{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:44:52Z","timestamp":1791949492246,"version":"4.3.4"},"reference-count":0,"publisher":"Annali Italiani di Chirurgia","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann. Ital. Chir."],"abstract":"AIM: This study aims to evaluate whether short-course mifepristone pre-treatment improves procedural efficiency and early recovery after uterine artery embolization (UAE), followed by dilation and curettage (D&C) for cesarean scar pregnancy.METHODS: This retrospective study recruited 108 patients with cesarean scar pregnancy who underwent dilation and D&C between January 2020 and July 2023. Patients were divided into 2 groups according to the pre-treatment approach. The control group (n = 65) received pre-treatment with UAE alone, while the study group (n = 43) received pre-treatment with mifepristone in addition to the treatment used in the control group. The two groups were compared for operative metrics, early recovery, and postoperative adverse events. Serum \u03b2-human chorionic gonadotrophin (\u03b2-hCG) levels were evaluated upon admission and again on postoperative day 1. Patients were followed for one year to assess pregnancy-related outcomes, and the findings were compared between the two groups.RESULTS: In the study group, the surgery duration was shorter, and the intraoperative blood loss was lower than in the control group (p < 0.05). The length of hospital stay was comparable between the two groups (p > 0.05). Similarly, the incidences of repeat D&C, massive hemorrhage, and re-embolization of the uterine artery were also comparable between groups (p > 0.05). There were no cases of conversion to laparotomy or hysterectomy in either group. At the time of admission, the \u03b2-hCG levels in the study group were not significantly different from those in the control group. However, on the first day after the procedure, the \u03b2-hCG levels in the study group were lower than those in the control group, but the difference did not reach statistical significance (p = 0.051). The study group had a shorter duration of vaginal bleeding and achieved normal menstrual function earlier than the control group (p < 0.05). The menstrual cycle was comparable between the two groups (p > 0.05). The incidences of fever, gastrointestinal symptoms, abnormal liver function, and intrauterine adhesions were also comparable between the two groups (p > 0.05). Follow-up analysis showed no significant differences between the two groups in subsequent pregnancy or recurrence of cesarean scar pregnancy (p > 0.05). Time to pregnancy was descriptively reported only among patients who achieved pregnancy and was not statistically compared because of the small number of events. CONCLUSIONS: Incorporating short-course mifepristone pre-treatment to a standard uterine artery embolization\u2013D&C strategy for cesarean scar pregnancy was associated with shorter operative time and better early recovery profiles, with satisfactory safety outcomes.<\/jats:p>","DOI":"10.62713\/aic.4535","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:47:15Z","timestamp":1791946035000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of Adjunctive Mifepristone Pre-treatment on Operative Efficiency and Postoperative Recovery in Cesarean Scar Pregnancy Undergoing Curettage After Uterine Artery Embolization"],"prefix":"10.62713","volume":"97","author":[{"given":"Jiajin","family":"Lv","sequence":"first","affiliation":[{"name":"Gynecology Department, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, 314000 Jiaxing, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafei","family":"Pan","sequence":"additional","affiliation":[{"name":"Gynecology Department, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, 314000 Jiaxing, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Weng","sequence":"additional","affiliation":[{"name":"Gynecology Department, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, 314000 Jiaxing, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Gynecology Department, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, 314000 Jiaxing, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Li","sequence":"additional","affiliation":[{"name":"Doppler Ultrasonic Department, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, 314000 Jiaxing, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Gynecology Department, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, 314000 Jiaxing, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Gynecology Department, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, 314000 Jiaxing, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48935","published-online":{"date-parts":[[2026,10,14]]},"container-title":["Annali Italiani di Chirurgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.annaliitalianidichirurgia.it\/journal\/AIC\/97\/10\/10.62713\/aic.4535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:47:17Z","timestamp":1791946037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.annaliitalianidichirurgia.it\/journal\/AIC\/97\/10\/10.62713\/aic.4535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2239-253X(26)00223-0"],"URL":"https:\/\/doi.org\/10.62713\/aic.4535","relation":{},"ISSN":["0003-469X","2239-253X"],"issn-type":[{"value":"0003-469X","type":"print"},{"value":"2239-253X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"article-number":"1872"}}