{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:27:56Z","timestamp":1773786476412,"version":"3.50.1"},"reference-count":26,"publisher":"e-Century Publishing Corporation","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/utcu8727","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T03:36:56Z","timestamp":1764128216000},"page":"8643-8651","source":"Crossref","is-referenced-by-count":1,"title":["Levothyroxine suppression therapy improves maternal and neonatal outcomes in pregnancy after thyroidectomy for differentiated thyroid carcinoma"],"prefix":"10.62347","volume":"17","author":[{"given":"Pingfa","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1001\/jama.2023.26348","article-title":"Thyroid cancer: a review","volume":"331","author":"Boucai","year":"2024","unstructured":"Boucai L, Zafereo M and Cabanillas ME. Thyroid cancer: a review. JAMA 2024; 331: 425-435.","journal-title":"JAMA"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"1138149","DOI":"10.3389\/fendo.2023.1138149","article-title":"Association between breast cancer and thyroid cancer risk: a two-sample Mendelian randomization study","volume":"14","author":"Tan","year":"2023","unstructured":"Tan H, Wang S, Huang F and Tong Z. Association between breast cancer and thyroid cancer risk: a two-sample Mendelian randomization study. Front Endocrinol (Lausanne) 2023; 14: 1138149.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"152042","DOI":"10.1016\/j.semperi.2025.152042","article-title":"Thyroid cancer","volume":"49","author":"Tang","year":"2025","unstructured":"Tang L and Angell TE. Thyroid cancer. Semin Perinatol 2025; 49: 152042.","journal-title":"Semin Perinatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1164789","DOI":"10.3389\/fendo.2023.1164789","article-title":"Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients","volume":"14","author":"Hou","year":"2023","unstructured":"Hou LY, Li X, Zhang GQ, Xi C, Shen CT, Song HJ, Bai WK, Qiu ZL and Luo QY. Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients. Front Endocrinol (Lausanne) 2023; 14: 1164789.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-0716-4252-8_1","article-title":"Thyroid hormones and co-workers: an overview","volume":"2876","author":"Contreras-Jurado","year":"2025","unstructured":"Contreras-Jurado C. Thyroid hormones and co-workers: an overview. Methods Mol Biol 2025; 2876: 3-16.","journal-title":"Methods Mol Biol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.ando.2023.01.004","article-title":"Thyrotropin-secreting tumor “TSH-PitNET”: from diagnosis to treatment","volume":"84","author":"Briet","year":"2023","unstructured":"Briet C, Suteau V, Illouz F and Rodien P. Thyrotropin-secreting tumor “TSH-PitNET”: from diagnosis to treatment. Ann Endocrinol (Paris) 2023; 84: 407-412.","journal-title":"Ann Endocrinol (Paris)"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.nutres.2019.08.008","article-title":"Reduced serum concentrations of vitamin B(12) and folate and elevated thyroid-stimulating hormone and homocysteine levels in first-trimester pregnant Saudi women with high A1C concentrations","volume":"72","author":"Hammouda","year":"2019","unstructured":"Hammouda SAI and Mumena WA. Reduced serum concentrations of vitamin B(12) and folate and elevated thyroid-stimulating hormone and homocysteine levels in first-trimester pregnant Saudi women with high A1C concentrations. Nutr Res 2019; 72: 105-110.","journal-title":"Nutr Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"576","DOI":"10.3803\/EnM.2024.401","article-title":"Levothyroxine dosing for thyroid-stimulating hormone suppression in patients with differentiated thyroid cancer after total thyroidectomy","volume":"39","author":"Kim","year":"2024","unstructured":"Kim M. Levothyroxine dosing for thyroid-stimulating hormone suppression in patients with differentiated thyroid cancer after total thyroidectomy. Endocrinol Metab (Seoul) 2024; 39: 576-578.","journal-title":"Endocrinol Metab (Seoul)"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1056\/NEJMoa2305969","article-title":"Intravenous levothyroxine for unstable brain-dead heart donors","volume":"389","author":"Dhar","year":"2023","unstructured":"Dhar R, Marklin GF, Klinkenberg WD, Wang J, Goss CW, Lele AV, Kensinger CD, Lange PA and Lebovitz DJ. Intravenous levothyroxine for unstable brain-dead heart donors. N Engl J Med 2023; 389: 2029-2038.","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/cen.14787","article-title":"Assesment of attainment of recommended TSH levels and levothyroxine compliance in differentiated thyroid cancer patients","volume":"97","author":"Yavuz","year":"2022","unstructured":"Yavuz DG, Yazan CD, Hekimsoy Z, Aydin K, Gokkaya N, Ersoy C, Akalin A, Topaloglu O, Aydogan BI, Dilekci ENA, Alphan Uc Z, Cansu GB, Ozsari L, Iyidir OT, Olgun ME, Keskin L, Mert M, Can B, Gungor K, Galip T, Canturk Z, Elbuken G, Pekkolay Z, Kutbay NO, Yorulmaz G, Kalkan AT, Unsal YA, Yay A, Karagun B and Bozkur E. Assesment of attainment of recommended TSH levels and levothyroxine compliance in differentiated thyroid cancer patients. Clin Endocrinol (Oxf) 2022; 97: 833-840.