{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:05:45Z","timestamp":1779365145652,"version":"3.53.0"},"reference-count":0,"publisher":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Crit Care Med (Targu Mures)"],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:p>Introduction: Severe COVID-19 is known to cause kidney injury via ACE2-mediated mechanisms, inflammation, and microvascular damage potentially leading to long-term renal impairment. Critically ill patients are particularly vulnerable  to muscle loss and sarcopenia due to immobility, poor nutrition, and cytokine storm\u2013induced catabolism. Post-COVID-19 syndrome often includes fatigue, muscle weakness, and reduced quality of life,  yet  evidence on long-term outcomes remains limited. This study evaluated kidney function, sarcopenia risk, and quality of life 12 months after intensive care unit (ICU) discharge in patients without pre-existing chronic kidney disease (CKD).\nMethods: This retrospective observational cohort included 82 patients without CKD admitted to the ICU between February 2020 and April 2022 who recovered from severe COVID-19. Data collected included serum creatinine, estimated glomerular filtration rate (eGFR), and sarcopenia risk assessed via the SARC-CalF (SARC-F combined with calf circumference). Functional outcomes were assessed by SF-36, pain by a Visual Analog Scale (VAS), and lower limb strength by the 30-second sit-to-stand test.\nResults: The mean age was 52 \u00b1 12 years; 90% were male, 46% had hypertension, and 31% diabetes. At 12 months, patients showed low functional scores (SF-36: 47 \u00b1 21), high pain prevalence (VAS: 57%), reduced lower limb strength (sit-to-stand: 8 \u00b1 5 repetitions), and high sarcopenia risk (SARC-F: 46%). Higher sarcopenia scores correlated with poorer physical functioning (r = -0.60; p   0.001) and greater pain (r = -0.44; p   0.001). In 49 patients without hypertension, diabetes, or prior acute kidney injury (AKI), creatinine significantly increased (0.95 \u00b1 0.2 to 1.10 \u00b1 0.2 mg\/dL; p = 0.007) and eGFR significantly declined (87 \u00b1 22 to 77 \u00b1 18 mL\/min; p = 0.001), representing a mean reduction of 10 mL\/min.<\/jats:p>","DOI":"10.62838\/jccm-2026-0004","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:06:20Z","timestamp":1779361580000},"page":"167-175","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of muscle strength and renal function in survivors of severe COVID-19: A 12-month follow-up study"],"prefix":"10.62838","volume":"12","author":[{"name":"Universidade Nove de Julho - Campus Vergueiro, S\u00e3o Paulo, Brazil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Marco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayane Marlla Silva","family":"Leite Montenegro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Instituto Federal de Pernambuco: Instituto Federal de Educacao Ciencia e Tecnologia de Pernambuco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Cassula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Universidade Nove de Julho - Campus Vergueiro, S\u00e3o Paulo, Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayline","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Universidade Nove de Julho - Campus Vergueiro, S\u00e3o Paulo, Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Lima da Silva Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Universidade Nove de Julho - Campus Vergueiro, S\u00e3o Paulo, Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosani Teresa","family":"De Siqueira e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Universidade Nove de Julho - Campus Vergueiro, S\u00e3o Paulo, Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosilene","family":"Motta Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Universidade Nove de Julho - Campus Vergueiro, S\u00e3o Paulo, Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\tAparecida","family":"Dalboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49540","published-online":{"date-parts":[[2026,4,30]]},"container-title":["Journal of Critical Care Medicine"],"original-title":[],"link":[{"URL":"https:\/\/ojs.jccm.ro\/index.php\/jccm\/article\/view\/88\/19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:06:22Z","timestamp":1779361582000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jccm.ro\/index.php\/jccm\/article\/view\/88"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,30]]},"published-print":{"date-parts":[[2026,4,30]]}},"URL":"https:\/\/doi.org\/10.62838\/jccm-2026-0004","relation":{},"ISSN":["2393-1809","2393-1817"],"issn-type":[{"value":"2393-1809","type":"print"},{"value":"2393-1817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}