{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:40:38Z","timestamp":1791261638286,"version":"4.1.0"},"reference-count":46,"publisher":"e-Century Publishing Corporation","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Cancer Res"],"DOI":"10.62347\/udbj5986","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T03:35:57Z","timestamp":1727667357000},"page":"4320-4336","source":"Crossref","is-referenced-by-count":6,"title":["RNASE4 promotes malignant progression and chemoresistance in hypoxic glioblastoma via activation of AXL\/AKT and NF-\u03baB\/cIAPs signaling pathways"],"prefix":"10.62347","volume":"14","author":[{"given":"Hsun-Hua","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Rabab’h O, Al-Ramadan A, Shah J, Lopez-Negrete H and Gharaibeh A. Twenty years after glioblastoma multiforme diagnosis: a case of long-term survival. Cureus 2021; 13: e16061.","DOI":"10.7759\/cureus.16061"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Nizamutdinov D, Stock EM, Dandashi JA, Vasquez EA, Mao Y, Dayawansa S, Zhang J, Wu E, Fonkem E and Huang JH. Prognostication of survival outcomes in patients diagnosed with glioblastoma. World Neurosurg 2018; 109: e67-e74.","DOI":"10.1016\/j.wneu.2017.09.104"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.37796\/2211-8039.1403","article-title":"Precision medicine advancements in glioblastoma: a systematic review","volume":"13","author":"Iyer","year":"2023","unstructured":"Iyer K, Saini S, Bhadra S, Kulavi S and Bandyopadhyay J. Precision medicine advancements in glioblastoma: a systematic review. Biomedicine (Taipei) 2023; 13: 1-13.","journal-title":"Biomedicine (Taipei)"},{"key":"ref3","unstructured":"Hanif F, Muzaffar K, Perveen K, Malhi SM and Simjee ShU. Glioblastoma multiforme: a review of its epidemiology and pathogenesis through clinical presentation and treatment. Asian Pac J Cancer Prev 2017; 18: 3-9."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1093\/neuonc\/nou283","article-title":"The worldwide incidence and prevalence of primary brain tumors: a systematic review and meta-analysis","volume":"17","author":"de Robles","year":"2015","unstructured":"de Robles P, Fiest KM, Frolkis AD, Pringsheim T, Atta C, St Germaine-Smith C, Day L, Lam D and Jette N. The worldwide incidence and prevalence of primary brain tumors: a systematic review and meta-analysis. Neuro Oncol 2015; 17: 776-783.","journal-title":"Neuro Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.mam.2019.03.003","article-title":"Functional roles of the human ribonuclease A superfamily in RNA metabolism and membrane receptor biology","volume":"70","author":"HH","year":"2019","unstructured":"Lee HH, Wang YN and Hung MC. Functional roles of the human ribonuclease A superfamily in RNA metabolism and membrane receptor biology. Mol Aspects Med 2019; 70: 106-116.","journal-title":"Mol Aspects Med"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Berezovsky AD, Poisson LM, Cherba D, Webb CP, Transou AD, Lemke NW, Hong X, Hasselbach LA, Irtenkauf SM, Mikkelsen T and deCarvalho AC. Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation. Neoplasia 2014; 16: 193-206, 206, e119-125.","DOI":"10.1016\/j.neo.2014.03.006"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s42003-022-03597-1","article-title":"Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer","volume":"5","author":"Vanli","year":"2022","unstructured":"Vanli N, Sheng J, Li S, Xu Z and Hu GF. Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer. Commun Biol 2022; 5: 625.","journal-title":"Commun Biol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1038\/s41467-021-23075-2","article-title":"Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation","volume":"12","author":"Lee","year":"2021","unstructured":"Lee HH, Wang YN, Yang WH, Xia W, Wei Y, Chan LC, Wang YH, Jiang Z, Xu S, Yao J, Qiu Y, Hsu YH, Hwang WL, Yan M, Cha JH, Hsu JL, Shen J, Ye Y, Wu X, Hou MF, Tseng LM, Wang SC, Pan MR, Yang CH, Wang YL, Yamaguchi H, Pang D, Hortobagyi GN, Yu D and Hung MC. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nat Commun 2021; 12: 2788.","journal-title":"Nat Commun"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1093\/glycob\/cwm002","article-title":"Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer","volume":"17","author":"Barrabes","year":"2007","unstructured":"Barrabes S, Pages-Pons L, Radcliffe CM, Tabares G, Fort E, Royle L, Harvey DJ, Moenner M, Dwek RA, Rudd PM, De Llorens R and Peracaula R. Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer. Glycobiology 2007; 17: 388-400.","journal-title":"Glycobiology"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"921083","DOI":"10.3389\/fonc.2022.921083","article-title":"Ribonuclease a family member 2 promotes the malignant progression of glioma through the PI3K\/Akt signaling pathway","volume":"12","author":"Wu","year":"2022","unstructured":"Wu T, Chen Y, Yang L, Wang X, Chen K and Xu D. Ribonuclease a family member 2 promotes the malignant progression of glioma through the PI3K\/Akt signaling pathway. Front Oncol 2022; 12: 921083.","journal-title":"Front Oncol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"7975","DOI":"10.18632\/aging.202848","article-title":"Development and validation of a RNA binding protein-associated prognostic model for head and neck squamous cell carcinoma","volume":"13","author":"Yang","year":"2021","unstructured":"Yang X, Han B, Zhang R, Su Y, Hosseini DK, Wu H, Yang M and Sun H. Development and validation of a RNA binding protein-associated prognostic model for head and neck squamous cell carcinoma. Aging (Albany NY) 2021; 13: 7975-7997.","journal-title":"Aging (Albany NY)"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Wang YN, Lee HH, Chou CK, Yang WH, Wei Y, Chen CT, Yao J, Hsu JL, Zhu C, Ying H, Ye Y, Wang WJ, Lim SO, Xia W, Ko HW, Liu X, Liu CG, Wu X, Wang H, Li D, Prakash LR, Katz MH, Kang Y, Kim M, Fleming JB, Fogelman D, Javle M, Maitra A and Hung MC. Angiogenin\/ribonuclease 5 is an EGFR ligand and a serum biomarker for erlotinib sensitivity in pancreatic cancer. Cancer Cell 2018; 33: 752-769, e8.","DOI":"10.1016\/j.ccell.2018.02.012"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"105284","DOI":"10.1016\/j.isci.2022.105284","article-title":"The role of human ribonuclease A family in health and diseases: a systematic review","volume":"25","author":"Sun","year":"2022","unstructured":"Sun D, Han C and Sheng J. The role of human ribonuclease A family in health and diseases: a systematic review. iScience 2022; 25: 105284.","journal-title":"iScience"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"12520","DOI":"10.1074\/jbc.M114.551762","article-title":"Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop","volume":"289","author":"Sheng","year":"2014","unstructured":"Sheng J, Luo C, Jiang Y, Hinds PW, Xu Z and Hu GF. Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop. J Biol Chem 2014; 289: 12520-12534.","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s10456-012-9322-9","article-title":"Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress","volume":"16","author":"Li","year":"2013","unstructured":"Li S, Sheng J, Hu JK, Yu W, Kishikawa H, Hu MG, Shima K, Wu D, Xu Z, Xin W, Sims KB, Landers JE, Brown RH Jr and Hu GF. Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress. Angiogenesis 2013; 16: 387-404.","journal-title":"Angiogenesis"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"5933","DOI":"10.1038\/s41388-020-01390-0","article-title":"DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT\/beta-catenin signaling and cancer stem cell traits","volume":"39","author":"Chi","year":"2020","unstructured":"Chi HC, Tsai CY, Wang CS, Yang HY, Lo CH, Wang WJ, Lee KF, Lai LY, Hong JH, Chang YF, Tsai MM, Yeh CT, Wu CH, Hsieh CC, Wang LH, Chen WJ and Lin KH. DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT\/beta-catenin signaling and cancer stem cell traits. Oncogene 2020; 39: 5933-5949.","journal-title":"Oncogene"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s13578-022-00858-8","article-title":"IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET\/AKT\/FOXO3\/c-MYC