{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:02:35Z","timestamp":1766023355278,"version":"3.48.0"},"reference-count":32,"publisher":"e-Century Publishing Corporation","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/wgse9643","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T01:50:46Z","timestamp":1752112246000},"page":"4663-4678","source":"Crossref","is-referenced-by-count":0,"title":["Benefit of nanohydroxyapatite combined with triamcinolone for non-surgical treatment of severe periodontitis: a retrospective study"],"prefix":"10.62347","volume":"17","author":[{"given":"Long","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"3113479","DOI":"10.1155\/2024\/3113479","article-title":"Evaluation of sterify gel as an adjunctive treatment to scaling and root planing in promoting healing of periodontal pockets: a split-mouth randomized controlled trial","volume":"2024","author":"Levrini","year":"2024","unstructured":"Levrini L, Rossini M, Truppello E, Sevi S, Fiorini E, Benedicenti S, Pasquale C and Farronato D. Evaluation of sterify gel as an adjunctive treatment to scaling and root planing in promoting healing of periodontal pockets: a split-mouth randomized controlled trial. Int J Dent 2024; 2024: 3113479.","journal-title":"Int J Dent"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Abu-Ta’a M and Marzouka D. Enamel Matrix Derivative (EMD) as an adjunct to non-surgical periodontal therapy: a systematic review. Cureus 2023; 15: e43530.","DOI":"10.7759\/cureus.43530"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.3390\/cancers16091671","article-title":"Association between periodontitis and hematologic cancer: an NHIRD cohort study in Taiwan","volume":"16","author":"Huang","year":"2024","unstructured":"Huang LG, Yu CC, Lin MC, Wang YH and Chang YC. Association between periodontitis and hematologic cancer: an NHIRD cohort study in Taiwan. Cancers (Basel) 2024; 16: 1671.","journal-title":"Cancers (Basel)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression","volume":"93","author":"NJ","year":"2014","unstructured":"Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ and Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res 2014; 93: 1045-1053.","journal-title":"J Dent Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1111\/jre.13337","article-title":"Burden of severe periodontitis and edentulism in 2021, with projections up to 2050: the global burden of disease 2021 study","volume":"59","author":"Nascimento","year":"2024","unstructured":"Nascimento GG, Alves-Costa S and Romandini M. Burden of severe periodontitis and edentulism in 2021, with projections up to 2050: the global burden of disease 2021 study. J Periodontal Res 2024; 59: 823-867.","journal-title":"J Periodontal Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/jcpe.13266","article-title":"Global prevalence of aggressive periodontitis: a systematic review and meta-analysis","volume":"47","author":"Bouziane","year":"2020","unstructured":"Bouziane A, Hamdoun R, Abouqal R and Ennibi O. Global prevalence of aggressive periodontitis: a systematic review and meta-analysis. J Clin Periodontol 2020; 47: 406-428.","journal-title":"J Clin Periodontol"},{"key":"ref6","unstructured":"Ijaz MH. Oral-systemic health connections: evidence linking periodontitis with cardiovascular and metabolic diseases. J Dent Care 2024; 1: 21-30."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"28","DOI":"10.15171\/japid.2019.005","article-title":"Effect of IL-36γ expression on chronic periodontitis with an increase in NF-KB signaling pathway","volume":"11","author":"Babaloo","year":"2019","unstructured":"Babaloo AR, Shirmohammadi A, Ghasemi S, Sandoghchian S, Parvan S and Fathi N. Effect of IL-36γ expression on chronic periodontitis with an increase in NF-KB signaling pathway. J Adv Periodontol Implant Dent 2019; 11: 28-33.","journal-title":"J Adv Periodontol Implant Dent"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"6578","DOI":"10.3390\/molecules26216578","article-title":"Synergistic effect of biphasic calcium phosphate and platelet-rich fibrin attenuate markers for inflammation and osteoclast differentiation by suppressing NF-κB\/MAPK signaling pathway in chronic periodontitis","volume":"26","author":"Kumar","year":"2021","unstructured":"Kumar A, Mahendra J, Mahendra L, Abdulkarim HH, Sayed M, Mugri MH, Ahmad ZH, Bhati AK, Faqehi HH, Algregri WO, Varadarajan S, Balaji TM, Baeshen HA and Patil S. Synergistic effect of biphasic calcium phosphate and platelet-rich fibrin attenuate markers for inflammation and osteoclast differentiation by suppressing NF-κB\/MAPK signaling pathway in chronic periodontitis. Molecules 2021; 26: 6578.","journal-title":"Molecules"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4103\/ccd.ccd_52_18","article-title":"A clinical and radiographic evaluation of the efficacy of Nanohydroxyapatite (Sybograf™) versus Bioactive Calcium Phosphosilicate Putty (Novabone®) in the treatment of human periodontal infrabony defects: a randomized clinical trial","volume":"10","author":"Koduru","year":"2019","unstructured":"Koduru S, Aghanashini S, Nadiger S, Apoorva SM, Bhat D and Puvvalla B. A clinical and radiographic evaluation of the