{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:03:31Z","timestamp":1766023411931,"version":"3.48.0"},"reference-count":57,"publisher":"e-Century Publishing Corporation","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Cancer Res"],"DOI":"10.62347\/zkzm8986","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T07:04:45Z","timestamp":1756451085000},"page":"3588-3602","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative red blood cell transfusion improves treatment response and survival in patients with locally advanced esophageal cancer and iron deficiency anemia"],"prefix":"10.62347","volume":"15","author":[{"given":"Jia","family":"Dai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1200\/JCO.20.03697","article-title":"Randomized study on dose escalation in definitive chemoradiation for patients with locally advanced esophageal cancer (ARTDECO Study)","volume":"39","author":"MCCM","year":"2021","unstructured":"Hulshof MCCM, Geijsen ED, Rozema T, Oppedijk V, Buijsen J, Neelis KJ, Nuyttens JJME, van der Sangen MJC, Jeene PM, Reinders JG, van Berge Henegouwen MI, Thano A, van Hooft JE, van Laarhoven HWM and van der Gaast A. Randomized study on dose escalation in definitive chemoradiation for patients with locally advanced esophageal cancer (ARTDECO Study). J Clin Oncol 2021; 39: 2816-2824.","journal-title":"J Clin Oncol"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0140-6736(24)00745-1","article-title":"Doublet chemotherapy, triplet chemotherapy, or doublet chemotherapy combined with radiotherapy as neoadjuvant treatment for locally advanced oesophageal cancer (JCOG1109 NExT): a randomised, controlled, open-label, phase 3 trial","volume":"404","author":"Kato","year":"2024","unstructured":"Kato K, Machida R, Ito Y, Daiko H, Ozawa S, Ogata T, Hara H, Kojima T, Abe T, Bamba T, Watanabe M, Kawakubo H, Shibuya Y, Tsubosa Y, Takegawa N, Kajiwara T, Baba H, Ueno M, Takeuchi H, Nakamura K and Kitagawa Y; JCOG1109 investigators. Doublet chemotherapy, triplet chemotherapy, or doublet chemotherapy combined with radiotherapy as neoadjuvant treatment for locally advanced oesophageal cancer (JCOG1109 NExT): a randomised, controlled, open-label, phase 3 trial. Lancet 2024; 404: 55-66.","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1051841","DOI":"10.3389\/fimmu.2022.1051841","article-title":"Neoadjuvant immunotherapy for resectable esophageal cancer: a review","volume":"13","author":"Li","year":"2022","unstructured":"Li Q, Liu T and Ding Z. Neoadjuvant immunotherapy for resectable esophageal cancer: a review. Front Immunol 2022; 13: 1051841.","journal-title":"Front Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.31729\/jnma.4299","article-title":"Management of locally advanced esophageal cancer","volume":"59","author":"Thakur","year":"2021","unstructured":"Thakur B, Devkota M and Chaudhary M. Management of locally advanced esophageal cancer. JNMA J Nepal Med Assoc 2021; 59: 409-416.","journal-title":"JNMA J Nepal Med Assoc"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s00595-019-01878-7","article-title":"Recent progress in multidisciplinary treatment for patients with esophageal cancer","volume":"50","author":"Watanabe","year":"2020","unstructured":"Watanabe M, Otake R, Kozuki R, Toihata T, Takahashi K, Okamura A and Imamura Y. Recent progress in multidisciplinary treatment for patients with esophageal cancer. Surg Today 2020; 50: 12-20.","journal-title":"Surg Today"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1001\/jamasurg.2021.2373","article-title":"Long-term efficacy of neoadjuvant chemoradiotherapy plus surgery for the treatment of locally advanced esophageal squamous cell carcinoma: the NEOCRTEC5010 randomized clinical trial","volume":"156","author":"Yang","year":"2021","unstructured":"Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M and Fu J. Long-term efficacy of neoadjuvant chemoradiotherapy plus surgery for the treatment of locally advanced esophageal squamous cell carcinoma: the NEOCRTEC5010 randomized