{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:01:04Z","timestamp":1766023264731,"version":"3.48.0"},"reference-count":35,"publisher":"e-Century Publishing Corporation","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/xzct4326","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T04:21:39Z","timestamp":1737519699000},"page":"480-488","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective analysis of the impact of pathogen spectrum and antibiotic resistance on the treatment efficacy of respiratory tract infections from 2012 to 2022"],"prefix":"10.62347","volume":"17","author":[{"given":"Yun","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Jiang M, Ma L, Huang Y, Wu H, Dou J and Zhou C. Antimicrobial activities of peptide Cbf-K(16) against drug-resistant Helicobacter pylori infection in vitro and in vivo. Microb Pathog 2020; 138: 103847.","DOI":"10.1016\/j.micpath.2019.103847"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Turner DN, Edwards L, Kornienko A, Frolova LV and Rogelj S. Synergistic action of substituted indole derivatives and clinically used antibiotics against drug-resistant bacteria. Future Microbiol 2020; 15: 579-590.","DOI":"10.2217\/fmb-2019-0094"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Arya SS, Sharma MM, Rookes JE, Cahill DM and Lenka SK. Vanilla modulates the activity of antibiotics and inhibits efflux pumps in drug-resistant Pseudomonas aeruginosa. Biologia 2021; 76: 781-791.","DOI":"10.2478\/s11756-020-00617-5"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Goddard TN, Patel J, Park HB and Crawford JM. Dimeric stilbene antibiotics target the bacterial cell wall in drug-resistant Gram-positive pathogens. Biochemistry 2020; 59: 1966-1971.","DOI":"10.1021\/acs.biochem.0c00213"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Gorlenko CL, Kiselev HY, Budanova EV, Zamyatnin AA Jr and Ikryannikova LN. Plant secondary metabolites in the battle of drugs and drug-resistant bacteria: new heroes or worse clones of antibiotics? Antibiotics (Basel) 2020; 9: 170.","DOI":"10.3390\/antibiotics9040170"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Yadav K, Shivahare R, Shaham SH, Joshi P, Sharma A and Tripathi R. Repurposing of existing therapeutics to combat drug-resistant malaria. Biomed Pharmacother 2021; 136: 111275.","DOI":"10.1016\/j.biopha.2021.111275"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Alhumaid S, Al Mutair A, Al Alawi Z, Alzahrani AJ, Tobaiqy M, Alresasi AM, Bu-Shehab I, Al-Hadary I, Alhmeed N, Alismail M, Aldera AH, AlHbabi F, Al-Shammari H, Rabaan AA and Al-Omari A. Antimicrobial susceptibility of Gram-positive and Gram-negative bacteria: a 5-year retrospective analysis at a multi-hospital healthcare system in Saudi Arabia. Ann Clin Microbiol Antimicrob 2021; 20: 43.","DOI":"10.1186\/s12941-021-00450-x"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Karaman R, Jubeh B and Breijyeh Z. Resistance of Gram-positive bacteria to current antibacterial agents and overcoming approaches. Molecules 2020; 25: 2888.","DOI":"10.3390\/molecules25122888"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Sundaramoorthy NS, Shankaran P, Gopalan V and Nagarajan S. New tools to mitigate drug resistance in Enterobacteriaceae - Escherichia coli and Klebsiella pneumoniae. Crit Rev Microbiol 2023; 49: 435-454.","DOI":"10.1080\/1040841X.2022.2080525"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Effah CY, Sun T, Liu S and Wu Y. Klebsiella pneumoniae: an increasing threat to public health. Ann Clin Microbiol Antimicrob 2020; 19: 1.","DOI":"10.1186\/s12941-019-0343-8"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Chang D, Sharma L, Dela Cruz CS and Zhang D. Clinical epidemiology, risk factors, and control strategies of Klebsiella pneumoniae infection. Front Microbiol 2021; 12: 750662.","DOI":"10.3389\/fmicb.2021.750662"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Acharya Y, Bhattacharyya S, Dhanda G and Haldar J. Emerging roles of glycopeptide antibiotics: moving beyond Gram-positive bacteria. ACS