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1386510","DOI":"10.3389\/fendo.2024.1386510","article-title":"Lactose intolerance and levothyroxine malabsorption: a review of the literature and report of a series of patients treated with liquid L-T4 without lactose","volume":"15","author":"Ferrari","year":"2024","unstructured":"Ferrari SM, Patrizio A, Mazzi V, Ragusa F, Botrini C, Elia G, Balestri E, Barozzi E, Rugani L, Bracchitta F, Stoppini G, Frenzilli G, Baldini E, Virili C, Benvenga S, Fallahi P and Antonelli A. Lactose intolerance and levothyroxine malabsorption: a review of the literature and report of a series of patients treated with liquid L-T4 without lactose. Front Endocrinol (Lausanne) 2024; 15: 1386510.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/jgf2.600","article-title":"Sample size determination: a practical guide for health researchers","volume":"24","author":"Althubaiti","year":"2023","unstructured":"Althubaiti A. Sample size determination: a practical guide for health researchers. J Gen Fam Med 2023; 24: 72-78.","journal-title":"J Gen Fam Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1089\/thy.2022.0055","article-title":"The prospective implementation of the 2015 ATA guidelines and modified ATA recurrence risk stratification system for treatment of differentiated thyroid cancer in a Canadian tertiary care referral setting","volume":"32","author":"Wu","year":"2022","unstructured":"Wu J, Hu XY, Ghaznavi S, Kinnear S, Symonds CJ, Grundy P, Parkins VM, Sharma P, Lamb D, Khalil M, Hyrcza M, Chandarana SP, Pasieka JL, Harvey A, Warshawski J, Hart R, Deutschman M, Randall DR and Paschke R. The prospective implementation of the 2015 ATA guidelines and modified ATA recurrence risk stratification system for treatment of differentiated thyroid cancer in a Canadian tertiary care referral setting. Thyroid 2022; 32: 1509-1518.","journal-title":"Thyroid"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Lu L, Wang JR, Henderson YC, Bai S, Yang J, Hu M, Shiau CK, Pan T, Yan Y, Tran TM, Li J, Kieser R, Zhao X, Wang J, Nurieva R, Williams MD, Cabanillas ME, Dadu R, Busaidy NL, Zafereo M, Navin N, Lai SY and Gao R. Anaplastic transformation in thyroid cancer revealed by single-cell transcriptomics. J Clin Invest 2023; 133: e169653.","DOI":"10.1172\/JCI169653"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"287","DOI":"10.17843\/rpmesp.2024.413.13378","article-title":"Characteristics and survival of adults with differentiated thyroid cancer in a Peruvian hospital","volume":"41","author":"Morales-Concha","year":"2024","unstructured":"Morales-Concha L, Huamani-Linares I, Saihua-Palomino K, Luque Florez E, Chavez Echevarria A, Tupayachi Palomino RJ, Zea Nunez CA, Mejia CR and Atamari-Anahui N. Characteristics and survival of adults with differentiated thyroid cancer in a Peruvian hospital. Rev Peru Med Exp Salud Publica 2024; 41: 287-293.","journal-title":"Rev Peru Med Exp Salud Publica"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1199563","DOI":"10.3389\/fendo.2023.1199563","article-title":"Global trends in research of endoscopic thyroidectomy from 2013 to 2022: a scientometric and visualization analysis","volume":"14","author":"Zheng","year":"2023","unstructured":"Zheng D, Yang Q, Wu J, Zhou Z, Cai J, Chen L, Ji Z, Tian H, Li Z and Chen Y. Global trends in research of endoscopic thyroidectomy from 2013 to 2022: a scientometric and visualization analysis. Front Endocrinol (Lausanne) 2023; 14: 1199563.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1186\/s12884-023-05588-4","article-title":"Pregnancy outcomes and neonatal thyroid function in women with thyroid cancer: a retrospective study","volume":"23","author":"Yuan","year":"2023","unstructured":"Yuan X, Zhao J, Wang J, Zheng W, Kong Y and Li G. Pregnancy outcomes and neonatal thyroid function in women with thyroid cancer: a retrospective study. BMC Pregnancy Childbirth 2023; 23: 383.","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2233039","DOI":"10.1080\/14767058.2023.2233039","article-title":"Effect of levothyroxine on the pregnancy outcomes in recurrent pregnancy loss women with subclinical hypothyroidism and thyroperoxidase antibody positivity: a systematic review and meta-analysis","volume":"36","author":"Yu","year":"2023","unstructured":"Yu M, Long Y, Wang Y, Zhang R and Tao L. Effect of levothyroxine on the pregnancy outcomes in recurrent pregnancy loss women with subclinical hypothyroidism and thyroperoxidase antibody positivity: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2023; 36: 2233039.