clinical trial. JAMA Surg 2021; 156: 721-729.","journal-title":"JAMA Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s12032-023-02097-4","article-title":"Current neoadjuvant therapy for operable locally advanced esophageal cancer","volume":"40","author":"Yang","year":"2023","unstructured":"Yang W, Niu Y and Sun Y. Current neoadjuvant therapy for operable locally advanced esophageal cancer. Med Oncol 2023; 40: 252.","journal-title":"Med Oncol"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Nandakumar S, Singh N, Tharani AR, Pankiw M and Brezden-Masley C. Intravenous iron and iron deficiency anemia in patients with gastrointestinal cancer: a systematic review. PLoS One 2024; 19: e0302964.","DOI":"10.1371\/journal.pone.0302964"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Kaur T, Upadhyay J, Nandave M, Alsayari A, Alshehri SA, Pukale S, Wahab S, Ahmad W, Rashid S and Ansari MN. Exploring progress in iron supplement formulation approaches for treating iron deficiency anemia through bibliometric and thematic analysis. Heliyon 2024; 10: e29058.","DOI":"10.1016\/j.heliyon.2024.e29058"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"5192","DOI":"10.3390\/molecules27165192","article-title":"Targeting HIF-1&#x3B1; by natural and synthetic compounds: a promising approach for anti-cancer therapeutics development","volume":"27","author":"Ghosh","year":"2022","unstructured":"Ghosh R, Samanta P, Sarkar R, Biswas S, Saha P, Hajra S and Bhowmik A. Targeting HIF-1&#x3B1; by natural and synthetic compounds: a promising approach for anti-cancer therapeutics development. Molecules 2022; 27: 5192.","journal-title":"Molecules"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/s41392-022-01080-1","article-title":"Hypoxia signaling in human health and diseases: implications and prospects for therapeutics","volume":"7","author":"Luo","year":"2022","unstructured":"Luo Z, Tian M, Yang G, Tan Q, Chen Y, Li G, Zhang Q, Li Y, Wan P and Wu J. Hypoxia signaling in human health and diseases: implications and prospects for therapeutics. Signal Transduct Target Ther 2022; 7: 218.","journal-title":"Signal Transduct Target Ther"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"163","DOI":"10.21873\/cdp.10196","article-title":"Iron deficiency anemia in colorectal cancer patients: is preoperative intravenous iron infusion indicated? A narrative review of the literature","volume":"3","author":"Chardalias","year":"2023","unstructured":"Chardalias L, Papaconstantinou I, Gklavas A, Politou M and Theodosopoulos T. Iron deficiency anemia in colorectal cancer patients: is preoperative intravenous iron infusion indicated? A narrative review of the literature. Cancer Diagn Progn 2023; 3: 163-168.","journal-title":"Cancer Diagn Progn"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5604\/01.3001.0054.5124","article-title":"Current approach to the management of preoperative iron deficiency anemia in colorectal cancer patients: a review of literature","volume":"96","author":"Rudzki","year":"2024","unstructured":"Rudzki J, Polewka M, Agopsowicz P, Nowak A, Porada M and Czempik PF. Current approach to the management of preoperative iron deficiency anemia in colorectal cancer patients: a review of literature. Pol Przegl Chir 2024; 96: 67-74.","journal-title":"Pol Przegl Chir"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1080\/01635581.2019.1658794","article-title":"Iron deficiency and anemia in cancer patients: the role of iron treatment in anemic cancer patients","volume":"72","author":"Abiri","year":"2020","unstructured":"Abiri B and Vafa M. Iron deficiency and anemia in cancer patients: the role of iron treatment in anemic cancer patients. Nutr Cancer 2020; 72: 864-872.","journal-title":"Nutr Cancer"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"9689","DOI":"10.3390\/curroncol30110703","article-title":"Seven-year single-center experience of the efficacy and safety of ferric carboxymaltose in cancer patients with iron-deficiency