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Journal of Clinical Acupuncture and Moxibustion 2009; 25: 40-42, 54."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1038\/jcbfm.2013.135","article-title":"Blood-brain barrier dysfunction as a cause and consequence of Alzheimer&#x2019;s disease","volume":"33","author":"Erickson","year":"2013","unstructured":"Erickson MA and Banks WA. Blood-brain barrier dysfunction as a cause and consequence of Alzheimer&#x2019;s disease. J Cereb Blood Flow Metab 2013; 33: 1500-1513.","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.3390\/ijms18091965","article-title":"Blood-brain barrier dysfunction and the pathogenesis of Alzheimer&#x2019;s disease","volume":"18","author":"Yamazaki","year":"2017","unstructured":"Yamazaki Y and Kanekiyo T. Blood-brain barrier dysfunction and the pathogenesis of Alzheimer&#x2019;s disease. 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Shaanxi Journal of Traditional Chinese Medicine 2020; 41: 292-296."},{"key":"ref109","unstructured":"Lu YR, Liu JY and Guo J. Effects of early electroacupuncture intervention on TDP-43 and HMGB1\/RhoA signaling pathway in cerebral cortex of mice with amyotrophic lateral sclerosis model. J Rehabil Med 2024; 39: 312-319."},{"key":"ref110","unstructured":"Liu JY, Lu YR, Guo J, Li H, Wang Y, Zhao YQ, Li J and Wang Q. Effect of electroacupuncture intervention on the spinal cord PPIA\/NF-&#x3BA;B signaling pathway in mice with amyotrophic lateral sclerosis. Zhen Ci Yan Jiu 2023; 48: 1009-1016."},{"key":"ref111","unstructured":"Wang SL, Sun YZ, Yu TY, Zhao GR and Sun Y. Early electroacupuncture intervention delays progression of disease in mice with amyotrophic lateral sclerosis by down-regulating TLR4\/NF-&#x3BA;B signaling. Zhen Ci Yan Jiu 2023; 48: 287-293."},{"key":"ref112","unstructured":"Sun L, Han MJ, Li N, Liu J and Qiao HF. Effects of electroacupuncture intervention on SOD1,GSH-Px and Bax,Bcl2 expression in spinal cord of SOD1 G93A transgenic mice. Global Traditional Chinese Medicine 2021; 14: 1932-1937."},{"key":"ref113","doi-asserted-by":"publisher","first-page":"111036","DOI":"10.1016\/j.brainresbull.2024.111036","article-title":"Electroacupuncture alleviates motor dysfunction by regulating neuromuscular junction disruption and neuronal degeneration in SOD1G93A mice","volume":"216","author":"Liu","year":"2024","unstructured":"Liu J, Zhao W, Guo J, Kang K, Li H, Yang X, Li J, Wang Q and Qiao H. Electroacupuncture alleviates motor dysfunction by regulating neuromuscular junction disruption and neuronal degeneration in SOD1G93A mice. 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Assessment of acupuncture&#x2019;s effectiveness in mitigating fatigue among patients afflicted with multiple sclerosis: a systematic review and meta-analysis. Complement Ther Clin Pract 2024; 57: 101902.","journal-title":"Complement Ther Clin Pract"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"103715","DOI":"10.1016\/j.msard.2022.103715","article-title":"Acupuncture for multiple sclerosis: a literature review","volume":"60","author":"Khodaie","year":"2022","unstructured":"Khodaie F, Abbasi N, Kazemi Motlagh AH, Zhao B and Naser Moghadasi A. Acupuncture for multiple sclerosis: a literature review. Mult Scler Relat Disord 2022; 60: 103715.","journal-title":"Mult Scler Relat Disord"},{"key":"ref119","unstructured":"Wang C, Chen Z, Wang L, Ma X, Xing Y, Li A, Zhang F and Zhang T. Relapsing-remitting multiple sclerosis at remission stage treated with acupuncture:a randomized controlled trial. Zhongguo Zhen Jiu 2017; 37: 576-580."},{"key":"ref120","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1089\/jicm.2022.0610","article-title":"Effect of acupuncture on sensorimotor function and mobility in patients with multiple sclerosis: a pilot study","volume":"29","author":"Karpatkin","year":"2023","unstructured":"Karpatkin H, Siminovich-Blok B, Rachwani J, Langer Z and Winsor S. Effect of acupuncture on sensorimotor function and mobility in patients with multiple sclerosis: a pilot study. J Integr Complement Med 2023; 29: 42-49.","journal-title":"J Integr Complement Med"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1089\/acm.2016.0355","article-title":"Effects of acupuncture on gait of patients with multiple sclerosis","volume":"23","author":"MB","year":"2017","unstructured":"Criado MB, Santos MJ, Machado J, Gon&#xE7;alves AM and Greten HJ. Effects of acupuncture on gait of patients with multiple sclerosis. J Altern Complement Med 2017; 23: 852-857.","journal-title":"J Altern Complement Med"},{"key":"ref122","unstructured":"Wang YY, Dong S, Sun FH, Chang L and Zang P. Effects of acupuncture on the levels of IBA-1, COX-2 in spinal cord and serum TNF-&#x3B1; in experimental autoimmune encephalomyelitis mice. Chinese Journal of Information on Traditional Chinese Medicine 2019; 26: 49-53."},{"key":"ref123","unstructured":"Song FY, Xin QL, Zhao DJ, Li Q and Wang YH. Effect of acupuncture on the level of p-p38MAPK in EAE mice. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology 2020; 22: 2080-2086."},{"key":"ref124","unstructured":"Kang Z, Zou ZF, Sun JX, Zhu KY, Jiang JW, Wu GC and Wang J. Electroacupuncture promotes regeneration and repair of myelin sheath of corpus callosum in demyelination mice. Zhen Ci Yan Jiu 2020; 45: 1-7."},{"key":"ref125","doi-asserted-by":"publisher","first-page":"1474841","DOI":"10.1155\/2023\/1474841","article-title":"Acupuncture alleviates CUMS-induced depression-like behaviors by restoring prefrontal cortex neuroplasticity","volume":"2023","author":"Li","year":"2023","unstructured":"Li P, Huang W, Chen Y, Aslam MS, Cheng W, Huang Y, Chen W, Huang Y, Wu X, Yan Y, Shen J, Tong T, Huang S and Meng X. Acupuncture alleviates CUMS-induced depression-like behaviors by restoring prefrontal cortex neuroplasticity. 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