{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:10:35Z","timestamp":1784826635236,"version":"3.55.0"},"reference-count":0,"publisher":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Crit Care Med (Targu Mures)"],"published-print":{"date-parts":[[2026,7,30]]},"abstract":"<jats:p>Objectives: The early diagnosis and prognostication of severity in sepsis plays a crucial role in determining appropriate treatment strategies. This study aimed to assess the role of cheaper prognostic factors including lactate\/albumin ratio and platelet count in patients with sepsis as they are correlated with the rate of multiorgan failure, and mortality rate. Methods: A cross-sectional study was conducted on 146 adult patients diagnosed with sepsis and septic shock according to the Sepsis-3 definition. All patients were admitted at either the intensive care unit of Hue University of Medicine and Pharmacy Hospital or Hue Central Hospital. Results: Average age of patients was 67 years-old, with 37.7% having sepsis and 62.3% with septic shock. The overall mortality rate in the study was 51.4% (75\/146 patients). Forty six patients (32.5%) had thrombocytopenia, with mild, moderate, and severe decreases accounting for 8.9%, 21.2%, and 1.4%, respectively. The lactate\/albumin ratio with a cutoff of 2.1 was the best prognostic factor for mortality with an AUROC of 0.76, sensitivity of 58.7%, and specificity of 88.7% compared to other biomarkers including lactate (AUROC = 0.71), albumin (AUROC = 0.74), platelet count (AUROC = 0.65), white blood cell count (AUROC = 0.48), procalcitonin (AUROC = 0.43), and BE (AUROC = 0.44). Multivariate regression analysis identified the L\/A ratio, platelet count, SOFA score as significant predictors of mortality? in sepsis. Conclusion: The lactate\/albumin ratio with a cutoff of 2.1 is an available effective tool for severity prognosis of patients with sepsis\/septic shock in developing countries.<\/jats:p>","DOI":"10.62838\/jccm-2026-0033","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:36:59Z","timestamp":1784824619000},"page":"401-408","source":"Crossref","is-referenced-by-count":0,"title":["Prioritized factors of severity prognosis in? patients admitted for sepsis or septic shock in? a resource-limited region of central Vietnam"],"prefix":"10.62838","volume":"12","author":[{"name":"Hue University of Medicine and Pharmacy, Hue University","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thinh","family":"Tran Xuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"Truong Thuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Anesthesiology, Vinmec Nha Trang International Hospital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh","family":"Nguyen Van","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Hue University of Medicine and Pharmacy, Hue University","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao Khoa","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhan","family":"Phuc Thanh Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PhD student, Faculty of Public Health, Thammasat University, Rangsit campus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thong","family":"Tran Huu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Center for Emergency Medicine, Bach Mai Hospital, Hano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Stanford University","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thang","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Hue University of Medicine and Pharmacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49540","published-online":{"date-parts":[[2026,7,30]]},"container-title":["Journal of Critical Care Medicine"],"original-title":[],"link":[{"URL":"https:\/\/ojs.jccm.ro\/index.php\/JCCM\/article\/view\/11\/40","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:37:03Z","timestamp":1784824623000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jccm.ro\/index.php\/JCCM\/article\/view\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,7,30]]},"published-print":{"date-parts":[[2026,7,30]]}},"URL":"https:\/\/doi.org\/10.62838\/jccm-2026-0033","relation":{},"ISSN":["2393-1809","2393-1817"],"issn-type":[{"value":"2393-1809","type":"print"},{"value":"2393-1817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}