{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:01:38Z","timestamp":1787763698488,"version":"build-2784847793"},"reference-count":101,"publisher":"e-Century Publishing Corporation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Stem Cells"],"DOI":"10.62347\/ygxa7976","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T02:28:17Z","timestamp":1751855297000},"page":"53-72","source":"Crossref","is-referenced-by-count":3,"title":["Mesenchymal stem cells in injury repair of vital organs: from mechanism to clinical application"],"prefix":"10.62347","volume":"14","author":[{"given":"Liwei","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1159\/000535894","article-title":"Pyroptosis: the determinator of cell death and fate in acute kidney injury","volume":"10","author":"Xiong","year":"2023","unstructured":"Xiong J and Zhao J. Pyroptosis: the determinator of cell death and fate in acute kidney injury. Kidney Dis (Basel) 2023; 10: 118-131.","journal-title":"Kidney Dis (Basel)"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"Reinke","year":"2012","unstructured":"Reinke JM and Sorg H. Wound repair and regeneration. Eur Surg Res 2012; 49: 35-43.","journal-title":"Eur Surg Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.actbio.2017.01.056","article-title":"Promoting tissue regeneration by modulating the immune system","volume":"53","author":"Julier","year":"2017","unstructured":"Julier Z, Park AJ, Briquez PS and Martino MM. Promoting tissue regeneration by modulating the immune system. Acta Biomater 2017; 53: 13-28.","journal-title":"Acta Biomater"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3390\/cells10020339","article-title":"Epithelial cells and inflammation in pulmonary wound repair","volume":"10","author":"Croasdell Lucchini","year":"2021","unstructured":"Croasdell Lucchini A, Gachanja NN, Rossi AG, Dorward DA and Lucas CD. Epithelial cells and inflammation in pulmonary wound repair. Cells 2021; 10: 339.","journal-title":"Cells"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop DJ and Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315-7.","journal-title":"Cytotherapy"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12964-019-0414-7","article-title":"Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells","volume":"17","author":"Vidoni","year":"2019","unstructured":"Vidoni C, Ferraresi A, Secomandi E, Vallino L, Gardin C, Zavan B, Mortellaro C and Isidoro C. Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells. Cell Commun Signal 2019; 17: 98.","journal-title":"Cell Commun Signal"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3960","DOI":"10.1038\/s41467-022-31697-3","article-title":"Mast4 determines the cell fate of MSCs for bone and cartilage development","volume":"13","author":"Kim","year":"2022","unstructured":"Kim P, Park J, Lee DJ, Mizuno S, Shinohara M, Hong CP, Jeong Y, Yun R, Park H, Park S, Yang KM, Lee MJ, Jang SP, Kim HY, Lee SJ, Song SU, Park KS, Tanaka M, Ohshima H, Cho JW, Sugiyama F, Takahashi S, Jung HS and Kim SJ. Mast4 determines the cell fate of MSCs for bone and cartilage development. Nat Commun 2022; 13: 3960.","journal-title":"Nat Commun"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nrm3198","article-title":"Forming functional fat: a growing understanding of adipocyte differentiation","volume":"12","author":"Cristancho","year":"2011","unstructured":"Cristancho AG and Lazar MA. Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 2011; 12: 722-734.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1021\/acsami.6b15354","article-title":"Construction of PLGA nanoparticles coated with polycistronic SOX5, SOX6, and SOX9 genes for chondrogenesis of human mesenchymal stem cells","volume":"9","author":"Park","year":"2017","unstructured":"Park JS, Yi SW, Kim HJ, Kim SM, Kim JH and Park KH. Construction of PLGA nanoparticles coated with polycistronic SOX5, SOX6, and SOX9 genes for chondrogenesis of human mesenchymal stem cells. Acs Appl Mater Interfaces 2017; 9: 1361-1372.","journal-title":"Acs Appl Mater Interfaces"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.1016\/j.yexcr.2009.05.009","article-title":"Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery","volume":"315","author":"Gang","year":"2009","unstructured":"Gang EJ, Darabi R, Bosnakovski D, Xu Z, Kamm KE, Kyba M and Perlingeiro RC. Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery. Exp Cell Res 2009; 315: 2624-2636.","journal-title":"Exp Cell Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.3109\/14653249.2011.597380","article-title":"GATA-4 promotes myocardial transdifferentiation of mesenchymal stromal cells via up-regulating IGFBP-4","volume":"13","author":"Li","year":"2011","unstructured":"Li H, Zuo S, Pasha Z, Yu B, He Z, Wang Y, Yang X, Ashraf M and Xu M. GATA-4 promotes myocardial transdifferentiation of mesenchymal stromal cells via up-regulating IGFBP-4. Cytotherapy 2011; 13: 1057-1065.","journal-title":"Cytotherapy"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"10335","DOI":"10.3390\/ijms221910335","article-title":"Generation and characterization of human mesenchymal stem cell-derived smooth muscle cells","volume":"22","author":"Sivaraman","year":"2021","unstructured":"Sivaraman S, Hedrick J, Ismail S, Slavin C and Rao RR. Generation and characterization of human mesenchymal stem cell-derived smooth muscle cells. Int J Mol Sci 2021; 22: 10335.","journal-title":"Int J Mol Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1136\/thoraxjnl-2021-218194","article-title":"Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis","volume":"78","author":"Su","year":"2023","unstructured":"Su Y, Silva JD, Doherty D, Simpson DA, Weiss DJ, Rolandsson-Enes S, McAuley DF, O&#x2019;Kane CM, Brazil DP and Krasnodembskaya AD. Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis. Thorax 2023; 78: 617-630.","journal-title":"Thorax"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s11658-022-00384-y","article-title":"The role of macrophage subtypes and exosomes in immunomodulation","volume":"27","author":"Gharavi","year":"2022","unstructured":"Gharavi AT, Hanjani NA, Movahed E and Doroudian M. The role of macrophage subtypes and exosomes in immunomodulation. Cell Mol Biol Lett 2022; 27: 83.","journal-title":"Cell Mol Biol Lett"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Giri J, Das R, Nylen E, Chinnadurai R and Galipeau J. CCL2 and CXCL12 derived from mesenchymal stromal cells cooperatively polarize IL-10+ tissue macrophages to mitigate gut injury. Cell Rep 2020; 30: 1923-1934, e4.","DOI":"10.1016\/j.celrep.2020.01.047"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1186\/s13287-022-03010-y","article-title":"Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6\/STAT3 pathway in macrophages","volume":"13","author":"Tian","year":"2022","unstructured":"Tian S, Zhou X, Zhang M, Cui L, Li B, Liu Y, Su R, Sun K, Hu Y, Yang F, Xuan G, Ma S, Zheng X, Zhou X, Guo C, Shang Y, Wang J and Han Y. Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6\/STAT3 pathway in macrophages. Stem Cell Res Ther 2022; 13: 330.","journal-title":"Stem Cell Res Ther"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12967-020-02410-z","article-title":"Mesenchymal stem cells activate Notch signaling to induce regulatory dendritic cells in LPS-induced acute lung injury","volume":"18","author":"Lu","year":"2020","unstructured":"Lu Z, Meng S, Chang W, Fan S, Xie J, Guo F, Yang Y, Qiu H and Liu L. Mesenchymal stem cells activate Notch signaling to induce regulatory dendritic cells in LPS-induced acute lung injury. J Transl Med 2020; 18: 241.","journal-title":"J Transl Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.3389\/fimmu.2018.02538","article-title":"Mesenchymal stromal cell-derived extracellular vesicles attenuate dendritic cell maturation and function","volume":"9","author":"Reis","year":"2018","unstructured":"Reis M, Mavin E, Nicholson L, Green K, Dickinson AM and Wang XN. Mesenchymal stromal cell-derived extracellular vesicles attenuate dendritic cell maturation and function. Front Immunol 2018; 9: 2538.","journal-title":"Front Immunol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13287-020-01612-y","article-title":"Mesenchymal stem cells regulate the Th17\/Treg cell balance partly through hepatocyte growth factor in vitro","volume":"11","author":"Chen","year":"2020","unstructured":"Chen QH, Wu F, Liu L, Chen HB, Zheng RQ, Wang HL and Yu LN. Mesenchymal stem cells regulate the Th17\/Treg cell balance partly through hepatocyte growth factor in vitro. Stem Cell Res Ther 2020; 11: 91.","journal-title":"Stem Cell Res Ther"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.jcyt.2018.02.372","article-title":"Mesenchymal stromal cell exosome-enhanced regulatory T-cell production through an antigen-presenting cell-mediated pathway","volume":"20","author":"Zhang","year":"2018","unstructured":"Zhang B, Yeo RWY, Lai RC, Sim EWK, Chin KC and Lim SK. Mesenchymal stromal cell exosome-enhanced regulatory T-cell production through an antigen-presenting cell-mediated pathway. Cytotherapy 2018; 20: 687-696.","journal-title":"Cytotherapy"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"121486","DOI":"10.1016\/j.biomaterials.2022.121486","article-title":"Extracellular vesicles derived from mesenchymal stromal cells as nanotherapeutics for liver ischaemia-reperfusion injury by transferring mitochondria to modulate the formation of neutrophil extracellular traps","volume":"284","author":"Lu","year":"2022","unstructured":"Lu T, Zhang J, Cai J, Xiao J, Sui X, Yuan X, Li R, Li Y, Yao J, Lv G, Chen X, Chen H, Zeng K, Liu Y, Chen W, Chen G, Yang Y, Zheng J and Zhang Y. Extracellular vesicles derived from mesenchymal stromal cells as nanotherapeutics for liver ischaemia-reperfusion injury by transferring mitochondria to modulate the formation of neutrophil extracellular traps. Biomaterials 2022; 284: 121486.","journal-title":"Biomaterials"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1182\/blood.2019001398","article-title":"Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress","volume":"134","author":"Burt","year":"2019","unstructured":"Burt R, Dey A, Aref S, Aguiar M, Akarca A, Bailey K, Day W, Hooper S, Kirkwood A, Kirschner K, Lee SW, Lo Celso C, Manji J, Mansour MR, Marafioti T, Mitchell RJ, Muirhead RC, Cheuk Yan Ng K, Pospori C, Puccio I, Zuborne-Alapi K, Sahai E and Fielding AK. Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress. Blood 2019; 134: 1415-1429.","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Zheng C, Sui B, Zhang X, Hu J, Chen J, Liu J, Wu D, Ye Q, Xiang L, Qiu X, Liu S, Deng Z, Zhou J, Liu S, Shi S and Jin Y. Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes. J Extracell Vesicles 2021; 10: e12109.","DOI":"10.1002\/jev2.12109"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"118821","DOI":"10.1016\/j.lfs.2020.118821","article-title":"hUCB-MSC derived exosomal miR-124 promotes rat liver regeneration after partial hepatectomy via downregulating Foxg1","volume":"265","author":"Song","year":"2021","unstructured":"Song XJ, Zhang L, Li Q, Li Y, Ding FH and Li X. hUCB-MSC derived exosomal miR-124 promotes rat liver regeneration after partial hepatectomy via downregulating Foxg1. Life Sci 2021; 265: 118821.","journal-title":"Life Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41419-022-04708-w","article-title":"Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury","volume":"13","author":"Lin","year":"2022","unstructured":"Lin F, Chen W, Zhou J, Zhu J, Yao Q, Feng B, Feng X, Shi X, Pan Q, Yu J, Li L and Cao H. Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury. Cell Death Dis 2022; 13: 271.","journal-title":"Cell Death Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"110793","DOI":"10.1016\/j.cellsig.2023.110793","article-title":"Small extracellular vesicles from HO-1-modified bone marrow-derived mesenchymal stem cells attenuate ischemia-reperfusion injury after steatotic liver transplantation by suppressing ferroptosis via miR-214-3p","volume":"109","author":"Zuo","year":"2023","unstructured":"Zuo H, Wang Y, Yuan M, Zheng W, Tian X, Pi Y, Zhang X and Song H. Small extracellular vesicles from HO-1-modified bone marrow-derived mesenchymal stem cells attenuate ischemia-reperfusion injury after steatotic liver transplantation by suppressing ferroptosis via miR-214-3p. Cell Signal 2023; 109: 110793.","journal-title":"Cell Signal"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s12951-022-01407-8","article-title":"miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia-reperfusion injury in steatotic grafts","volume":"20","author":"Wu","year":"2022","unstructured":"Wu L, Tian X, Zuo H, Zheng W, Li X, Yuan M, Tian X and Song H. miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia-reperfusion injury in steatotic grafts. J Nanobiotechnology 2022; 20: 196.","journal-title":"J Nanobiotechnology"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"893","DOI":"10.7150\/ijbs.39725","article-title":"Mesenchymal stromal cells promote liver regeneration