{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:11:27Z","timestamp":1778105487591,"version":"3.51.4"},"reference-count":0,"publisher":"Tunisian Society of Medical Sciences","issue":"02","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tunis Med"],"abstract":"<jats:p>Introduction\u00a0: Le lien de causalit\u00e9 entre les troponines hypersensibles (hs-cTn) et le risque cardiovasculaire chez les adultes asymptomatiques reste insuffisamment \u00e9tabli. L\u2019objectif de cette revue syst\u00e9matique est d\u2019\u00e9tudier la valeur pronostique des hs-cTn (hs-cTnI et hs-cTnT) dans la population g\u00e9n\u00e9rale indemne de maladies cardiovasculaires, ainsi que leur capacit\u00e9 \u00e0 am\u00e9liorer la pr\u00e9diction du risque cardiovasculaire futur lorsqu\u2019elles sont int\u00e9gr\u00e9es aux mod\u00e8les classiques de stratification du risque cardiovasculaire.\nM\u00e9thodes\u00a0: La recherche a \u00e9t\u00e9 effectu\u00e9e dans les bases de donn\u00e9es \u00e9lectroniques suivantes : PubMed, Google Scholar, ScienceDirect et SpringerLink, afin d\u2019identifier les \u00e9tudes de cohorte prospectives publi\u00e9es du 01\/01\/2016 au 28\/02\/2024, portant sur la relation entre les hs-cTn et le risque cardiovasculaire chez une population adulte asymptomatique. La qualit\u00e9 des \u00e9tudes incluses a \u00e9t\u00e9 \u00e9valu\u00e9e \u00e0 l\u2019aide de l\u2019\u00e9chelle de Newcastle-Ottawa (NOS).\nR\u00e9sultats\u00a0: Les 19 \u00e9tudes incluses dans cette revue ont port\u00e9 sur un total de 250513 participants. Les r\u00e9sultats confirment une association significative entre les hs-cTn et les \u00e9v\u00e9nements cardiovasculaires \u00e9tudi\u00e9s. L\u2019ajout ce ces biomarqueurs aux mod\u00e8les classiques de pr\u00e9dictionam\u00e9liore souvent leur potentiel pr\u00e9dictif, comme en t\u00e9moigne l\u2019augmentation du C-index (Concordance index), du NRI (Net Reclassification Improvement) et de l\u2019IDI (Integrated Discrimination Improvement). La hs-cTnI et la hs-cTnT \u00e9taient mod\u00e9r\u00e9ment ou faiblement corr\u00e9l\u00e9es, mais compl\u00e9mentaires, car associ\u00e9es \u00e0 diff\u00e9rents types d\u2019\u00e9v\u00e9nements cardiovasculaires.\nConclusion\u00a0: L\u2019int\u00e9gration des hs-cTn auxscores pr\u00e9dictifs am\u00e9liore l\u00e9g\u00e8rement la pr\u00e9cision de leur pr\u00e9diction. N\u00e9anmoins,il reste n\u00e9cessaire de d\u00e9monter leur b\u00e9n\u00e9fice clinique \u00e0 travers des essais randomis\u00e9s avant leur int\u00e9gration dans les pratiques de routine.<\/jats:p>","DOI":"10.62438\/tunismed.v104i02.6337","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T21:26:55Z","timestamp":1778102815000},"source":"Crossref","is-referenced-by-count":0,"title":["Place des Troponines Hypersensibles dans l\u2019\u00e9valuation du Risque Cardiovasculaire chez les adultes asymptomatiques : Une Revue Syst\u00e9matique"],"prefix":"10.62438","volume":"104","author":[{"given":"Abderrazak","family":"Sabri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Omari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hind","family":"Kechkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Aziz","family":"Bousfiha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabiha","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31112","published-online":{"date-parts":[[2026,4,1]]},"container-title":["La Tunisie M\u00e9dicale"],"original-title":[],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T21:26:56Z","timestamp":1778102816000},"score":1,"resource":{"primary":{"URL":"https:\/\/latunisiemedicale.com\/index.php\/tunismed\/article\/view\/6337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.62438\/tunismed.v104i02.6337","relation":{},"ISSN":["2724-7031","0041-4131"],"issn-type":[{"value":"2724-7031","type":"electronic"},{"value":"0041-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}