{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:23:02Z","timestamp":1719966182514},"reference-count":0,"publisher":"Tunisian Society of Medical Sciences","issue":"6","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tunis Med"],"abstract":"<jats:p>Introduction : Le purpura thrombotique thrombocytop\u00e9nique (PTT) est une pathologie h\u00e9matologique rare mais potentiellement fatale en l\u2019absence d\u2019une prise en charge th\u00e9rapeutique rapide par des \u00e9changes plasmatiques (EP) qui doivent \u00eatre d\u00e9but\u00e9s en urgence.\n\u00a0Objectif : Evaluer les EP en termes de r\u00e9ponses et de complications dans le traitement du PTT.\nM\u00e9thodes : il s\u2019agit d\u2019une \u00e9tude monocentrique descriptive r\u00e9trospective incluant les PTT diagnostiqu\u00e9s et trait\u00e9s par EP au service d\u2019h\u00e9matologie clinique \u00e0 l\u2019h\u00f4pital Aziza Othmana entre Janvier 2010 et D\u00e9cembre 2020.\nR\u00e9sultats : Nous avons inclus 26 patients. Les EP \u00e9taient d\u00e9but\u00e9s dans un d\u00e9lai m\u00e9dian de 1 jour avec un rythme quotidien chez 22 patients. On a not\u00e9 20 complications, l\u2019hypocalc\u00e9mie \u00e9tait la plus fr\u00e9quente dans 30% des cas. Une r\u00e9ponse compl\u00e8te (RC) a \u00e9t\u00e9 obtenue chez 15 patients apr\u00e8s EP seuls, 9 \u00e9taient r\u00e9fractaires, 6 ont re\u00e7u un traitement de 2\u00e8me ligne avec l\u2019obtention d\u2019une RC chez 5 patients. Six patients ont rechut\u00e9 (40%), trait\u00e9s par EP et un patient a re\u00e7u le rituximab\u00a0: 4 \u00e9taient en r\u00e9ponse. Le taux de r\u00e9ponse globale \u00e9tait de 69% et la mortalit\u00e9 \u00e9tait de 30%. La SG \u00e0 2 ans \u00e9tait de 68,3% et la SSR \u00e9tait de 56,7%. La baisse des LDH \u00e0 J5 du traitement (p=0,027, OR=0,59\u00a0;IC 95%[0,32-1,08]) et le rythme quotidien des EP (p=0,005, OR=0,35\u00a0;IC 95%[0,14-0,91]) avaient un impact sur la RC.\nConclusions : Nos r\u00e9sultats en termes de r\u00e9ponse \u00e9taient comparables avec ceux de la litt\u00e9rature, mais avec un taux\u00a0 ...(r\u00e9sum\u00e9 tronqu\u00e9 \u00e0 250 mots).<\/jats:p>","DOI":"10.62438\/tunismed.v102i6.4614","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T11:11:33Z","timestamp":1719918693000},"source":"Crossref","is-referenced-by-count":0,"title":["Echanges plasmatiques au cours des purpuras thrombotiques thrombocytop\u00e9niques"],"prefix":"10.62438","volume":"102","author":[{"given":"Dorra","family":"Jabr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roua","family":"Hsasna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"K\u00e9fi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachid","family":"Kharrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hend","family":"Ben N\u00e9ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raihane","family":"Ben Lakhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31112","published-online":{"date-parts":[[2024,5,30]]},"container-title":["La Tunisie M\u00e9dicale"],"original-title":[],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T11:11:33Z","timestamp":1719918693000},"score":1,"resource":{"primary":{"URL":"https:\/\/latunisiemedicale.com\/index.php\/tunismed\/article\/view\/4614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,5,30]]}},"URL":"https:\/\/doi.org\/10.62438\/tunismed.v102i6.4614","relation":{},"ISSN":["2724-7031","0041-4131"],"issn-type":[{"value":"2724-7031","type":"electronic"},{"value":"0041-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,30]]}}}