anemia","volume":"30","author":"Akta&#x15F","year":"2023","unstructured":"Akta&#x15F; BY, Ata EB, &#xC7;e&#x15F;meci E, &#xC7;ak&#x131;r &#x130;Y, Co&#x15F;kunp&#x131;nar M, Tahillio&#x11F;lu Y, G&#xFC;ner G, G&#xFC;ven DC, Ar&#x131;k Z, Kertmen N, Dizdar &#xD6;, Yal&#xE7;&#x131;n &#x15E; and Aksoy S. Seven-year single-center experience of the efficacy and safety of ferric carboxymaltose in cancer patients with iron-deficiency anemia. Curr Oncol 2023; 30: 9689-9700.","journal-title":"Curr Oncol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"13699","DOI":"10.1038\/s41598-021-93155-2","article-title":"Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia","volume":"11","author":"Al-Hassi","year":"2021","unstructured":"Al-Hassi HO, Ng O, Evstatiev R, Mangalika M, Worton N, Jambrich M, Khare V, Phipps O, Keeler B, Gasche C, Acheson AG and Brookes MJ. Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia. Sci Rep 2021; 11: 13699.","journal-title":"Sci Rep"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.pop.2023.03.008","article-title":"Colorectal cancer screening and iron deficiency anemia","volume":"50","author":"Berg","year":"2023","unstructured":"Berg EP, Mohammed A, Shipp ZJ and Tenegra JC. Colorectal cancer screening and iron deficiency anemia. Prim Care 2023; 50: 481-491.","journal-title":"Prim Care"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Blonk L, Gooszen JAH, Fakkert RA, Eshuis WJ, Rietveld SCM, Wierdsma NJ, Straatman J, van Berge Henegouwen MI and Gisbertz SS. Micronutrient deficiencies and anemia in the follow-up after gastroesophageal cancer surgery. Dis Esophagus 2024; 37: doae053.","DOI":"10.1093\/dote\/doae053"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Kumar A, Sharma E, Marley A, Samaan MA and Brookes MJ. Iron deficiency anaemia: pathophysiology, assessment, practical management. BMJ Open Gastroenterol 2022; 9: e000759.","DOI":"10.1136\/bmjgast-2021-000759"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1002\/cam4.4761","article-title":"Iron imbalance in cancer: intersection of deficiency and overload","volume":"11","author":"Basak","year":"2022","unstructured":"Basak T and Kanwar RK. Iron imbalance in cancer: intersection of deficiency and overload. Cancer Med 2022; 11: 3837-3853.","journal-title":"Cancer Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1186\/s12885-022-09542-z","article-title":"Underdiagnosis of iron deficiency anemia among patients with colorectal cancer: an examination of electronic medical records","volume":"22","author":"Bhurosy","year":"2022","unstructured":"Bhurosy T, Jishan A, Boland PM, Lee YH and Heckman CJ. Underdiagnosis of iron deficiency anemia among patients with colorectal cancer: an examination of electronic medical records. BMC Cancer 2022; 22: 435.","journal-title":"BMC Cancer"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.3390\/medicina58091202","article-title":"Absolute and functional iron deficiency in colon cancer: a cohort study","volume":"58","author":"F&#x103","year":"2022","unstructured":"F&#x103;g&#x103;r&#x103;&#x219;an V, Andra&#x219; D, Amarinei G, Seicean RI, Bin&#x21B;in&#x21B;an VV, Dindelegan GC and C&#x103;inap CI. Absolute and functional iron deficiency in colon cancer: a cohort study. Medicina (Kaunas) 2022; 58: 1202.","journal-title":"Medicina (Kaunas)"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s44313-024-00030-w","article-title":"Functional iron deficiency anemia in patients with cancer","volume":"59","author":"Koh","year":"2024","unstructured":"Koh JS and Song IC. Functional iron deficiency anemia in patients with cancer. Blood Res 2024; 59: 26.","journal-title":"Blood Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00432-023-05534-z","article-title":"Association between iron deficiency anemia and subsequent stomach and colorectal cancer diagnosis in Germany","volume":"150","author":"Krieg","year":"2024","unstructured":"Krieg S, Loosen S, Krieg A, Luedde T, Roderburg C and Kostev K. Association between iron deficiency anemia and subsequent stomach and colorectal cancer