{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:04:05Z","timestamp":1747886645714,"version":"3.41.0"},"reference-count":0,"publisher":"Editorial Office of Chinese Journal of Applied Physiology","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJAP"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Purpose: Nanogels (NGs) represent a new generation of nanoscale hydrogel particles with immense biomedical applications, especially drug delivery System (DDS). Nanogels (NGs) are soft and water-retentive materials that deliver drugs in controlled and sustained release while maintaining high biocompatibility and biodegradability. \nMethod: This review paper primarily focuses on the applications, mechanism, therapies. The capability to react with environmental signals, such as pH, temperature, or enzymatic activity, makes nanogels a promising platform for targeted therapy. Polysaccharide-based nanogels increase biocompatibility and reduce toxicity, allowing for extended therapeutic applications. \nResult: This reviews the structural properties, drug release mechanisms, and newer developments in nanogel formulations. It also presents the future outlook for nanogels in precision medicine, highlighting their potential in transcending pharmacological obstacles towards enhancing drug delivery and therapeutic efficacies in various branches of medicine. \nConclusion: By overcoming existing drawbacks, nanogels have the potential to revolutionize drug delivery and therapeutic interventions in diverse clinical settings.<\/jats:p>","DOI":"10.62958\/j.cjap.2025.006","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T03:05:31Z","timestamp":1747796731000},"page":"e20250006","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic Insights and Emerging Applications of Nanogel-Based Topical Drug Delivery Systems"],"prefix":"10.62958","author":[{"name":"Department of Pharmaceutical Chemistry, SMBT college of Pharmacy, Dhamangaon, Nashik, Affiliated to Savitribai Phule Pune University, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Kumbhare","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1764-6070","authenticated-orcid":false,"given":"Prajakta","family":"Shinde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pharmaceutics, SMBT college of Pharmacy, Dhamangaon, Nashik, Affiliated to Savitribai Phule Pune University, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49313","published-online":{"date-parts":[[2025]]},"container-title":["Chinese Journal of Applied Physiology"],"original-title":[],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T03:05:31Z","timestamp":1747796731000},"score":1,"resource":{"primary":{"URL":"http:\/\/47.94.85.12:8889\/article\/1924634851862081536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"URL":"https:\/\/doi.org\/10.62958\/j.cjap.2025.006","relation":{},"ISSN":["1000-6834"],"issn-type":[{"value":"1000-6834","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}