{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:21Z","timestamp":1791945921236,"version":"4.3.4"},"reference-count":21,"publisher":"e-Century Publishing Corporation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Neurodegener Dis"],"DOI":"10.62347\/qhvi3317","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T22:44:54Z","timestamp":1745966694000},"page":"51-57","source":"Crossref","is-referenced-by-count":20,"title":["Advances in nanotechnology for targeted drug delivery in neurodegenerative diseases"],"prefix":"10.62347","volume":"14","author":[{"given":"Diana","family":"Rafieezadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/s41591-021-01382-x","article-title":"Biomarkers for neurodegenerative diseases","volume":"27","author":"Hansson","year":"2021","unstructured":"Hansson O. Biomarkers for neurodegenerative diseases. Nat Med 2021; 27: 954-963.","journal-title":"Nat Med"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12987-024-00557-1","article-title":"Cellular and molecular mechanisms of the blood-brain barrier dysfunction in neurodegenerative diseases","volume":"21","author":"Chen","year":"2024","unstructured":"Chen T, Dai Y, Hu C, Lin Z, Wang S, Yang J, Zeng L, Li S and Li W. Cellular and molecular mechanisms of the blood-brain barrier dysfunction in neurodegenerative diseases. Fluids Barriers CNS 2024; 21: 60.","journal-title":"Fluids Barriers CNS"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.jconrel.2020.11.021","article-title":"Neurodegenerative diseases and effective drug delivery: a review of challenges and novel therapeutics","volume":"330","author":"Akhtar","year":"2021","unstructured":"Akhtar A, Andleeb A, Waris TS, Bazzar M, Moradi AR, Awan NR and Yar M. Neurodegenerative diseases and effective drug delivery: a review of challenges and novel therapeutics. J Control Release 2021; 330: 1152-1167.","journal-title":"J Control Release"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.62347\/TUVQ7468","article-title":"Marine bioactive peptides with anticancer potential, a narrative review","volume":"15","author":"Rafieezadeh","year":"2024","unstructured":"Rafieezadeh D and Esfandyari G. Marine bioactive peptides with anticancer potential, a narrative review. Int J Biochem Mol Biol 2024; 15: 118-126.","journal-title":"Int J Biochem Mol Biol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"106476","DOI":"10.1016\/j.jff.2024.106476","article-title":"Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases","volume":"122","author":"Sun","year":"2024","unstructured":"Sun Q, Lv M and Li Y. Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases. J Funct Foods 2024; 122: 106476.","journal-title":"J Funct Foods"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"153","DOI":"10.52711\/2231-5691.2024.00026","article-title":"Exploring Aquasomes: a promising frontier in nanotechnology-based drug delivery","volume":"14","author":"Sarella","year":"2024","unstructured":"Sarella PNK, Vegi S, Vendi VK, Vipparthi AK and Valluri S. Exploring Aquasomes: a promising frontier in nanotechnology-based drug delivery. Asian J Pharm Res 2024; 14: 153-161.","journal-title":"Asian J Pharm Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"114995","DOI":"10.1016\/j.ejmech.2022.114995","article-title":"5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy","volume":"246","author":"Valencia-Lazcano AA","year":"2023","unstructured":"Valencia-Lazcano AA, Hassan D, Pourmadadi M, Behzadmehr R, Rahdar A, Medina DI and D&#xED;ez-Pascual AM. 5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy. Eur J Med Chem 2023; 246: 114995.","journal-title":"Eur J Med Chem"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.62347\/QPAG5693","article-title":"Extracellular vesicles and their therapeutic applications: a review article (part1)","volume":"16","author":"Rafieezadeh","year":"2024","unstructured":"Rafieezadeh D and Rafieezadeh A. Extracellular vesicles and their therapeutic applications: a review article (part1). Int J Physiol Pathophysiol Pharmacol 2024; 16: 1-9.","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.3390\/biomedicines10092137","article-title":"Lipid-based drug delivery systems for diseases managements","volume":"10","author":"Gbian","year":"2022","unstructured":"Gbian DL and Omri A. Lipid-based drug delivery systems for diseases managements. Biomedicines 2022; 10: 2137.","journal-title":"Biomedicines"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1007\/s13346-021-01071-9","article-title":"Lipid-based emulsion drug delivery systems - a comprehensive review","volume":"12","author":"Dhaval","year":"2022","unstructured":"Dhaval M, Vaghela P, Patel K, Sojitra K, Patel M, Patel S, Dudhat K, Shah S, Manek R and Parmar R. Lipid-based emulsion drug delivery systems - a comprehensive review. Drug Deliv Transl Res 2022; 12: 1616-1639.","journal-title":"Drug Deliv Transl Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"100","DOI":"10.62347\/JGQA3746","article-title":"Exploring the seas for cancer cures: the promise of marine-derived bioactive peptide","volume":"15","author":"Rafieezadeh","year":"2024","unstructured":"Rafieezadeh D and Abbaspour M. Exploring the seas for cancer cures: the promise of marine-derived bioactive peptide. Int J Biochem Mol Biol 