{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T07:08:42Z","timestamp":1771139322030,"version":"3.50.1"},"reference-count":0,"publisher":"Juan Jos\u00e9 L\u00f3pez-Ibor Foundation","issue":"1","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Actas Esp Psiquiatr"],"abstract":"<jats:p>Background: Adolescents with moderate depression and suicidal ideation constitute a high-risk psychiatric population. Major depressive disorder with suicidal ideation in this age group is a disabling psychiatric disorder. Current selective serotonin reuptake inhibitor treatments are limited by their low efficacy rates (approximately 50%\u201360%) and delayed onset of action. Informed by the gut\u2013brain axis theory, this study aimed to evaluate the synergistic efficacy and anti-inflammatory mechanisms of sertraline combined with a Bacillus subtilis probiotic preparation in this high-risk population.\nMethods: This retrospective cohort study included 160 adolescents meeting International Classification of Diseases 10th Revision diagnostic criteria were identified and categorised into either monotherapy (sertraline) or combination therapy (sertraline + probiotics) groups. Over a 12-week treatment period, clinical symptoms were assessed using the Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale and Beck Scale for Suicide Ideation-Chinese Version, and serum inflammatory factors, namely, interleukin-6 (IL-6), interleukin-1\u03b2 (IL-1\u03b2), tumour necrosis factor-\u03b1 (TNF-\u03b1) and C-reactive protein (CRP) and peripheral blood inflammatory ratios, namely, platelet-to-lymphocyte, neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios, were measured.\nResults: The proportion of patients with severe depression was significantly reduced in the combination group (1.25% vs. 7.5%, p = 0.004), and anxiety symptoms showed significant improvement (severe anxiety proportion: 1.25% vs. 11.25%, p = 0.008). Biomarker analysis revealed significantly reduced levels of IL-6 (p = 0.007), IL-1\u03b2 (p = 0.002), TNF-\u03b1 (p = 0.005) and CRP (p = 0.001) in the combination group, and IL-6 and CRP showed strong positive correlations with depression scores (r = 0.35\u20130.39).\nConclusions: This study confirms that modulating the intestinal smicroecology can enhance antidepressant efficacy by reducing neuroinflammation.<\/jats:p>","DOI":"10.62641\/aep.v54i1.2127","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T06:56:27Z","timestamp":1771138587000},"page":"152-162","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Sertraline Combined With Intestinal Microecological Therapy in Adolescents With Moderate Depression and Suicidal Ideation and Its Effects on Serum Inflammatory Factors"],"prefix":"10.62641","volume":"54","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongrong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naihong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48925","published-online":{"date-parts":[[2026,2,15]]},"container-title":["Actas Espa\u00f1olas de Psiquiatr\u00eda"],"original-title":[],"link":[{"URL":"https:\/\/actaspsiquiatria.es\/index.php\/actas\/article\/download\/2127\/2815","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaspsiquiatria.es\/index.php\/actas\/article\/download\/2127\/2815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T06:56:27Z","timestamp":1771138587000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaspsiquiatria.es\/index.php\/actas\/article\/view\/2127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2,15]]}},"URL":"https:\/\/doi.org\/10.62641\/aep.v54i1.2127","relation":{},"ISSN":["1578-2735","1139-9287"],"issn-type":[{"value":"1578-2735","type":"electronic"},{"value":"1139-9287","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,15]]}}}