{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:08:57Z","timestamp":1789150137063,"version":"build-2803163510"},"reference-count":30,"publisher":"Molecular Vision","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":81,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the potential protective effects of fluvoxamine (FVX), a selective serotonin reuptake inhibitor with known anti-inflammatory properties, on corneal, limbal, and retinal tissues in a rat model of endotoxin-induced uveitis (EIU), clinical and histopathologic evaluations were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-eight female Wistar Albino rats were divided into four groups: controls, EIU, EIU + FVX, and FVX (n = 7 per group). EIU was induced by a single intraperitoneal injection of lipopolysaccharide (LPS). FVX or normal saline (NS) was administered 30 min before LPS or NS injection. Clinical ocular inflammation was assessed using slit-lamp biomicroscopy 6 h postinjection. Following euthanasia, enucleated eyes were processed for histopathologic analysis of corneal, limbal, and retinal tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total corneal and epithelial thickness were measured, while limbal and retinal lesions were semiquantitatively graded. The EIU group exhibited significantly increased clinical ocular inflammation scores compared to the control, EIU + FVX, and FVX groups (p &amp;lt; 0.0001 for all). At the microscopical analysis, the EIU group showed significant corneal epithelial thickening, cellular changes, edema, hemorrhage, and increased total corneal thickness compared to the control group (p &amp;lt; 0.001). In addition, histopathologic analysis revealed retinal hyperemia and edema in the EIU group but not in the EIU + FVX, FVX, or control groups. Histopathologic scores confirmed significant retinal changes in the EIU group compared to the others (p &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FVX significantly reduced clinical signs of ocular inflammation and mitigated histopathologic damage in the cornea, limbus, and retina.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.63500\/mv_v32_255","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:31:54Z","timestamp":1789147914000},"page":"255-263","source":"Crossref","is-referenced-by-count":0,"title":["Anti-inflammatory action of fluvoxamine in an endotoxin-induced uveitis rat model: Histopathological evidence"],"prefix":"10.63500","volume":"32","author":[{"given":"G\u00fcl\u015fah Usta","family":"Sofu","sequence":"first","affiliation":[{"name":"Suleyman Demirel University, Faculty of Medicine, Department of Ophthalmology, Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"A\u015fc\u0131","sequence":"additional","affiliation":[{"name":"Suleyman Demirel University, Faculty of Medicine, Department of Pharmacology, Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eerife","family":"Ta\u015fan","sequence":"additional","affiliation":[{"name":"Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Laboratory Animals Production and Experimental Research Center, Burdur, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"\u00d6zkaya","sequence":"additional","affiliation":[{"name":"Suleyman Demirel University, Faculty of Medicine, Department of Ophthalmology, Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9818-5212","authenticated-orcid":true,"given":"Simge","family":"Garl\u0131","sequence":"additional","affiliation":[{"name":"Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Laboratory Animals Production and Experimental Research Center, Burdur, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"52877","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"2026091113314222900_r1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s11926-006-0006-6","article-title":"Uveitis: advances in understanding of pathogenesis and treatment","volume":"8","author":"Read","year":"2006","journal-title":"Curr Rheumatol Rep"},{"key":"2026091113314222900_r2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.iio.0000155938.83083.94","article-title":"Epidemiology of 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