{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:55:53Z","timestamp":1766022953893,"version":"3.48.0"},"reference-count":37,"publisher":"e-Century Publishing Corporation","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/pyxc6104","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T04:02:40Z","timestamp":1743134560000},"page":"2112-2123","source":"Crossref","is-referenced-by-count":0,"title":["Serum IL-18R1 and its effect on immune cell infiltration in asthma"],"prefix":"10.62347","volume":"17","author":[{"given":"Qingqin","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"The Global Asthma Report 2022. Int J Tuberc Lung Dis 2022; 26: 1-104.","DOI":"10.5588\/ijtld.22.1010"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1164\/rccm.201804-0682CI","article-title":"Underdiagnosis and overdiagnosis of asthma","volume":"198","author":"Aaron","year":"2018","unstructured":"Aaron SD, Boulet LP, Reddel HK and Gershon AS. Underdiagnosis and overdiagnosis of asthma. Am J Respir Crit Care Med 2018; 198: 1012-1020.","journal-title":"Am J Respir Crit Care Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.3390\/cells11172764","article-title":"Current understanding of asthma pathogenesis and biomarkers","volume":"11","author":"Habib","year":"2022","unstructured":"Habib N, Pasha MA and Tang DD. Current understanding of asthma pathogenesis and biomarkers. Cells 2022; 11: 2764.","journal-title":"Cells"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1149203","DOI":"10.3389\/fimmu.2023.1149203","article-title":"T-helper cells and their cytokines in pathogenesis and treatment of asthma","volume":"14","author":"Ji","year":"2023","unstructured":"Ji T and Li H. T-helper cells and their cytokines in pathogenesis and treatment of asthma. Front Immunol 2023; 14: 1149203.","journal-title":"Front Immunol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1056\/NEJMra2032506","article-title":"Biologic therapies for severe asthma","volume":"386","author":"Brusselle","year":"2022","unstructured":"Brusselle GG and Koppelman GH. Biologic therapies for severe asthma. N Engl J Med 2022; 386: 157-171.","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Fu Y, Wang J, Zhou B, Pajulas A, Gao H, Ramdas B, Koh B, Ulrich BJ, Yang S, Kapur R, Renauld JC, Paczesny S, Liu Y, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Tepper RS, Sun J and Kaplan MH. An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment. Sci Immunol 2022; 7: eabi9768.","DOI":"10.1126\/sciimmunol.abi9768"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s00408-024-00760-9","article-title":"Increase in blood eosinophil count over time and sputum IL8 are associated with FEV(1) decline in asthma","volume":"203","author":"Graff","year":"2024","unstructured":"Graff S, Moermans C, Gerday S, Henket M, Paulus V, Guissard F, Louis R and Schleich F. Increase in blood eosinophil count over time and sputum IL8 are associated with FEV(1) decline in asthma. Lung 2024; 203: 8.","journal-title":"Lung"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Bullens DM, Truyen E, Coteur L, Dilissen E, Hellings PW, Dupont LJ and Ceuppens JL. IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir Res 2006; 7: 135.","DOI":"10.1186\/1465-9921-7-135"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1111\/all.14768","article-title":"Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment","volume":"76","author":"Niessen","year":"2021","unstructured":"Niessen NM, Gibson PG, Baines KJ, Barker D, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Marks GB, Baraket M, Simpson JL and Fricker M. Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment. Allergy 2021; 76: 2090-2101.","journal-title":"Allergy"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3390\/ijms20030649","article-title":"Interleukin-18 in health and disease","volume":"20","author":"Yasuda","year":"2019","unstructured":"Yasuda K, Nakanishi K and Tsutsui H. Interleukin-18 in health and disease. Int J Mol Sci 2019; 20: 649.","journal-title":"Int J Mol Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","article-title":"A large-scale, consortium-based genomewide association study of asthma","volume":"363","author":"MF","year":"2010","unstructured":"Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M and Cookson WOCM; GABRIEL Consortium. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010; 363: 1211-1221.","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1021\/acs.jproteome.3c00389","article-title":"IL18R1-related molecules as biomarkers for asthma severity and prognostic markers for idiopathic pulmonary fibrosis","volume":"22","author":"Lin","year":"2023","unstructured":"Lin K, Wang T, Tang Q, Chen T, Lin M, Jin J, Cao J, Zhang S, Xing Y, Qiao L and Liang Y. IL18R1-related molecules as biomarkers for asthma severity and prognostic markers for idiopathic pulmonary fibrosis. J Proteome Res 2023; 22: 3320-3331.","journal-title":"J Proteome Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1426875","DOI":"10.3389\/fimmu.2024.1426875","article-title":"Evaluating the significance of ECSCR in the diagnosis of ulcerative colitis and drug efficacy assessment","volume":"15","author":"Feng","year":"2024","unstructured":"Feng B, Zhang Y, Qiao L, Tang Q, Zhang Z, Zhang S, Qiu J, Zhou X, Huang C and Liang Y. Evaluating the significance of ECSCR in the diagnosis of ulcerative colitis and drug efficacy assessment. Front Immunol 2024; 15: 1426875.","journal-title":"Front Immunol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"105","DOI":"10.62347\/XTLJ1335","article-title":"Prognostic significance of LRPPRC and its association with immune infiltration in liver hepatocellular carcinoma","volume":"13","author":"Zhang","year":"2024","unstructured":"Zhang Y, Feng B, Liang Y, Tang Q, Zhang S, Zhang Z, Xu L and Yin J. Prognostic significance of LRPPRC and its association with immune infiltration in liver hepatocellular carcinoma. Am J Clin Exp Immunol 2024; 13: 105-116.","journal-title":"Am J Clin Exp Immunol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"875588","DOI":"10.3389\/fmed.2022.875588","article-title":"The effect of elevated alanine transaminase on non-invasive prenatal screening failures","volume":"9","author":"Chen","year":"2022","unstructured":"Chen P, Qiao L, Zhang S, Jin J, Cao J, Zhang Y, Tang H, Yu Z, Shi J, Yin J, Liang Y and Wu X. The effect of elevated alanine transaminase on non-invasive prenatal screening failures. Front Med (Lausanne) 2022; 9: 875588.","journal-title":"Front Med (Lausanne)"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"811385","DOI":"10.3389\/fmed.2021.811385","article-title":"Lipid metabolism affects fetal fraction and screen failures in non-invasive prenatal testing","volume":"8","author":"Cao","year":"2021","unstructured":"Cao J, Qiao L, Jin J, Zhang S, Chen P, Tang H, Yu Z, Shi J, Wang T and Liang Y. Lipid metabolism affects fetal fraction and screen failures in non-invasive prenatal testing. Front Med (Lausanne) 2021; 8: 811385.","journal-title":"Front Med (Lausanne)"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/j.jaci.2021.10.001","article-title":"Advances in asthma: new understandings of asthma’s natural history, risk factors, underlying mechanisms, and clinical management","volume":"148","author":"RL","year":"2021","unstructured":"Miller RL, Grayson MH and Strothman K. Advances in asthma: new understandings of asthma’s natural history, risk factors, underlying mechanisms, and clinical management. J Allergy Clin Immunol 2021; 148: 1430-1441.","journal-title":"J Allergy Clin Immunol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1164\/ajrccm.160.3.9812110","article-title":"Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics","volume":"160","author":"Wenzel","year":"1999","unstructured":"Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL and Chu HW. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999; 160: 1001-1008.","journal-title":"Am J Respir Crit Care Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.mucimm.2024.03.005","article-title":"IL-5 antagonism reverses priming and activation of eosinophils in severe eosinophilic asthma","volume":"17","author":"Luo","year":"2024","unstructured":"Luo J, Chen W, Liu W, Jiang S, Ye Y, Shrimanker R, Hynes G, Klenerman P, Pavord ID and Xue L. IL-5 antagonism reverses priming and activation of eosinophils in severe eosinophilic asthma. Mucosal Immunol 2024; 17: 524-536.","journal-title":"Mucosal Immunol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12890-023-02383-x","article-title":"Peripheral blood eosinophilia in adult asthmatic patients and its association with the severity of asthma","volume":"23","author":"Solomon","year":"2023","unstructured":"Solomon Y, Malkamu B, Berhan A, Eyayu T, Almaw A, Legese B and Woldu B. Peripheral blood eosinophilia in adult asthmatic patients and its association with the severity of asthma. BMC Pulm Med 2023; 23: 96.","journal-title":"BMC Pulm Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.anai.2022.02.021","article-title":"Allergic and eosinophilic asthma in the era of biomarkers and biologics: similarities, differences and misconceptions","volume":"129","author":"Oppenheimer","year":"2022","unstructured":"Oppenheimer J, Hoyte FCL, Phipatanakul W, Silver J, Howarth P and Lugogo NL. Allergic and eosinophilic asthma in the era of biomarkers and biologics: similarities, differences and misconceptions. Ann Allergy Asthma Immunol 2022; 129: 169-180.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1201160","DOI":"10.3389\/fimmu.2023.1201160","article-title":"Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018","volume":"14","author":"Wen","year":"2023","unstructured":"Wen J, Wang C, Xia J, Giri M and Guo S. Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018. Front Immunol 2023; 14: 1201160.","journal-title":"Front Immunol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1146\/annurev-immunol-093019-125918","article-title":"Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies","volume":"39","author":"Jacobsen","year":"2021","unstructured":"Jacobsen EA, Jackson DJ, Heffler E, Mathur SK, Bredenoord AJ, Pavord ID, Akuthota P, Roufosse F and Rothenberg ME. Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies. Annu Rev Immunol 2021; 39: 719-757.","journal-title":"Annu Rev Immunol"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Li Y, Yang T and Jiang B. Neutrophil and neutrophil extracellular trap involvement in neutrophilic asthma: a review. Medicine (Baltimore) 2024; 103: e39342.","DOI":"10.1097\/MD.0000000000039342"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1136\/thorax.57.10.875","article-title":"Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids","volume":"57","author":"Green","year":"2002","unstructured":"Green RH, Brightling CE, Woltmann G, Parker D, Wardlaw AJ and Pavord ID. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002; 57: 875-879.","journal-title":"Thorax"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.it.2017.07.003","article-title":"Neutrophilic inflammation in asthma and association with disease severity","volume":"38","author":"Ray","year":"2017","unstructured":"Ray A and Kolls JK. Neutrophilic inflammation in asthma and association with disease severity. Trends Immunol 2017; 38: 942-954.","journal-title":"Trends Immunol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"974066","DOI":"10.3389\/fimmu.2022.974066","article-title":"Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma","volume":"13","author":"Luo","year":"2022","unstructured":"Luo W, Hu J, Xu W and Dong J. Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma. Front Immunol 2022; 13: 974066.","journal-title":"Front Immunol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"975914","DOI":"10.3389\/fimmu.2022.975914","article-title":"Epithelial cell alarmin cytokines: frontline mediators of the asthma inflammatory response","volume":"13","author":"Duchesne","year":"2022","unstructured":"Duchesne M, Okoye I and Lacy P. Epithelial cell alarmin cytokines: frontline mediators of the asthma inflammatory response. Front Immunol 2022; 13: 975914.","journal-title":"Front Immunol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"59","DOI":"10.18388\/abp.2015_1153","article-title":"Interleukin 18 (IL-18) as a target for immune intervention","volume":"63","author":"Wawrocki","year":"2016","unstructured":"Wawrocki S, Druszczynska M, Kowalewicz-Kulbat M and Rudnicka W. Interleukin 18 (IL-18) as a target for immune intervention. Acta Biochim Pol 2016; 63: 59-63.","journal-title":"Acta Biochim Pol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/mi.2015.13","article-title":"Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine","volume":"8","author":"Harrison","year":"2015","unstructured":"Harrison OJ, Srinivasan N, Pott J, Schiering C, Krausgruber T, Ilott NE and Maloy KJ. Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine. Mucosal Immunol 2015; 8: 1226-1236.","journal-title":"Mucosal Immunol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.mucimm.2023.05.004","article-title":"IL-18 is required for the T(H)1-adaptation of T(REG) cells and the selective suppression of T(H)17 responses in acute and chronic infections","volume":"16","author":"Alvarez","year":"2023","unstructured":"Alvarez F, Istomine R, Da Silva Lira Filho A, Al-Aubodah TA, Huang D, Okde R, Olivier M, Fritz JH and Piccirillo CA. IL-18 is required for the T(H)1-adaptation of T(REG) cells and the selective suppression of T(H)17 responses in acute and chronic infections. Mucosal Immunol 2023; 16: 462-475.","journal-title":"Mucosal Immunol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3109\/08830189809043005","article-title":"Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist","volume":"16","author":"Dinarello","year":"1998","unstructured":"Dinarello CA. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int Rev Immunol 1998; 16: 457-499.","journal-title":"Int Rev Immunol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-immunol-061020-053712","article-title":"IgE, IgE receptors and anti-igE biologics: protein structures and mechanisms of action","volume":"41","author":"McDonnell","year":"2023","unstructured":"McDonnell JM, Dhaliwal B, Sutton BJ and Gould HJ. IgE, IgE receptors and anti-igE biologics: protein structures and mechanisms of action. Annu Rev Immunol 2023; 41: 255-275.","journal-title":"Annu Rev Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"7049","DOI":"10.1080\/21655979.2022.2044278","article-title":"The role of human mast cells in allergy and asthma","volume":"13","author":"Banafea","year":"2022","unstructured":"Banafea GH, Bakhashab S, Alshaibi HF, Natesan Pushparaj P and Rasool M. The role of human mast cells in allergy and asthma. Bioengineered 2022; 13: 7049-7064.","journal-title":"Bioengineered"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2017.09.002","article-title":"Macrophage polarization and allergic asthma","volume":"191","author":"Saradna","year":"2018","unstructured":"Saradna A, Do DC, Kumar S, Fu QL and Gao P. Macrophage polarization and allergic asthma. Transl Res 2018; 191: 1-14.","journal-title":"Transl Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"585595","DOI":"10.3389\/fimmu.2021.585595","article-title":"Safranal alleviated OVA-induced asthma model and inhibits mast cell activation","volume":"12","author":"Lertnimitphun","year":"2021","unstructured":"Lertnimitphun P, Zhang W, Fu W, Yang B, Zheng C, Yuan M, Zhou H, Zhang X, Pei W, Lu Y and Xu H. Safranal alleviated OVA-induced asthma model and inhibits mast cell activation. Front Immunol 2021; 12: 585595.","journal-title":"Front Immunol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13223-015-0081-1","article-title":"Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma","volume":"11","author":"Chu","year":"2015","unstructured":"Chu DK, Al-Garawi A, Llop-Guevara A, Pillai RA, Radford K, Shen P, Walker TD, Goncharova S, Calhoun WJ, Nair P and Jordana M. Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma. Allergy Asthma Clin Immunol 2015; 11: 14.","journal-title":"Allergy Asthma Clin Immunol"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/3\/ajtr0163424.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:51:00Z","timestamp":1766022660000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/3\/ajtr0163424.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/pyxc6104","relation":{},"ISSN":["1943-8141"],"issn-type":[{"type":"electronic","value":"1943-8141"}],"subject":[],"published":{"date-parts":[[2025]]}}}