{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:12:19Z","timestamp":1779354739436,"version":"3.51.4"},"reference-count":26,"publisher":"e-Century Publishing Corporation","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/wbaf3073","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:53:17Z","timestamp":1777348397000},"page":"3015-3025","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic nomogram for acute cerebral infarction based on risk factors: treatment with urinary kallidinogenase and edaravone-dexborneol"],"prefix":"10.62347","volume":"18","author":[{"given":"Fengqiao","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/17474930211065917","article-title":"World Stroke Organization (WSO): Global Stroke Fact Sheet 2022","volume":"17","author":"Feigin","year":"2022","unstructured":"Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, Fisher M, Pandian J and Lindsay P. World Stroke Organization (WSO): Global Stroke Fact Sheet 2022. Int J Stroke 2022; 17: 18-29.","journal-title":"Int J Stroke"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Tu WJ, Zhao Z, Yin P, Cao L, Zeng J, Chen H, Fan D, Fang Q, Gao P, Gu Y, Tan G, Han J, He L, Hu B, Hua Y, Kang D, Li H, Liu J, Liu Y, Lou M, Luo B, Pan S, Peng B, Ren L, Wang L, Wu J, Xu Y, Xu Y, Yang Y, Zhang M, Zhang S, Zhu L, Zhu Y, Li Z, Chu L, An X, Wang L, Yin M, Li M, Yin L, Yan W, Li C, Tang J, Zhou M and Wang L. Estimated burden of stroke in China in 2020. JAMA Netw Open 2023; 6: e231455.","DOI":"10.1001\/jamanetworkopen.2023.1455"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12951-023-02206-5","article-title":"Thrombolytic therapy based on lyophilized platelet-derived nanocarriers for ischemic stroke","volume":"22","author":"Migliavacca","year":"2024","unstructured":"Migliavacca M, Correa-Paz C, Perez-Mato M, Bielawski PB, Zhang I, Marie P, Hervella P, Rubio M, Maysinger D, Vivien D, Del Pino P, Pelaz B, Polo E and Campos F. Thrombolytic therapy based on lyophilized platelet-derived nanocarriers for ischemic stroke. J Nanobiotechnology 2024; 22: 10.","journal-title":"J Nanobiotechnology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1177\/1129729818819735","article-title":"Comparison of alteplase and urokinase for pharmacomechanical thrombolysis of clotted hemodialysis access","volume":"20","author":"Tan","year":"2019","unstructured":"Tan RY, Pang SC, Teh SP, Lee KG, Chong TT, Gogna A and Tan CS. Comparison of alteplase and urokinase for pharmacomechanical thrombolysis of clotted hemodialysis access. J Vasc Access 2019; 20: 501-506.","journal-title":"J Vasc Access"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.jocn.2022.05.022","article-title":"Safety and efficacy of a new modified intravenous recombinant tissue plasminogen activator (rt-PA) regimen in Chinese patients with acute ischemic stroke: a descriptive retrospective cohort study with subgroup-analysis of different rt-PA dose","volume":"101","author":"Luo","year":"2022","unstructured":"Luo Y, Li J, Huang L, Liu X, Zhang B, Lin J, Jiang A and Zhao J. Safety and efficacy of a new modified intravenous recombinant tissue plasminogen activator (rt-PA) regimen in Chinese patients with acute ischemic stroke: a descriptive retrospective cohort study with subgroup-analysis of different rt-PA dose. J Clin Neurosci 2022; 101: 244-251.","journal-title":"J Clin Neurosci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"300060519895352","DOI":"10.1177\/0300060519895352","article-title":"Comparative study of intravenous thrombolysis with rt-PA and urokinase for patients with acute cerebral infarction","volume":"48","author":"Sun","year":"2020","unstructured":"Sun F, Liu H, Fu HX, Zhang S, Qian XD, Li JJ, Zhu YB, Zhang XX, Zhang J, Qiu HP, Kang LL, Hu YJ, Zhao L, Mi YJ, Gao YJ, Dou ZJ and Ma Z. Comparative study of intravenous thrombolysis with rt-PA and urokinase for patients with acute cerebral infarction. J Int Med Res 2020; 48: 300060519895352.","journal-title":"J Int Med Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3233\/THC-202382","article-title":"Comparative study on the efficacy and safety of alteplase and urokinase in the treatment of acute cerebral infarction","volume":"29","author":"Bao","year":"2021","unstructured":"Bao H, Gao HR, Pan ML, Zhao L and Sun HB. Comparative study on the efficacy and safety of alteplase and urokinase in the treatment of acute cerebral infarction. Technol Health Care 2021; 29: 85-90.","journal-title":"Technol Health Care"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"939","DOI":"10.23736\/s2724-5276.23.07327-5","article-title":"Research progress in acute anticoagulation therapy for cerebral