diagnosis in Germany. J Cancer Res Clin Oncol 2024; 150: 53.","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1002\/kjm2.12533","article-title":"Iron-deficiency anemia caused by duodenal paraganglioma in an adolescent","volume":"38","author":"Lin","year":"2022","unstructured":"Lin PC, Shih HH, Chen YT and Chang YT. Iron-deficiency anemia caused by duodenal paraganglioma in an adolescent. Kaohsiung J Med Sci 2022; 38: 716-718.","journal-title":"Kaohsiung J Med Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"7722","DOI":"10.3390\/curroncol30080560","article-title":"Anemia, iron deficiency, and iron regulators in pancreatic ductal adenocarcinoma patients: a comprehensive analysis","volume":"30","author":"Osmola","year":"2023","unstructured":"Osmola M, Gierej B, Mleczko-Sanecka K, Jo&#x144;czy A, Ciepiela O, Kraj L, Ziarkiewicz-Wr&#xF3;blewska B and Basak GW. Anemia, iron deficiency, and iron regulators in pancreatic ductal adenocarcinoma patients: a comprehensive analysis. Curr Oncol 2023; 30: 7722-7739.","journal-title":"Curr Oncol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1186\/s13063-024-08624-6","article-title":"Intravenous versus oral iron supplementation for iron deficiency anemia in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy: a study protocol for a randomized controlled trial","volume":"25","author":"Park","year":"2024","unstructured":"Park HM, Lee J, Lee SY, Kim CH and Kim HR. Intravenous versus oral iron supplementation for iron deficiency anemia in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy: a study protocol for a randomized controlled trial. Trials 2024; 25: 771.","journal-title":"Trials"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1053\/j.gastro.2022.01.038","article-title":"Iron deficiency anemia and hematochezia are red flags for colorectal cancer in young patients","volume":"162","author":"Patel","year":"2022","unstructured":"Patel SG. Iron deficiency anemia and hematochezia are red flags for colorectal cancer in young patients. Gastroenterology 2022; 162: 2101-2102.","journal-title":"Gastroenterology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1093\/nutrit\/nuaa040","article-title":"Iron deficiency, immunology, and colorectal cancer","volume":"79","author":"Phipps","year":"2021","unstructured":"Phipps O, Brookes MJ and Al-Hassi HO. Iron deficiency, immunology, and colorectal cancer. Nutr Rev 2021; 79: 88-97.","journal-title":"Nutr Rev"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Talboom K, Borstlap WAA, Roodbeen SX, Bruns ERJ, Buskens CJ, Hompes R, Tytgat KMAJ, Tuynman JB, Consten ECJ, Heuff G, Kuiper T, van Geloven AAW, Veldhuis GJ, van der Hoeven JAB, Gerhards MF, Sietses C, Spinelli A, van de Ven AWH, van der Zaag ES, Westerterp M, van Westreenen HL, Dijkgraaf ML, Juffermans NP and Bemelman WA; FIT collaborative group. Ferric carboxymaltose infusion versus oral iron supplementation for preoperative iron deficiency anaemia in patients with colorectal cancer (FIT): a multicentre, open-label, randomised, controlled trial. Lancet Haematol 2023; 10: e250-e260.","DOI":"10.1016\/S2352-3026(22)00402-1"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"161","DOI":"10.14423\/SMJ.0000000000001226","article-title":"Esophageal cancer: an updated review","volume":"114","author":"DiSiena","year":"2021","unstructured":"DiSiena M, Perelman A, Birk J and Rezaizadeh H. Esophageal cancer: an updated review. South Med J 2021; 114: 161-168.","journal-title":"South Med J"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Iolascon A, Andolfo I, Russo R, Sanchez M, Busti F, Swinkels D, Aguilar Martinez P, Bou-Fakhredin R, Muckenthaler MU, Unal S, Porto G, Ganz T, Kattamis A, De Franceschi L, Cappellini MD, Munro MG and Taher A; from EHA-SWG Red Cell and Iron. Recommendations for diagnosis, treatment, and prevention of iron deficiency and iron deficiency anemia. Hemasphere 2024; 8: e108.","DOI":"10.1002\/hem3.108"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12885-023-10579-x","article-title":"Pre-operative