efficacy of Nanohydroxyapatite (Sybograf™) versus Bioactive Calcium Phosphosilicate Putty (Novabone®) in the treatment of human periodontal infrabony defects: a randomized clinical trial. Contemp Clin Dent 2019; 10: 16-23.","journal-title":"Contemp Clin Dent"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/jcpe.12392","article-title":"Standards for reporting chronic periodontitis prevalence and severity in epidemiologic studies: proposed standards from the Joint EU\/USA Periodontal Epidemiology Working Group","volume":"42","author":"Holtfreter","year":"2015","unstructured":"Holtfreter B, Albandar JM, Dietrich T, Dye BA, Eaton KA, Eke PI, Papapanou PN and Kocher T; Joint EU\/USA Periodontal Epidemiology Working Group. Standards for reporting chronic periodontitis prevalence and severity in epidemiologic studies: proposed standards from the Joint EU\/USA Periodontal Epidemiology Working Group. J Clin Periodontol 2015; 42: 407-412.","journal-title":"J Clin Periodontol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"148","DOI":"10.4103\/tdj.tdj_60_17","article-title":"Nanohydroxyapatite versus melatonin loaded on nanohydroxyapatite and nanohydroxyapatite with platelet rich fibrin on the treatment of intrabony defects","volume":"15","author":"Yousef","year":"2018","unstructured":"Yousef DA, Al Hessy AA, Saeed AAAA and El Shamy ES. Nanohydroxyapatite versus melatonin loaded on nanohydroxyapatite and nanohydroxyapatite with platelet rich fibrin on the treatment of intrabony defects. Tanta Dent J 2018; 15: 148-163.","journal-title":"Tanta Dent J"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"786353","DOI":"10.1155\/2014\/786353","article-title":"Clinical outcomes after treatment of periodontal intrabony defects with nanocrystalline hydroxyapatite (Ostim) or enamel matrix derivatives (Emdogain): a randomized controlled clinical trial","volume":"2014","author":"Al Machot","year":"2014","unstructured":"Al Machot E, Hoffmann T, Lorenz K, Khalili I and Noack B. Clinical outcomes after treatment of periodontal intrabony defects with nanocrystalline hydroxyapatite (Ostim) or enamel matrix derivatives (Emdogain): a randomized controlled clinical trial. Biomed Res Int 2014; 2014: 786353.","journal-title":"Biomed Res Int"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1902\/jop.2012.110722","article-title":"Platelet-rich fibrin combined with a porous hydroxyapatite graft for the treatment of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial","volume":"88","author":"Pradeep","year":"2017","unstructured":"Pradeep AR, Bajaj P, Rao NS, Agarwal E and Naik SB. Platelet-rich fibrin combined with a porous hydroxyapatite graft for the treatment of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol 2017; 88: 1288-1296.","journal-title":"J Periodontol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"289360","DOI":"10.1155\/2010\/289360","article-title":"Neutrophils compromise retinal pigment epithelial barrier integrity","volume":"2010","author":"Zhou","year":"2010","unstructured":"Zhou J, He S, Zhang N, Spee C, Zhou P, Ryan SJ, Kannan R and Hinton DR. Neutrophils compromise retinal pigment epithelial barrier integrity. J Biomed Biotechnol 2010; 2010: 289360.","journal-title":"J Biomed Biotechnol"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Rakhee, Kumar V, Singh CK, Arvind A, Ahsan A, Kumar S, Das D and Kumari S. A comparative study of dexamethasone ointment along with triamcinolone acetonide in treatment of recurrent aphthous stomatitis. J Pharm Bioallied Sci 2023; 15 Suppl 2: S1325-S1328.","DOI":"10.4103\/jpbs.jpbs_102_23"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Boitsaniuk S, Levkiv M and Kochan O. Application of nanotechnology in periodontal therapy: narrative review. Characterization Appl Nanomater 2024; 7.","DOI":"10.24294\/can.v7i1.4306"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Mg V, Ravindran DM, Sk B and Ashokkumar L. Comparison and estimation of salivary sTREM-1 and IL-1β in periodontitis and diabetes mellitus patients before and after nonsurgical periodontal therapy using hyaluronic acid and Diode LASER: a clinical trial. J Pharmacol Pharmacother 2024.","DOI":"10.1177\/0976500X241306178"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"151877","DOI":"10.1016\/j.aanat.2021.151877","article-title":"Nanocrystalline hydroxyapatite in regeneration of periodontal intrabony defects: a systematic review and meta-analysis","volume":"240","author":"Shaikh","year":"2022","unstructured":"Shaikh MS, Zafar MS, Alnazzawi A and Javed F. Nanocrystalline hydroxyapatite in regeneration of periodontal intrabony defects: a systematic review and meta-analysis. Ann Anat 2022; 240: 151877.","journal-title":"Ann Anat"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/jcpe.13085","article-title":"Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: preliminary findings of 3 months","volume":"46","author":"MM","year":"2019","unstructured":"Montenegro MM, Ribeiro IWJ, Kampits C, Saffi MAL, Furtado MV, Polanczyk CA, Haas AN and Rösing CK. Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: preliminary findings of 3 months. J Clin Periodontol 2019; 46: 321-331.","journal-title":"J Clin Periodontol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"121743","DOI":"10.1016\/j.biomaterials.2022.121743","article-title":"Gold nanoparticles targeting the autophagy-lysosome system to combat the inflammation-compromised osteogenic potential of periodontal ligament stem cells: from mechanism to therapy","volume":"288","author":"Yin","year":"2022","unstructured":"Yin Y, Tian BM, Li X, Yu YC, Deng DK, Sun LJ, Qu HL, Wu RX, Xu XY, Sun HH, An Y, He XT and Chen FM. Gold nanoparticles targeting the autophagy-lysosome system to combat the inflammation-compromised osteogenic potential of periodontal ligament stem cells: from mechanism to therapy. Biomaterials 2022; 288: 121743.","journal-title":"Biomaterials"},{"key":"ref21","unstructured":"Zhou SY, Duan XQ, Hu R and Ouyang XY. Effect of non-surgical periodontal therapy on serum levels of TNF-a, IL-6 and C-reactive protein in periodontitis subjects with stable coronary heart disease. Chin J Dent Res 2013; 16: 145-151."},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Tonetti MS, Greenwell H and Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol 2018; 89 Suppl 1: S159-S172.","DOI":"10.1002\/JPER.18-0006"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"681","DOI":"10.17219\/acem\/188258","article-title":"The impact of systemic and topical antimicrobial therapy combined with non-surgical periodontal therapy: a meta-analysis","volume":"34","author":"Sun","year":"2025","unstructured":"Sun G. The impact of systemic and topical antimicrobial therapy combined with non-surgical periodontal therapy: a meta-analysis. Adv Clin Exp Med 2025; 34: 681-692.","journal-title":"Adv Clin Exp Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"289647","DOI":"10.1155\/2015\/289647","article-title":"Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment","volume":"2015","author":"Shyu","year":"2015","unstructured":"Shyu KG, Choy CS, Wang DC, Huang WC, Chen SY, Chen CH, Lin CT, Chang CC and Huang YK. Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment. Sci World J 2015; 2015: 289647.","journal-title":"Sci World J"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","article-title":"NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses","volume":"16","author":"Ghosh","year":"1998","unstructured":"Ghosh S, May MJ and Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998; 16: 225-260.","journal-title":"Annu Rev Immunol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.3390\/nano11102569","article-title":"Nano-hydroxyapatite as a delivery system for promoting bone regeneration in vivo: a systematic review","volume":"11","author":"Mohd Zaffarin","year":"2021","unstructured":"Mohd Zaffarin AS, Ng SF, Ng MH, Hassan H and Alias E. Nano-hydroxyapatite as a delivery system for promoting bone regeneration in vivo: a systematic review. Nanomaterials 2021; 11: 2569.","journal-title":"Nanomaterials"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Van Dyke TE and Sima C. Understanding resolution of inflammation in periodontal diseases: is chronic inflammatory periodontitis a failure to resolve? Periodontol 2000 2020; 82: 205-213.","DOI":"10.1111\/prd.12317"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"706432","DOI":"10.3389\/fimmu.2021.706432","article-title":"Serum C-reactive protein and periodontitis: a systematic review and meta-analysis","volume":"12","author":"Machado","year":"2021","unstructured":"Machado V, Botelho J, Escalda C, Hussain SB, Luthra S, Mascarenhas P, Orlandi M, Mendes JJ and D’Aiuto F. Serum C-reactive protein and periodontitis: a systematic review and meta-analysis. Front Immunol 2021; 12: 706432.","journal-title":"Front Immunol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/WNF.0000000000000518","article-title":"Evidence for anti-inflammatory effects of adalimumab in treatment of patients with major depressive disorder: a pilot, randomized, controlled Trial","volume":"45","author":"Abbasian","year":"2022","unstructured":"Abbasian F, Bagheri S, Moradi K, Keykhaei M, Etemadi A, Shalbafan M, Shariati B, Vaseghi S, Samsami FS and Akhondzadeh S. Evidence for anti-inflammatory effects of adalimumab in treatment of patients with major depressive disorder: a pilot, randomized, controlled Trial. Clin Neuropharmacol 2022; 45: 128-134.","journal-title":"Clin Neuropharmacol"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Umesh SG and Malaiappan S. Caspase-3 levels alter with non-surgical periodontal therapy in patients with periodontitis. Cureus 2024; 16: e54119.","DOI":"10.7759\/cureus.54119"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Knie LV, Leknes KN, Xue Y, Lie SA and Bunæs DF. Serum biomarker levels in smokers and non-smokers following periodontal therapy. A prospective cohort study. BMC Oral Health 2024; 24: 463.","DOI":"10.1186\/s12903-024-04196-8"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/6\/ajtr0165377.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:57:40Z","timestamp":1766023060000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/6\/ajtr0165377.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/wgse9643","relation":{},"ISSN":["1943-8141"],"issn-type":[{"type":"electronic","value":"1943-8141"}],"subject":[],"published":{"date-parts":[[2025]]}}}