Steingrub JS, Talmor D, Thompson BT, Yealy DM and Self WH. Early restrictive or liberal fluid management for sepsis-induced hypotension. N Engl J Med 2023; 388: 499-510.","journal-title":"N Engl J Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1164\/rccm.202209-1831CI","article-title":"Evolving management practices for early sepsis-induced hypoperfusion: a narrative review","volume":"207","author":"Munroe","year":"2023","unstructured":"Munroe ES, Hyzy RC, Semler MW, Shankar-Hari M, Young PJ, Zampieri FG and Prescott HC. Evolving management practices for early sepsis-induced hypoperfusion: a narrative review. Am J Respir Crit Care Med 2023; 207: 1283-1299.","journal-title":"Am J Respir Crit Care Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1002\/phar.2764","article-title":"Restrictive resuscitation in patients with sepsis and mortality: a systematic review and meta-analysis with trial sequential analysis","volume":"43","author":"PM","year":"2023","unstructured":"Reynolds PM, Stefanos S and MacLaren R. Restrictive resuscitation in patients with sepsis and mortality: a systematic review and meta-analysis with trial sequential analysis. Pharmacotherapy 2023; 43: 104-114.","journal-title":"Pharmacotherapy"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1097\/MCC.0000000000000834","article-title":"Hemodynamic clinical phenotyping in septic shock","volume":"27","author":"Daulasim","year":"2021","unstructured":"Daulasim A, Vieillard-Baron A and Geri G. Hemodynamic clinical phenotyping in septic shock. Curr Opin Crit Care 2021; 27: 290-297.","journal-title":"Curr Opin Crit Care"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1097\/ACO.0000000000001098","article-title":"Sepsis and the microcirculation: the impact on outcomes","volume":"35","author":"Yajnik","year":"2022","unstructured":"Yajnik V and Maarouf R. Sepsis and the microcirculation: the impact on outcomes. Curr Opin Anaesthesiol 2022; 35: 230-235.","journal-title":"Curr Opin Anaesthesiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1097\/SHK.0000000000002235","article-title":"Restrictive fluid resuscitation in septic shock patients has lower mortality and organ dysfunction rates than standard therapy","volume":"60","author":"Jiang","year":"2023","unstructured":"Jiang Z, Luo F, Liu Y, Sun X, Tan G, Chen Z and Chen Y. Restrictive fluid resuscitation in septic shock patients has lower mortality and organ dysfunction rates than standard therapy. Shock 2023; 60: 739-745.","journal-title":"Shock"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1097\/CCM.0000000000005952","article-title":"Multiple electrolytes solution versus saline as bolus fluid for resuscitation in pediatric septic shock: a multicenter randomized clinical trial","volume":"51","author":"Sankar","year":"2023","unstructured":"Sankar J, Muralidharan J, Lalitha AV, Rameshkumar R, Pathak M, Das RR, Nadkarni VM, Ismail J, Subramanian M, Nallasamy K, Dev N, Kumar UV, Kumar K, Sharma T, Jaravta K, Thakur N, Aggarwal P, Jat KR, Kabra SK and Lodha R. Multiple electrolytes solution versus saline as bolus fluid for resuscitation in pediatric septic shock: a multicenter randomized clinical trial. Crit Care Med 2023; 51: 1449-1460.","journal-title":"Crit Care Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ccc.2017.08.005","article-title":"Pathophysiology of septic shock","volume":"34","author":"JA","year":"2018","unstructured":"Russell JA, Rush B and Boyd J. Pathophysiology of septic shock. Crit Care Clin 2018; 34: 43-61.","journal-title":"Crit Care Clin"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.ajem.2020.10.037","article-title":"Aggressive versus conservative fluid resuscitation in septic hemodialysis patients","volume":"46","author":"Rajdev","year":"2021","unstructured":"Rajdev K, Leifer L, Sandhu G, Mann B, Pervaiz S, Lahan S, Siddiqui AH, Habib S, Joseph B and El-Sayegh S. Aggressive versus conservative fluid resuscitation in septic hemodialysis patients. Am J Emerg Med 2021; 46: 416-419.","journal-title":"Am J Emerg Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1097\/SHK.0000000000001783","article-title":"Evaluation of evidence, pharmacology, and interplay of fluid resuscitation and vasoactive therapy in sepsis and septic shock","volume":"56","author":"Barlow","year":"2021","unstructured":"Barlow B and Bissell BD. Evaluation of evidence, pharmacology, and interplay of fluid resuscitation and vasoactive therapy in sepsis and septic shock. Shock 2021; 56: 484-492.","journal-title":"Shock"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1001\/jama.2023.7560","article-title":"Fluid therapy for critically ill adults with sepsis: a review","volume":"329","author":"FG","year":"2023","unstructured":"Zampieri FG, Bagshaw SM and Semler MW. Fluid therapy for critically ill adults with sepsis: a review. JAMA 2023; 329: 1967-1980.","journal-title":"JAMA"},{"key":"ref31","unstructured":"Zhou Y, Wang Y, Li Q, Sheng H, Mao E and Jiang W. The effects of early restrictive fluid resuscitation on the clinical outcomes in sepsis patients. Am J Transl Res 2021; 13: 11482-11490."}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/3\/ajtr0162094.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:50:25Z","timestamp":1766022625000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/3\/ajtr0162094.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/pgbb6148","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}