{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:02:10Z","timestamp":1766023330811,"version":"3.48.0"},"reference-count":31,"publisher":"e-Century Publishing Corporation","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/wzao9129","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T23:56:06Z","timestamp":1751241366000},"page":"4135-4147","source":"Crossref","is-referenced-by-count":0,"title":["Altered expression of TEF gene in childhood constipation leads to a decrease in CD56+ NK cells"],"prefix":"10.62347","volume":"17","author":[{"given":"Yingying","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Bradshaw O, Foy R, Seal AK and Darling JC. Childhood constipation. BMJ 2021; 375: e065046.","DOI":"10.1136\/bmj-2021-065046"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jpeds.2004.10.046","article-title":"Prevalence, symptoms and outcome of constipation in infants and toddlers","volume":"146","author":"Loening-Baucke","year":"2005","unstructured":"Loening-Baucke V. Prevalence, symptoms and outcome of constipation in infants and toddlers. J Pediatr 2005; 146: 359-63.","journal-title":"J Pediatr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"63","DOI":"10.11622\/smedj.2020014","article-title":"Chronic constipation in infants and children","volume":"61","author":"JMD","year":"2020","unstructured":"Ho JMD and How CH. Chronic constipation in infants and children. Singapore Med J 2020; 61: 63-68.","journal-title":"Singapore Med J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1111\/j.1572-0241.2006.00771.x","article-title":"Epidemiology of childhood constipation: a systematic review","volume":"101","author":"den Berg MM","year":"2006","unstructured":"van den Berg MM, Benninga MA and Di Lorenzo C. Epidemiology of childhood constipation: a systematic review. Am J Gastroenterol 2006; 101: 2401-2409.","journal-title":"Am J Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Classen M, Righini-Grunder F, Schumann S, Gontard Av and Laffolie JD. Constipation in children and adolescents. Dtsch Arztebl Int 2022; 119: 697-708.","DOI":"10.3238\/arztebl.m2022.0309"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3748\/wjg.v29.i8.1261","article-title":"Functional constipation in children: What physicians should know","volume":"29","author":"Tran","year":"2023","unstructured":"Tran DL and Sintusek P. Functional constipation in children: What physicians should know. World J Gastroenterol 2023; 29: 1261-1288.","journal-title":"World J Gastroenterol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/S0140-6736(77)90485-8","article-title":"Chronic constipation in childhood","volume":"2","author":"Howard","year":"1977","unstructured":"Howard ER and Garrett JR. Chronic constipation in childhood. Lancet 1977; 2: 1237.","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/j.1753-4887.2009.00189.x","article-title":"Health benefits of dietary fiber","volume":"67","author":"Anderson","year":"2009","unstructured":"Anderson JW, Baird P, Davis RH Jr, Ferreri S, Knudtson M, Koraym A, Waters V and Williams CL. Health benefits of dietary fiber. Nutr Rev 2009; 67: 188-205.","journal-title":"Nutr Rev"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1136\/archdischild-2021-323571","article-title":"Benefits of dietary fibre for children in health and disease","volume":"107","author":"Hojsak","year":"2022","unstructured":"Hojsak I, Benninga MA, Hauser B, Kansu A, Kelly VB, Stephen AM, Morais Lopez A, Slavin J and Tuohy K. Benefits of dietary fibre for children in health and disease. Arch Dis Child 2022; 107: 973-979.","journal-title":"Arch Dis Child"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"778747","DOI":"10.3389\/fped.2021.778747","article-title":"A narrative review on the update in the prevalence of infantile colic, regurgitation, and constipation in young children: implications of the ROME IV criteria","volume":"9","author":"Muhardi","year":"2022","unstructured":"Muhardi L, Aw MM, Hasosah M, Ng RT, Chong SY, Hegar B, Toro-Monjaraz E, Darma A, Cetinkaya M, Chow CM, Kudla U and Vandenplas Y. A narrative review on the update in the prevalence of infantile colic, regurgitation, and constipation in young children: implications of the ROME IV criteria. Front Pediatr 2022; 9: 