through regulation of immune cells","volume":"16","author":"Hu","year":"2020","unstructured":"Hu C, Wu Z and Li L. Mesenchymal stromal cells promote liver regeneration through regulation of immune cells. Int J Biol Sci 2020; 16: 893-903.","journal-title":"Int J Biol Sci"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Xu J, Chen P, Yu C, Shi Q, Wei S, Li Y, Qi H, Cao Q, Guo C, Wu X and Di G. Hypoxic bone marrow mesenchymal stromal cells-derived exosomal miR-182-5p promotes liver regeneration via FOXO1-mediated macrophage polarization. FASEB J 2022; 36: e22553.","DOI":"10.1096\/fj.202101868RRR"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"106229","DOI":"10.1016\/j.phrs.2022.106229","article-title":"Mesenchymal stem cell treatment restores liver macrophages homeostasis to alleviate mouse acute liver injury revealed by single-cell analysis","volume":"179","author":"Zhou","year":"2022","unstructured":"Zhou J, Feng X, Zhu J, Feng B, Yao Q, Pan Q, Yu J, Yang J, Li L and Cao H. Mesenchymal stem cell treatment restores liver macrophages homeostasis to alleviate mouse acute liver injury revealed by single-cell analysis. Pharmacol Res 2022; 179: 106229.","journal-title":"Pharmacol Res"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1903746","DOI":"10.1002\/advs.201903746","article-title":"Extracellular vesicles derived from human umbilical cord mesenchymal stem cells protect liver Ischemia\/Reperfusion injury by reducing CD154 expression on CD4+ T cells via CCT2","volume":"7","author":"Zheng","year":"2020","unstructured":"Zheng J, Lu T, Zhou C, Cai J, Zhang X, Liang J, Sui X, Chen X, Chen L, Sun Y, Zhang J, Chen W, Zhang Y, Yao J, Chen G and Yang Y. Extracellular vesicles derived from human umbilical cord mesenchymal stem cells protect liver Ischemia\/Reperfusion injury by reducing CD154 expression on CD4+ T cells via CCT2. Adv Sci (Weinh) 2020; 7: 1903746.","journal-title":"Adv Sci (Weinh)"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13287-019-1539-8","article-title":"Japonicum-infected mice","volume":"11","author":"Dong","year":"2020","unstructured":"Dong L, Pu Y, Chen X, Qi X, Zhang L, Xu L, Li W, Ma Y, Zhou S, Zhu J, Li Y, Wang X and Su C. HUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. Japonicum-infected mice. Stem Cell Res Ther 2020; 11: 21.","journal-title":"Stem Cell Res Ther"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s13287-022-02906-z","article-title":"Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt\/&#x3B2;-catenin signaling pathway in mice","volume":"13","author":"Liu","year":"2022","unstructured":"Liu QW, Ying YM, Zhou JX, Zhang WJ, Liu ZX, Jia BB, Gu HC, Zhao CY, Guan XH, Deng KY and Xin HB. Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt\/&#x3B2;-catenin signaling pathway in mice. Stem Cell Res Ther 2022; 13: 224.","journal-title":"Stem Cell Res Ther"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/s12951-023-01942-y","article-title":"Mesenchymal stem cell-derived exosomal miR-27b-3p alleviates liver fibrosis via downregulating YAP\/LOXL2 pathway","volume":"21","author":"Cheng","year":"2023","unstructured":"Cheng F, Yang F, Wang Y, Zhou J, Qian H and Yan Y. Mesenchymal stem cell-derived exosomal miR-27b-3p alleviates liver fibrosis via downregulating YAP\/LOXL2 pathway. J Nanobiotechnology 2023; 21: 195.","journal-title":"J Nanobiotechnology"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12951-023-01788-4","article-title":"Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K\/Akt\/mTOR pathway and remodeling choline metabolism","volume":"21","author":"Zhang","year":"2023","unstructured":"Zhang Z, Shang J, Yang Q, Dai Z, Liang Y, Lai C, Feng T, Zhong D, Zou H, Sun L, Su Y, Yan S, Chen J, Yao Y, Shi Y and Huang X. Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K\/Akt\/mTOR pathway and remodeling choline metabolism. J Nanobiotechnology 2023; 21: 29.","journal-title":"J Nanobiotechnology"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s12012-022-09743-9","article-title":"Mesenchymal stem cell-derived exosome-loaded microRNA-129-5p inhibits TRAF3 expression to alleviate apoptosis and oxidative stress in heart failure","volume":"22","author":"Yan","year":"2022","unstructured":"Yan F, Cui W and Chen Z. Mesenchymal stem cell-derived exosome-loaded microRNA-129-5p inhibits TRAF3 expression to alleviate apoptosis and oxidative stress in heart failure. Cardiovasc Toxicol 2022; 22: 631-645.","journal-title":"Cardiovasc Toxicol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"685","DOI":"10.7150\/thno.73568","article-title":"Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia\/reperfusion injury in mice and swine","volume":"13","author":"Gao","year":"2023","unstructured":"Gao L, Qiu F, Cao H, Li H, Dai G, Ma T, Gong Y, Luo W, Zhu D, Qiu Z, Zhu P, Chu S, Yang H and Liu Z. Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia\/reperfusion injury in mice and swine. Theranostics 2023; 13: 685-703.","journal-title":"Theranostics"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.imlet.2021.06.007","article-title":"Combination of mesenchymal stem cells and FK506 prolongs heart allograft survival by inhibiting TBK1\/IRF3-regulated-IFN-&#x3B3; production","volume":"238","author":"Chen","year":"2021","unstructured":"Chen Y, Yan G, Ma Y, Zhong M, Yang Y, Guo J, Wang C, Han W, Zhang L, Xu S, Huang J, Dai H and Qi Z. Combination of mesenchymal stem cells and FK506 prolongs heart allograft survival by inhibiting TBK1\/IRF3-regulated-IFN-&#x3B3; production. Immunol Lett 2021; 238: 21-28.","journal-title":"Immunol Lett"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/cvr\/cvz139","article-title":"Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19","volume":"116","author":"Huang","year":"2020","unstructured":"Huang P, Wang L, Li Q, Tian X, Xu J, Xu J, Xiong Y, Chen G, Qian H, Jin C, Yu Y, Cheng K, Qian L and Yang Y. Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19. Cardiovasc Res 2020; 116: 353-367.","journal-title":"Cardiovasc Res"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13062-023-00361-1","article-title":"ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis","volume":"18","author":"Wang","year":"2023","unstructured":"Wang T, Li T, Niu X, Hu L, Cheng J, Guo D, Ren H, Zhao R, Ji Z, Liu P, Li Y and Guo Y. ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis. Biol Direct 2023; 18: 6.","journal-title":"Biol Direct"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1186\/s13287-020-01881-7","article-title":"HIF-1&#x3B1; overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis","volume":"11","author":"Sun","year":"2020","unstructured":"Sun J, Shen H, Shao L, Teng X, Chen Y, Liu X, Yang Z and Shen Z. HIF-1&#x3B1; overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis. Stem Cell Res Ther 2020; 11: 373.","journal-title":"Stem Cell Res Ther"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/s41419-020-03025-4","article-title":"Correction: exosomal miR-25-3p from mesenchymal stem cells alleviates myocardial infarction by targeting pro-apoptotic proteins and EZH2","volume":"11","author":"Peng","year":"2020","unstructured":"Peng Y, Zhao JL, Peng ZY, Xu WF and Yu GL. Correction: exosomal miR-25-3p from mesenchymal stem cells alleviates myocardial infarction by targeting pro-apoptotic proteins and EZH2. Cell Death Dis 2020; 11: 845.","journal-title":"Cell Death Dis"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s10565-020-09530-8","article-title":"Human umbilical cord blood-derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice","volume":"37","author":"Song","year":"2021","unstructured":"Song Y, Wang B, Zhu X, Hu J, Sun J, Xuan J and Ge Z. Human umbilical cord blood-derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice. Cell Biol Toxicol 2021; 37: 51-64.","journal-title":"Cell Biol Toxicol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"109812","DOI":"10.1016\/j.cellsig.2020.109812","article-title":"Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF\/PI3k\/Akt\/eNOS pathway","volume":"77","author":"Ning","year":"2021","unstructured":"Ning W, Li S, Yang W, Yang B, Xin C, Ping X, Huang C, Gu Y and Guo L. Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF\/PI3k\/Akt\/eNOS pathway. Cell Signal 2021; 77: 109812.","journal-title":"Cell Signal"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s13287-020-01737-0","article-title":"Hypoxia-challenged MSC-derived exosomes deliver miR-210 to attenuate post-infarction cardiac apoptosis","volume":"11","author":"Cheng","year":"2020","unstructured":"Cheng H, Chang S, Xu R, Chen L, Song X, Wu J, Qian J, Zou Y and Ma J. Hypoxia-challenged MSC-derived exosomes deliver miR-210 to attenuate post-infarction cardiac apoptosis. Stem Cell Res Ther 2020; 11: 224.","journal-title":"Stem Cell Res Ther"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s13287-021-02276-y","article-title":"Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6-p-STAT3-p63-JAG2 pathway","volume":"12","author":"Peng","year":"2021","unstructured":"Peng W, Chang M, Wu Y, Zhu W, Tong L, Zhang G, Wang Q, Liu J, Zhu X, Cheng T, Li Y, Chen X, Weng D, Liu S, Zhang H, Su Y, Zhou J, Li H and Song Y. Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6-p-STAT3-p63-JAG2 pathway. Stem Cell Res Ther 2021; 12: 216.","journal-title":"Stem Cell Res Ther"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"6646","DOI":"10.7150\/thno.33741","article-title":"Reversal of bleomycin-induced rat pulmonary fibrosis by a xenograft of human umbilical mesenchymal stem cells from Wharton&#x2019;s jelly","volume":"9","author":"Chu","year":"2019","unstructured":"Chu KA, Wang SY, Yeh CC, Fu TW, Fu YY, Ko TL, Chiu MM, Chen TH, Tsai PJ and Fu YS. Reversal of bleomycin-induced rat pulmonary fibrosis by a xenograft of human umbilical mesenchymal stem cells from Wharton&#x2019;s jelly. Theranostics 2019; 9: 6646-6664.","journal-title":"Theranostics"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/s41419-020-03034-3","article-title":"Mesenchymal stem cells reverse EMT process through blocking the activation of NF-&#x3BA;B and Hedgehog pathways in LPS-induced acute lung injury","volume":"11","author":"Xiao","year":"2020","unstructured":"Xiao K, He W, Guan W, Hou F, Yan P, Xu J, Zhou T, Liu Y and Xie L. Mesenchymal stem cells reverse EMT process through blocking the activation of NF-&#x3BA;B and Hedgehog pathways in LPS-induced acute lung injury. Cell Death Dis 2020; 11: 863.","journal-title":"Cell Death Dis"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1089\/ars.2019.7965","article-title":"Mesenchymal stem cell-derived extracellular vesicles attenuate radiation-induced lung injury via miRNA-214-3p","volume":"35","author":"Lei","year":"2020","unstructured":"Lei X, He N, Zhu L, Zhou M, Zhang K, Wang C, Huang H, Chen S, Li Y, Liu Q, Han Z, Guo Z, Han Z and Li Z. Mesenchymal stem cell-derived extracellular vesicles attenuate radiation-induced lung injury via miRNA-214-3p. Antioxid Redox Signal 2020; 35: 849-862.","journal-title":"Antioxid Redox Signal"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/s41419-020-03036-1","article-title":"Mesenchymal stem cells alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of Ly6C+ CD8+ T cells","volume":"11","author":"Zhu","year":"2020","unstructured":"Zhu J, Feng B, Xu Y, Chen W, Sheng X, Feng X, Shi X, Liu J, Pan Q, Yu J, Li L and Cao H. Mesenchymal stem cells alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of Ly6C+ CD8+ T cells. Cell Death Dis 2020; 11: 829.","journal-title":"Cell Death Dis"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"334","DOI":"10.21037\/atm.2020.02.105","article-title":"Mesenchymal stromal cells ameliorate acute lung injury induced by LPS mainly through stanniocalcin-2 mediating macrophage polarization","volume":"8","author":"Lv","year":"2020","unstructured":"Lv H, Liu Q, Sun Y, Yi X, Wei X, Liu W, Zhang Q, Yi H and Chen G. Mesenchymal stromal cells ameliorate acute lung injury induced by LPS mainly through stanniocalcin-2 mediating macrophage polarization. Ann Transl Med 2020; 8: 334.","journal-title":"Ann Transl Med"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/s13287-021-02328-3","article-title":"Heat shock preconditioning mesenchymal stem cells attenuate acute lung injury via reducing NLRP3 inflammasome activation in macrophages","volume":"12","author":"Lv","year":"2021","unstructured":"Lv H, Yuan X, Zhang J, Lu T, Yao J, Zheng J, Cai J, Xiao J, Chen H, Xie S, Ruan Y, An Y, Sui X and Yi H. Heat shock preconditioning mesenchymal stem cells attenuate acute lung injury via reducing NLRP3 inflammasome activation in macrophages. Stem Cell Res Ther 2021; 12: 290.","journal-title":"Stem Cell Res Ther"},{"key":"ref52","unstructured":"Xie KJ, Dong MY and Bai JX. Recent research on the mechanism of mesenchymal stem cells in the treatment of bronchopulmonary dysplasia. Zhongguo Dang Dai Er Ke Za Zhi 2022; 24: 108-114."},{"key":"ref53","unstructured":"Silva JD, Su Y, Calfee CS, Delucchi KL, Weiss D, McAuley DF, O&#x2019;Kane C and Krasnodembskaya AD. MSC extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS. Eur Respir J 2020."