infarction","volume":"75","author":"Li","year":"2023","unstructured":"Li H, Feng X, Wang J and Yang Y. Research progress in acute anticoagulation therapy for cerebral infarction. Minerva Pediatr (Torino) 2023; 75: 939-942.","journal-title":"Minerva Pediatr (Torino)"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1253\/circj.CJ-16-0923","article-title":"Timing of treatment initiation with oral anticoagulants for acute ischemic stroke in patients with nonvalvular atrial fibrillation","volume":"81","author":"Deguchi","year":"2017","unstructured":"Deguchi I, Tanahashi N and Takao M. Timing of treatment initiation with oral anticoagulants for acute ischemic stroke in patients with nonvalvular atrial fibrillation. Circ J 2017; 81: 180-184.","journal-title":"Circ J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1177\/2047487316676037","article-title":"European Heart Rhythm Association (EHRA)\/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS)","volume":"24","author":"Gorenek","year":"2017","unstructured":"Gorenek B, Pelliccia A, Benjamin EJ, Boriani G, Crijns HJ, Fogel RI, Van Gelder IC, Halle M, Kudaiberdieva G, Lane DA, Bjerregaard Larsen T, Lip GY, Lochen ML, Marin F, Niebauer J, Sanders P, Tokgozoglu L, Vos MA, Van Wagoner DR; Document reviewers:, Fauchier L, Savelieva I, Goette A, Agewall S, Chiang CE, Figueiredo M, Stiles M, Dickfeld T, Patton K, Piepoli M, Corra U, Manuel Marques-Vidal P, Faggiano P, Schmid JP and Abreu A. European Heart Rhythm Association (EHRA)\/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS). Eur J Prev Cardiol 2017; 24: 4-40.","journal-title":"Eur J Prev Cardiol"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV and Tirschwell DL. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 2019; 50: e344-e418.","DOI":"10.1161\/STR.0000000000000211"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1136\/svn-2020-000457","article-title":"China Stroke Statistics 2019: a report from the national center for healthcare quality management in neurological diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations","volume":"5","author":"YJ","year":"2020","unstructured":"Wang YJ, Li ZX, Gu HQ, Zhai Y, Jiang Y, Zhao XQ, Wang YL, Yang X, Wang CJ, Meng X, Li H, Liu LP, Jing J, Wu J, Xu AD, Dong Q, Wang D and Zhao JZ; China Stroke Statistics 2019 Writing Committee. China Stroke Statistics 2019: a report from the national center for healthcare quality management in neurological diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations. Stroke Vasc Neurol 2020; 5: 211-239.","journal-title":"Stroke Vasc Neurol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.04.027","article-title":"The risk of hemorrhagic transformation after thrombolysis for acute ischemic stroke in Chinese Versus North Americans: a comparative study","volume":"27","author":"Xu","year":"2018","unstructured":"Xu X, Wang D, Wang F, Norton C, Liu X and Selim M. The risk of hemorrhagic transformation after thrombolysis for acute ischemic stroke in Chinese Versus North Americans: a comparative study. J Stroke Cerebrovasc Dis 2018; 27: 2381-2387.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.2174\/1871527322666221004113752","article-title":"Circadian rhythm and risk of hemorrhagic transformation after acute ischemic stroke treated with intravenous thrombolysis - A systematic review","volume":"22","author":"Stan","year":"2023","unstructured":"Stan A, Dragos H, Strilciuc S, Ilut S, Vacaras V, Cozma A, Panaitescu PS, Stan H and Muresanu DF. Circadian rhythm and risk of hemorrhagic transformation after acute ischemic stroke treated with intravenous thrombolysis - A systematic review. CNS Neurol Disord Drug Targets 2023; 22: 1493-1506.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1136\/neurintsurg-2021-017963","article-title":"Predictors of futile recanalization after endovascular treatment in acute ischemic stroke: a meta-analysis","volume":"14","author":"Deng","year":"2022","unstructured":"Deng G, Xiao J, Yu H, Chen M, Shang K, Qin C and Tian DS. Predictors of futile recanalization after endovascular treatment in acute ischemic stroke: a meta-analysis. J Neurointerv Surg 2022; 14: 881-885.","journal-title":"J Neurointerv Surg"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"429","DOI":"10.23736\/S0031-0808.22.04707-3","article-title":"Clinical effect of urinary kallindinogenase in the treatment of acute cerebral infarction of different TOAST types","volume":"65","author":"Kang","year":"2023","unstructured":"Kang T, Han Z, Xue Y, Yang Q, Lei Q and Wang Q. Clinical effect of urinary kallindinogenase in the treatment of acute cerebral infarction of different TOAST types. Panminerva Med 2023; 65: 