{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:38:54Z","timestamp":1790912334635,"version":"4.1.0"},"reference-count":25,"publisher":"e-Century Publishing Corporation","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/touh6376","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T02:29:19Z","timestamp":1727663359000},"page":"5122-5129","source":"Crossref","is-referenced-by-count":3,"title":["Expression of SIRT6 and VNN1 in children with primary nephrotic syndrome and their correlation with acute kidney injury"],"prefix":"10.62347","volume":"16","author":[{"given":"Fang","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"100958","DOI":"10.1016\/j.jbc.2021.100958","article-title":"Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A","volume":"297","author":"Xu","year":"2021","unstructured":"Xu Y, Guo C, Pan W, Zhao C, Ding Y, Xie X, Wei Z, Sun Y and Yu C. Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A. J Biol Chem 2021; 297: 100958.","journal-title":"J Biol Chem"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/s41581-020-00384-1","article-title":"Management of congenital nephrotic syndrome: consensus recommendations of the ERKNet-ESPN Working Group","volume":"17","author":"Boyer","year":"2021","unstructured":"Boyer O, Schaefer F, Haffner D, Bockenhauer D, H&#xF6;ltt&#xE4; T, B&#xE9;rody S, Webb H, Heselden M, Lipska-Zie Tkiewicz BS, Ozaltin F, Levtchenko E and Vivarelli M. Management of congenital nephrotic syndrome: consensus recommendations of the ERKNet-ESPN Working Group. Nat Rev Nephrol 2021; 17: 277-289.","journal-title":"Nat Rev Nephrol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"133","DOI":"10.5455\/medarh.2021.75.133-137","article-title":"Vascular endothelial growth factor (VEGF) and neopterin levels in children with steroid-sensitive and steroid-resistant nephrotic syndrome","volume":"75","author":"RH","year":"2021","unstructured":"Ruslie RH, Darmadi D and Siregar GA. Vascular endothelial growth factor (VEGF) and neopterin levels in children with steroid-sensitive and steroid-resistant nephrotic syndrome. Med Arch 2021; 75: 133-137.","journal-title":"Med Arch"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1681\/ASN.2021050643","article-title":"Mycophenolate mofetil after rituximab for childhood-onset complicated frequently-relapsing or steroid-dependent nephrotic syndrome","volume":"33","author":"Iijima","year":"2022","unstructured":"Iijima K, Sako M, Oba M, Tanaka S, Hamada R, Sakai T, Ohwada Y, Ninchoji T, Yamamura T, Machida H, Shima Y, Tanaka R, Kaito H, Araki Y, Morohashi T, Kumagai N, Gotoh Y, Ikezumi Y, Kubota T, Kamei K, Fujita N, Ohtsuka Y, Okamoto T, Yamada T, Tanaka E, Shimizu M, Horinochi T, Konishi A, Omori T, Nakanishi K, Ishikura K, Ito S, Nakamura H and Nozu K; Japanese Study Group of Kidney Disease in Children. Mycophenolate mofetil after rituximab for childhood-onset complicated frequently-relapsing or steroid-dependent nephrotic syndrome. J Am Soc Nephrol 2022; 33: 401-419.","journal-title":"J Am Soc Nephrol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s10157-021-02074-z","article-title":"Factors predicting the recovery from acute kidney injury in children with primary nephrotic syndrome","volume":"25","author":"Guan","year":"2021","unstructured":"Guan N, Yao Y, Xiao H, Ding J, Zhong X, Wang F, Liu X, Zhang H and Su B. Factors predicting the recovery from acute kidney injury in children with primary nephrotic syndrome. Clin Exp Nephrol 2021; 25: 1011-1017.","journal-title":"Clin Exp Nephrol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"109211","DOI":"10.1016\/j.clim.2022.109211","article-title":"Efficacy and safety of rituximab for primary nephrotic syndrome with acute kidney injury: a two-center prospective cohort study","volume":"246","author":"Xu","year":"2023","unstructured":"Xu Y, Huang Y, Zhang C, Sun L, Sun Z, Wang L, Zhang B, Yuan Y, Xing C and Mao H. Efficacy and safety of rituximab for primary nephrotic syndrome with acute kidney injury: a two-center prospective cohort study. Clin Immunol 2023; 246: 109211.","journal-title":"Clin Immunol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s12882-022-02882-9","article-title":"Prediction model of renal function recovery for primary membranous nephropathy with acute kidney injury","volume":"23","author":"Chen","year":"2022","unstructured":"Chen T, Zhou Y, Zhu J, Chen X and Pan J. Prediction model of renal function recovery for primary membranous nephropathy with acute kidney injury. BMC Nephrol 2022; 23: 247.","journal-title":"BMC Nephrol"},{"key":"ref7","unstructured":"Zhang LJ, Xue XX and Deng ZD. Value of renal injury molecule-1 and cystatin C in the early diagnosis of acute kidney injury caused by primary nephrotic syndrome in the elderly. Chin J Emerg Resusc Disaster Med 2022; 17: 495-497, 506."