{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:05:03Z","timestamp":1779365103395,"version":"3.53.0"},"reference-count":0,"publisher":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Crit Care Med (Targu Mures)"],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:p>Background: Acute kidney injury (AKI) is a common and serious complication in critically ill patients with non-kidney organ dysfunction. Early prediction of AKI is crucial for timely intervention and improved outcomes. This study aimed to identify readily available non-renal predictors of AKI and to develop an exploratory prediction model in a specific cohort of critically ill patients with COVID-19-related septic shock requiring mechanical ventilation.\nMaterials and methods: This was a single-center, observational, retrospective cohort study conducted in the respiratory ICU of Hospital H+ Quer\u00e9taro between April and December 2020. The study included 42 mechanically ventilated patients with septic shock secondary to SARS-CoV-2 infection and non-kidney organ dysfunction. AKI was defined using the KDIGO criteria. Trend analysis, bivariate and multivariate linear regression, were used to identify predictors of AKI and severe AKI.\nResults: AKI occurred in 23 (54.8%) patients, with 6 (14.3%) developing severe AKI. Trend analysis revealed differences in norepinephrine dose, hemoglobin, and lactate trends between groups. A simplified logistic regression model, validated internally with bootstrapping to prevent overfitting, identified a protective trend associated with higher hemoglobin levels on admission. Quantitative analysis of a forecasting model for daily renal function showed moderate predictive accuracy.\nConclusions: This study identified several readily available non-kidney organ dysfunction variables that can predict AKI and its severity in critically ill patients with COVID-19-related septic shock. These findings may help in the early identification of at-risk patients and facilitate timely interventions to potentially improve outcomes. Further validation in larger and more diverse populations is warranted.<\/jats:p>","DOI":"10.62838\/jccm-2026-0005","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:06:20Z","timestamp":1779361580000},"page":"176-185","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of acute kidney injury in mechanically ventilated patients with COVID-19-related septic shock:  An exploratory analysis of non-renal organ dysfunction markers"],"prefix":"10.62838","volume":"12","author":[{"name":"Centro Uniersitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose J.","family":"Zaragoza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Ch\u00e1vez-I\u00f1iguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Nephrology Department, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Vazquez-Rangel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Nephrology Department, Instituto Nacional de Cardiologia, Mexico City, Mexico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49540","published-online":{"date-parts":[[2026,4,30]]},"container-title":["Journal of Critical Care Medicine"],"original-title":[],"link":[{"URL":"https:\/\/ojs.jccm.ro\/index.php\/jccm\/article\/view\/89\/33","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:06:23Z","timestamp":1779361583000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jccm.ro\/index.php\/jccm\/article\/view\/89"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,30]]},"published-print":{"date-parts":[[2026,4,30]]}},"URL":"https:\/\/doi.org\/10.62838\/jccm-2026-0005","relation":{},"ISSN":["2393-1809","2393-1817"],"issn-type":[{"value":"2393-1809","type":"print"},{"value":"2393-1817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}