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"2004216","DOI":"10.1183\/13993003.04216-2020","article-title":"Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury","volume":"59","author":"Dos Santos","year":"2022","unstructured":"Dos Santos CC, Amatullah H, Vaswani CM, Maron-Gutierrez T, Kim M, Mei SHJ, Szaszi K, Monteiro APT, Varkouhi AK, Herreroz R, Lorente JA, Tsoporis JN, Gupta S, Ektesabi A, Kavantzas N, Salpeas V, Marshall JC, Rocco PRM, Marsden PA, Weiss DJ, Stewart DJ, Hu P and Liles WC. Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury. Eur Respir J 2022; 59: 2004216.","journal-title":"Eur Respir J"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"684197","DOI":"10.3389\/fimmu.2021.684197","article-title":"Mesenchymal stem cell protects injured renal tubular epithelial cells by regulating mTOR-Mediated Th17\/Treg axis","volume":"12","author":"Luo","year":"2021","unstructured":"Luo Y, Guo J, Zhang P, Cheuk YC, Jiang Y, Wang J, Xu S and Rong R. Mesenchymal stem cell protects injured renal tubular epithelial cells by regulating mTOR-Mediated Th17\/Treg axis. Front Immunol 2021; 12: 684197.","journal-title":"Front Immunol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s13287-022-03075-9","article-title":"Exosome from indoleamine 2,3-dioxygenase-overexpressing bone marrow mesenchymal stem cells accelerates repair process of ischemia\/reperfusion-induced acute kidney injury by regulating macrophages polarization","volume":"13","author":"Xie","year":"2022","unstructured":"Xie X, Yang X, Wu J, Tang S, Yang L, Fei X and Wang M. Exosome from indoleamine 2,3-dioxygenase-overexpressing bone marrow mesenchymal stem cells accelerates repair process of ischemia\/reperfusion-induced acute kidney injury by regulating macrophages polarization. Stem Cell Res Ther 2022; 13: 367.","journal-title":"Stem Cell Res Ther"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"Zhao Y, Zhu XY, Song T, Zhang L, Eirin A, Conley S, Tang H, Saadiq I, Jordan K, Lerman A and Lerman LO. Mesenchymal stem cells protect renal tubular cells via TSG-6 regulating macrophage function and phenotype switching. Am J Physiol Renal Physiol 2021; 320: F454-F463.","DOI":"10.1152\/ajprenal.00426.2020"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1097\/shk.0000000000002191","article-title":"Treatment with human umbilical cord-derived mesenchymal stem cells in a pig model of Sepsis-induced acute kidney injury: effects on microvascular endothelial cells and tubular cells in the kidney","volume":"60","author":"Ramos Maia","year":"2023","unstructured":"Ramos Maia DR, Otsuki DA, Rodrigues CE, Zboril S, Sanches TR, Neto AND, Andrade L and Auler JOC Jr. Treatment with human umbilical cord-derived mesenchymal stem cells in a pig model of Sepsis-induced acute kidney injury: effects on microvascular endothelial cells and tubular cells in the kidney. Shock 2023; 60: 469-477.","journal-title":"Shock"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/CM9.0000000000000720","article-title":"Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-&#x3B2;1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro","volume":"133","author":"He","year":"2020","unstructured":"He J, Jiang YL, Wang Y, Tian XJ and Sun SR. Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-&#x3B2;1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro. Chin Med J (Engl) 2020; 133: 800-807.","journal-title":"Chin Med J (Engl)"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"13562","DOI":"10.3390\/ijms222413562","article-title":"Human MSC-derived exosomes reduce cellular senescence in renal epithelial cells","volume":"22","author":"Liao","year":"2021","unstructured":"Liao CM, Luo T, von der Ohe J, de Juan Mora B, Schmitt R and Hass R. Human MSC-derived exosomes reduce cellular senescence in renal epithelial cells. Int J Mol Sci 2021; 22: 13562.","journal-title":"Int J Mol Sci"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2177082","DOI":"10.1080\/0886022X.2023.2177082","article-title":"Bone marrow mesenchymal stem cell-derived exosomal miR-30e-5p ameliorates high-glucose induced renal proximal tubular cell pyroptosis by inhibiting ELAVL1","volume":"45","author":"Lv","year":"2023","unstructured":"Lv J, Hao YN, Wang XP, Lu WH, Xie LY and Niu D. Bone marrow mesenchymal stem cell-derived exosomal miR-30e-5p ameliorates high-glucose induced renal proximal tubular cell pyroptosis by inhibiting ELAVL1. Ren Fail 2023; 45: 2177082.","journal-title":"Ren Fail"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.bj.2021.07.009","article-title":"Bone marrow-derived mesenchymal stem cells transplantation ameliorates renal injury through anti-fibrotic and anti-inflammatory effects in chronic experimental renovascular disease","volume":"45","author":"Almeida","year":"2022","unstructured":"Almeida A, Lira R, Oliveira M, Martins M, Azevedo Y, Silva KR, Carvalho S, Cortez E, Stumbo AC, Carvalho L and Thole A. Bone marrow-derived mesenchymal stem cells transplantation ameliorates renal injury through anti-fibrotic and anti-inflammatory effects in chronic experimental renovascular disease. Biomed J 2022; 45: 629-641","journal-title":"Biomed J"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"3847171","DOI":"10.1155\/2020\/3847171","article-title":"Mouse umbilical cord mesenchymal stem cell paracrine alleviates renal fibrosis in diabetic nephropathy by reducing myofibroblast transdifferentiation and cell proliferation and upregulating MMPs in mesangial cells","volume":"2020","author":"Li","year":"2020","unstructured":"Li H, Rong P, Ma X, Nie W, Chen Y, Zhang J, Dong Q, Yang M and Wang W. Mouse umbilical cord mesenchymal stem cell paracrine alleviates renal fibrosis in diabetic nephropathy by reducing myofibroblast transdifferentiation and cell proliferation and upregulating MMPs in mesangial cells. J Diabetes Res 2020; 2020: 3847171.","journal-title":"J Diabetes Res"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.ymthe.2021.10.012","article-title":"Bone marrow mesenchymal stem cell-derived exosomal miR-34c-5p ameliorates RIF by inhibiting the core fucosylation of multiple proteins","volume":"30","author":"Hu","year":"2022","unstructured":"Hu X, Shen N, Liu A, Wang W, Zhang L, Sui Z, Tang Q, Du X, Yang N, Ying W, Qin B, Li Z, Li L, Wang N and Lin H. Bone marrow mesenchymal stem cell-derived exosomal miR-34c-5p ameliorates RIF by inhibiting the core fucosylation of multiple proteins. Mol Ther 2022; 30: 763-781.","journal-title":"Mol Ther"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13287-021-02148-5","article-title":"Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p\/145-5p-mediated NGF\/TrkA signaling pathway in rats","volume":"12","author":"Wang","year":"2021","unstructured":"Wang Y, Lai X, Wu D, Liu B, Wang N and Rong L. Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p\/145-5p-mediated NGF\/TrkA signaling pathway in rats. Stem Cell Res Ther 2021; 12: 117.","journal-title":"Stem Cell Res Ther"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"120448","DOI":"10.1016\/j.biomaterials.2020.120448","article-title":"MSC spheroids-loaded collagen hydrogels simultaneously promote neuronal differentiation and suppress inflammatory reaction through PI3K-Akt signaling pathway","volume":"265","author":"He","year":"2021","unstructured":"He J, Zhang N, Zhu Y, Jin R and Wu F. MSC spheroids-loaded collagen hydrogels simultaneously promote neuronal differentiation and suppress inflammatory reaction through PI3K-Akt signaling pathway. Biomaterials 2021; 265: 120448.","journal-title":"Biomaterials"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1038\/s41598-021-81039-4","article-title":"Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation","volume":"11","author":"Giunti","year":"2021","unstructured":"Giunti D, Marini C, Parodi B, Usai C, Milanese M, Bonanno G, Kerlero de Rosbo N and Uccelli A. Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation. Sci Rep 2021; 11: 1740.","journal-title":"Sci Rep"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"10268","DOI":"10.1111\/jcmm.16965","article-title":"MSC derived EV loaded with miRNA-22 inhibits the inflammatory response and nerve function recovery after spinal cord injury in rats","volume":"25","author":"Sheng","year":"2021","unstructured":"Sheng Y, Zhou X, Wang J, Shen H, Wu S, Guo W and Yang Y. MSC derived EV loaded with miRNA-22 inhibits the inflammatory response and nerve function recovery after spinal cord injury in rats. J Cell Mol Med 2021; 25: 10268-10278.","journal-title":"J Cell Mol Med"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00125-019-05043-0","article-title":"Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes","volume":"63","author":"Fan","year":"2020","unstructured":"Fan B, Li C, Szalad A, Wang L, Pan W, Zhang R, Chopp M, Zhang ZG and Liu XS. Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes. Diabetologia 2020; 63: 431-443","journal-title":"Diabetologia"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.brainresbull.2021.02.015","article-title":"Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5","volume":"170","author":"Chang","year":"2021","unstructured":"Chang Q, Hao Y, Wang Y, Zhou Y, Zhuo H and Zhao G. Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5. Brain Res Bull 2021; 170: 199-210.","journal-title":"Brain Res Bull"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13075-020-2146-x","article-title":"Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization","volume":"22","author":"Li","year":"2020","unstructured":"Li R, Zhao K, Ruan Q, Meng C and Yin F. Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization. Arthritis Res Ther 2020; 22: 75.","journal-title":"Arthritis Res Ther"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"4805040","DOI":"10.1155\/2021\/4805040","article-title":"OM-MSCs alleviate the Golgi Apparatus Stress response following Cerebral Ischemia\/Reperfusion Injury via the PEDF-PI3K\/Akt\/mTOR signaling pathway","volume":"2021","author":"He","year":"2021","unstructured":"He J, Liu J, Huang Y, Tang X, Xiao H, Liu Z, Jiang Z, Zeng L, Hu Z and Lu M. OM-MSCs alleviate the Golgi Apparatus Stress response following Cerebral Ischemia\/Reperfusion Injury via the PEDF-PI3K\/Akt\/mTOR signaling pathway. Oxid Med Cell Longev 2021; 2021: 4805040.","journal-title":"Oxid Med Cell Longev"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s10735-020-09950-0","article-title":"Exosomes with high level of miR-181c from bone marrow-derived mesenchymal stem cells inhibit inflammation and apoptosis to alleviate spinal cord injury","volume":"52","author":"Zhang","year":"2021","unstructured":"Zhang M, Wang L, Huang S and He X. Exosomes with high level of miR-181c from bone marrow-derived mesenchymal stem cells inhibit inflammation and apoptosis to alleviate spinal cord injury. J Mol Histol 2021; 52: 301-311.","journal-title":"J Mol Histol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.neuroscience.2019.10.043","article-title":"Exosomes derived from miR-126-modified MSCs promote angiogenesis and neurogenesis and attenuate apoptosis after spinal cord injury in rats","volume":"424","author":"Huang","year":"2020","unstructured":"Huang JH, Xu Y, Yin XM and Lin FY. Exosomes derived from miR-126-modified MSCs promote angiogenesis and neurogenesis and attenuate apoptosis after spinal cord injury in rats. Neuroscience 2020; 424: 133-145.","journal-title":"Neuroscience"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1186\/s13287-022-03050-4","article-title":"The potential use of mesenchymal stem cells and their exosomes in Parkinson&#x2019;s disease treatment","volume":"13","author":"Heris","year":"2022","unstructured":"Heris RM, Shirvaliloo M, Abbaspour-Aghdam S, Hazrati A, Shariati A, Youshanlouei HR, Niaragh FJ, Valizadeh H and Ahmadi M. The potential use of mesenchymal stem cells and their exosomes in Parkinson&#x2019;s disease treatment. Stem Cell Res Ther 2022; 13: 371.","journal-title":"Stem Cell Res Ther"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"10811","DOI":"10.1021\/acsnano.2c02898","article-title":"Stimulation by exosomes from hypoxia preconditioned human umbilical vein endothelial cells facilitates mesenchymal stem cells angiogenic function for spinal cord repair","volume":"16","author":"Li","year":"2022","unstructured":"Li L, Mu J, Zhang Y, Zhang C, Ma T, Chen L, Huang T, Wu J, Cao J, Feng S, Cai Y, Han M and Gao J. Stimulation by exosomes from hypoxia preconditioned human umbilical vein endothelial cells facilitates mesenchymal stem cells angiogenic function for spinal cord repair. ACS Nano 2022; 16: 10811-10823.","journal-title":"ACS Nano"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s13287-019-1332-8","article-title":"Exosomes derived from mesenchymal stem cells reverse EMT via TGF-&#x3B2;1\/Smad pathway and promote repair of damaged endometrium","volume":"10","author":"Yao","year":"2019","unstructured":"Yao Y, Chen R, Wang G, Zhang Y and Liu F. Exosomes