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1002\/med.21753","article-title":"Emerging roles of SIRT6 in human diseases and its modulators","volume":"41","author":"Liu","year":"2021","unstructured":"Liu G, Chen H, Liu H, Zhang W and Zhou J. Emerging roles of SIRT6 in human diseases and its modulators. Med Res Rev 2021; 41: 1089-1137.","journal-title":"Med Res Rev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.bbrc.2021.08.080","article-title":"SIRT6 silencing overcomes resistance to sorafenib by promoting ferroptosis in gastric cancer","volume":"577","author":"Cai","year":"2021","unstructured":"Cai S, Fu S, Zhang W, Yuan X, Cheng Y and Fang J. SIRT6 silencing overcomes resistance to sorafenib by promoting ferroptosis in gastric cancer. Biochem Biophys Res Commun 2021; 577: 158-164.","journal-title":"Biochem Biophys Res Commun"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1007\/s10753-020-01249-2","article-title":"Protective effects of SIRT6 against inflammation, oxidative stress, and cell apoptosis in spinal cord injury","volume":"43","author":"Zhaohui","year":"2020","unstructured":"Zhaohui C and Shuihua W. Protective effects of SIRT6 against inflammation, oxidative stress, and cell apoptosis in spinal cord injury. Inflammation 2020; 43: 1751-1758.","journal-title":"Inflammation"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"176220","DOI":"10.1016\/j.ejphar.2023.176220","article-title":"Vanin1 (VNN1) in chronic diseases: future directions for targeted therapy","volume":"962","author":"Yu","year":"2024","unstructured":"Yu H, Cui Y, Guo F, Zhu Y, Zhang X, Shang D, Dong D and Xiang H. Vanin1 (VNN1) in chronic diseases: future directions for targeted therapy. Eur J Pharmacol 2024; 962: 176220.","journal-title":"Eur J Pharmacol"},{"key":"ref12","unstructured":"Nephrology group, Society of Pediatrics and Chinese Medical Association. Evidence-based guidelines for the diagnosis and treatment of steroid-sensitive, relapsed\/dependent nephrotic syndrome in children (2016). Chin J Pediatr 2017; 55: 729-734."},{"key":"ref13","unstructured":"Y&#x131;lmaz Ayd&#x131;n F, Eynel E, Oru&#xE7; &#x130;, Ince H, Y&#xFC;ksel E and Ayd&#x131;n E. The role of monocyte to high-density lipoprotein cholesterol ratio in predicting the severity of proteinuria and renal dysfunction in primary nephrotic syndrome. Cureus 2021; 13: e20345."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"109211","DOI":"10.1016\/j.clim.2022.109211","article-title":"Efficacy and safety of rituximab for primary nephrotic syndrome with acute kidney injury: a two-center prospective cohort study","volume":"246","author":"Xu","year":"2023","unstructured":"Xu Y, Huang Y, Zhang C, Sun L, Sun Z, Wang L, Zhang B, Yuan Y, Xing C and Mao H. Efficacy and safety of rituximab for primary nephrotic syndrome with acute kidney injury: a two-center prospective cohort study. Clin Immunol 2023; 246: 109211.","journal-title":"Clin Immunol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.21037\/apm-19-480","article-title":"The status and model of children primary nephrotic syndrome in continuing nursing","volume":"10","author":"FX","year":"2021","unstructured":"Li FX, Hou YL, Zhou LS, Dong Y, Zhao JW and Li ZX. The status and model of children primary nephrotic syndrome in continuing nursing. Ann Palliat Med 2021; 10: 2398-2407.","journal-title":"Ann Palliat Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.ccc.2021.05.007","article-title":"Acute kidney injury and acute respiratory distress syndrome","volume":"37","author":"Park","year":"2021","unstructured":"Park BD and Faubel S. Acute kidney injury and acute respiratory distress syndrome. Crit Care Clin 2021; 37: 835-849.","journal-title":"Crit Care Clin"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12882-022-02720-y","article-title":"Acute kidney injury in patients with primary nephrotic syndrome: influencing factors and coping