2024; 15: 100-106.","journal-title":"Int J Biochem Mol Biol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.3390\/pharmaceutics16111376","article-title":"Lipid-based nanoformulations for drug delivery: an ongoing perspective","volume":"16","author":"Rehman","year":"2024","unstructured":"Rehman M, Tahir N, Sohail MF, Qadri MU, Duarte SO, Brand&#xE3;o P, Esteves T, Javed I and Fonte P. Lipid-based nanoformulations for drug delivery: an ongoing perspective. Pharmaceutics 2024; 16: 1376.","journal-title":"Pharmaceutics"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"12924","DOI":"10.3390\/ijms232112924","article-title":"Amyloid beta in aging and Alzheimer&#x2019;s disease","volume":"23","author":"Sehar","year":"2022","unstructured":"Sehar U, Rawat P, Reddy AP, Kopel J and Reddy PH. Amyloid beta in aging and Alzheimer&#x2019;s disease. Int J Mol Sci 2022; 23: 12924.","journal-title":"Int J Mol Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.62347\/AUPQ6330","article-title":"Extracellular vesicles and their therapeutic applications: a review article (part 2)","volume":"16","author":"Rafieezadeh","year":"2024","unstructured":"Rafieezadeh D. Extracellular vesicles and their therapeutic applications: a review article (part 2). Int J Physiol Pathophysiol Pharmacol 2024; 16: 81-88.","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"2400256","DOI":"10.1002\/adtp.202400256","article-title":"Plant-derived extracellular vesicles as potential emerging tools for cancer therapeutics","volume":"7","author":"Ding","year":"2024","unstructured":"Ding L, Chang CJ, Liang ML, Dong KM and Li FR. Plant-derived extracellular vesicles as potential emerging tools for cancer therapeutics. Adv Therap 2024; 7: 2400256.","journal-title":"Adv Therap"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.62347\/HFPU3214","article-title":"Safety and effectiveness of micropigmentation skin grafting using the Meek method","volume":"14","author":"Rafieezadeh","year":"2024","unstructured":"Rafieezadeh D and Abbaspour M. Safety and effectiveness of micropigmentation skin grafting using the Meek method. Int J Burn Trauma 2024; 14: 107-114.","journal-title":"Int J Burn Trauma"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"604274","DOI":"10.3389\/fphys.2020.604274","article-title":"Extracellular vesicles and exosomes: insights from exercise science","volume":"11","author":"Nederveen","year":"2021","unstructured":"Nederveen JP, Warnier G, Di Carlo A, Nilsson MI and Tarnopolsky MA. Extracellular vesicles and exosomes: insights from exercise science. Front Physiol 2021; 11: 604274.","journal-title":"Front Physiol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.ijbiomac.2022.03.203","article-title":"Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer&#x2019;s disease pathology in transgenic mouse model","volume":"208","author":"Arora","year":"2022","unstructured":"Arora S, Kanekiyo T and Singh J. Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer&#x2019;s disease pathology in transgenic mouse model. Int J Biol Macromol 2022; 208: 901-911.","journal-title":"Int J Biol Macromol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"5851","DOI":"10.3390\/ijms24065851","article-title":"RVG peptide-functionalized favipiravir nanoparticle delivery system facilitates antiviral therapy of neurotropic virus infection in a mouse model","volume":"24","author":"Ren","year":"2023","unstructured":"Ren M, Zhou Y, Tu T, Jiang D, Pang M, Li Y, Luo Y, Yao X, Yang Z and Wang Y. RVG peptide-functionalized favipiravir nanoparticle delivery system facilitates antiviral therapy of neurotropic virus infection in a mouse model. Int J Mol Sci 2023; 24: 5851.","journal-title":"Int J Mol Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"986668","DOI":"10.3389\/fphar.2022.986668","article-title":"Recent developments in nucleic acid-based therapies for Parkinson&#x2019;s disease: current status, clinical potential, and future strategies","volume":"13","author":"Pandey","year":"2022","unstructured":"Pandey SK and Singh RK. Recent developments in nucleic acid-based therapies for Parkinson&#x2019;s disease: current status, clinical potential, and future strategies. Front Pharmacol 2022; 13: 986668.","journal-title":"Front Pharmacol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1444437","DOI":"10.3389\/fimmu.2024.1444437","article-title":"Advances in delivery systems for CRISPR\/Cas-mediated cancer treatment: a focus on viral vectors and extracellular vesicles","volume":"15","author":"Song","year":"2024","unstructured":"Song Z, Tao Y, Liu Y and Li J. Advances in delivery systems for CRISPR\/Cas-mediated cancer treatment: a focus on viral vectors and extracellular vesicles. Front Immunol 2024; 15: 1444437.","journal-title":"Front Immunol"}],"container-title":["American Journal of Neurodegenerative Disease"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajnd\/14\/2\/ajnd0163638.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:55:24Z","timestamp":1766022924000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajnd\/14\/2\/ajnd0163638.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/qhvi3317","relation":{},"ISSN":["2165-591X"],"issn-type":[{"value":"2165-591X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}