Infect Dis 2022; 8: 1-28.","DOI":"10.1021\/acsinfecdis.1c00367"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Acharya Y, Dhanda G, Sarkar P and Haldar J. Pursuit of next-generation glycopeptides: a journey with vancomycin. Chem Commun (Camb) 2022; 58: 1881-1897.","DOI":"10.1039\/D1CC06635H"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Boluki E, Pourhajibagher M and Bahador A. The combination of antimicrobial photocatalysis and antimicrobial photodynamic therapy to eradicate the extensively drug-resistant colistin resistant Acinetobacter baumannii. Photodiagnosis Photodyn Ther 2020; 31: 101816.","DOI":"10.1016\/j.pdpdt.2020.101816"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Fashina B and Deng Y. Smectite, sepiolite, and palygorskite for inactivation of pyocyanin, a biotoxin produced by drug-resistant Pseudomonas aeruginosa. Micropor Mesopor Mat 2022; 331: 111668.","DOI":"10.1016\/j.micromeso.2021.111668"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Zaidan N, Hornak JP and Reynoso D. Extensively drug-resistant acinetobacter baumannii nosocomial pneumonia successfully treated with a novel antibiotic combination. Antimicrob Agents Chemother 2021; 65: e0092421.","DOI":"10.1128\/AAC.00924-21"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Huang D, Hu X, Wang C, Zhu D and Tang M. &#x201C;One body and two wings&#x201D; novel nanozyme combined with photothermal therapy for combat drug-resistant bacteria. J Biomater Appl 2022; 37: 474-481.","DOI":"10.1177\/08853282221092222"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Mukherjee S, Ghosh S and Haldar J. Amphiphilic cationic macromolecule potentiates tetracycline against multi-drug resistant Gram-negative bacteria. B Mater Sci 2020; 43: 311.","DOI":"10.1007\/s12034-020-02284-3"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Nasir S, Vohra MS, Gul D, Swaiba UE, Aleem M, Mehmood K and Andleeb S. Novel antibiotic combinations of diverse subclasses for effective suppression of extensively drug-resistant methicillin-resistant staphylococcus aureus (MRSA). Int J Microbiol 2020; 2020: 8831322.","DOI":"10.1155\/2020\/8831322"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Paukner S, Moran GJ, Sandrock C, File TM Jr, Vidal JE, Waites KB, Gelone SP and Yu K. A plain language summary of how lefamulin alone can be used to treat pneumonia caught outside of the hospital due to common bacterial causes, including drug-resistant bacteria. Future Microbiol 2022; 17: 397-410.","DOI":"10.2217\/fmb-2021-0276"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Lim J, Hong J, Jung Y, Ha J, Kim H, Myung H and Song M. Bactericidal effect of cecropin a fused endolysin on drug-resistant Gram-negative pathogens. J Microbiol Biotechnol 2022; 32: 816-823.","DOI":"10.4014\/jmb.2205.05009"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Ma Y, Zhang Y, Gao J, Ouyang H, He Y and Fu Z. PEGylated Ni single-atom catalysts as ultrasensitive electrochemiluminescent probes with favorable aqueous dispersibility for assaying drug-resistant pathogens. Anal Chem 2022; 94: 14047-14053.","DOI":"10.1021\/acs.analchem.2c03546"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Haeili M, Abdollahi A, Ahmadi A and Khoshbayan A. Molecular characterization of tigecycline non-susceptibility among extensively drug-resistant acinetobacter baumannii isolates of clinical origin. Chemotherapy 2021; 66: 99-106.","DOI":"10.1159\/000515100"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Bassetti M, Carnelutti A, Castaldo N and Peghin M. Important new therapies for methicillin-resistant Staphylococcus aureus. Expert Opin Pharmacother 2019; 20: 2317-2334.","DOI":"10.1080\/14656566.2019.1675637"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Reinert JP, Brown M and Ofori R. Dosing considerations for combination antistaphylococcal &#x3B2;-Lactam and Glyco\/lipopeptide salvage therapy for resistant Gram-positive infections: a systematic review. Ann Pharmacother 2022; 56: 193-204.","DOI":"10.1177\/10600280211021421"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Koch