anemia and peri-operative transfusion are associated with poor oncologic outcomes in cancers of the esophagus: potential impact of patient blood management on cancer outcomes","volume":"23","author":"Connor","year":"2023","unstructured":"Connor JP, Destrampe E, Robbins D, Hess AS, McCarthy D and Maloney J. Pre-operative anemia and peri-operative transfusion are associated with poor oncologic outcomes in cancers of the esophagus: potential impact of patient blood management on cancer outcomes. BMC Cancer 2023; 23: 99.","journal-title":"BMC Cancer"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ad.2019.05.009","article-title":"0) to evaluate the severity of adverse events of anticancer therapies","volume":"112","author":"Freites-Martinez","year":"2021","unstructured":"Freites-Martinez A, Santana N, Arias-Santiago S and Viera A. Using the common terminology criteria for adverse events (CTCAE - Version 5.0) to evaluate the severity of adverse events of anticancer therapies. Actas Dermosifiliogr (Engl Ed) 2021; 112: 90-92.","journal-title":"Actas Dermosifiliogr (Engl Ed)"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"1)","volume":"45","author":"Eisenhauer","year":"2009","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D and Verweij J. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 2009; 45: 228-247.","journal-title":"Eur J Cancer"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"National Health Commission of The People&#x2019;s Republic of China. National guidelines for diagnosis and treatment of esophageal carcinoma 2022 in China (English version). Chin J Cancer Res 2022; 34: 309-334.","DOI":"10.21147\/j.issn.1000-9604.2022.04.01"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"&#xC7;obano&#x11F;lu B, Balsak A and Kandaz M. Effect of baseline hemoglobin level on prognosis in nasopharyngeal cancer patients receiving chemoradiotherapy. 2023. doi: 10.47191\/ijmscrs\/v3-i7-21.","DOI":"10.47191\/ijmscrs\/v3-i7-21"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.3390\/diagnostics14182073","article-title":"The significance of C-reactive protein value and tumor grading for malignant tumors: a systematic review","volume":"14","author":"&#x218","year":"2024","unstructured":"&#x218;iancu P, Oprinca GC, Vulcu AC, P&#x103;tran M, Croitoru AE, T&#x103;n&#x103;sescu D, Bratu D, Boicean A and T&#x103;n&#x103;sescu C. The significance of C-reactive protein value and tumor grading for malignant tumors: a systematic review. Diagnostics (Basel) 2024; 14: 2073.","journal-title":"Diagnostics (Basel)"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"900","DOI":"10.3389\/fimmu.2017.00900","article-title":"Invariant natural killer t cells as suppressors of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation","volume":"8","author":"Mavers","year":"2017","unstructured":"Mavers M, Maas-Bauer K and Negrin RS. Invariant natural killer t cells as suppressors of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. Front Immunol 2017; 8: 900.","journal-title":"Front Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3390\/cancers15020376","article-title":"The tumor microenvironment in tumorigenesis and therapy resistance revisited","volume":"15","author":"Dzobo","year":"2023","unstructured":"Dzobo K, Senthebane DA and Dandara C. The tumor microenvironment in tumorigenesis and therapy resistance revisited. Cancers (Basel) 2023; 15: 376.","journal-title":"Cancers (Basel)"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Bayat M and Nahand JS. Battlegrounds of treatment resistance: decoding the tumor microenvironment. Naunyn Schmiedebergs Arch Pharmacol 2025; [Epub ahead of print].","DOI":"10.1007\/s00210-025-04055-5"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"113068","DOI":"10.1016\/j.biopha.2022.113068","article-title":"Hypoxia, a key factor in the immune microenvironment","volume":"151","author":"Hu","year":"2022","unstructured":"Hu J, Li X, Yang L and Li H. Hypoxia, a key factor in the immune microenvironment. Biomed Pharmacother 2022; 151: 113068.","journal-title":"Biomed Pharmacother"},{"key":"ref42","unstructured":"Ramli NA, Iberahim S, Che Ismail AA and Hussin H. Incidence of anemia and red blood cell (RBC) transfusion requirement in breast cancer. Caspian J Intern Med 2023; 14: 237-248."