derived from mesenchymal stem cells reverse EMT via TGF-&#x3B2;1\/Smad pathway and promote repair of damaged endometrium. Stem Cell Res Ther 2019; 10: 225.","journal-title":"Stem Cell Res Ther"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12958-022-00988-1","article-title":"Bone marrow mesenchymal stem cells combined with estrogen synergistically promote endometrial regeneration and reverse EMT via Wnt\/&#x3B2;-catenin signaling pathway","volume":"20","author":"Yuan","year":"2022","unstructured":"Yuan L, Cao J, Hu M, Xu D, Li Y, Zhao S, Yuan J, Zhang H, Huang Y, Jin H, Chen M and Liu D. Bone marrow mesenchymal stem cells combined with estrogen synergistically promote endometrial regeneration and reverse EMT via Wnt\/&#x3B2;-catenin signaling pathway. Reprod Biol Endocrinol 2022; 20: 121.","journal-title":"Reprod Biol Endocrinol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.placenta.2022.11.013","article-title":"Exosomal miR-543 derived from umbilical cord mesenchymal stem cells ameliorates endometrial fibrosis in intrauterine adhesion via downregulating N-cadherin","volume":"131","author":"Yuan","year":"2023","unstructured":"Yuan D, Guo T, Qian H, Jin C, Ge H, Zhao Y, Zhu D, Lin M, Wang H and Yu H. Exosomal miR-543 derived from umbilical cord mesenchymal stem cells ameliorates endometrial fibrosis in intrauterine adhesion via downregulating N-cadherin. Placenta 2023; 131: 75-81.","journal-title":"Placenta"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.rbmo.2022.05.018","article-title":"Umbilical cord mesenchymal stem cell-derived exosomes reverse endometrial fibrosis by the miR-145-5p\/ZEB2 axis in intrauterine adhesions","volume":"46","author":"Li","year":"2023","unstructured":"Li X, Duan H, Wang S and Lv CX. Umbilical cord mesenchymal stem cell-derived exosomes reverse endometrial fibrosis by the miR-145-5p\/ZEB2 axis in intrauterine adhesions. Reprod Biomed Online 2023; 46: 234-243.","journal-title":"Reprod Biomed Online"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1186\/s13287-022-02990-1","article-title":"Human umbilical cord blood-derived MSCs trans-differentiate into endometrial cells and regulate Th17\/Treg balance through NF-&#x3BA;B signaling in rabbit intrauterine adhesions endometrium","volume":"13","author":"Hua","year":"2022","unstructured":"Hua Q, Zhang Y, Li H, Li H, Jin R, Li L, Xiang Y, Tian M, Wang J, Sun L and Wang Y. Human umbilical cord blood-derived MSCs trans-differentiate into endometrial cells and regulate Th17\/Treg balance through NF-&#x3BA;B signaling in rabbit intrauterine adhesions endometrium. Stem Cell Res Ther 2022; 13: 301.","journal-title":"Stem Cell Res Ther"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"945234","DOI":"10.3389\/fimmu.2022.945234","article-title":"Tumor necrosis factor-&#x3B1;-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarization via Galectin-1 and modify intrauterine adhesion on a novel murine model","volume":"13","author":"Li","year":"2022","unstructured":"Li J, Pan Y, Yang J, Wang J, Jiang Q, Dou H and Hou Y. Tumor necrosis factor-&#x3B1;-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarization via Galectin-1 and modify intrauterine adhesion on a novel murine model. Front Immunol 2022; 13: 945234.","journal-title":"Front Immunol"},{"key":"ref83","doi-asserted-by":"publisher","unstructured":"Qin W, Wang J, Hu Q, Qin R, Ma N, Zheng F, Tian W, Jiang J, Li T and Jin Y. Melatonin-pretreated HucMSCs improved endometrium regeneration and fertility recovery through macrophage immunomodulation in rats with intrauterine adhesions. Biol Reprod 2023; ioad102-ioad102.","DOI":"10.1093\/biolre\/ioad102"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.actbio.2020.06.029","article-title":"A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation","volume":"113","author":"Xin","year":"2020","unstructured":"Xin L, Lin X, Zhou F, Li C, Wang X, Yu H, Pan Y, Fei H, Ma L and Zhang S. A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation. Acta Biomater 2020; 113: 252-266.","journal-title":"Acta Biomater"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s13287-015-0240-9","article-title":"The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy","volume":"6","author":"Zhang","year":"2015","unstructured":"Zhang J, Huang X, Wang H, Liu X, Zhang T, Wang Y and Hu D. The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy. Stem Cell Res Ther 2015; 6: 234.","journal-title":"Stem Cell Res Ther"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s13287-018-0904-3","article-title":"Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial","volume":"9","author":"Cao","year":"2018","unstructured":"Cao Y, Sun H, Zhu H, Zhu X, Tang X, Yan G, Wang J, Bai D, Wang J, Wang L, Zhou Q, Wang H, Dai C, Ding L, Xu B, Zhou Y, Hao J, Dai J and Hu Y. Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. Stem Cell Res Ther 2018; 9: 192.","journal-title":"Stem Cell Res Ther"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1093\/humrep\/dew042","article-title":"Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman&#x2019;s syndrome and endometrial atrophy: a pilot cohort study","volume":"31","author":"Santamaria","year":"2016","unstructured":"Santamaria X, Cabanillas S, Cervell&#xF3; I, Arbona C, Raga F, Ferro J, Palmero J, Remoh&#xED; J, Pellicer A and Sim&#xF3;n C. Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman&#x2019;s syndrome and endometrial atrophy: a pilot cohort study. Hum Reprod 2016; 31: 1087-1096.","journal-title":"Hum Reprod"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/s41419-022-05264-z","article-title":"Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis","volume":"13","author":"Pan","year":"2022","unstructured":"Pan Y, Li J, Wang J, Jiang Q, Yang J, Dou H, Liang H, Li K and Hou Y. Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis. Cell Death Dis 2022; 13: 825.","journal-title":"Cell Death Dis"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1177\/03635465231179223","article-title":"Clinical efficacy and safety of the intra-articular injection of autologous adipose-derived mesenchymal stem cells for knee osteoarthritis: a phase iii, randomized, double-blind, placebo-controlled trial","volume":"51","author":"Kim","year":"2023","unstructured":"Kim KI, Lee MC, Lee JH, Moon YW, Lee WS, Lee HJ, Hwang SC, In Y, Shon OJ, Bae KC, Song SJ, Park KK and Kim JH. Clinical efficacy and safety of the intra-articular injection of autologous adipose-derived mesenchymal stem cells for knee osteoarthritis: a phase iii, randomized, double-blind, placebo-controlled trial. Am J Sports Med 2023; 51: 2243-2253.","journal-title":"Am J Sports Med"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.ijcard.2016.02.016","article-title":"Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and impaired left ventricular function: results of the MESAMI 1 pilot trial","volume":"209","author":"Guijarro","year":"2016","unstructured":"Guijarro D, Lebrin M, Lairez O, Bourin P, Piriou N, Pozzo J, Lande G, Berry M, Le Tourneau T, Cussac D, Sensebe L, Gross F, Lamirault G, Huynh A, Manrique A, Ruidavet JB, Elbaz M, Trochu JN, Parini A, Kramer S, Galinier M, Lemarchand P and Roncalli J. Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and impaired left ventricular function: results of the MESAMI 1 pilot trial. Int J Cardiol 2016; 209: 258-265.","journal-title":"Int J Cardiol"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13287-022-02900-5","article-title":"Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot study","volume":"13","author":"Zhu","year":"2022","unstructured":"Zhu YG, Shi MM, Monsel A, Dai CX, Dong X, Shen H, Li SK, Chang J, Xu CL, Li P, Wang J, Shen MP, Ren CJ, Chen DC and Qu JM. Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot study. Stem Cell Res Ther 2022; 13: 220.","journal-title":"Stem Cell Res Ther"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"120718","DOI":"10.1016\/j.biomaterials.2021.120718","article-title":"Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2\/Acvr2b competitive receptor-activated Smad pathway","volume":"272","author":"Liu","year":"2021","unstructured":"Liu A, Lin D, Zhao H, Chen L, Cai B, Lin K and Shen SG. Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2\/Acvr2b competitive receptor-activated Smad pathway. Biomaterials 2021; 272: 120718.","journal-title":"Biomaterials"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"18472","DOI":"10.1021\/acsami.0c22671","article-title":"Umbilical mesenchymal stem cell-derived exosome-encapsulated hydrogels accelerate bone repair by enhancing angiogenesis","volume":"13","author":"Zhang","year":"2021","unstructured":"Zhang Y, Xie Y, Hao Z, Zhou P, Wang P, Fang S, Li L, Xu S and Xia Y. Umbilical mesenchymal stem cell-derived exosome-encapsulated hydrogels accelerate bone repair by enhancing angiogenesis. ACS Appl Mater Interfaces 2021; 13: 18472-18487.","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.actbio.2022.07.015","article-title":"Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p\/EFNA3\/PI3K pathway","volume":"150","author":"Zhuang","year":"2022","unstructured":"Zhuang Y, Cheng M, Li M, Cui J, Huang J, Zhang C, Si J, Lin K and Yu H. Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p\/EFNA3\/PI3K pathway. Acta Biomater 2022; 150: 413-426.","journal-title":"Acta Biomater"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00441-022-03673-2","article-title":"MicroRNA-196a-5p overexpression in Wharton&#x2019;s jelly umbilical cord stem cells promotes their osteogenic differentiation and new bone formation in bone defects in the rat calvarium","volume":"390","author":"Wang","year":"2022","unstructured":"Wang Y, Zhang S, Yang H, Cao Y, Yu D, Zhao Y and Cao Y. MicroRNA-196a-5p overexpression in Wharton&#x2019;s jelly umbilical cord stem cells promotes their osteogenic differentiation and new bone formation in bone defects in the rat calvarium. Cell Tissue Res 2022; 390: 245-260.","journal-title":"Cell Tissue Res"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"4517","DOI":"10.1080\/21655979.2022.2033465","article-title":"Exosomes from miR-374a-5p-modified mesenchymal stem cells inhibit the progression of renal fibrosis by regulating MAPK6\/MK5\/YAP axis","volume":"13","author":"Liang","year":"2022","unstructured":"Liang M, Zhang D, Zheng D, He W and Jin J. Exosomes from miR-374a-5p-modified mesenchymal stem cells inhibit the progression of renal fibrosis by regulating MAPK6\/MK5\/YAP axis. Bioengineered 2022; 13: 4517-4527.","journal-title":"Bioengineered"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/s41374-019-0321-y","article-title":"Bone marrow mesenchymal stem cell-derived exosomal miR-144-5p improves rat ovarian function after chemotherapy-induced ovarian failure by targeting PTEN","volume":"100","author":"Yang","year":"2020","unstructured":"Yang M, Lin L, Sha C, Li T, Zhao D, Wei H, Chen Q, Liu Y, Chen X, Xu W, Li Y and Zhu X. Bone marrow mesenchymal stem cell-derived exosomal miR-144-5p improves rat ovarian function after chemotherapy-induced ovarian failure by targeting PTEN. Lab Invest 2020; 100: 342-352.","journal-title":"Lab Invest"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1186\/s13287-019-1442-3","article-title":"miR-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis","volume":"10","author":"Sun","year":"2019","unstructured":"Sun B, Ma Y, Wang F, Hu L and Sun Y. miR-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis. Stem Cell Res Ther 2019; 10: 360.","journal-title":"Stem Cell Res Ther"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/cvr\/cvz040","article-title":"Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization","volume":"115","author":"Zhao","year":"2019","unstructured":"Zhao J, Li X, Hu J, Chen F, Qiao S, Sun X, Gao L, Xie J and Xu B. Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization. Cardiovasc Res 2019; 115: 1205-1216.","journal-title":"Cardiovasc Res"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"888949","DOI":"10.3389\/fimmu.2022.888949","article-title":"MSC-derived small extracellular vesicles attenuate autoimmune dacryoadenitis by promoting M2 macrophage polarization and inducing tregs via miR-100-5p","volume":"13","author":"Li","year":"2022","unstructured":"Li N, Gao Z, Zhao L, Du B, Ma B, Nian H and Wei R. MSC-derived small extracellular vesicles attenuate autoimmune dacryoadenitis by promoting M2 macrophage polarization and inducing tregs via miR-100-5p. Front Immunol 2022; 13: 888949.","journal-title":"Front Immunol"}],"container-title":["American Journal of Stem Cells"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajsc\/14\/2\/ajsc0164690.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:50:32Z","timestamp":1766022632000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajsc\/14\/2\/ajsc0164690.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":101,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/ygxa7976","relation":{},"ISSN":["2160-4150"],"issn-type":[{"value":"2160-4150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}