{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:18:41Z","timestamp":1778318321868,"version":"3.51.4"},"reference-count":0,"publisher":"Annali Italiani di Chirurgia","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann. Ital. Chir."],"abstract":"<jats:p>AIM: To investigate the clinical value of early (\u22647 days) versus delayed (&gt;6 weeks) laparoscopic cholecystectomy (LC) after ultrasound-guided percutaneous transhepatic gallbladder drainage (PTGBD) in high-risk acute cholecystitis (AC), with PTGBD serving as a bridging intervention. METHODS: A retrospective analysis was performed on 110 high-risk AC patients admitted between August 2021 and January 2025. Patients were divided into an early LC group (52 cases) and a delayed LC group (58 cases). Surgical indicators, inflammatory response control, hospitalization duration, treatment costs, quality of life, and postoperative complications were compared between the two groups. RESULTS: The early LC group demonstrated significantly superior outcomes in operative time (22.51 \u00b1 4.32 vs. 65.28 \u00b1 15.12 minutes, p &lt; 0.001), intraoperative blood loss (12.16 \u00b1 2.13 vs. 52.47 \u00b1 6.11 mL, p &lt; 0.001), length of hospital stay (7.12 \u00b1 0.58 vs. 10.11 \u00b1 1.62 days, p &lt; 0.001), and total treatment costs (2.36 \u00b1 0.32 vs. 3.80 \u00b1 0.52 ten thousand yuan, p &lt; 0.001, 1 dollar = 6.91 yuan). The incidence of moderate to severe adhesions was significantly lower in the early LC group (28.85% vs. 56.90%, p = 0.003). However, the delayed LC group exhibited lower postoperative C-reactive protein levels (12.45 \u00b1 2.23 vs. 15.32 \u00b1 2.78 mg\/L, p &lt; 0.001) and procalcitonin levels (0.25 \u00b1 0.06 vs. 0.38 \u00b1 0.05 ng\/mL, p &lt; 0.001), as well as significantly higher quality-of-life scores at 3 months postoperatively (all p &lt; 0.001). No statistically significant differences were observed in complication rates (9.62% vs. 15.52%) or conversion-to-laparotomy rates (3.85% vs. 10.34%) between groups (p &gt; 0.05). CONCLUSIONS: Early LC following PTGBD effectively shortens overall treatment duration, reduces healthcare costs, and lowers surgical complexity. However, careful consideration should be given to the potential influence of residual inflammation on long-term quality of life. Further multi-center prospective studies are warranted to validate long-term safety and to optimize individualized treatment strategies.<\/jats:p>","DOI":"10.62713\/aic.4479","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:03:07Z","timestamp":1778317387000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Clinical Efficacy of Early Versus Delayed Laparoscopic Cholecystectomy Following Ultrasound-Guided Percutaneous Transhepatic Gallbladder Drainage"],"prefix":"10.62713","volume":"97","author":[{"given":"Rui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Suizhou Central Hospital, 441300 Suizhou, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangwu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Imaging, Pu Ren Hospital Affiliated to Wuhan University of Science and Technology, 430081 Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Huanggang Central Hospital, 438000 Huanggang, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Emergency, Huanggang Central Hospital, 438000 Huanggang, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48935","published-online":{"date-parts":[[2026,5,10]]},"container-title":["Annali Italiani di Chirurgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.annaliitalianidichirurgia.it\/journal\/AIC\/97\/5\/10.62713\/aic.4479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:03:14Z","timestamp":1778317394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.annaliitalianidichirurgia.it\/journal\/AIC\/97\/5\/10.62713\/aic.4479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,10]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"alternative-id":["S0003-469X(26)00084-0"],"URL":"https:\/\/doi.org\/10.62713\/aic.4479","relation":{},"ISSN":["0003-469X","2239-253X"],"issn-type":[{"value":"0003-469X","type":"print"},{"value":"2239-253X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,10]]},"article-number":"841"}}