{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:00:38Z","timestamp":1777111238931,"version":"3.51.4"},"reference-count":16,"publisher":"Associa\u00e7\u00e3o de Medicina Intensiva Brasileira","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,28]]},"DOI":"10.62675\/2965-2774.20250159","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T14:31:07Z","timestamp":1740753067000},"source":"Crossref","is-referenced-by-count":2,"title":["Caffeine-clarithromycin coadministration and hyperlactatemia in a young infant: a case report"],"prefix":"10.62675","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4950-3760","authenticated-orcid":false,"given":"Leila Costa","family":"Volpon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7356-4021","authenticated-orcid":false,"given":"Flavia Maria","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2760-8801","authenticated-orcid":false,"given":"Ana Paula de Carvalho Panzeri","family":"Carlotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49293","reference":[{"issue":"20","key":"key20250228143103_B1","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1056\/NEJMoa054065","article-title":"Caffeine therapy for apnea of prematurity","volume":"354","author":"Schmidt","year":"2006","unstructured":"1. Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, Solimano A, Tin W; Caffeine for Apnea of Prematurity Trial Group. Caffeine therapy for apnea of prematurity. N Engl J Med. 2006;354(20):2112-21.","journal-title":"N Engl J Med"},{"issue":"2","key":"key20250228143103_B2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.xkme.2020.11.012","article-title":"Severe caffeine intoxication treated with hemodialysis: a case report","volume":"3","author":"Elbokl","year":"2021","unstructured":"2. Elbokl M, Randall I, Lok C. Severe caffeine intoxication treated with hemodialysis: a case report. Kidney Med. 2021;3(2):299-302.","journal-title":"Kidney Med"},{"key":"key20250228143103_B3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jpeds.2016.04.060","article-title":"Caffeine for the treatment of apnea in bronchiolitis: a randomized trial","volume":"177","author":"Alansari","year":"2016","unstructured":"3. Alansari K, Toaimah FH, Khalafalla H, El Tatawy LA, Davidson BL, Ahmed W. Caffeine for the treatment of apnea in bronchiolitis: a randomized trial. J Pediatr. 2016;177:204-211.e3.","journal-title":"J Pediatr"},{"issue":"7","key":"key20250228143103_B4","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/j.1399-6576.2008.01680.x","article-title":"Caffeine poisoning and lactate rise: an overlooked toxic effect?","volume":"52","author":"Schmidt","year":"2008","unstructured":"4. Schmidt A, Karlson-Stiber C. Caffeine poisoning and lactate rise: an overlooked toxic effect? Acta Anaesthesiol Scand. 2008;52(7):1012-4.","journal-title":"Acta Anaesthesiol Scand"},{"issue":"3","key":"key20250228143103_B5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ams2.28","article-title":"Plasma lactate concentration as an indicator of plasma caffeine concentration in acute caffeine poisoning","volume":"1","author":"Morita","year":"2014","unstructured":"5. Morita S, Yamagiwa T, Aoki H, Sakurai K, Inokuchi S. Plasma lactate concentration as an indicator of plasma caffeine concentration in acute caffeine poisoning. Acute Med Surg. 2014;1(3):159-62.","journal-title":"Acute Med Surg"},{"key":"key20250228143103_B6","author":"Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria (ANVISA)","unstructured":"6. Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria (ANVISA). Consultas. Bul\u00e1rio Eletr\u00f4nico. [citado 2023 Ago 13]. ANVISA; sd. Disponivel em: https:\/\/consultas.anvisa.gov.br\/#\/bulario\/q\/?numeroRegistro=102350482.","journal-title":"Consultas. Bul\u00e1rio Eletr\u00f4nico"},{"issue":"10","key":"key20250228143103_B7","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1080\/15563650.2021.1891243","article-title":"Massive suicidal ingestion of caffeine: a case report with investigation of the cardiovascular effect\/concentration relationships","volume":"59","author":"Gr\u00e9main","year":"2021","unstructured":"7. Gr\u00e9main V, Chevillard L, Saussereau E, Schnell G, M\u00e9garbane B. Massive suicidal ingestion of caffeine: a case report with investigation of the cardiovascular effect\/concentration relationships. Clin Toxicol (Phila). 