{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:54:32Z","timestamp":1787741672358,"version":"build-2784847793"},"reference-count":0,"publisher":"Tunisian Society of Medical Sciences","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tunis Med"],"abstract":"<jats:p>Introduction\u00a0: La confirmation biologique du diagnostic de leishmaniose cutan\u00e9e (LC) ainsi que l\u2019identification de la forme en question, LC zoonotique (LCZ) et LC sporadique (LCS) ne sont pas toujours accessibles et ais\u00e9es.\nObjectif\u00a0: Etablir des crit\u00e8res \u00e9pid\u00e9miologiques et cliniques simples permettant d\u2019orienter vers le diagnostic de LC et sa forme noso-g\u00e9ographique.\nM\u00e9thodes\u00a0: Les frottis dermiques archiv\u00e9s de 227 patients suspects de LC ont \u00e9t\u00e9 examin\u00e9s au microscope puis gratt\u00e9s, les ADN extraits et test\u00e9s en PCR. Des fiches anonymes comprenant des informations \u00e9pid\u00e9miologiques et cliniques ont \u00e9t\u00e9 remplies.\nR\u00e9sultats\u00a0: Le diagnostic de LC a \u00e9t\u00e9 confirm\u00e9 chez 101 sujets positifs, 76 contamin\u00e9s au centre-sud (LCZ) et 24 au nord (LCS). Comparativement aux sujets n\u00e9gatifs, les cas av\u00e9r\u00e9s ont consult\u00e9 majoritairement entre octobre et janvier (66,3% versus 46% (p=0,003)). Leurs l\u00e9sions \u00e9taient davantage multiples (48,5% versus 32,5% (p=0,002)).\nLes cas de LCZ consultaient davantage entre octobre et janvier (73,7% versus 45,8% pour ceux de LCS (p&lt;0,01)), avaient un nombre de l\u00e9sions plus \u00e9lev\u00e9 (3,3\u00b10,4 contre 1,2\u00b10,1\u00a0; p&lt;0,0001) et des localisations pr\u00e9f\u00e9rentielles aux membres (80,3% versus 25% (p&lt;0,001)). Les l\u00e9sions de LCZ \u00e9taient plus r\u00e9centes (2,2\u00b10,2 mois d\u2019anciennet\u00e9 contre 6\u00b11,2 (p&lt;0,001)) avec un aspect ulc\u00e9ro-crouteux plus prononc\u00e9 (77,6% versus 41,6% ; p=0,009).\nConclusion\u00a0: Certaines donn\u00e9es \u00e9pid\u00e9mio-cliniques s\u2019av\u00e8rent suggestives du diagnostic de LC ainsi que de la forme noso-g\u00e9ographique de la maladie. Elles seraient utiles \u00e0 la PEC des cas particuli\u00e8rement dans les zones rurales peu \u00e9quip\u00e9es en outils performants de diagnostic et d\u2019identification d\u2019esp\u00e8ces.<\/jats:p>","DOI":"10.62438\/tunismed.v103i6.5724","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T17:00:03Z","timestamp":1765904403000},"source":"Crossref","is-referenced-by-count":1,"title":["Crit\u00e8res \u00e9pid\u00e9miologiques et cliniques d\u2019orientation du diagnostic de leishmaniose cutan\u00e9e en Tunisie"],"prefix":"10.62438","volume":"103","author":[{"given":"Karim","family":"Aoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fida","family":"Maatallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafa","family":"Aissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfa","family":"Souissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Boulehmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emna","family":"Siala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rym","family":"Ben Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00efda","family":"Bouratbine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31112","published-online":{"date-parts":[[2025,6,1]]},"container-title":["La Tunisie M\u00e9dicale"],"original-title":[],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T17:00:03Z","timestamp":1765904403000},"score":1,"resource":{"primary":{"URL":"https:\/\/latunisiemedicale.com\/index.php\/tunismed\/article\/view\/5724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,1]]}},"URL":"https:\/\/doi.org\/10.62438\/tunismed.v103i6.5724","relation":{},"ISSN":["2724-7031","0041-4131"],"issn-type":[{"value":"2724-7031","type":"electronic"},{"value":"0041-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,1]]}}}