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"25176","DOI":"10.1038\/s41598-024-75210-w","article-title":"Associations between gestational exposure to perfluoroalkyl substances, fetal growth, and the mediation effect of thyroid hormones","volume":"14","author":"Wang","year":"2024","unstructured":"Wang Z, Yang W, Xu M, Li B, Chen M, Hu J, Wu P and Wu W. Associations between gestational exposure to perfluoroalkyl substances, fetal growth, and the mediation effect of thyroid hormones. Sci Rep 2024; 14: 25176.","journal-title":"Sci Rep"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1089\/thy.2009.0457","article-title":"The relationship of preconception thyrotropin levels to requirements for increasing the levothyroxine dose during pregnancy in women with primary hypothyroidism","volume":"20","author":"Abalovich","year":"2010","unstructured":"Abalovich M, Alcaraz G, Kleiman-Rubinsztein J, Pavlove MM, Cornelio C, Levalle O and Gutierrez S. The relationship of preconception thyrotropin levels to requirements for increasing the levothyroxine dose during pregnancy in women with primary hypothyroidism. Thyroid 2010; 20: 1175-1178.","journal-title":"Thyroid"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"863286","DOI":"10.3389\/fsurg.2022.863286","article-title":"Correlation between hypothyroidism during pregnancy and glucose and lipid metabolism in pregnant women and its influence on pregnancy outcome and fetal growth and development","volume":"9","author":"Xu","year":"2022","unstructured":"Xu D and Zhong H. Correlation between hypothyroidism during pregnancy and glucose and lipid metabolism in pregnant women and its influence on pregnancy outcome and fetal growth and development. Front Surg 2022; 9: 863286.","journal-title":"Front Surg"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.placenta.2023.01.003","article-title":"Pre-natal dietary imbalance of folic acid and vitamin B12 deficiency adversely impacts placental development and fetal growth","volume":"132","author":"Sapehia","year":"2023","unstructured":"Sapehia D, Mahajan A, Srinivasan R and Kaur J. Pre-natal dietary imbalance of folic acid and vitamin B12 deficiency adversely impacts placental development and fetal growth. Placenta 2023; 132: 44-54.","journal-title":"Placenta"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s12020-023-03420-9","article-title":"Hypothyroidism, lipids, and lipidomics","volume":"84","author":"Jonklaas","year":"2024","unstructured":"Jonklaas J. Hypothyroidism, lipids, and lipidomics. Endocrine 2024; 84: 293-300.","journal-title":"Endocrine"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"859487","DOI":"10.3389\/fendo.2022.859487","article-title":"An overview on different L-Thyroxine (l-T(4)) formulations and factors potentially influencing the treatment of congenital hypothyroidism during the first 3 years of life","volume":"13","author":"Stagi","year":"2022","unstructured":"Stagi S, Municchi G, Ferrari M and Wasniewska MG. An overview on different L-Thyroxine (l-T(4)) formulations and factors potentially influencing the treatment of congenital hypothyroidism during the first 3 years of life. Front Endocrinol (Lausanne) 2022; 13: 859487.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.3390\/jcm11133776","article-title":"High first trimester levels of TSH as an independent risk factor for gestational diabetes mellitus: a retrospective cohort study","volume":"11","author":"Fernandez Alba","year":"2022","unstructured":"Fernandez Alba JJ, Castillo Lara M, Jimenez Heras JM, Moreno Cortes R, Gonzalez Macias C, Vilar Sanchez A, San Laureano FC and Moreno Corral LJ. High first trimester levels of TSH as an independent risk factor for gestational diabetes mellitus: a retrospective cohort study. J Clin Med 2022; 11: 3776.","journal-title":"J Clin Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.62347\/POGR1624","article-title":"Thyroid-stimulating hormone and total bile acids can predict adverse pregnancy outcome among patients with gestational hypertension","volume":"16","author":"Tian","year":"2024","unstructured":"Tian L, Wang J, Wang Y, Fan X and Wang L. Thyroid-stimulating hormone and total bile acids can predict adverse pregnancy outcome among patients with gestational hypertension. Am J Transl Res 2024; 16: 1199-1208.","journal-title":"Am J Transl Res"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/11\/ajtr0167480.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:43:08Z","timestamp":1769150588000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/11\/ajtr0167480.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":26,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/utcu8727","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}