{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:05:45Z","timestamp":1779365145624,"version":"3.53.0"},"reference-count":0,"publisher":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Crit Care Med (Targu Mures)"],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:p>Background: This study aimed to evaluate the prognostic value of key admission biomarkers in predicting mortality among hospitalized COVID-19 patients and to establish optimal cut-off thresholds for clinical decision-making.\nMethods: Retrospective cohort study included 269 COVID-19 patients treated at Thu Duc City Hospital, Vietnam, during the peak of the fourth pandemic wave in 2021. Logistic regression identified independent predictors of mortality, and receiver operating characteristic (ROC) curve analysis assessed the diagnostic performance of biomarkers. The area under the ROC curve (AUROC), Sensitivity, Specificity and Accuracy Index were used to determine optimal cut-off values.\nResults: Among the 269 patients, 53 (19.7%) died and 216 (80.3%) survived. Non-survivors exhibited elevated D-dimer (4.48 \u03bcg\/mL vs 0.93 \u03bcg\/mL, p   0.0001), neutrophil counts (6.8 \u00d7 10\u2079\/L vs 3.5 \u00d7 10\u2079\/L, p   0.0001) and white blood cell counts (11.68 \u00d7 10\u2079\/L vs. 7.87 \u00d7 10\u2079\/L, p   0.0001). Lymphocyte counts and fibrinogen levels were significantly lower in non-survivors (p   0.05). Logistic regression identified D-dimer (OR = 1.05, 95% CI: 1.02\u20131.09, p = 0.001), neutrophil counts (OR = 1.32, 95% CI: 1.10\u20131.63, p = 0.005) and lymphocyte counts (OR = 0.51, 95% CI: 0.26\u20130.92, p = 0.033) as significant predictors of mortality. ROC analysis revealed that D-dimer (AUROC = 0.809) and neutrophil counts (AUROC = 0.726) demonstrated strong discriminatory power, with cut-off values of  \u22651.126 \u03bcg\/mL (sensitivity = 90.57%, specificity = 60.19%) and \u22656.715 \u00d7 10\u2079\/L (sensitivity = 52.83%, specificity = 82.87%), respectively. \nConclusion: These findings support the use of admission biomarkers to guide early interventions and improve patient outcomes in severe COVID-19 cases. Further studies are warranted to validate these results and explore their applicability in other settings.<\/jats:p>","DOI":"10.62838\/jccm-2026-0003","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:06:20Z","timestamp":1779361580000},"page":"158-166","source":"Crossref","is-referenced-by-count":0,"title":["Admission biomarkers and COVID-19 mortality: A retrospective study during Vietnam\u2019s pandemic peak"],"prefix":"10.62838","volume":"12","author":[{"name":"Department of Nephrology and Hemodialysis, Le Van Viet Hospital, Ho Chi Minh City, Vietnam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Thanh","family":"Tran-Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hau Phuc","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Outpatient Clinic for HIV-AIDS Patients, Chau Thanh District Medical Center, Tra Vinh Province, Vietnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu Hoang Anh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Psychosomatic Medicine, Thu Duc City Hospital, Ho Chi Minh City, Vietnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Thanh","family":"Tran-Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Psychosomatic Medicine, Thu Duc City Hospital, Ho Chi Minh City, Vietnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49540","published-online":{"date-parts":[[2026,4,30]]},"container-title":["Journal of Critical Care Medicine"],"original-title":[],"link":[{"URL":"https:\/\/ojs.jccm.ro\/index.php\/jccm\/article\/view\/87\/20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:06:22Z","timestamp":1779361582000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jccm.ro\/index.php\/jccm\/article\/view\/87"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,30]]},"published-print":{"date-parts":[[2026,4,30]]}},"URL":"https:\/\/doi.org\/10.62838\/jccm-2026-0003","relation":{},"ISSN":["2393-1809","2393-1817"],"issn-type":[{"value":"2393-1809","type":"print"},{"value":"2393-1817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}