{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:47:05Z","timestamp":1776314825319,"version":"3.50.1"},"reference-count":0,"publisher":"University Health Partners of Hawai\u02bbi","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hawai\u2018i Journal of Health &amp; Social Welfare"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>Genetic testing is recommended for young women diagnosed with breast cancer. While studies have demonstrated an increased likelihood of variants of unknown significance (VUS) among racial\/ethnic minorities compared to non-Hispanic Whites, results in the ethnically diverse population of Hawai&amp;#x2018;i are largely unknown. Additionally, current consensus guidelines dictate that VUS mutations are not clinically actionable and surgical decision-making is not standardized. This study aims to examine the utilization of genetic testing in Hawai&amp;#x2018;i and evaluate for any subsequent impacts on surgical practice patterns. A retrospective chart review of women age &amp;#x003C;45 diagnosed with breast cancer between 2016 and 2020 was performed at a single institution in Honolulu, Hawai&amp;#x2018;i. Ethnicity, cancer history, detected genes\/variants, and surgical intervention were extracted. Of 236 patients identified, 134 (56.7%) were Asian, 57 (24.1%) Native Hawaiian\/Pacific Islander (NHPI), and 45 (19.1%) Other. The majority (n=201, 85.2%) underwent genetic testing. A family history of breast cancer was predictive of testing (P&amp;#x003C;.001). The most common finding was VUS (n= 95, 47.2%) with no statistical difference by ethnicity. Pathogenic mutations were more common in Other (Non-Asian\/Non-NHPI) populations (P=.047). All patients with pathogenic mutations underwent bilateral mastectomy (n=16). In contrast, patients with VUS were more likely to undergo partial (n=53, 50.9%) or unilateral mastectomy (n=28, 26.9%) rather than bilateral mastectomy (n=21, 20.2%) regardless of tumor staging (P&amp;#x003C;.001). This study demonstrated high utilization of genetic testing among young women diagnosed with breast cancer. Pathogenic and non-pathogenic mutations varied according to race. The high prevalence of VUS in this ethnically diverse cohort emphasizes the importance of genetic testing in this population and warrants further research.<\/jats:p>","DOI":"10.62547\/zfyg5300","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T05:07:36Z","timestamp":1765429656000},"page":"251","source":"Crossref","is-referenced-by-count":0,"title":["Utilization of Genetic Testing and Surgical Implications in an Ethnically Diverse Hawaiian Population"],"prefix":"10.62547","volume":"84","author":[{"given":"Amelia","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katlyn","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Seto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Kieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeong Jun","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Marumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48151","published-online":{"date-parts":[[2025,11,1]]},"container-title":["Hawai\u2018i Journal of Health &amp; Social Welfare"],"original-title":[],"link":[{"URL":"https:\/\/hawaiijournalhealth.org\/past_issues\/hjhsw8411_0251.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:58:20Z","timestamp":1776311900000},"score":1,"resource":{"primary":{"URL":"https:\/\/hawaiijournalhealth.org\/past_issues\/hjhsw8411_0251.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,1]]},"published-print":{"date-parts":[[2025,11,1]]}},"URL":"https:\/\/doi.org\/10.62547\/zfyg5300","relation":{},"ISSN":["2641-5216","2641-5224"],"issn-type":[{"value":"2641-5216","type":"print"},{"value":"2641-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]}}}