{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:50:48Z","timestamp":1776325848876,"version":"3.50.1"},"reference-count":0,"publisher":"Annali Italiani di Chirurgia","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann. Ital. Chir."],"abstract":"<jats:p>AIM: Colorectal adenocarcinoma in young adults should prompt evaluation for hereditary syndromes such as familial adenomatous polyposis (FAP), attenuated FAP, MUTYH-associated polyposis (MAP) and other inherited cancer predisposition syndromes. The purpose of this case report is to highlight management options of incidental MAP diagnosis. CASE PRESENTATION: We report the case of a 41-year-old man presenting to the emergency department with intestinal obstruction due to adenocarcinoma of the splenic flexure, colonic polyposis with rectal sparing, and a significant family history of cancer. RESULTS: After successful endoscopic stenting, a multidisciplinary approach including surgical resection, adjuvant treatment and genetic counseling was carried out. CONCLUSIONS: A minimally invasive subtotal colectomy was proposed to a 41-year-old man whose genetic testing for polyposis and hereditary cancer syndromes revealed a rare homozygotic variation of uncertain significance (VUS)+ in the MUTYH gene. Absence of rectal involvement made rectal sparing possible in association with close endoscopic follow-up.<\/jats:p>","DOI":"10.62713\/aic.4277","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:57:23Z","timestamp":1775807843000},"source":"Crossref","is-referenced-by-count":0,"title":["Multistage Management of Splenic Flexure Adenocarcinoma in Suspected MUTYH-Associated Polyposis: A Case Report"],"prefix":"10.62713","volume":"97","author":[{"given":"Andrea","family":"Costanzi","sequence":"first","affiliation":[{"name":"General Surgery Residency Program, University of Milan, 20122 Milano, Italy"},{"name":"General Surgery Unit, San Leopoldo Mandic Hospital, ASST Lecco, 23807 Merate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto","family":"Tapia Gomez","sequence":"additional","affiliation":[{"name":"General Surgery Residency Program, University of Milan, 20122 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Schievano","sequence":"additional","affiliation":[{"name":"General Surgery Residency Program, University of Milan, 20122 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"General Surgery Unit, San Leopoldo Mandic Hospital, ASST Lecco, 23807 Merate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Olmetti","sequence":"additional","affiliation":[{"name":"General Surgery Unit, San Leopoldo Mandic Hospital, ASST Lecco, 23807 Merate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Scaini","sequence":"additional","affiliation":[{"name":"General Surgery Unit, San Leopoldo Mandic Hospital, ASST Lecco, 23807 Merate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"General Surgery Unit, San Leopoldo Mandic Hospital, ASST Lecco, 23807 Merate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Bonfanti","sequence":"additional","affiliation":[{"name":"General Surgery Unit, San Leopoldo Mandic Hospital, ASST Lecco, 23807 Merate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Canfora","sequence":"additional","affiliation":[{"name":"General Surgery Unit, San Leopoldo Mandic Hospital, ASST Lecco, 23807 Merate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi","family":"Bicelli","sequence":"additional","affiliation":[{"name":"General Surgery Unit, San Leopoldo Mandic Hospital, ASST Lecco, 23807 Merate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Carissimi","sequence":"additional","affiliation":[{"name":"General Surgery Unit, San Leopoldo Mandic Hospital, ASST Lecco, 23807 Merate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Fazzini","sequence":"additional","affiliation":[{"name":"General Surgery Unit, San Leopoldo Mandic Hospital, ASST Lecco, 23807 Merate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Bonfanti","sequence":"additional","affiliation":[{"name":"General Surgery Unit, San Leopoldo Mandic Hospital, ASST Lecco, 23807 Merate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Sassun","sequence":"additional","affiliation":[{"name":"General Surgery Unit, Pio XI Hospital, ASST Brianza, 20832 Desio, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48935","published-online":{"date-parts":[[2026,4,10]]},"container-title":["Annali Italiani di Chirurgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.annaliitalianidichirurgia.it\/journal\/AIC\/97\/4\/10.62713\/aic.4277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:07:49Z","timestamp":1776323269000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.annaliitalianidichirurgia.it\/journal\/AIC\/97\/4\/10.62713\/aic.4277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"alternative-id":["S0003-469X(26)00059-0"],"URL":"https:\/\/doi.org\/10.62713\/aic.4277","relation":{},"ISSN":["0003-469X","2239-253X"],"issn-type":[{"value":"0003-469X","type":"print"},{"value":"2239-253X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"article-number":"625"}}