429-431.","journal-title":"Panminerva Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1136\/svn-2018-000221","article-title":"Safety and efficacy of edaravone dexborneol versus edaravone for patients with acute ischaemic stroke: a phase II, multicentre, randomised, double-blind, multiple-dose, active-controlled clinical trial","volume":"4","author":"Xu","year":"2019","unstructured":"Xu J, Wang Y, Wang A, Gao Z, Gao X, Chen H, Zhou J, Zhao X and Wang Y. Safety and efficacy of edaravone dexborneol versus edaravone for patients with acute ischaemic stroke: a phase II, multicentre, randomised, double-blind, multiple-dose, active-controlled clinical trial. Stroke Vasc Neurol 2019; 4: 109-114.","journal-title":"Stroke Vasc Neurol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"548","DOI":"10.33314\/jnhrc.v17i4.1042","article-title":"The declaration of helsinki on medical research involving human subjects: a review of seventh revision","volume":"17","author":"Shrestha","year":"2020","unstructured":"Shrestha B and Dunn L. The declaration of helsinki on medical research involving human subjects: a review of seventh revision. J Nepal Health Res Counc 2020; 17: 548-552.","journal-title":"J Nepal Health Res Counc"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jphys.2022.05.017","article-title":"Clinimetrics: modified rankin scale (mRS)","volume":"68","author":"Haggag","year":"2022","unstructured":"Haggag H and Hodgson C. Clinimetrics: modified rankin scale (mRS). J Physiother 2022; 68: 281.","journal-title":"J Physiother"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Han L, Li J, Chen Y, Zhang M, Qian L, Chen Y, Wu Z, Xu Y and Li J. Human urinary kallidinogenase promotes angiogenesis and cerebral perfusion in experimental stroke. PLoS One 2015; 10: e0134543.","DOI":"10.1371\/journal.pone.0134543"},{"key":"ref20","unstructured":"Song X, Han L and Liu Y. Remodeling of motor cortex function in acute cerebral infarction patients following human urinary kallidinogenase: a functional magnetic resonance imaging evaluation after 6 months. Neural Regen Res 2012; 7: 867-873."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"4013707","DOI":"10.1155\/2022\/4013707","article-title":"Edaravone dexborneol alleviates cerebral ischemic injury via MKP-1-mediated inhibition of MAPKs and activation of Nrf2","volume":"2022","author":"Zhang","year":"2022","unstructured":"Zhang W, Yang H, Gao M, Zhang H, Shi L, Yu X, Zhao R, Song J and Du G. Edaravone dexborneol alleviates cerebral ischemic injury via MKP-1-mediated inhibition of MAPKs and activation of Nrf2. Biomed Res Int 2022; 2022: 4013707.","journal-title":"Biomed Res Int"},{"key":"ref22","unstructured":"Zhou Q, Xu LE, Lin LL, Huang XR, Chi WZ, Lin J and Lin P. Clinical study of tirofiban compared to low molecular weight heparin in the antithrombotic treatment of progressive pontine infarction. Eur Rev Med Pharmacol Sci 2024; 28: 2186-2191."},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Yang QF and Shu CM. Massive brainstem infarction and high-risk pulmonary embolism successfully treated with pharmaco-invasive approach: a case report. Medicine (Baltimore) 2025; 104: e42434.","DOI":"10.1097\/MD.0000000000042434"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s12028-021-01266-5","article-title":"Causes, predictors, and timing of early neurological deterioration and symptomatic intracranial hemorrhage after administration of IV tPA","volume":"36","author":"Shah","year":"2022","unstructured":"Shah K, Clark A, Desai SM and Jadhav AP. Causes, predictors, and timing of early neurological deterioration and symptomatic intracranial hemorrhage after administration of IV tPA. Neurocrit Care 2022; 36: 123-129.","journal-title":"Neurocrit Care"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1038\/s41598-024-84912-0","article-title":"Risk prediction model for poor prognosis after intravenous thrombolysis among ischemic stroke patients aged ≥ 80 years and analysis of follow-up","volume":"15","author":"Wang","year":"2025","unstructured":"Wang Y, Liu D, Aldhabi M, Chen Z, Feng L, Gao H and Yin L. Risk prediction model for poor prognosis after intravenous thrombolysis among ischemic stroke patients aged ≥ 80 years and analysis of follow-up. Sci Rep 2025; 15: 1354.","journal-title":"Sci Rep"}],"container-title":["American Journal of Translational Research"],"original-title":[],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:01:19Z","timestamp":1779354079000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/18\/4\/ajtr0168568.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.62347\/wbaf3073","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}