axis","volume":"12","author":"Chu","year":"2022","unstructured":"Chu PY, Huang WC, Tung SL, Tsai CY, Chen CJ, Liu YC, Lee CW, Lin YH, Lin HY, Chen CY, Yeh CT, Lin KH and Chi HC. IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET\/AKT\/FOXO3\/c-MYC axis. Cell Biosci 2022; 12: 124.","journal-title":"Cell Biosci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1158\/1078-0432.CCR-13-1221","article-title":"Interleukin-32 increases human gastric cancer cell invasion associated with tumor progression and metastasis","volume":"20","author":"Tsai","year":"2014","unstructured":"Tsai CY, Wang CS, Tsai MM, Chi HC, Cheng WL, Tseng YH, Chen CY, Lin CD, Wu JI, Wang LH and Lin KH. Interleukin-32 increases human gastric cancer cell invasion associated with tumor progression and metastasis. Clin Cancer Res 2014; 20: 2276-2288.","journal-title":"Clin Cancer Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jneumeth.2008.05.003","article-title":"The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting","volume":"172","author":"Aldridge","year":"2008","unstructured":"Aldridge GM, Podrebarac DM, Greenough WT and Weiler IJ. The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting. J Neurosci Methods 2008; 172: 250-254.","journal-title":"J Neurosci Methods"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.3390\/ijms24043075","article-title":"Expanding the disease network of glioblastoma multiforme via topological analysis","volume":"24","author":"Badkas","year":"2023","unstructured":"Badkas A, De Landtsheer S and Sauter T. Expanding the disease network of glioblastoma multiforme via topological analysis. Int J Mol Sci 2023; 24: 3075.","journal-title":"Int J Mol Sci"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.cell.2015.12.028","article-title":"Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma","volume":"164","author":"Ceccarelli","year":"2016","unstructured":"Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH; TCGA Research Network; Noushmehr H, Iavarone A and Verhaak RG. Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma. Cell 2016; 164: 550-563.","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1101\/gad.324301.119","article-title":"Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer","volume":"33","author":"Gimple","year":"2019","unstructured":"Gimple RC, Bhargava S, Dixit D and Rich JN. Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer. Genes Dev 2019; 33: 591-609.","journal-title":"Genes Dev"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Xie XP, Laks DR, Sun D, Ganbold M, Wang Z, Pedraza AM, Bale T, Tabar V, Brennan C, Zhou X and Parada LF. Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy. Dev Cell 2022; 57: 32-46, e8.","DOI":"10.1016\/j.devcel.2021.12.007"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.7150\/ijbs.84592","article-title":"Ribonuclease 1 enhances antitumor immunity against breast cancer by boosting T cell activation","volume":"19","author":"YN","year":"2023","unstructured":"Wang YN, Lee HH, Jiang Z, Chan LC, Hortobágyi GN, Yu D and Hung MC. Ribonuclease 1 enhances antitumor immunity against breast cancer by boosting T cell activation. Int J Biol Sci 2023; 19: 2957-2973.","journal-title":"Int J Biol Sci"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Miao Y, Zhang H, Su B, Wang J, Quan W, Li Q and Mi D. Construction and validation of an RNA-binding protein-associated prognostic model for colorectal cancer. PeerJ 2021; 9: e11219.","DOI":"10.7717\/peerj.11219"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1101\/gad.261982.115","article-title":"Cancer stem cells in glioblastoma","volume":"29","author":"Lathia","year":"2015","unstructured":"Lathia JD, Mack SC, Mulkearns-Hubert EE, Valentim CL and Rich JN. Cancer stem cells in glioblastoma. Genes Dev 2015; 29: 1203-1217.","journal-title":"Genes Dev"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3389\/fonc.2020.00486","article-title":"Hypoxia-induced epithelial-mesenchymal transition in cancers: HIF-1alpha