{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:43:36Z","timestamp":1709253816688},"reference-count":0,"publisher":"Tunisian Society of Medical Sciences","issue":"2","license":[{"start":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T00:00:00Z","timestamp":1708214400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tunis Med"],"abstract":"<jats:p>Introduction-Objectif\u00a0: Les bl\u00e9pharites chroniques sont fr\u00e9quentes et d\u2019\u00e9tiologies diff\u00e9rentes.\nLe but de cette \u00e9tude est de d\u00e9terminer le r\u00f4le pathog\u00e8ne du Demodex dans la gen\u00e8se des bl\u00e9pharites chroniques, tout en analysant les particularit\u00e9s \u00e9pid\u00e9miologiques, cliniques, diagnostiques et th\u00e9rapeutiques.\n\u00a0\nM\u00e9thodes: Il s\u2019agit d\u2019une \u00e9tude prospective, cas-t\u00e9moins, r\u00e9alis\u00e9e au service de parasitologie mycologie au sein du CHU Habib Bourguiba de Sfax sur une p\u00e9riode de 12 mois portant sur 100 cas atteints de bl\u00e9pharite chronique et 87 cas t\u00e9moins.\nApr\u00e8s un interrogatoire minutieux, un examen clinique et un pr\u00e9l\u00e8vement des cils ont \u00e9t\u00e9 r\u00e9alis\u00e9s. Les cils ont \u00e9t\u00e9 soumis \u00e0 un examen direct pour une analyse qualitative et quantitative avant et apr\u00e8s traitement. Les cas de bl\u00e9pharites \u00e0 Demodex ont \u00e9t\u00e9 trait\u00e9s par une pommade ophtalmique d\u2019oxyde mercurique jaune.\n\u00a0\nR\u00e9sultats: Demodex a \u00e9t\u00e9 significativement plus fr\u00e9quents chez les malades que chez les t\u00e9moins (48% vs 13,8%). De m\u00eame, l\u2019analyse quantitative a montr\u00e9 une diff\u00e9rence significative entre les deux groupes avec 52,1% de Demodex (+++) pour les malades contre 8,3% pour les t\u00e9moins.\nLe taux de gu\u00e9rison \u00e9tait de 81,3%.\n\u00a0\nConclusion: Bien qu\u2019il soit admis \u00eatre un saprophyte de la peau, un grand nombre d\u2019arguments plaide pour l\u2019incrimination de Demodex dans l\u2019\u00e9tiopathog\u00e9nie des bl\u00e9pharites chroniques, d\u2019o\u00f9 l\u2019int\u00e9r\u00eat d\u2019un pr\u00e9l\u00e8vement des cils avec recherche parasitaire devant toute bl\u00e9pharite chronique r\u00e9sistante aux traitements usuels.\u00a0 En cas de recherche positive, un traitement sp\u00e9cifique devra \u00eatre instaur\u00e9, dont l\u2019efficacit\u00e9 est un argument de plus pour le diagnostic \u00e9tiologique.<\/jats:p>","DOI":"10.62438\/tunismed.v102i2.4449","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T13:51:27Z","timestamp":1709214687000},"source":"Crossref","is-referenced-by-count":0,"title":["Les bl\u00e9pharites chroniques \u00e0 Demodex \u00e0 Sfax (Tunisie): Etude prospective"],"prefix":"10.62438","volume":"102","author":[{"given":"Mohamed Slim","family":"Werda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Cheikhrouhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeineb","family":"Ben Zina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fattouma","family":"Makni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ayadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31112","published-online":{"date-parts":[[2024,2,18]]},"container-title":["La Tunisie M\u00e9dicale"],"original-title":[],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T13:51:27Z","timestamp":1709214687000},"score":1,"resource":{"primary":{"URL":"https:\/\/latunisiemedicale.com\/index.php\/tunismed\/article\/view\/4449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,18]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,18]]}},"URL":"https:\/\/doi.org\/10.62438\/tunismed.v102i2.4449","relation":{},"ISSN":["2724-7031","0041-4131"],"issn-type":[{"value":"2724-7031","type":"electronic"},{"value":"0041-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,18]]}}}