778747.","journal-title":"Front Pediatr"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.3390\/ijms24021526","article-title":"Pathophysiology of inflammatory bowel disease: innate immune system","volume":"24","author":"Saez","year":"2023","unstructured":"Saez A, Herrero-Fernandez B, Gomez-Bris R, S&#xE1;nchez-Martinez H and Gonzalez-Granado JM. Pathophysiology of inflammatory bowel disease: innate immune system. Int J Mol Sci 2023; 24: 1526.","journal-title":"Int J Mol Sci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"100042","DOI":"10.1016\/j.bbih.2020.100042","article-title":"T cell populations in children with autism spectrum disorder and co-morbid gastrointestinal symptoms","volume":"2","author":"Rose","year":"2020","unstructured":"Rose DR, Yang H, Careaga M, Angkustsiri K, Van de Water J and Ashwood P. T cell populations in children with autism spectrum disorder and co-morbid gastrointestinal symptoms. Brain Behav Immun Health 2020; 2: 100042.","journal-title":"Brain Behav Immun Health"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1152\/physrev.00031.2021","article-title":"Trained immunity: adaptation within innate immune mechanisms","volume":"103","author":"Dom&#xED","year":"2023","unstructured":"Dom&#xED;nguez-Andr&#xE9;s J, Dos Santos JC, Bekkering S, Mulder WJM, van der Meer JWM, Riksen NP, Joosten LAB and Netea MG. Trained immunity: adaptation within innate immune mechanisms. Physiol Rev 2023; 103: 313-346.","journal-title":"Physiol Rev"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41590-022-01387-9","article-title":"TH17 cell heterogeneity and its role in tissue inflammation","volume":"24","author":"Schnell","year":"2023","unstructured":"Schnell A, Littman DR and Kuchroo VK. TH17 cell heterogeneity and its role in tissue inflammation. Nat Immunol 2023; 24: 19-29.","journal-title":"Nat Immunol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"8813558","DOI":"10.1155\/2020\/8813558","article-title":"The function and role of the Th17\/Treg cell balance in inflammatory bowel disease","volume":"2020","author":"Yan","year":"2020","unstructured":"Yan JB, Luo MM, Chen ZY and He BH. The function and role of the Th17\/Treg cell balance in inflammatory bowel disease. J Immunol Res 2020; 2020: 8813558.","journal-title":"J Immunol Res"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Brockmann L, Tran A, Huang Y, Edwards M, Ronda C, Wang HH and Ivanov II. Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10. Immunity 2023; 56: 2719-2735, e7.","DOI":"10.1016\/j.immuni.2023.11.003"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"669992","DOI":"10.3389\/fimmu.2021.669992","article-title":"Epigenetic reprogramming of CD4+ helper T cells as a strategy to improve anticancer immunotherapy","volume":"12","author":"Renaude","year":"2021","unstructured":"Renaude E, Kroemer M, Borg C, Peixoto P, Hervouet E, Loyon R and Adot&#xE9;vi O. Epigenetic reprogramming of CD4+ helper T cells as a strategy to improve anticancer immunotherapy. Front Immunol 2021; 12: 669992.","journal-title":"Front Immunol"},{"key":"ref17","unstructured":"Chen Y, Yu M, Liu X, Qu H, Chen Q, Qian W, Wei D, Xu W, Ma B and Wu W. Clinical characteristics and peripheral T cell subsets in Parkinson&#x2019;s disease patients with constipation. Int J Clin Exp Pathol 2015; 8: 2495-2504."},{"key":"ref18","unstructured":"Buckley MM, O&#x2019;Mahony SM and O&#x2019;Malley D. Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome. World J Gastroenterol 2014; 20: 8846-8858."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1254198","DOI":"10.3389\/fcimb.2023.1254198","article-title":"Lactobacillus reuteri in digestive system diseases: focus on clinical trials and mechanisms","volume":"13","author":"Peng","year":"2023","unstructured":"Peng Y, Ma Y, Luo Z, Jiang Y, Xu Z and Yu R. Lactobacillus reuteri in digestive system diseases: focus on clinical trials and mechanisms. Front Cell Infect Microbiol 2023; 13: 1254198.","journal-title":"Front Cell Infect Microbiol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/j.1365-2567.2008.03027.x","article-title":"CD56bright natural killer (NK) cells: an important NK cell subset","volume":"126","author":"Poli","year":"2009","unstructured":"Poli A, Michel T, Th&#xE9;r&#xE9;sine M, Andr&#xE8;s