and beyond","volume":"10","author":"SY","year":"2020","unstructured":"Tam SY, Wu VWC and Law HKW. Hypoxia-induced epithelial-mesenchymal transition in cancers: HIF-1alpha and beyond. Front Oncol 2020; 10: 486.","journal-title":"Front Oncol"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Jawhari S, Ratinaud MH and Verdier M. Glioblastoma, hypoxia and autophagy: a survival-prone ‘menage-a-trois’. Cell Death Dis 2016; 7: e2434.","DOI":"10.1038\/cddis.2016.318"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"13373","DOI":"10.1073\/pnas.1404848111","article-title":"Direct regulation of GAS6\/AXL signaling by HIF promotes renal metastasis through SRC and MET","volume":"111","author":"Rankin","year":"2014","unstructured":"Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ and Giaccia AJ. Direct regulation of GAS6\/AXL signaling by HIF promotes renal metastasis through SRC and MET. Proc Natl Acad Sci U S A 2014; 111: 13373-13378.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1158\/1541-7786.MCR-11-0569","article-title":"Hypoxia stabilizes GAS6\/Axl signaling in metastatic prostate cancer","volume":"10","author":"Mishra","year":"2012","unstructured":"Mishra A, Wang J, Shiozawa Y, McGee S, Kim J, Jung Y, Joseph J, Berry JE, Havens A, Pienta KJ and Taichman RS. Hypoxia stabilizes GAS6\/Axl signaling in metastatic prostate cancer. Mol Cancer Res 2012; 10: 703-712.","journal-title":"Mol Cancer Res"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/cells5010010","article-title":"Hypoxia Induced NF-kappaB","volume":"5","author":"D&#x2019","year":"2016","unstructured":"D’Ignazio L and Rocha S. Hypoxia Induced NF-kappaB. Cells 2016; 5: 10.","journal-title":"Cells"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Silke J and Meier P. Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation. Cold Spring Harb Perspect Biol 2013; 5: a008730.","DOI":"10.1101\/cshperspect.a008730"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1007\/s10495-017-1375-1","article-title":"Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)","volume":"22","author":"Rathore","year":"2017","unstructured":"Rathore R, McCallum JE, Varghese E, Florea AM and Busselberg D. Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs). Apoptosis 2017; 22: 898-919.","journal-title":"Apoptosis"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"10373","DOI":"10.3390\/ijms221910373","article-title":"Prognostic and predictive biomarkers in gliomas","volume":"22","author":"Sledzinska","year":"2021","unstructured":"Sledzinska P, Bebyn MG, Furtak J, Kowalewski J and Lewandowska MA. Prognostic and predictive biomarkers in gliomas. Int J Mol Sci 2021; 22: 10373.","journal-title":"Int J Mol Sci"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 2016; 131: 803-820.","journal-title":"Acta Neuropathol"},{"key":"ref36","unstructured":"Li YC, Yamaguchi H, Liu YY, Hsu KC, Sun TH, Sun PC and Hung MC. Structural insights into EphA4 unconventional activation from prediction of the EphA4 and its complex with ribonuclease 1. Am J Cancer Res 2022; 12: 4865-4878."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12943-019-1090-3","article-title":"AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications","volume":"18","author":"Zhu","year":"2019","unstructured":"Zhu C, Wei Y and Wei X. AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications. Mol Cancer 2019; 18: 153.","journal-title":"Mol Cancer"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.neo.2018.08.005","article-title":"AXL mediates esophageal adenocarcinoma cell invasion through regulation of extracellular acidification and lysosome trafficking","volume":"20","author":"Maacha","year":"2018","unstructured":"Maacha S, Hong J, von Lersner A, Zijlstra A and Belkhiri A. AXL mediates esophageal adenocarcinoma cell invasion through regulation of extracellular acidification and lysosome trafficking. Neoplasia 2018; 20: 1008-1022.","journal-title":"Neoplasia"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s11060-010-0346-y","article-title":"An NF-κB P65-cIAP2 