{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T09:06:44Z","timestamp":1765184804904},"reference-count":0,"publisher":"Editorial Office of Chinese Journal of Applied Physiology","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJAP"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>Introduction: The traditional medicinal system of India, Ayurveda, has mentioned Cordia Dichotoma as a potential treatment for various ailments. In the current research, the extracts of Cordia Dichotoma was examined to evaluate their antidepressant potential. Materials and methods: Here, green leaves of Cordia Dichotoma were used to prepare chloroform, ethanol, and aqueous extracts (referred to as CdCe, CdEe, and CdAe respectively). The research focused on investigating the antidepressant effects of these extracts using behavioral models in experimental animals. Additionally, locomotor activity was assessed as part of the evaluation process. Results: Immobility time was reduced with CdEe Cordia Dichotoma rFST &amp; mTST when at 200 mg\/kg and 400 mg\/kg body weight. The CdAe showed reduction in immobility time in the repeated rFST) at 400 mg\/kg, while in the mTST, significant effects were observed at 200 and 400 mg\/kg. Regarding the chloroform extract, it only exhibited a significant reduction in immobility time in the modified Tail Suspension Test (mTST) at a low dose of 200 mg\/kg. However, no noticeable change in motor dysfunction was observed with CCl4 and aqueous extracts at doses of 200 and 400 mg\/kg. It is worth noting that the chloroform extract (CdCe) did lead to a significant decrease in locomotor activity at the same dosage level. Taken together, these findings suggest that extracts obtained from Cordia Dichotoma leaves may possess antidepressant properties.<\/jats:p>","DOI":"10.62958\/j.cjap.2024.020","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T01:28:02Z","timestamp":1724722082000},"page":"e20240020","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Antidepresant Activity and Phytochemical Screening of Plant Cordia Dichotoma"],"prefix":"10.62958","volume":"40","author":[{"name":"Professor ,Chandigarh Pharmacy College-Jhanjeri, Chandigarh Group of Colleges- Jhanjeri (Mohali) Punjab 140307, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Sudan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkateswara Rao","family":"Jallepalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Assistant Professor, Dept of Pharmacy Practice,MB School of Pharmaceutical Sciences, Mohan Babu University, Tirupati, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Ramu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Professor,Depaertment of Pharmaceutics, K.V.K College of Pharmacy, Surmaiguda, Hyderabad, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhargav","family":"Bhongiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Associate Director,Department of Pharmacology, Synpharma Research Lab, Dilsukhnagar,  Hyderabad, Telangana 500060, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S D Shanmuga","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Associate professor, Dept., Pharmaceutical Chemistry, Jyothismathi Institute of Pharmaceutical Sciences, Affliated to JNTUH, Thimmapur(M), Karimnagar, Telangana, 505527, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meruva sathish","family":"kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Associate Professor,M.N.R College of Pharmacy, MNR Higher Education and Research Academy Campus, Fasalwadi (V), Sangareddy, Telangana, 502294, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V Ravi","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Professor,M.N.R College of Pharmacy, MNR Higher Education and Research Academy Campus, Fasalwadi (V), Sangareddy, Telangana, 502294, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49313","published-online":{"date-parts":[[2024]]},"container-title":["Chinese Journal of Applied Physiology"],"original-title":[],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T01:28:03Z","timestamp":1724722083000},"score":1,"resource":{"primary":{"URL":"http:\/\/47.94.85.12:8889\/article\/1828242138695196672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"URL":"https:\/\/doi.org\/10.62958\/j.cjap.2024.020","relation":{},"ISSN":["1000-6834"],"issn-type":[{"value":"1000-6834","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}