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1007\/s00595-020-02192-3","article-title":"Red blood cell transfusions and the survival in patients with cancer undergoing curative surgery: a systematic review and meta-analysis","volume":"51","author":"Petrelli","year":"2021","unstructured":"Petrelli F, Ghidini M, Ghidini A, Sgroi G, Vavassori I, Petr&#xF2; D, Cabiddu M, Aiolfi A, Bonitta G, Zaniboni A and Rausa E. Red blood cell transfusions and the survival in patients with cancer undergoing curative surgery: a systematic review and meta-analysis. Surg Today 2021; 51: 1535-1557.","journal-title":"Surg Today"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Zheng Y, Zhang W, Chen Y, Yang X and Dong R. Impact of perioperative red blood cell transfusion on the prognosis of patients with epithelial ovarian cancer. Heliyon 2023; 9: e23081.","DOI":"10.1016\/j.heliyon.2023.e23081"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1007\/s12013-024-01386-7","article-title":"The importance of hypoxia-related to hemoglobin concentration in breast cancer","volume":"82","author":"Chen","year":"2024","unstructured":"Chen X, Zhou H and Lv J. The importance of hypoxia-related to hemoglobin concentration in breast cancer. Cell Biochem Biophys 2024; 82: 1893-1906.","journal-title":"Cell Biochem Biophys"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s40104-024-01068-7","article-title":"The influence of iron nutrition on the development of intestine and immune cell divergency in neonatal pigs","volume":"15","author":"Liu","year":"2024","unstructured":"Liu Y, Wu A, Yu B, He J, Yu J, Mao X, Zheng P, Luo Y, Luo J, Pu J, Yan H and Chen D. The influence of iron nutrition on the development of intestine and immune cell divergency in neonatal pigs. J Anim Sci Biotechnol 2024; 15: 111.","journal-title":"J Anim Sci Biotechnol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/s41590-024-01816-x","article-title":"A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron","volume":"25","author":"Sharma","year":"2024","unstructured":"Sharma G, Sharma A, Kim I, Cha DG, Kim S, Park ES, Noh JG, Lee J, Ku JH, Choi YH, Kong J, Lee H, Ko H, Lee J, Notaro A, Hong SH, Rhee JH, Kim SG, De Castro C, Molinaro A, Shin K, Kim S, Kim JK, Rudra D and Im SH. A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron. Nat Immunol 2024; 25: 790-801.","journal-title":"Nat Immunol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1186\/s12967-025-06291-y","article-title":"New insights on anti-tumor immunity of CD8(+) T cells: cancer stem cells, tumor immune microenvironment and immunotherapy","volume":"23","author":"Lin","year":"2025","unstructured":"Lin Y, Song Y, Zhang Y, Li X, Kan L and Han S. New insights on anti-tumor immunity of CD8(+) T cells: cancer stem cells, tumor immune microenvironment and immunotherapy. J Transl Med 2025; 23: 341.","journal-title":"J Transl Med"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.htct.2020.03.003","article-title":"Implications of perioperative allogeneic red blood cell transfusion on the immune-inflammatory response","volume":"43","author":"Aguilar-Nascimento","year":"2021","unstructured":"Aguilar-Nascimento JE, Zampieri-Filho JP and Bordin JO. Implications of perioperative allogeneic red blood cell transfusion on the immune-inflammatory response. Hematol Transfus Cell Ther 2021; 43: 58-64.","journal-title":"Hematol Transfus Cell Ther"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1080\/17474086.2024.2375265","article-title":"Update on iron supplementation in patients with cancer-related anemia","volume":"17","author":"Rodgers","year":"2024","unstructured":"Rodgers GM. Update on iron supplementation in patients with cancer-related anemia. Expert Rev Hematol 2024; 17: 