{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:18:41Z","timestamp":1778318321855,"version":"3.51.4"},"reference-count":0,"publisher":"Annali Italiani di Chirurgia","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann. Ital. Chir."],"abstract":"<jats:p>AIM: To evaluate the association between preoperative systemic inflammatory indices (systemic immune-inflammation index [SII], systemic inflammation response index [SIRI], and aggregate index of systemic inflammation [AISI]) and poor visual outcomes following cataract surgery. METHODS: This retrospective study included 240 patients who underwent cataract surgery between April 2022 and June 2025. SII, SIRI, and AISI were calculated from complete blood counts obtained within 7 days preoperatively. Poor visual outcome at 4 weeks postoperatively was analyzed using multivariable logistic regression and restricted cubic spline models, with adjustment for potential confounders. RESULTS: The mean age was 69 years, and 67.1% of participants were female. SII demonstrated a nonlinear association with poor postoperative visual outcomes (p for nonlinearity = 0.029), with increased odds observed at SII values of 500\u20131000 and at extremely low levels. Compared with the lowest tertile, the highest SII tertile was associated with a significantly increased risk (adjusted odds ratio [OR] 2.790, 95% confidence interval [CI] 1.209\u20136.615; p = 0.018). After adjustment for sex, body mass index (BMI), and intraocular pressure, SIRI (tertile 3 vs. tertile 1: OR 2.019, 95% CI 1.035\u20133.997; p = 0.041) and AISI (tertile 2 vs. tertile 1: OR 1.977, 95% CI 1.017\u20133.898; p = 0.046) were also associated with poor visual outcomes. In multivariable analyses, SII and AISI remained independently associated with poor postoperative vision (OR 2.790, 95% CI 1.209\u20136.615; p = 0.018; OR 2.104, 95% CI 1.016\u20134.432; p = 0.047). CONCLUSIONS: Preoperative SII, SIRI, and AISI were significantly associated with worse short-term visual outcomes after cataract surgery. These indices, particularly SII and AISI, may provide clinically useful information for perioperative risk stratification. Further prospective validation studies and investigation of targeted anti-inflammatory strategies are warranted.<\/jats:p>","DOI":"10.62713\/aic.4639","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:51:53Z","timestamp":1778230313000},"source":"Crossref","is-referenced-by-count":0,"title":["Association Between Preoperative Systemic Inflammatory Indices and Visual Outcomes After Cataract Surgery"],"prefix":"10.62713","volume":"97","author":[{"given":"Gaofang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), 563000 Zunyi, Guizhou, China"},{"name":"Zunyi Medical University, 563002 Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), 563000 Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), 563000 Zunyi, Guizhou, China"},{"name":"Zunyi Medical University, 563002 Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), 563000 Zunyi, Guizhou, China"},{"name":"Zunyi Medical University, 563002 Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), 563000 Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohan","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), 563000 Zunyi, Guizhou, China"},{"name":"Zunyi Medical University, 563002 Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penghao","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), 563000 Zunyi, Guizhou, China"},{"name":"Zunyi Medical University, 563002 Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48935","published-online":{"date-parts":[[2026,5,8]]},"container-title":["Annali Italiani di Chirurgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.annaliitalianidichirurgia.it\/journal\/AIC\/97\/5\/10.62713\/aic.4639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:03:22Z","timestamp":1778317402000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.annaliitalianidichirurgia.it\/journal\/AIC\/97\/5\/10.62713\/aic.4639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"alternative-id":["S0003-469X(26)00077-0"],"URL":"https:\/\/doi.org\/10.62713\/aic.4639","relation":{},"ISSN":["0003-469X","2239-253X"],"issn-type":[{"value":"0003-469X","type":"print"},{"value":"2239-253X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"article-number":"799"}}