{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:38:49Z","timestamp":1709253529414},"reference-count":0,"publisher":"Tunisian Society of Medical Sciences","issue":"2","license":[{"start":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T00:00:00Z","timestamp":1708214400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tunis Med"],"abstract":"<jats:p>Background: Pemphigus is a therapeutically challenging disease with high morbidity and economic burden. First-line prescription of rituximab remains limited in Tunisia due to its high cost. Systemic steroids remain the standard of care but are associated with a major risk of morbidities and higher treatment costs.\nAim: To assess the direct medical costs of pemphigus in Tunisia.\nMethods: Retrospective estimation of direct medical costs during the 18 months following the diagnosis using the \u201cbottom-up approach\u201d in the Dermatology Department of Hedi Chaker Hospital, Sfax, Tunisia.\nResults: Total medical costs were estimated at 38745.7 \u20ac, with an average cost of 1 210 \u20ac per patient and per year: paraclinical investigations (46%), medical treatment (30%), hospitalization (21%) and outpatient visits (3%). The average cost was the highest in the age group of 15-24 years (1553 \u20ac). Treatment costs related to corticosteroid-induced morbidity were estimated at 1208 \u20ac.\nConclusions: The management of pemphigus in Tunisia needs to be adapted to take into account the health economic analysis in order to reduce overall disease costs and the burden of steroid-induced morbidities.<\/jats:p>","DOI":"10.62438\/tunismed.v102i2.4651","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T13:51:13Z","timestamp":1709214673000},"source":"Crossref","is-referenced-by-count":0,"title":["Direct medical cost related to the management of pemphigus: A pilot Tunisian study"],"prefix":"10.62438","volume":"102","author":[{"given":"Faten","family":"Hayder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emna","family":"Bahloul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sourour","family":"Yaich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Turki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadija","family":"Sellami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noureddine","family":"Litaiem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatem","family":"Masmoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Turki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamida","family":"Turki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31112","published-online":{"date-parts":[[2024,2,18]]},"container-title":["La Tunisie M\u00e9dicale"],"original-title":[],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T13:51:13Z","timestamp":1709214673000},"score":1,"resource":{"primary":{"URL":"https:\/\/latunisiemedicale.com\/index.php\/tunismed\/article\/view\/4651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,18]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,18]]}},"URL":"https:\/\/doi.org\/10.62438\/tunismed.v102i2.4651","relation":{},"ISSN":["2724-7031","0041-4131"],"issn-type":[{"value":"2724-7031","type":"electronic"},{"value":"0041-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,18]]}}}