505-514.","journal-title":"Expert Rev Hematol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"976011","DOI":"10.3389\/fimmu.2022.976011","article-title":"Red blood cell transfusions impact response rates to immunotherapy in patients with solid malignant tumors","volume":"13","author":"Mispelbaum","year":"2022","unstructured":"Mispelbaum R, Hattenhauer ST, Brossart P and Heine A. Red blood cell transfusions impact response rates to immunotherapy in patients with solid malignant tumors. Front Immunol 2022; 13: 976011.","journal-title":"Front Immunol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1097\/CJI.0000000000000438","article-title":"Prognostic effect of the controlling nutritional status score in patients with esophageal cancer treated with immune checkpoint inhibitor","volume":"45","author":"Chang","year":"2022","unstructured":"Chang L, Cheng Q, Ma Y, Wu C, Zhang X, Ma Q, He L, Li Q and Tao J. Prognostic effect of the controlling nutritional status score in patients with esophageal cancer treated with immune checkpoint inhibitor. J Immunother 2022; 45: 415-422.","journal-title":"J Immunother"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"13","DOI":"10.21037\/jgo-21-784","article-title":"Combining the systemic inflammation response index and prognostic nutritional index to predict the prognosis of locally advanced elderly esophageal squamous cell carcinoma patients undergoing definitive radiotherapy","volume":"13","author":"Yan","year":"2022","unstructured":"Yan K, Wei W, Shen W, Du X, Zhu S, Zhao H, Wang X, Yang J, Zhang X and Deng W. Combining the systemic inflammation response index and prognostic nutritional index to predict the prognosis of locally advanced elderly esophageal squamous cell carcinoma patients undergoing definitive radiotherapy. J Gastrointest Oncol 2022; 13: 13-25.","journal-title":"J Gastrointest Oncol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"4156","DOI":"10.3390\/cancers16244156","article-title":"The impact of iron on cancer-related immune functions in oncology: molecular mechanisms and clinical evidence","volume":"16","author":"Badran","year":"2024","unstructured":"Badran O, Cohen I and Bar-Sela G. The impact of iron on cancer-related immune functions in oncology: molecular mechanisms and clinical evidence. Cancers (Basel) 2024; 16: 4156.","journal-title":"Cancers (Basel)"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.18632\/oncotarget.13679","article-title":"Hemoglobin level trajectories in the early treatment period are related with survival outcomes in patients with breast cancer","volume":"8","author":"Lee","year":"2017","unstructured":"Lee CL, Tsai CH, Yeh DC, Lin CS, Li YF and Tzeng HE. Hemoglobin level trajectories in the early treatment period are related with survival outcomes in patients with breast cancer. Oncotarget 2017; 8: 1569-1579.","journal-title":"Oncotarget"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"5173","DOI":"10.21873\/anticanres.16718","article-title":"Intraoperative blood loss impacts recurrence and survival in patients with locally advanced esophageal cancer","volume":"43","author":"Watanabe","year":"2023","unstructured":"Watanabe H, Kano K, Hashimoto I, Tanabe M, Onuma S, Morita J, Nagasawa S, Kanematsu K, Aoyama T, Yamada T, Ogata T, Rino Y, Saito A and Oshima T. Intraoperative blood loss impacts recurrence and survival in patients with locally advanced esophageal cancer. Anticancer Res 2023; 43: 5173-5179.","journal-title":"Anticancer Res"}],"container-title":["American Journal of Cancer Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/8\/ajcr0165106.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:58:31Z","timestamp":1766023111000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/8\/ajcr0165106.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":57,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/zkzm8986","relation":{},"ISSN":["2156-6976"],"issn-type":[{"type":"electronic","value":"2156-6976"}],"subject":[],"published":{"date-parts":[[2025]]}}}