E, Hentges F and Zimmer J. CD56bright natural killer (NK) cells: an important NK cell subset. Immunology 2009; 126: 458-465.","journal-title":"Immunology"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S1471-4906(01)02060-9","article-title":"The biology of human natural killer-cell subsets","volume":"22","author":"MA","year":"2001","unstructured":"Cooper MA, Fehniger TA and Caligiuri MA. The biology of human natural killer-cell subsets. Trends Immunol 2001; 22: 633-640.","journal-title":"Trends Immunol"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Cichocki F, Grzywacz B and Miller JS. Human NK cell development: one road or many? Front Immunol 2019; 10: 2078.","DOI":"10.3389\/fimmu.2019.02078"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1042\/BST20221374","article-title":"The CD56-CD16+ NK cell subset in chronic infections","volume":"51","author":"ATH","year":"2023","unstructured":"Cocker ATH, Guethlein LA and Parham P. The CD56-CD16+ NK cell subset in chronic infections. Biochem Soc Trans 2023; 51: 1201-1212.","journal-title":"Biochem Soc Trans"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41577-021-00558-3","article-title":"Natural killer cells in antiviral immunity","volume":"22","author":"Bj&#xF6","year":"2022","unstructured":"Bj&#xF6;rkstr&#xF6;m NK, Strunz B and Ljunggren HG. Natural killer cells in antiviral immunity. Nat Rev Immunol 2022; 22: 112-123.","journal-title":"Nat Rev Immunol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1002\/eji.202249868","article-title":"Human NK cells responses are enhanced by CD56 engagement","volume":"52","author":"Picard","year":"2022","unstructured":"Picard LK, Claus M, Fasbender F and Watzl C. Human NK cells responses are enhanced by CD56 engagement. Eur J Immunol 2022; 52: 1441-1451.","journal-title":"Eur J Immunol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.autrev.2017.11.018","article-title":"NK cells in autoimmune diseases: linking innate and adaptive immune responses","volume":"17","author":"Gianchecchi","year":"2018","unstructured":"Gianchecchi E, Delfino DV and Fierabracci A. NK cells in autoimmune diseases: linking innate and adaptive immune responses. Autoimmun Rev 2018; 17: 142-154.","journal-title":"Autoimmun Rev"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"622306","DOI":"10.3389\/fimmu.2021.622306","article-title":"The role of natural killer cells in autoimmune diseases","volume":"12","author":"Kucuksezer","year":"2021","unstructured":"Kucuksezer UC, Aktas Cetin E, Esen F, Tahrali I, Akdeniz N, Gelmez MY and Deniz G. The role of natural killer cells in autoimmune diseases. Front Immunol 2021; 12: 622306.","journal-title":"Front Immunol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/s41392-024-02005-w","article-title":"Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization","volume":"9","author":"Chen","year":"2024","unstructured":"Chen S, Zhu H and Jounaidi Y. Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization. Signal Transduct Target Ther 2024; 9: 302.","journal-title":"Signal Transduct Target Ther"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1343718","DOI":"10.3389\/fimmu.2023.1343718","article-title":"Role of CD1d and iNKT cells in regulating intestinal inflammation","volume":"14","author":"Lee","year":"2024","unstructured":"Lee SW, Park HJ, Van Kaer L and Hong S. Role of CD1d and iNKT cells in regulating intestinal inflammation. Front Immunol 2024; 14: 1343718.","journal-title":"Front Immunol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41577-019-0139-2","article-title":"Immunometabolism and natural killer cell responses","volume":"19","author":"O&#x2019","year":"2019","unstructured":"O&#x2019;Brien KL and Finlay DK. Immunometabolism and natural killer cell responses. Nat Rev Immunol 2019; 19: 282-290.","journal-title":"Nat Rev Immunol"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/6\/ajtr0163359.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:57:17Z","timestamp":1766023037000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/6\/ajtr0163359.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/wzao9129","relation":{},"ISSN":["1943-8141"],"issn-type":[{"type":"electronic","value":"1943-8141"}],"subject":[],"published":{"date-parts":[[2025]]}}}