2021;59(10):937-41.","journal-title":"Clin Toxicol (Phila)"},{"issue":"5","key":"key20250228143103_B8","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1542\/peds.99.5.736","article-title":"Intentional caffeine poisoning in an infant","volume":"99","author":"Rivenes","year":"1997","unstructured":"8. Rivenes SM, Bakerman PR, Miller MB. Intentional caffeine poisoning in an infant. Pediatrics. 1997;99(5):736-8.","journal-title":"Pediatrics"},{"issue":"5","key":"key20250228143103_B9","doi-asserted-by":"crossref","DOI":"10.3390\/nu10050611","article-title":"Caffeine-related deaths: manner of deaths and categories at risk","volume":"10","author":"Cappelletti","year":"2018","unstructured":"9. Cappelletti S, Piacentino D, Fineschi V, Frati P, Cipolloni L, Aromatario M. Caffeine-related deaths: manner of deaths and categories at risk. Nutrients. 2018;10(5):611.","journal-title":"Nutrients"},{"issue":"3","key":"key20250228143103_B10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/0310057X9902700316","article-title":"Caffeine overdose in a premature infant: clinical course and pharmacokinetics","volume":"27","author":"Anderson","year":"1999","unstructured":"10. Anderson BJ, Gunn TR, Holford NH, Johnson R. Caffeine overdose in a premature infant: clinical course and pharmacokinetics. Anaesth Intensive Care. 1999;27(3):307-11.","journal-title":"Anaesth Intensive Care"},{"issue":"5","key":"key20250228143103_B11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/jp.2010.126","article-title":"Apnea of prematurity: pathogenesis and management strategies","volume":"31","author":"Mathew","year":"2011","unstructured":"11. Mathew OP. Apnea of prematurity: pathogenesis and management strategies. J Perinatol. 2011;31(5):302-10.","journal-title":"J Perinatol"},{"key":"key20250228143103_B12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jpeds.2017.08.064","article-title":"Caffeine citrate dosing adjustments to assure stable caffeine concentrations in preterm neonates","volume":"191","author":"Koch","year":"2017","unstructured":"12. Koch G, Datta AN, Jost K, Schulzke SM, van den Anker J, Pfister M. Caffeine citrate dosing adjustments to assure stable caffeine concentrations in preterm neonates. J Pediatr. 2017;191:50-56.e1.","journal-title":"J Pediatr"},{"issue":"12","key":"key20250228143103_B13","article-title":"Methylxanthine treatment for apnoea in preterm infants","author":"Henderson-Smart","year":"2010","unstructured":"13. Henderson-Smart DJ, De Paoli AG. Methylxanthine treatment for apnoea in preterm infants. Cochrane Database Syst Rev. 2010;(12):CD000140.","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"key20250228143103_B14","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2174\/138920008784220664","article-title":"Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4","volume":"9","author":"Zhou","year":"2008","unstructured":"14. Zhou SF. Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr Drug Metab. 2008;9(4):310-22.","journal-title":"Curr Drug Metab"},{"issue":"7","key":"key20250228143103_B15","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s40264-020-00930-7","article-title":"Evidence of clinically meaningful drug-drug interaction with concomitant use of colchicine and clarithromycin","volume":"43","author":"Villa Zapata","year":"2020","unstructured":"15. Villa Zapata L, Hansten PD, Horn JR, Boyce RD, Gephart S, Subbian V, et al. Evidence of clinically meaningful drug-drug interaction with concomitant use of colchicine and clarithromycin. Drug Saf. 2020;43(7):661-8.","journal-title":"Drug Saf"},{"issue":"4","key":"key20250228143103_B16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0736-4679(01)00379-1","article-title":"An unusual case of clarithromycin associated ergotism","volume":"21","author":"Ausband","year":"2001","unstructured":"16. Ausband SC, Goodman PE. An unusual case of clarithromycin associated ergotism. J Emerg Med. 2001;21(4):411-3.","journal-title":"J Emerg Med"}],"container-title":["Critical Care Science"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T14:31:12Z","timestamp":1740753072000},"score":1,"resource":{"primary":{"URL":"https:\/\/criticalcarescience.org\/article\/caffeine-clarithromycin-coadministration-and-hyperlactatemia-in-a-young-infant-a-case-report\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":16,"alternative-id":["10.62675\/2965-2774.20250159"],"URL":"https:\/\/doi.org\/10.62675\/2965-2774.20250159","relation":{},"ISSN":["2965-2774"],"issn-type":[{"value":"2965-2774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20250159"}}