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J Mol Med (Berl) 2021; 99: 193-212.","journal-title":"J Mol Med (Berl)"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3390\/life15010126","article-title":"Post-Translational modifications of proteins orchestrate all hallmarks of cancer","volume":"15","author":"Bruno","year":"2025","unstructured":"Bruno PS, Arshad A, Gogu MR, Waterman N, Flack R, Dunn K, Darie CC and Neagu AN. Post-Translational modifications of proteins orchestrate all hallmarks of cancer. Life (Basel) 2025; 15: 126.","journal-title":"Life (Basel)"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"211","DOI":"10.20517\/2394-4722.2023.21","article-title":"Crosstalk between cell fate and survival pathways during uterine cervical carcinoma progression: a molecular and clinical perspective","volume":"9","author":"Samadder","year":"2023","unstructured":"Samadder S, Paul P and De A. 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