{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:31:50Z","timestamp":1773268310674,"version":"3.50.1"},"reference-count":0,"publisher":"Annali Italiani di Chirurgia","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann. Ital. Chir."],"abstract":"<jats:p>AIM: Soft tissue sarcomas are rare, accounting for only 1% of adult malignancies, with liposarcoma being a common subtype. However, mediastinal liposarcomas are extremely uncommon, comprising less than 1% of cases. Dedifferentiated liposarcoma (DDLPS) is a particularly aggressive variant, characterized by a transition from well-differentiated to high-grade non-lipogenic sarcoma. Due to its rarity and often asymptomatic nature until significant progression, mediastinal DDLPS presents a unique diagnostic and therapeutic challenge. CASE PRESENTATION: An 83-year-old woman with ischemic heart disease presented with progressive dyspnea over two months. Imaging revealed a giant, well-circumscribed mediastinal mass (21 \u00d7 23 \u00d7 25 cm), occupying 80% of the thoracic cavity and causing significant pulmonary compression and mediastinal shift. A multidisciplinary tumor board recommended surgical resection. RESULTS: Initial uniportal video-assisted thoracic surgery exploration confirmed no pleural invasion. This was followed by a posterolateral thoracotomy for complete tumor excision. The patient recovered without complications. Histopathology confirmed DDLPS with complex histological architecture, including both well-differentiated and dedifferentiated sarcomatous components. The patient is disease-free three years postoperatively. CONCLUSIONS: Our case report emphasizes the requirement of a multidisciplinary approach to treat massive chest malignancy. Complete surgical resection remains the gold standard to obtain long-term survival.<\/jats:p>","DOI":"10.62713\/aic.4072","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:08:36Z","timestamp":1773112116000},"source":"Crossref","is-referenced-by-count":0,"title":["Giant Dedifferentiated Liposarcoma of the Mediastinum"],"prefix":"10.62713","volume":"97","author":[{"given":"Jibran Ahmad","family":"Khan","sequence":"first","affiliation":[{"name":"College of Medicine, Alfaisal University, 11533 Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Umair","family":"Aleem","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University, 11533 Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turki","family":"Alhawiti","sequence":"additional","affiliation":[{"name":"Thoracic Surgery & Lung Transplant, Lung Health Centre, Organ Transplant Center of Excellence (OTCoE), King Faisal Specialist Hospital & Research Center, 11211 Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Nardini","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Leeds Teaching Hospitals NHS Trust, LS9 7TF Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Broggi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cG.F. Ingrassia\u201d, Anatomic Pathology, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Magro","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cG.F. Ingrassia\u201d, Anatomic Pathology, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Migliore","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University, 11533 Riyadh, Saudi Arabia"},{"name":"Thoracic Surgery & Lung Transplant, Lung Health Centre, Organ Transplant Center of Excellence (OTCoE), King Faisal Specialist Hospital & Research Center, 11211 Riyadh, Saudi Arabia"},{"name":"Department of General Surgery and Medical Specialties, University of Catania, 95131 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48935","published-online":{"date-parts":[[2026,3,10]]},"container-title":["Annali Italiani di Chirurgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.annaliitalianidichirurgia.it\/journal\/AIC\/97\/3\/10.62713\/aic.4072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:38:17Z","timestamp":1773211097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.annaliitalianidichirurgia.it\/journal\/AIC\/97\/3\/10.62713\/aic.4072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"alternative-id":["S0003-469X(26)00039-0"],"URL":"https:\/\/doi.org\/10.62713\/aic.4072","relation":{},"ISSN":["0003-469X","2239-253X"],"issn-type":[{"value":"0003-469X","type":"print"},{"value":"2239-253X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]},"article-number":"435"}}