strategies","volume":"23","author":"Lu","year":"2022","unstructured":"Lu H, Xiao L, Song M, Liu X and Wang F. Acute kidney injury in patients with primary nephrotic syndrome: influencing factors and coping strategies. BMC Nephrol 2022; 23: 90.","journal-title":"BMC Nephrol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3892\/or.2023.8557","article-title":"VNN1 overexpression in pancreatic cancer cells inhibits paraneoplastic islet function by increasing oxidative stress and inducing &#x3B2;-cell dedifferentiation","volume":"49","author":"Qin","year":"2023","unstructured":"Qin W, Kang M, Li C, Zheng W and Guo Q. VNN1 overexpression in pancreatic cancer cells inhibits paraneoplastic islet function by increasing oxidative stress and inducing &#x3B2;-cell dedifferentiation. Oncol Rep 2023; 49: 120.","journal-title":"Oncol Rep"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jns.2017.09.012","article-title":"Klotho gene expression decreases in peripheral blood mononuclear cells (PBMCs) of patients with relapsing-remitting multiple sclerosis","volume":"381","author":"Karami","year":"2017","unstructured":"Karami M, Mehrabi F, Allameh A, Pahlevan Kakhki M, Amiri M and Emami Aleagha MS. Klotho gene expression decreases in peripheral blood mononuclear cells (PBMCs) of patients with relapsing-remitting multiple sclerosis. J Neurol Sci 2017; 381: 305-307.","journal-title":"J Neurol Sci"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Chen Z, Liang W, Hu J, Zhu Z, Feng J, Ma Y, Yang Q and Ding G. Sirt6 deficiency contributes to mitochondrial fission and oxidative damage in podocytes via ROCK1-Drp1 signalling pathway. Cell Prolif 2022; 55: e13296.","DOI":"10.1111\/cpr.13296"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s11306-021-01788-1","article-title":"Metabolomics analysis of serum in pediatric nephrotic syndrome based on targeted and non-targeted platforms","volume":"17","author":"Guo","year":"2021","unstructured":"Guo J, Zhao J, Liu R, Yu J, Zhang M, Wang H and Liu L. Metabolomics analysis of serum in pediatric nephrotic syndrome based on targeted and non-targeted platforms. Metabolomics 2021; 17: 38.","journal-title":"Metabolomics"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"4019","DOI":"10.1007\/s00467-021-05124-6","article-title":"Worsening anasarca on a child with severe steroid-dependent nephrotic syndrome without proteinuria: answers","volume":"36","author":"Tripathi","year":"2021","unstructured":"Tripathi N, Singh A and Agarwal P. Worsening anasarca on a child with severe steroid-dependent nephrotic syndrome without proteinuria: answers. Pediatr Nephrol 2021; 36: 4019-4020.","journal-title":"Pediatr Nephrol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1007\/s00467-021-04960-w","article-title":"APOL1 in an ethnically diverse pediatric population with nephrotic syndrome: implications in focal segmental glomerulosclerosis and other diagnoses","volume":"36","author":"Watanabe","year":"2021","unstructured":"Watanabe A, Guaragna MS, Belangero VMS, Casimiro FMS, Pesquero JB, de Santis Feltran L, Palma LMP, Varela P, de Menezes Neves PDM, Lerario AM, de Souza ML, de Mello MP, de Brito Lutaif ACG, Ferrari CR, Sampson MG, Onuchic LF and Nogueira PCK. APOL1 in an ethnically diverse pediatric population with nephrotic syndrome: implications in focal segmental glomerulosclerosis and other diagnoses. Pediatr Nephrol 2021; 36: 2327-2336.","journal-title":"Pediatr Nephrol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"7465","DOI":"10.7150\/thno.45003","article-title":"Sirt6 deficiency aggravates angiotensin II-induced cholesterol accumulation and injury in podocytes","volume":"10","author":"Yang","year":"2020","unstructured":"Yang Q, Hu J, Yang Y, Chen Z, Feng J, Zhu Z, Wang H, Yang D, Liang W and Ding G. Sirt6 deficiency aggravates angiotensin II-induced cholesterol accumulation and injury in podocytes. Theranostics 2020; 10: 7465-7479.","journal-title":"Theranostics"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/16\/9\/ajtr0158392.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:51:48Z","timestamp":1766022708000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/16\/9\/ajtr0158392.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":25,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.62347\/touh6376","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}