{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:21:46Z","timestamp":1769023306056,"version":"3.49.0"},"reference-count":24,"publisher":"e-Century Publishing Corporation","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Cancer Res"],"DOI":"10.62347\/ydtg3680","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T03:33:23Z","timestamp":1764732803000},"page":"4923-4933","source":"Crossref","is-referenced-by-count":0,"title":["WDR3 drives pancreatic cancer metastasis by enhancing TGF-&amp;#x3B1; mRNA stability through YTHDC1"],"prefix":"10.62347","volume":"15","author":[{"given":"Longhao","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","unstructured":"Siegel RL, Miller KD, Wagle NS and Jemal A. Cancer statistics, 2023. CA Cancer J Clin 2023; 73: 17-48.","journal-title":"CA Cancer J Clin"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: a review","volume":"326","author":"Park","year":"2021","unstructured":"Park W, Chawla A and O&#x2019;Reilly EM. Pancreatic cancer: a review. JAMA 2021; 326: 851-862.","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/S0140-6736(25)00261-2","article-title":"Pancreatic cancer","volume":"405","author":"Stoop","year":"2025","unstructured":"Stoop TF, Javed AA, Oba A, Koerkamp BG, Seufferlein T, Wilmink JW and Besselink MG. Pancreatic cancer. Lancet 2025; 405: 1182-1202.","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"16022","DOI":"10.1038\/nrdp.2016.22","article-title":"Pancreatic cancer","volume":"2","author":"Kleeff","year":"2016","unstructured":"Kleeff J, Korc M, Apte M, La Vecchia C, Johnson CD, Biankin AV, Neale RE, Tempero M, Tuveson DA, Hruban RH and Neoptolemos JP. Pancreatic cancer. Nat Rev Dis Primers 2016; 2: 16022.","journal-title":"Nat Rev Dis Primers"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/nrclinonc.2015.53","article-title":"Pancreatic cancer: from state-of-the-art treatments to promising novel therapies","volume":"12","author":"Garrido-Laguna","year":"2015","unstructured":"Garrido-Laguna I and Hidalgo M. Pancreatic cancer: from state-of-the-art treatments to promising novel therapies. Nat Rev Clin Oncol 2015; 12: 319-334.","journal-title":"Nat Rev Clin Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1200\/JCO.2008.17.7188","article-title":"DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer","volume":"27","author":"Iacobuzio-Donahue","year":"2009","unstructured":"Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson CM, Vilardell F, Wang Z, Keller JW, Banerjee P, Herman JM, Cameron JL, Yeo CJ, Halushka MK, Eshleman JR, Raben M, Klein AP, Hruban RH, Hidalgo M and Laheru D. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol 2009; 27: 1806-1813.","journal-title":"J Clin Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"166213","DOI":"10.1016\/j.bbadis.2021.166213","article-title":"TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation","volume":"1867","author":"Sun","year":"2021","unstructured":"Sun Y, Ren D, Yang C, Yang W, Zhao J, Zhou Y, Jin X and Wu H. TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation. Biochim Biophys Acta Mol Basis Dis 2021; 1867: 166213.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref7","unstructured":"Yang C, Zhu S, Yang H, Deng S, Fan P, Li M and Jin X. USP44 suppresses pancreatic cancer progression and overcomes gemcitabine resistance by deubiquitinating FBP1. Am J Cancer Res 2019; 9: 1722-1733."},{"key":"ref8","unstructured":"Yang C, Zhu S, Yang H, Fan P, Meng Z, Zhao J, Zhang K and Jin X. FBP1 binds to the bromodomain of BRD4 to inhibit pancreatic cancer progression. Am J Cancer Res 2020; 10: 523-535."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"448","DOI":"10.62347\/UAKN9541","article-title":"Neuron-derived neurotensin promotes pancreatic cancer invasiveness and gemcitabine resistance via the NTSR1\/Akt pathway","volume":"14","author":"Hung","year":"2024","unstructured":"Hung YH, Wang HC, Hsu SH, Wang LY, Tsai YL, Su YY, Hung WC and Chen LT. Neuron-derived neurotensin promotes pancreatic cancer invasiveness and gemcitabine resistance via the NTSR1\/Akt pathway. Am J Cancer Res 2024; 14: 448-466.","journal-title":"Am J Cancer Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"6269","DOI":"10.1074\/jbc.M116.764407","article-title":"CDK5\/FBW7-dependent ubiquitination and degradation of EZH2 inhibits pancreatic cancer cell migration and invasion","volume":"292","author":"Jin","year":"2017","unstructured":"Jin X, Yang C, Fan P, Xiao J, Zhang W, Zhan S, Liu T, Wang D and Wu H. CDK5\/FBW7-dependent ubiquitination and degradation of EZH2 inhibits pancreatic cancer cell migration and invasion. J Biol Chem 2017; 292: 6269-6280.","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/978-0-387-09595-0_3","article-title":"Diversity of WD-repeat proteins","volume":"48","author":"Smith","year":"2008","unstructured":"Smith TF. Diversity of WD-repeat proteins. Subcell Biochem 2008; 48: 20-30.","journal-title":"Subcell Biochem"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"18309","DOI":"10.1074\/jbc.M110.108555","article-title":"Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation","volume":"285","author":"McMahon","year":"2010","unstructured":"McMahon M, Ayllon V, Panov KI and O&#x2019;Connor R. Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation. J Biol Chem 2010; 285: 18309-18318.","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"22314","DOI":"10.1074\/jbc.M111.222802","article-title":"RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response","volume":"286","author":"Liu","year":"2011","unstructured":"Liu S, Chu J, Yucer N, Leng M, Wang SY, Chen BP, Hittelman WN and Wang Y. RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response. J Biol Chem 2011; 286: 22314-22322.","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1089\/thy.2010.0072","article-title":"WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population","volume":"20","author":"Akdi","year":"2010","unstructured":"Akdi A, Gimenez EM, Garcia-Quispes W, Pastor S, Castell J, Biarnes J, Marcos R and Velazquez A. WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population. Thyroid 2010; 20: 803-809.","journal-title":"Thyroid"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Garcia-Quispes WA, Pastor S, Galofre P, Biarnes J, Castell J, Velazquez A and Marcos R. Possible role of the WDR3 gene on genome stability in thyroid cancer patients. PLoS One 2012; 7: e44288.","DOI":"10.1371\/journal.pone.0044288"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/s13046-025-03456-x","article-title":"WDR3 undergoes phase separation to mediate the therapeutic mechanism of Nilotinib against osteosarcoma","volume":"44","author":"Li","year":"2025","unstructured":"Li M, Li N, Fan Y, Zhang Z, Zhou L, Yu Y, Ni M, Tan M, Huang W and Zhu T. WDR3 undergoes phase separation to mediate the therapeutic mechanism of Nilotinib against osteosarcoma. J Exp Clin Cancer Res 2025; 44: 201.","journal-title":"J Exp Clin Cancer Res"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Liu W, Xie A, Xiong J, Li S, Yang L and Liu W. WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A. J Gene Med 2023; 25: e3498.","DOI":"10.1002\/jgm.3498"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1158\/1055-9965.EPI-15-0652","article-title":"A comprehensive meta-analysis of case-control association studies to evaluate polymorphisms associated with the risk of differentiated thyroid carcinoma","volume":"25","author":"Figlioli","year":"2016","unstructured":"Figlioli G, Elisei R, Romei C, Melaiu O, Cipollini M, Bambi F, Chen B, Kohler A, Cristaudo A, Hemminki K, Gemignani F, Forsti A and Landi S. A comprehensive meta-analysis of case-control association studies to evaluate polymorphisms associated with the risk of differentiated thyroid carcinoma. Cancer Epidemiol Biomarkers Prev 2016; 25: 700-713.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1158\/0008-5472.CAN-17-1346","article-title":"PHD3 controls lung cancer metastasis and resistance to EGFR inhibitors through TGFalpha","volume":"78","author":"Dopeso","year":"2018","unstructured":"Dopeso H, Jiao HK, Cuesta AM, Henze AT, Jurida L, Kracht M, Acker-Palmer A, Garvalov BK and Acker T. PHD3 controls lung cancer metastasis and resistance to EGFR inhibitors through TGFalpha. Cancer Res 2018; 78: 1805-1819.","journal-title":"Cancer Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.bbrc.2018.10.137","article-title":"Transforming growth factor alpha promotes tumorigenesis and regulates epithelial-mesenchymal transition modulation in colon cancer","volume":"506","author":"CY","year":"2018","unstructured":"Yu CY, Chang WC, Zheng JH, Hung WH and Cho EC. Transforming growth factor alpha promotes tumorigenesis and regulates epithelial-mesenchymal transition modulation in colon cancer. Biochem Biophys Res Commun 2018; 506: 901-906.","journal-title":"Biochem Biophys Res Commun"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Roundtree IA, Luo GZ, Zhang Z, Wang X, Zhou T, Cui Y, Sha J, Huang X, Guerrero L, Xie P, He E, Shen B and He C. YTHDC1 mediates nuclear export of N(6)-methyladenosine methylated mRNAs. Elife 2017; 6: e31311.","DOI":"10.7554\/eLife.31311"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m(6)A reader YTHDC1 regulates mRNA splicing","volume":"61","author":"Xiao","year":"2016","unstructured":"Xiao W, Adhikari S, Dahal U, Chen YS, Hao YJ, Sun BF, Sun HY, Li A, Ping XL, Lai WY, Wang X, Ma HL, Huang CM, Yang Y, Huang N, Jiang GB, Wang HL, Zhou Q, Wang XJ, Zhao YL and Yang YG. Nuclear m(6)A reader YTHDC1 regulates mRNA splicing. Mol Cell 2016; 61: 507-519.","journal-title":"Mol Cell"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1038\/s41419-020-03186-2","article-title":"YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA","volume":"11","author":"Zhang","year":"2020","unstructured":"Zhang Z, Wang Q, Zhao X, Shao L, Liu G, Zheng X, Xie L, Zhang Y, Sun C and Xu R. YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA. Cell Death Dis 2020; 11: 977.","journal-title":"Cell Death Dis"}],"container-title":["American Journal of Cancer Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/11\/ajcr0168002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:00:48Z","timestamp":1768964448000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/11\/ajcr0168002.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":24,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/ydtg3680","relation":{},"ISSN":["2156-6976"],"issn-type":[{"value":"2156-6976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}