BCP, Muller AE, Hunfeld NGM, de Winter BCM, Ewoldt TMJ, Abdulla A and Endeman H. Therapeutic drug monitoring of antibiotics in critically ill patients: current practice and future perspectives with a focus on clinical outcome. Ther Drug Monit 2022; 44: 11-18.","DOI":"10.1097\/FTD.0000000000000942"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Karampatakis T, Tsergouli K and Behzadi P. Carbapenem-resistant Klebsiella pneumoniae: virulence factors, molecular epidemiology and latest updates in treatment options. Antibiotics (Basel) 2023; 12: 234.","DOI":"10.3390\/antibiotics12020234"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Zhang J, Yu L, Fu Y, Zhao Y, Wang Y, Zhao J, Guo Y, Li C and Zhang X. Tigecycline in combination with other antibiotics against clinical isolates of carbapenem-resistant Klebsiella pneumoniae in vitro. Ann Palliat Med 2019; 8: 622-631.","DOI":"10.21037\/apm.2019.09.11"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Yu WL, Lee NY, Wang JT, Ko WC, Ho CH and Chuang YC. Tigecycline therapy for infections caused by extended-spectrum &#x3B2;-lactamase-producing enterobacteriaceae in critically Ill patients. Antibiotics (Basel) 2020; 9: 231.","DOI":"10.3390\/antibiotics9050231"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Kanj SS, Bassetti M, Kiratisin P, Rodrigues C, Villegas MV, Yu Y and van Duin D. Clinical data from studies involving novel antibiotics to treat multidrug-resistant Gram-negative bacterial infections. Int J Antimicrob Agents 2022; 60: 106633.","DOI":"10.1016\/j.ijantimicag.2022.106633"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Halder U, Banerjee A, Biswas R, Sharma A, Pal S, Adhikary A and Bandopadhyay R. Production of prodigiosin by a drug-resistant Serratia rubidaea HB01 isolated from sewage. Environmental Sustainability 2020; 3: 279-287.","DOI":"10.1007\/s42398-020-00115-z"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Ejaz H, Younas S, Qamar MU, Junaid K, Abdalla AE, Abosalif KOA, Alameen AAM, Elamir MYM, Ahmad N, Hamam SSM, Salem EHM and Bukhari SNA. Molecular epidemiology of extensively drug-resistant mcr encoded colistin-resistant bacterial strains co-expressing multifarious &#x3B2;-lactamases. Antibiotics (Basel) 2021; 10: 467.","DOI":"10.3390\/antibiotics10040467"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Broger T, Koeppel L, Huerga H, Miller P, Gupta-Wright A, Blanc FX, Esmail A, Reeve BWP, Floridia M, Kerkhoff AD, Ciccacci F, Kasaro MP, Thit SS, Bastard M, Ferlazzo G, Yoon C, Van Hoving DJ, Sossen B, Garc&#xED;a JI, Cummings MJ, Wake RM, Hanson J, Cattamanchi A, Meintjes G, Maartens G, Wood R, Theron G, Dheda K, Olaru ID and Denkinger CM; TBYield Study Consortium. Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data. Lancet Glob Health 2023; 11: e903-e916.","DOI":"10.2139\/ssrn.4243688"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Durand-Reville TF, Miller AA, O&#x2019;Donnell JP, Wu X, Sylvester MA, Guler S, Iyer R, Shapiro AB, Carter NM, Velez-Vega C, Moussa SH, McLeod SM, Chen A, Tanudra AM, Zhang J, Comita-Prevoir J, Romero JA, Huynh H, Ferguson AD, Horanyi PS, Mayclin SJ, Heine HS, Drusano GL, Cummings JE, Slayden RA and Tommasi RA. Rational design of a new antibiotic class for drug-resistant infections. Nature 2021; 597: 698-702.","DOI":"10.1038\/s41586-021-03899-0"},{"key":"ref34","unstructured":"Guo X, Wang L, Zhang C and Xing XH. Technology development and instrumentation of a high-throughput and automated microbial microdroplet culture system for microbial evolution and screening. Sheng Wu Gong Cheng Xue Bao 2021; 37: 991-1003."}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/1\/ajtr0159035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:56:05Z","timestamp":1766022965000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/1\/ajtr0159035.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/xzct4326","relation":{},"ISSN":["1943-8141"],"issn-type":[{"type":"electronic","value":"1943-8141"}],"subject":[],"published":{"date-parts":[[2025]]}}}