link is necessary for mediating resistance to TNF-α induced cell death in gliomas","volume":"102","author":"Zhao","year":"2011","unstructured":"Zhao X, Laver T, Hong SW, Twitty GB Jr, DeVos A, DeVos M, Benveniste EN and Nozell SE. An NF-κB P65-cIAP2 link is necessary for mediating resistance to TNF-α induced cell death in gliomas. J Neurooncol 2011; 102: 367-381.","journal-title":"J Neurooncol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"4809","DOI":"10.1038\/s41388-018-0297-x","article-title":"Inhibitor of apoptosis proteins (IAPs) mediate collagen type XI alpha 1-driven cisplatin resistance in ovarian cancer","volume":"37","author":"Rada","year":"2018","unstructured":"Rada M, Nallanthighal S, Cha J, Ryan K, Sage J, Eldred C, Ullo M, Orsulic S and Cheon DJ. Inhibitor of apoptosis proteins (IAPs) mediate collagen type XI alpha 1-driven cisplatin resistance in ovarian cancer. Oncogene 2018; 37: 4809-4820.","journal-title":"Oncogene"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"108073","DOI":"10.1016\/j.celrep.2020.108073","article-title":"BIRC2 expression impairs anti-cancer immunity and immunotherapy efficacy","volume":"32","author":"Samanta","year":"2020","unstructured":"Samanta D, Huang TY, Shah R, Yang Y, Pan F and Semenza GL. BIRC2 expression impairs anti-cancer immunity and immunotherapy efficacy. Cell Rep 2020; 32: 108073.","journal-title":"Cell Rep"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"466","DOI":"10.3390\/cancers14030466","article-title":"AXL receptor tyrosine kinase as a promising therapeutic target directing multiple aspects of cancer progression and metastasis","volume":"14","author":"Goyette","year":"2022","unstructured":"Goyette MA and Cote JF. AXL receptor tyrosine kinase as a promising therapeutic target directing multiple aspects of cancer progression and metastasis. Cancers (Basel) 2022; 14: 466.","journal-title":"Cancers (Basel)"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.3390\/biom10111509","article-title":"Antitumour activity of the ribonuclease binase from bacillus pumilus in the RLS40 tumour model is associated with the reorganisation of the mirna network and reversion of cancer-related cascades to normal functioning","volume":"10","author":"ISE","year":"2020","unstructured":"Mohamed ISE, Sen’kova AV, Nadyrova AI, Savin IA, Markov AV, Mitkevich VA, Makarov АА, Ilinskaya ОN, Мironova NL and Zenkova MA. Antitumour activity of the ribonuclease binase from bacillus pumilus in the RLS40 tumour model is associated with the reorganisation of the mirna network and reversion of cancer-related cascades to normal functioning. Biomolecules 2020; 10: 1509.","journal-title":"Biomolecules"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.3390\/molecules26051319","article-title":"The selectivity for tumor cells of nuclear-directed cytotoxic rnases is mediated by the nuclear\/cytoplasmic distribution of P27KIP1","volume":"26","author":"Garc&#xED","year":"2021","unstructured":"García-Galindo G, Castro J, Mates J, Bravo M, Ribó M, Vilanova M and Benito A. The selectivity for tumor cells of nuclear-directed cytotoxic rnases is mediated by the nuclear\/cytoplasmic distribution of P27KIP1. Molecules 2021; 26: 1319.","journal-title":"Molecules"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Shukla S, Bjerke GA, Muhlrad D, Yi R and Parker R. The RNase PARN controls the levels of specific miRNAs that contribute to p53 regulation. Mol Cell 2019; 73: 1204-1216, e1204.","DOI":"10.1016\/j.molcel.2019.01.010"}],"container-title":["American Journal of Cancer Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajcr\/14\/9\/ajcr0159191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:56:15Z","timestamp":1766022975000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajcr\/14\/9\/ajcr0159191.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":46,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.62347\/udbj5986","relation":{},"ISSN":["2156-6976"],"issn-type":[{"value":"2156-6976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}